LOCUS       NM_015897               3069 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein inhibitor of activated STAT 4 (PIAS4), mRNA.
ACCESSION   NM_015897
VERSION     NM_015897.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Han,M.M., Hirakawa,M., Yamauchi,M. and Matsuda,N.
  TITLE     Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA
            double-strand break repair by homologous recombination
  JOURNAL   Biochem Biophys Res Commun 591, 95-101 (2022)
   PUBMED   35007836
  REMARK    GeneRIF: Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4,
            in DNA double-strand break repair by homologous recombination.
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Krastev,D.B., Li,S., Sun,Y., Wicks,A.J., Hoslett,G., Weekes,D.,
            Badder,L.M., Knight,E.G., Marlow,R., Pardo,M.C., Yu,L.,
            Talele,T.T., Bartek,J., Choudhary,J.S., Pommier,Y., Pettitt,S.J.,
            Tutt,A.N.J., Ramadan,K. and Lord,C.J.
  TITLE     The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1
            from chromatin
  JOURNAL   Nat Cell Biol 24 (1), 62-73 (2022)
   PUBMED   35013556
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Xing,Z., Wang,X., Liu,J., Liu,G., Zhang,M., Feng,K. and Wang,X.
  TITLE     Effect of MiR-210 on the Chemosensitivity of Breast Cancer by
            Regulating JAK-STAT Signaling Pathway
  JOURNAL   Biomed Res Int 2021, 7703159 (2021)
   PUBMED   34423038
  REMARK    GeneRIF: Effect of MiR-210 on the Chemosensitivity of Breast Cancer
            by Regulating JAK-STAT Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Yu,F., Wei,J., Cui,X., Yu,C., Ni,W., Bungert,J., Wu,L., He,C. and
            Qian,Z.
  TITLE     Post-translational modification of RNA m6A demethylase ALKBH5
            regulates ROS-induced DNA damage response
  JOURNAL   Nucleic Acids Res 49 (10), 5779-5797 (2021)
   PUBMED   34048572
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Sachdev,S., Bruhn,L., Sieber,H., Pichler,A., Melchior,F. and
            Grosschedl,R.
  TITLE     PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1
            activity by sequestration into nuclear bodies
  JOURNAL   Genes Dev 15 (23), 3088-3103 (2001)
   PUBMED   11731474
REFERENCE   7  (bases 1 to 3069)
  AUTHORS   Gross,M., Liu,B., Tan,J., French,F.S., Carey,M. and Shuai,K.
  TITLE     Distinct effects of PIAS proteins on androgen-mediated gene
            activation in prostate cancer cells
  JOURNAL   Oncogene 20 (29), 3880-3887 (2001)
   PUBMED   11439351
REFERENCE   8  (bases 1 to 3069)
  AUTHORS   Nelson,V., Davis,G.E. and Maxwell,S.A.
  TITLE     A putative protein inhibitor of activated STAT (PIASy) interacts
            with p53 and inhibits p53-mediated transactivation but not
            apoptosis
  JOURNAL   Apoptosis 6 (3), 221-234 (2001)
   PUBMED   11388671
REFERENCE   9  (bases 1 to 3069)
  AUTHORS   Liu,B., Gross,M., ten Hoeve,J. and Shuai,K.
  TITLE     A transcriptional corepressor of Stat1 with an essential LXXLL
            signature motif
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3203-3207 (2001)
   PUBMED   11248056
REFERENCE   10 (bases 1 to 3069)
  AUTHORS   Liu,B., Liao,J., Rao,X., Kushner,S.A., Chung,C.D., Chang,D.D. and
            Shuai,K.
  TITLE     Inhibition of Stat1-mediated gene activation by PIAS1
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10626-10631 (1998)
   PUBMED   9724754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016586.9.
