LOCUS       XM_011522126            9084 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein inhibitor of activated STAT 1
            (PIAS1), transcript variant X1, mRNA.
ACCESSION   XM_011522126
VERSION     XM_011522126.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011522126.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..9084
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /note="protein inhibitor of activated STAT 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 7 mRNAs, 79 ESTs, 1549 long SRA reads, 14 Proteins,
                     and 99% coverage of the annotated genomic feature by
                     RNAseq alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
     CDS             1090..3072
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS1 isoform X1"
                     /protein_id="XP_011520428.1"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
                     /translation="MKLNGKRNHNYKSYYECQMVMSLRVSELQVLLGYAGRNKHGRKH
                     ELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPST
                     IPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELI
                     KPTSLASDNSQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSC
                     PQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIV
                     VSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIA
                     TTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPY
                     EHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKKEVQEVSASYNGVDGCLSSTLE
                     HQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRTCPSLSPTSPLNNKGILSLP
                     HQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYN
                     TSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPTTNGSSSGSNSSL
                     VSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD"
ORIGIN      
        1 gacagacgca agatggcgga cagtgcggaa ctaaaggtaa agcgcagctc gaattcactt
       61 ctaatattcg gccgcggaga cggcgccgct gctgccaggg gggatgggtc cgaccctggg
      121 gggcctctcg ggcctgactc cacccgggcc tggagttgta gggagagagg cgcgcccggt
      181 ctcagcagag ggggcccgcc tgcggcgggc cgcgggcccc gggtgcctcg ggggcgctga
      241 cgggtcgtcc ccggcgtgtt attgttgtgg gcgcctctgg cgggggtggc gggggaagag
      301 atagggagtc cggaggtagg ggctgcagct gtctcatggg ctcggctttt tcaccttcca
      361 gttagcctcc ctgcccccca tggggagctg gggctggggg cagggtgctc tcgtaggggg
      421 gattgggaaa gctccccgtg gccgcttcct cttcctcctt tgcagtcccg ggctcctgtc
      481 aggcgctctt ctcagacccc cgggaacttg gcttcggccg ccccgcccct ccgtggatcc
      541 cagtagcccc cgccccggac tcggctttcc ccggctgctc gcttgtcagg aagcgcctgg
      601 ggtgccccgc ttgtgggaag cgcgatcccg gggcgatagg gtggggatct gggggagaag
      661 ctctggtaaa gtttagcgag ccccgggccg gcgttggggt tcggctgaga ggtagtgagc
      721 gggacgttac tctttctctc tgattccggg cagccgaggg gagaaacccc ctcgaagagt
      781 gtgtctttgg aagcagtgtt gggagggggg gatgcagcta cctctctccc ttcttttgcc
      841 ttagctggtg tggagggtga gaggagcctt tgggggtctc tgcacacacc atgatggcga
      901 tgctgtagct gatggaggtg aatgaacaac caaatgccag atttgattct gtagagtttt
      961 tcctgtggaa tatcctcacc gaaagagctt ttctcctaat aacttcacaa tgtttacact
     1021 ccaagattcg tatgttaagg aagaagagtg ggagagaaga agtccatcag cattttagtg
     1081 gagtaaataa tgaaattaaa tgggaagaga aaccataatt ataaaagtta ctatgagtgt
