LOCUS       NM_006099               2902 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens protein inhibitor of activated STAT 3 (PIAS3), mRNA.
ACCESSION   NM_006099
VERSION     NM_006099.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Jansen,L.R., Welch,M.A., Plant,L.D. and Baro,D.J.
  TITLE     Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel
            SUMOylation
  JOURNAL   Cell Commun Signal 22 (1), 422 (2024)
   PUBMED   39223673
  REMARK    GeneRIF: Crosstalk between PKA and PIAS3 regulates cardiac Kv4
            channel SUMOylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Li,C., Wang,R., Zhang,Y., Hu,C. and Ma,Q.
  TITLE     PIAS3 suppresses damage in an Alzheimer's disease cell model by
            inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway
  JOURNAL   Mol Med 27 (1), 150 (2021)
   PUBMED   34837964
  REMARK    GeneRIF: PIAS3 suppresses damage in an Alzheimer's disease cell
            model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Zhao,Q., Zhao,F., Liu,C., Xu,T. and Song,K.
  TITLE     LncRNA FOXD2-AS1 promotes cell proliferation and invasion of
            fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3
            pathway in rheumatoid arthritis
  JOURNAL   Autoimmunity 54 (5), 254-263 (2021)
   PUBMED   34030529
  REMARK    GeneRIF: LncRNA FOXD2-AS1 promotes cell proliferation and invasion
            of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3
            pathway in rheumatoid arthritis.
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Jiang,M., Zhang,W., Zhang,R., Liu,P., Ye,Y., Yu,W., Guo,X. and
            Yu,J.
  TITLE     Cancer exosome-derived miR-9 and miR-181a promote the development
            of early-stage MDSCs via interfering with SOCS3 and PIAS3
            respectively in breast cancer
  JOURNAL   Oncogene 39 (24), 4681-4694 (2020)
   PUBMED   32398867
  REMARK    GeneRIF: Cancer exosome-derived miR-9 and miR-181a promote the
            development of early-stage MDSCs via interfering with SOCS3 and
            PIAS3 respectively in breast cancer.
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Kotaja,N., Aittomaki,S., Silvennoinen,O., Palvimo,J.J. and
            Janne,O.A.
  TITLE     ARIP3 (androgen receptor-interacting protein 3) and other PIAS
            (protein inhibitor of activated STAT) proteins differ in their
            ability to modulate steroid receptor-dependent transcriptional
            activation
  JOURNAL   Mol Endocrinol 14 (12), 1986-2000 (2000)
   PUBMED   11117529
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   Junicho,A., Matsuda,T., Yamamoto,T., Kishi,H., Korkmaz,K.,
            Saatcioglu,F., Fuse,H. and Muraguchi,A.
  TITLE     Protein inhibitor of activated STAT3 regulates androgen receptor
            signaling in prostate carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 278 (1), 9-13 (2000)
   PUBMED   11071847
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Rodel,B., Tavassoli,K., Karsunky,H., Schmidt,T., Bachmann,M.,
            Schaper,F., Heinrich,P., Shuai,K., Elsasser,H.P. and Moroy,T.
  TITLE     The zinc finger protein Gfi-1 can enhance STAT3 signaling by
            interacting with the STAT3 inhibitor PIAS3
  JOURNAL   EMBO J 19 (21), 5845-5855 (2000)
   PUBMED   11060035
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Ueki,N., Seki,N., Yano,K., Saito,T., Masuho,Y. and Muramatsu,M.
  TITLE     Isolation and chromosomal assignment of a human gene encoding
            protein inhibitor of activated STAT3 (PIAS3)
  JOURNAL   J Hum Genet 44 (3), 193-196 (1999)
   PUBMED   10319586
REFERENCE   10 (bases 1 to 2902)
  AUTHORS   Chung,C.D., Liao,J., Liu,B., Rao,X., Jay,P., Berta,P. and Shuai,K.
