LOCUS       NM_001244014            2711 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens PILR alpha associated neural protein (PIANP),
            transcript variant 2, mRNA.
ACCESSION   NM_001244014
VERSION     NM_001244014.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2711)
  AUTHORS   Evdokimov,K., Biswas,S., Schledzewski,K., Winkler,M.,
            Gorzelanny,C., Schneider,S.W., Goerdt,S. and Geraud,C.
  TITLE     Leda-1/Pianp is targeted to the basolateral plasma membrane by a
            distinct intracellular juxtamembrane region and modulates barrier
            properties and E-Cadherin processing
  JOURNAL   Biochem Biophys Res Commun 475 (4), 342-349 (2016)
   PUBMED   27216462
  REMARK    GeneRIF: Functionally, Leda-1/Pianp increased the transepithelial
            electrical resistance generated by a polarized cell sheet. While
            Claudin 1 and 4 expression and activities of small GTPases were not
            affected, gamma-Secretase-mediated cleavage of E-Cadherin was
            attenuated by Leda-1/Pianp.
REFERENCE   3  (bases 1 to 2711)
  AUTHORS   Evdokimov,K., Biswas,S., Adrian,M., Weber,J., Schledzewski,K.,
            Winkler,M., Goerdt,S. and Geraud,C.
  TITLE     Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein
            convertases precedes its plasma membrane localization
  JOURNAL   Biochem Biophys Res Commun 434 (1), 22-27 (2013)
   PUBMED   23558288
  REMARK    GeneRIF: Furin-like proprotein convertase-dependent processing
            precedes the plasma membrane localization of LEDA-1/PIANP that is
            required for functional receptor-ligand interactions in vitro and
            in vivo.
REFERENCE   4  (bases 1 to 2711)
  AUTHORS   Kogure,A., Shiratori,I., Wang,J., Lanier,L.L. and Arase,H.
  TITLE     PANP is a novel O-glycosylated PILRalpha ligand expressed in neural
            tissues
  JOURNAL   Biochem Biophys Res Commun 405 (3), 428-433 (2011)
   PUBMED   21241660
  REMARK    GeneRIF: These results suggest that PANP is involved in immune
            regulation as a ligand of the PILRalpha.
REFERENCE   5  (bases 1 to 2711)
  AUTHORS   Geraud,C., Schledzewski,K., Demory,A., Klein,D., Kaus,M., Peyre,F.,
            Sticht,C., Evdokimov,K., Lu,S., Schmieder,A. and Goerdt,S.
  TITLE     Liver sinusoidal endothelium: a microenvironment-dependent
            differentiation program in rat including the novel junctional
            protein liver endothelial differentiation-associated protein-1
  JOURNAL   Hepatology 52 (1), 313-326 (2010)
   PUBMED   20578158
REFERENCE   6  (bases 1 to 2711)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA090039.1 and AY358534.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001244014.1.
            
            Summary: This gene encodes a ligand for the paired
            immunoglobin-like type 2 receptor alpha, and so may be involved in
            immune regulation. Alternate splicing results in multiple
            transcript variants encoding different proteins. [provided by
            RefSeq, Sep 2011].
            
            Transcript Variant: This variant (2) includes an alternate segment
            in the 3' coding region and UTR, compared to variant 1. It encodes
            isoform b, which is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358534.1, AK091656.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534837.6/ ENSP00000443919.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               DA090039.1         5-192
            189-2711            AY358534.1         1-2523
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2711
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /note="PILR alpha associated neural protein"
                     /db_xref="GeneID:196500"
                     /db_xref="HGNC:HGNC:25338"
                     /db_xref="MIM:616065"
     exon            1..202
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /inference="alignment:Splign:2.1.0"
     exon            203..262
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1076
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; PILR-associating neural protein; paired
                     immunoglobin-like type 2 receptor-associating neural
                     protein; liver endothelial differentiation-associated