     1141 caaatggtta tgagccttag agtttctgaa ctccaagtac tgttgggcta cgccgggaga
     1201 aacaagcacg gacgcaaaca cgaacttctc acaaaagccc tgcatttgct aaaggctggc
     1261 tgtagtcctg ctgtgcaaat gaaaattaag gaactctata ggcggcggtt cccacagaaa
     1321 atcatgacgc ctgcagactt gtccatcccc aacgtacatt caagtcctat gccagcaact
     1381 ttgtctccat ctaccattcc acaactcact tacgatggtc accctgcatc atcgccatta
     1441 ctccctgttt ctcttctggg acctaaacat gaactggaac tcccacatct tacatcagct
     1501 cttcacccag tccatccgga tataaaactt caaaaattac cattttatga tttactggat
     1561 gaactgataa aacccaccag tctagcatca gacaacagtc agcgctttcg agaaacctgt
     1621 tttgcatttg ccttgacacc acaacaagtg cagcaaatca gtagttccat ggatatttct
     1681 gggaccaaat gtgacttcac agtacaggtc cagttaaggt tttgtttatc agaaaccagt
     1741 tgtccacaag aagatcactt cccacccaat ctttgtgtga aagtgaatac aaaaccttgc
     1801 agccttccag gttaccttcc acctacaaaa aatggcgtgg aaccaaagcg acccagccga
     1861 ccaattaata tcacctcact tgtccgactg tccacaacag taccaaacac gattgttgtt
     1921 tcttggactg cagaaattgg aagaaactat tccatggcag tatatcttgt aaaacagttg
     1981 tcctcaacag ttcttcttca gaggttacga gcaaagggaa taaggaatcc ggatcattct
     2041 agagctttaa ttaaagagaa gttgactgcg gatccagaca gtgaaatagc tacaaccagc
     2101 ctaagggttt ctctactatg tccacttggt aaaatgcggc tgacaattcc gtgtcgggcc
     2161 cttacatgtt ctcatctaca atgttttgac gcaactcttt acattcagat gaatgagaaa
     2221 aaaccaacct gggtttgtcc tgtctgtgat aagaaggctc catatgaaca ccttattatt
     2281 gatggcttgt ttatggaaat cctaaagtac tgtacagact gtgatgaaat acaatttaag
     2341 gaggatggca cttgggcacc gatgagatca aaaaaggaag tacaggaagt ttctgcctct
     2401 tacaatggag tcgatggatg cttgagctcc acattggagc atcaggtagc gtctcaccac
     2461 cagtcctcaa ataaaaacaa gaaagtagaa gtgattgacc taaccataga cagttcatct
     2521 gatgaagagg aagaagagcc atctgccaag aggacctgtc cttccctatc tcccacatca
     2581 ccactaaata ataaaggcat tttaagtctt ccacatcaag catctccagt atcccgcacc
     2641 ccaagccttc ctgctgtaga cacaagctac attaatacct ccctcatcca agactatagg
     2701 catcctttcc acatgacacc catgccttac gacttacaag gattagattt ctttcctttc
     2761 ttatcaggag acaatcagca ttacaacacc tccttgcttg ccgctgcagc agcagcagtt
     2821 tcagatgatc aagacctcct acactcgtct cggtttttcc cgtatacctc ctcacagatg
     2881 tttcttgatc agttaagtgc aggaggcagt acttctctgc caaccaccaa tggaagcagt
     2941 agtggcagta acagcagcct ggtttcttcc aacagcctaa gggaaagcca tagccacacc
     3001 gtcacaaaca ggagcagcac ggacacggca tccatctttg gcatcatacc agacattatt
     3061 tcattggact gattcccagg ccctgctgct cccatcccca ccccagatcg aatgaacttg
     3121 gcagaaagaa gagaactttg tgctctgttt taccttactc tgtttagaaa agtatacaag
     3181 cgtgtttttt ttcctttttt tagggaaaaa attaaaagaa atgtacagag aacaaaacta
     3241 tattttcagt tttacttttg tatataaatc taagactgcc tgtgtgataa aacacttgtt
     3301 taaaaaaaaa aaggaaagaa aagaaaaaag aaaaacaagc acccacaaac caccttcagt
     3361 tcattttttt ctggattctg aagatttttc attatttgtc ctatggtttt ggttttattt
     3421 gacttcgatg gcattatttt atttgcaata acagaaaagg aattgcatgt atgaagtttt
     3481 caatcgtggg cttttctttg ttgtggggag ggggtcgggg gatagtttga tttccatttt
     3541 ctgaaaacga cagacttgga ttctgtttgt gtgtgcatat tttatccagc cttaagttat
     3601 aaagctcatc tgtcccgctg cattccctgt gtattttcag gacatggctc gtgggtgtgt
     3661 gtgttcattg tgtgcgtctg tatgtatttt tctgtcatca ctgttccctc tcctcccgag
     3721 tgtgcattca gttaatataa tcagttgctt gcttctttca aagtgctttg aaggtcttga