  TITLE     Specific inhibition of Stat3 signal transduction by PIAS3
  JOURNAL   Science 278 (5344), 1803-1805 (1997)
   PUBMED   9388184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE247489.1, AK027557.1 and
            AL160282.18.
            
            On Sep 22, 2006 this sequence version replaced NM_006099.2.
            
            Summary: This gene encodes a member of the PIAS [protein inhibitor
            of activated STAT (signal transducer and activator of
            transcription)] family of transcriptional modulators. The protein
            functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which
            catalyzes the covalent attachment of a SUMO protein to specific
            target substrates. It directly binds to several transcription
            factors and either blocks or enhances their activity. Alternatively
            spliced transcript variants of this gene have been identified, but
            the full-length nature of some of these variants has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030556.1, AK027557.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393045.7/ ENSP00000376765.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BE247489.1         1-1
            2-830               AK027557.1         1-829
            831-831             AL160282.18        141683-141683
            832-2902            AK027557.1         831-2901
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..2902
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /note="protein inhibitor of activated STAT 3"
                     /db_xref="GeneID:10401"
                     /db_xref="HGNC:HGNC:16861"
                     /db_xref="MIM:605987"
     exon            1..115
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1978
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /note="zinc finger, MIZ-type containing 5; protein
                     inhibitor of activated STAT protein 3; E3 SUMO-protein
                     transferase PIAS3"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS3"
                     /protein_id="NP_006090.2"
                     /db_xref="CCDS:CCDS72866.1"
                     /db_xref="GeneID:10401"
                     /db_xref="HGNC:HGNC:16861"
                     /db_xref="MIM:605987"
                     /translation="MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHL
                     LKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLA
                     PGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHF
                     TFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGK
                     LCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYL
                     VRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRL
                     TVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCS
                     DCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDL
                     TIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFL
                     SSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDALGHFFQYRGTP
                     SHFLGPLAPTLGSSHCSATPAPPPGRVSSIVAPGGALREGHGGPLPSGPSLTGCRSDI
                     ISLD"
     exon            116..533
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            534..618
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            619..669
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            670..760
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            761..895
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1001
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1075
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1236
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1370
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1539
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1673
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1711
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2902