            
            On Nov 23, 2018 this sequence version replaced NM_015897.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022481.1, SRR3476690.849332.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262971.3/ ENSP00000262971.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC016586.9         32773-32824
            53-479              AC016586.9         37960-38386
            480-564             AC016586.9         49073-49157
            565-606             AC016586.9         53183-53224
            607-697             AC016586.9         53547-53637
            698-826             AC016586.9         53757-53885
            827-932             AC016586.9         53968-54073
            933-1006            AC016586.9         58137-58210
            1007-1167           AC016586.9         58457-58617
            1168-1298           AC016586.9         62411-62541
            1299-3069           AC016586.9         62653-64423
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3069
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /note="protein inhibitor of activated STAT 4"
                     /db_xref="GeneID:51588"
                     /db_xref="HGNC:HGNC:17002"
                     /db_xref="MIM:605989"
     exon            1..52
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1558
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /EC_number="2.3.2.27"
                     /note="protein inhibitor of activated STAT protein PIASy;
                     zinc finger, MIZ-type containing 6; protein inhibitor of
                     activated STAT protein 4; protein inhibitor of activated
                     STAT protein gamma; RING-type E3 ubiquitin transferase
                     PIAS4"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS4"
                     /protein_id="NP_056981.2"
                     /db_xref="CCDS:CCDS12118.1"
                     /db_xref="GeneID:51588"
                     /db_xref="HGNC:HGNC:17002"
                     /db_xref="MIM:605989"
                     /translation="MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQ
                     LVQFDCSPELFKKIKELYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTPLA
                     GPNIDYPVLYGKYLNGLGRLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQ
                     ESPCIFALTPRQVELIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNH
                     SYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLV
                     RQLTSSELLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLS
                     VPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSECED
                     ADEIEYLVDGSWCPIRAEKERSCSPQGAILVLGPSDANGLLPAPSVNGSGALGSTGGG
                     GPVGSMENGKPGADVVDLTLDSSSSSEDEEEEEEEEEDEDEEGPRPKRRCPFQKGLVP
                     AC"
     exon            53..479
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            480..564
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            565..606
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            607..697
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..826
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            827..932
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1006
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1167
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1298
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..3069
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /note="hexamer: AATAAA"
     polyA_site      3069
                     /gene="PIAS4"
                     /gene_synonym="PIAS-gamma; Piasg; PIASY; ZMIZ6"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggggg acgctggtga ccaagatggc ggcggagctg gtggaggcca aaaacatggt