     3781 actcacgtgt gagcatcttt atcaactatc ccaattgcat gttctccatc acatattctc
     3841 ttatttgctc tgtaccccct gagaatatgt tttagagata ttggaataaa gctgtctggg
     3901 taaggagtag gcttagccga cctatgaata atacacttta gtctagttct ttattctaaa
     3961 tctggattgc cagtattgtg tatttaaacc aagtctgtga atacctgctt tttttggcca
     4021 cagagtaaca agttttcatg taagatcttc ataccaaagt aggaagtaaa aatagcttag
     4081 aaagctctgt caggtgtttt gtgcagctga cagaggtaat gttacatcac ctaaaaaaga
     4141 aagatacacg gtcagttatc ctaaaaataa attgtttgga aagtacaatg caccacattt
     4201 ttgtagaagt ctactatttg ataaacagtt gaaattcaag atgtgtttga cccttagtca
     4261 tttttactct ttggttctga gtatacctat tttcttagcg tatctgcctt gtttatcttt
     4321 ttcttcacct tttaacaagt atgacatagg aaagtcattt ttttttagaa ttcatggatc
     4381 agtctgatct actcttattc ataatggaac atgtaaatat actgaaaact gtttttcagg
     4441 agagaaatat gagttggagg gaaggaaaag tggttctact aatgttccaa aatcctcatc
     4501 agagaaggta tgatgttctc aggtgtggaa aatatttttt agttgattga gaatgcaggt
     4561 ttaacagaag agataagggg cataatgact gctggttttc cagactggat tttcctaccg
     4621 caactattaa tgttctcaga gttgatgagg accacctttg tgtatacact tgtagtttta
     4681 aaccttgcat tggtaacaaa atgatcaact ttaatccagg tagaattcaa gatggctgta
     4741 cttcagttgt atgataaaat taatggttct catgacttgt gtggcatcta aaaataatgt
     4801 ttttatagca tctctctgcc actaaattgt tgacttgaat tttgggaaaa aaaaaagttg
     4861 gtgttgatat gtatatgtgt gtgtgtatat atgtatttat aaacaagtgt gtttgagtaa
     4921 caagtgagtt tcatagtctt cccctacgca tgtgtattcc acacacaaat ggctgagtta
     4981 tagtcataaa acaatttgca ataaaaaaaa aaccaaaaca gattgtcagt taaccaggaa
     5041 acagttaatg ttttttaatg aatctggcat tatagtgagc aaatgtcgta ttaatttagg
     5101 ctaatttcta atactaccat aatttgtgtc taaatttctg ttggggtaga aattactaaa
     5161 attgtgggga gttttttctg atttttacat tgctttagga aacattttta ctaattcagc
     5221 tgtcttaggt aaaatgaata gttttcttcc tgttttttta tgtgtcattg ttagtggtct
     5281 cagaattctg atcagtaact ttgtgtatga tgctgaatta caaaccgttt gaatgatcca
     5341 gttgaaaacg tatccctcta ctttcttcag ttgtagaaaa ggttaatttc cctcagtgtc
     5401 ccacattata ccaacctaag agaagaacag gtaataggga gaaataaaca tacggtggtt
     5461 tcagtggttt tggtcatgtg tccacaggag aaactaacca ttcagttgtc ttaattttag
     5521 ttcgttctac cctgtgagga gtttgtttcc atcagttgtt gactttccaa aatgttgcat
     5581 taagtaatag ttgtcactct gttggtctca tggtcaatat caatcagact ttcatgatct
     5641 ctactaatta ttagtagagt cctgtactat gtctgtaact actaagttta aagaaaagca
     5701 catagtcact tcatctcttt ttttcttagc ctacgctcac tccccaaccc atcccaacat
     5761 tgacatgcta tctgtggaca aatagcagtt ctcagaatct agtcaagttg ccatcatccc
     5821 ccttgccttg gccgttcata gtaggtatgc atatgtttgt ttctgtacag tactgtgtgt
     5881 gtgtgtgtgt atatatatat acatctgtat gcacacatct ttgataaaat agctatttga
     5941 ctagcagggt taaagtggct tttaattact tcgtgagtgt tattggatac atcttaaaaa
     6001 aaaaaaatct gaaccagaac catgccatac ttggttgact attttgagca ttaaaattgc
     6061 tttactaatt atttagacat gatcacaatt ctgtatcttt actgaggaaa gattcacgta
     6121 agctctgaaa aatcggattc tttggcagat tttcctttga gtcaagtgtc tgaaatggag
     6181 tgaaaatata tcctaactaa attaatgtgg aaagagcatt tttttagaca atttcaattt
     6241 taaacacata aaactttcaa gatcttcagg actttttaaa gcacatttga aattatttta
     6301 gtaagaattt tgttttatca atagatgttg aattctgttt tttaattaaa tacaaagctt
     6361 agatttcaga aagagaggga aaatagctgg tggtcccaga gtgtgctgct gttaattgtt