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2883..2888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /note="hexamer: AATAAA"
     polyA_site      2902
                     /gene="PIAS3"
                     /gene_synonym="ZMIZ5"
                     /note="major polyA site"
ORIGIN      
        1 ggcatttgcg gccggcgcca gggtggagag ttgtgcgccg gtccctgggc ctgagctccg
       61 gctccggctg gggcgcctgc gatgtctcaa gatggcggag ctgggcgaat taaagcacat
      121 ggtgatgagt ttccgggtgt ctgagctcca ggtgcttctt ggctttgctg gccggaacaa
      181 gagtggacgg aagcacgagc tcctggccaa ggctctgcac ctcctgaagt ccagctgtgc
      241 ccctagtgtc cagatgaaga tcaaagagct ttaccgacga cgctttcccc ggaagaccct
      301 ggggccctct gatctctccc ttctctcttt gccccctggc acctctcctg taggctcccc
      361 tggtcctcta gctcccattc ccccaacgct gttggcccct ggcaccctgc tgggccccaa
      421 gcgtgaggtg gacatgcacc cccctctgcc ccagcctgtg caccctgatg tcaccatgaa
      481 accattgccc ttctatgaag tctatgggga gctcatccgg cccaccaccc ttgcatccac
      541 ttctagccag cggtttgagg aagcgcactt tacctttgcc ctcacacccc agcaagtgca
      601 gcagattctt acatccagag aggttctgcc aggagccaaa tgtgattata ccatacaggt
      661 gcagctaagg ttctgtctct gtgagaccag ctgcccccag gaagattatt ttccccccaa
      721 cctctttgtc aaggtcaatg ggaaactgtg ccccctgccg ggttaccttc ccccaaccaa
      781 gaatggggcc gagcccaaga ggcccagccg ccccatcaac atcacacccc tggctcgact
      841 ctcagccact gttcccaaca ccattgtggt caattggtca tctgagttcg gacggaatta
      901 ctccttgtct gtgtacctgg tgaggcagtt gactgcagga acccttctac aaaaactcag
      961 agcaaagggt atccggaacc cagaccactc gcgggcactg atcaaggaga aattgactgc
     1021 tgaccctgac agtgaggtgg ccactacaag tctccgggtg tcactcatgt gcccgctagg
     1081 gaagatgcgc ctgactgtcc cttgtcgtgc cctcacctgc gcccacctgc agagcttcga
     1141 tgctgccctt tatctacaga tgaatgagaa gaagcctaca tggacatgtc ctgtgtgtga
     1201 caagaaggct ccctatgaat ctcttatcat tgatggttta tttatggaga ttcttagttc
     1261 ctgttcagat tgtgatgaga tccaattcat ggaagatgga tcctggtgcc caatgaaacc
     1321 caagaaggag gcatctgagg tttgcccccc gccagggtat gggctggatg gcctccagta
     1381 cagcccagtc caggggggag atccatcaga gaataagaag aaggtcgaag ttattgactt
     1441 gacaatagaa agctcatcag atgaggagga tctgccccct accaagaagc actgttctgt
     1501 cacctcagct gccatcccgg ccctacctgg aagcaaagga gtcctgacat ctggccacca
     1561 gccatcctcg gtgctaagga gccctgctat gggcacgttg ggtggggatt tcctgtccag
     1621 tctcccacta catgagtacc cacctgcctt cccactggga gccgacatcc aaggtttaga
     1681 tttattttca tttcttcaga cagagagtca gcactatggc ccctctgtca tcacctcact
     1741 agatgaacag gatgcccttg gccacttctt ccagtaccga gggacccctt ctcactttct
     1801 gggcccactg gcccccacgc tggggagctc ccactgcagc gccactccgg cgccccctcc
     1861 tggccgtgtc agcagcattg tggcccctgg gggggccttg agggaggggc atggaggacc
     1921 cctgccctca ggtccctctt tgactggctg tcggtcagac atcatttccc tggactgagt
     1981 tccctggatt atggaaactt cgctgtcccc caacactgag caagtatgct gtggagtccc
     2041 aaccccagct actctgatcc ctctgggggc tctggccaag ggccagacag accttcacag
     2101 atgcctactt ttggcctcat ctctgcctga caaggccagc acccaaaggg ttaatattta
     2161 acctcttttt aaggacactg gggtctgttt ctggaaatgt tctttagatg gtggcacatt
     2221 cctttgggta tgttaaccta ggcagtggga ggcaaatggg atggtatgtg agctaggaga
     2281 agggctgaac cctcagcctt gactatgtct agagcctctt ggggaagggg cacctctctt
     2341 gaaccccaaa tgctctctct tcttattacc caaacccatg gctctatttc ttcttcacat
     2401 ccattgtctc ttcatgtcta ttccattccc ttcggccaaa cagacaggtg gaaaaactga
     2461 gacaggcagt ttcagagatg gacagagaac tttattttgg attgtggatg tggacttttt
     2521 tgtacataaa taagaaaaac caaaatactc caaagatgac ttcccctgcc tcctactcca
     2581 gtatgacaga ggaggatgta aggccttagc catgatctgc aggggtctgg gagtcaggcc
     2641 cggcctattg cttgggtctc tctctattta tatatctaag ttcacagtgt ttcttattcc
     2701 cccctaagct tctagaggct catggccctg tagttaggcc tggctcattc tgcacctttc
     2761 cagggaggtg gaaggaccct gtgccctcct tcccaatctt ctttttcagg ctcgccaagg
     2821 cctaggacct atgttgtaat tttacttttt atttctaaag ttgtagtgaa gctctcaccc
     2881 ataataaagg ttgtgaatgt tc
//