       61 gatgagtttt cgagtctccg accttcagat gctcctgggt ttcgtgggcc ggagtaagag
      121 tggactgaag cacgagctcg tcaccagggc cctccagctg gtgcagtttg actgtagccc
      181 tgagctgttc aagaagatca aggagctgta cgagacccgc tacgccaaga agaactcgga
      241 gcctgcccca cagccgcacc ggcccctgga ccccctgacc atgcactcca cctacgaccg
      301 ggccggcgct gtgcccagga ctccgctggc aggccccaat attgactacc ccgtgctcta
      361 cggaaagtac ttaaacggac tgggacggtt gcccgccaag accctcaagc cagaagtccg
      421 cctggtgaag ctgccgttct ttaatatgct ggatgagctg ctgaagccca ccgaattagt
      481 cccacagaac aacgagaagc ttcaggagag cccgtgcatc ttcgcattga cgccaagaca
      541 ggtggagttg atccggaact ccagggaact gcagcccgga gttaaagccg tgcaggtcgt
      601 cctgagaatc tgttactcag acaccagctg ccctcaggag gaccagtacc cgcccaacat
      661 cgctgtgaag gtcaaccaca gctactgctc cgtcccgggc tactacccct ccaataagcc
      721 cggggtggag cccaagaggc cgtgccgccc catcaacctc acccacctca tgtacctgtc
      781 ctcggccacc aaccgcatca ctgtcacctg ggggaactac ggcaagagct actcggtggc
      841 cctgtacctg gtgcggcagc tgacctcatc ggagctgctg cagaggctga agaccattgg
      901 ggtaaagcac ccggagctgt gcaaggcact ggtcaaggag aagctgcgcc ttgatcctga
      961 cagcgagatc gccaccaccg gtgtgcgggt gtccctcatc tgtccgctgg tgaagatgcg
     1021 gctctccgtg ccctgccggg cagagacctg tgcccacctg cagtgcttcg acgccgtctt
     1081 ctacctgcag atgaacgaga agaagcccac ctggatgtgc cccgtgtgcg acaagccagc
     1141 cccctacgac cagctcatca tcgacgggct cctctcgaag atcctgagcg agtgtgagga
     1201 cgccgacgag atcgagtacc tggtggacgg ctcgtggtgc ccgatccgcg ccgaaaagga
     1261 gcgcagctgc agcccgcagg gcgccatcct cgtgctgggc ccctcggacg ccaatgggct
     1321 cctgcccgcc cccagcgtca acgggagcgg tgccctgggc agcacgggtg gcggcggccc
     1381 ggtgggcagc atggagaatg ggaagccggg cgccgatgtg gtggacctca cgctggacag
     1441 ctcatcgtcc tcggaggatg aggaggagga ggaagaggag gaggaagacg aggacgaaga
     1501 ggggccccgg cccaagcgcc gctgcccctt ccagaagggc ctggtgccgg cctgctgacc
     1561 ccggccgcac actcgacttt cctggtgctc accacgcaga ggggcacggg ccagcctcgg
     1621 gcgcagaggg aggagtgacc tttctttttc tttttattgt cgttcgtttt gtttttccac
     1681 ccttttgcct ggctcctggc acctgtacct ctggactctc ctatcggggg attaaaaaaa
     1741 aaagtaaaat gacaaaaaaa gatacaaaaa agaaaaatga aacaaaaaag tcaaactctt
     1801 aaaaacaagg ccggccaccc acacagccgc ctccccggct ggagtccgag ccgggaaggg
     1861 gtagtgggcg ggagggacca ggacgccgcc ccgcgccctc ccctccggat gccccgccgc
     1921 ccgccgccct ctgcccacga ccattccagc cagtgcgcgg ggacccgggc ggcgggcggt
     1981 ggggcgcagc ccctctctgg cgaccacttt gacgtttgtc tcttcctttg ctttttctct
     2041 gcaaatgcat cctcgcccag agaccctcac gcgccgagca gcgagcgttt tagccgagaa
     2101 gccatggagt gggttggggc ggggaggggc agtagggtgg ggggatgggt gggcaggatg
     2161 ggggtacagt gggcggctgg ggagggttta gccacagatg tgttgtattt tttgaaagtg
     2221 caataatttg gtattttgaa gacccggcgt gtggtcagga acccccgggg aaggcggggg
     2281 cccagggtgc ggcaccgtgt ggcgtggggg ggtctcagtt ttctagccag ctacctcggt
     2341 aattccaatt caggttaact tccctacgga acagcacaga tgtccacaga tgtccacagc
     2401 tgccgccgcc gccgccgcca ccataccccg gtccttgggg catgggttgc ggtcgcttcc
     2461 caaggggcag cagggacccc ggccaccccg gctctcggtt tgggttgatt cctctccttt
     2521 ttgctcttgg ttttccgacg ggtacgaggc tggcccggca ccctgtcccc cgggagcctc
     2581 actcttccag caggaccaga ccaggggcct ccttcctgtc cccaggcgtt cccggcccct
     2641 cgcaggcccc acccatgccc ttggcctcag ggtccaacaa ctgggggagc taccagggct
     2701 ctgccttcag gagcccacag ctgggcaccc cccttgcccc gcaggagacc ggggcgcagg
     2761 cggggcaccg gcctcacctg gttctccaac accgctgcct gcggtctgtt ttgcttttgt
     2821 cctccccagc ccagaatttt cctttgtata aacagaactc ctagtcagga agcaatatca
     2881 tttcaggtct aaagaaaggg acgtgcatct ggccgagggc agttcagtct cactgcagag
     2941 cccgcagccc gctgcgcagc tcggcccctc ccgcccgcac gggcagctga aggccgctgt
     3001 tttctaatat ttgtattcta atttaattgt ttttaaaaaa tgcaaataaa aaaggtcgag
     3061 gtgaagcca
//