     6421 taacaaaggg gaaaatgtac ataaacagat aaagttacca taaattccat gaacttaaat
     6481 ctgtgattca ttgccttaaa actttctctc ttagaatttc cataccgcat gccaaaccag
     6541 taaaatggct tttaaaaatg tatagtagac aatgtcagtt tgtataaaag taccaagtga
     6601 aaatatttat tacatgcatt ggaaaaaaat tgtttaccta ttgaatgtta cctgtttatg
     6661 tagagctctt tagatgtaat aaaagaaaag ccttcagtta atttgtcttc tgtaaaataa
     6721 cactgctgga tgttcaaggg gacaatccct atgagacaag tgataatggt ttgtgcttcc
     6781 aaagcacctt tcatccagag atttcaaagc atgacaagta actaactaat tttcttgcag
     6841 catgctttga ggtaagtaat gaatatagcc atcatttccc tttcttgttg aaatatggct
     6901 aactctttaa taaatcacag catctgttta gtatctgcag tttgaatgct aagagcaccg
     6961 tggccttctt gtaaacaaca ctaggtgcta gagaaaccag ctggaatttc aggaatgagc
     7021 ttgaaaccag gaccaggagt aaggtaacag cccttcctcg ggtagaggtt tgaatcaaac
     7081 acttaatagg atcttagact ctggaccact gaatccctta atgagcaggg agtccgtgaa
     7141 gaggagcccc aggttctaat gaccattcca caccaactgt gtgtttttgg caagttatat
     7201 ttcagattcc tgttaggcaa atgagattca taaaacttgc tttaaaacca tactgggact
     7261 attcagtgat aaatatagac atagaaaagc tttgacggaa agtaccctca tttattatat
     7321 ccagaacttg ctcttcctgt gccatctaaa tcattggtat ctatctccca tctaatcttt
     7381 ggtattccag gttggctgtg caggatttac ttcctaatgt ccatgactgg agctcaaaag
     7441 aactgtgggc ctaggacctt tgagctttgc ctgaaagtga cagcagttct ctcggcgggg
     7501 ccagcatcta accggccctc tggtggattt accatgaagg taatgaagtt taagcaccag
     7561 gacccttcac ttgttctggt cctaggagca gccccagaaa ttctgcattt ctgtttttgt
     7621 attcttaagg cagccaaatc tcgtaaacct cagaccccac aaaacatctg ctcctacact
     7681 gtgtggacct gggcttccca gccagatggt cacaacttca cctagttggc atttgggcca
     7741 tttatttacc ctcaccccac aaaactcttt ggctcctagg aattcctcct ctccttgcag
     7801 ttatgcttgg ggaaatgaga gtctccttcc tcagggcctt gtttgggtct gaagccacac
     7861 agcatcgttg agacagttgc actaacacta caactcttgt tccctgcagt tttccctgtg
     7921 cccggtgcct agtgaaagat ttgtgtcttg tacatcctcc caaaagacac atcccatttg
     7981 atttggtttt cttctacttt agccactgtg gtactactag acaaagccac agcccagaga
     8041 acccactttt gatacataca tggatgcaaa tctttgtact tgaagccctg cacccctacc
     8101 tgtgttggtg tggtactcca gcccttttag gactgtgctg gcactacgaa tgatccagat
     8161 ttgacaagtg tatggcacct ctgaatctct ggcagcacca acctggcacc ttctagctgt
     8221 gtaactcact caaagccact ccagctggat ggactcccag aaagcctagt gctcctacta
     8281 ctgttttcca gggctgttgt accctggcca ttgctggtta catcccctta tttctctccg
     8341 taagtcctgg ggaggtggct taaggcaatg accagtgtgg gccacttgag cagaccatcc
     8401 cggaacctct ctgcctgtta acagagccca gggaacagct cggaattctc acagcattgg
     8461 aagccccctt cttgagctct gcaaggccag tcaatttagc agctcacatc tggtttcctt
     8521 tggtgtgggg tgtaaagtag atcgctcttc ctgctctcag ctgatgctgc ctcattgtag
     8581 catgtgtttt cactctagtg ttttcactct acactctgtg tttatgaatg aatagcctga
     8641 gctatgtcac tatatctgtt gagatggaaa tgagaatttg taaatgggcc tctggcactg
     8701 caagaattgt tgtcataagt gttacagctt tctgttcatt gctgcttctc agctagcact
     8761 ggcttcatct tggaaaatct tggaaatatg gaagatggtt ctagccccca aatacagaat
     8821 aagtctcttg gtagattgcc cttaagtcat cagctcaatc cttcctcaac aggctccatg
     8881 aggtaagaag tgggaatcca gcttgtgtgg gggggctttg aggagtgaaa tgatttgccc
     8941 aaagtcacag tgggaagcag cagagccagg actggaaccc aggccagact ccaaaccgca
     9001 ggctccttcc atgcttgaaa gggccggact cacggtagtt aataaaatca atacaaatct
     9061 tttattaaag atctactcat acca
//