                     protein-1"
                     /codon_start=1
                     /product="PILR alpha-associated neural protein isoform b
                     precursor"
                     /protein_id="NP_001230943.1"
                     /db_xref="CCDS:CCDS58205.1"
                     /db_xref="GeneID:196500"
                     /db_xref="HGNC:HGNC:25338"
                     /db_xref="MIM:616065"
                     /translation="MESRMWPALLLSHLLPLWPLLLLPLPPPAQGSSSSPRTPPAPAR
                     PPCARGGPSAPRHVCVWERAPPPSRSPRVPRSRRQVLPGTAPPATPSGFEEGPPSSQY
                     PWAIVWGPTVSREDGGDPNSANPGFLDYGFAAPHGLATPHPNSDSMRGDGDGLILGEA
                     PATLRPFLFGGRGEGVDPQLYVTITISIIIVLVATGIIFKFCWDRSQKRRRPSGQQGA
                     LRQEESQQPLTDLSPAGVTVLGAFGDSPTPTPDHEEPRGGPRPGMPHPKGAPAFQLNR
                     "
     exon            263..768
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /inference="alignment:Splign:2.1.0"
     exon            769..850
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /inference="alignment:Splign:2.1.0"
     exon            851..2711
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2692..2697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /note="hexamer: AATAAA"
     polyA_site      2711
                     /gene="PIANP"
                     /gene_synonym="C12orf53; leda-1; LEDA1; PANP"
                     /note="major polyA site"
ORIGIN      
        1 gagccgagcc gagccgagcc gaggcgagca tctcccaccg ccgccgcccc gcgccccagg
       61 cgcccgcccc ccacccgctc cagcgccctg ccgcgggcca aacctcccca ccatgccccg
      121 caccccgccc gctcctgcga ccccccagcc ccgctcagtc ccgagcgccc gcagtcgtcg
      181 cgccgccgcg ccaagcatgc agtaaaggct gaaaatctgg gtcacagctg aggaagacct
      241 cagacatgga gtccaggatg tggcctgcgc tgctgctgtc ccacctcctc cctctctggc
      301 cactgctgtt gctgcccctc ccaccgcctg ctcagggctc ttcatcctcc cctcgaaccc
      361 caccagcccc agcccgcccc ccgtgtgcca ggggaggccc ctcggcccca cgtcatgtgt
      421 gcgtgtggga gcgagcacct ccaccaagcc gatctcctcg ggtcccaaga tcacgtcggc
      481 aagtcctgcc tggcactgca cccccagcca ccccatcagg ctttgaggag gggccgccct
      541 catcccaata cccctgggct atcgtgtggg gtcccaccgt gtctcgagag gatggagggg
      601 accccaactc tgccaatccc ggatttctgg actatggttt tgcagcccct catgggctcg
      661 caaccccaca ccccaactca gactccatgc gaggtgatgg agatgggctt atccttggag
      721 aggcacctgc caccctgcgg ccattcctgt tcgggggccg tggggaaggt gtggaccccc
      781 agctctatgt cacaattacc atctccatca tcattgttct cgtggccact ggcatcatct
      841 tcaagttctg ctgggaccgc agccagaagc gacgcagacc ctcagggcag caaggtgccc
      901 tgaggcagga ggagagccag cagccactga cagacctgtc cccggctgga gtcactgtgc
      961 tgggggcctt cggggactca cctaccccca cccctgacca tgaggagccc cgagggggac
     1021 cccggcctgg gatgccccac cccaaggggg ctccagcctt ccagttgaac cggtgagggc
     1081 aggggcaatg ggatgggagg gcaaagaggg aaggcaactt aggtcttcag agctggggtg
     1141 ggggtgccct ctggatgggt agtgaggagg caggcgtggc ctcccacagc ccctggccct
     1201 cccaaggggg ctggaccagc tcctctctgg gaggcaccct tccttctccc agtctctcag
     1261 gatctgtgtc ctattctctg ctgcccataa ctccaactct gccctctttg gttttttctc
     1321 atgccacctt gtctaagaca actctgccct cttaaccttg attccccctc tttgtcttga
     1381 acttcccctt ctattctggc ctaccccttg gttcctgact gtgccctttc cctcttcctc
     1441 tcaggattcc cctggtgaat ctgtgatgcc cccaatgttg gggtgcagcc aagcaggagg
     1501 ccaaggggcc ggcacagccc ccatcccact gagggtgggg cagctgtggg gagctggggc
     1561 cacaggggct cctggctcct gccccttgca caccacccgg aacactcccc agccccacgg
     1621 gcaatcctat ctgctcgccc tcctgcaggt gggggcctca catatctgtg acttcgggtc
     1681 cctgtcccca cccttgtgca ctcacatgaa agccttgcac actcacctcc accttcacag
     1741 gccatttgca cacgctcctg caccctctcc ccgtccatac cgctccgctc agctgactct
     1801 catgttctct cgtctcacat ttgcactctc tccttcccac attctgtgct cagctcactc
     1861 agtggtcagc gtttcctgca cactttacct ctcatgtgcg tttcccggcc tgatgttgtg
     1921 gtggtgtgcg gcgtgctcac tctctccctc atgaacaccc acccacctcg tttccgcagc
     1981 ccctgcgtgc tgctccagag gtgggtggga ggtgagctgg gggctccttg ggccctcatc
     2041 ggtcatggtc tcgtcccatt ccacaccatt tgtttctctg tctccccatc ctactccaag
     2101 gatgccggca tcaccctgag ggctccccct tgggaatggg gtagtgaggc cccagacttc
     2161 acccccagcc cactgctaaa atctgttttc tgacagatgg gttttgggga gtcgcctgct
     2221 gcactacatg agaaagggac tcccatttgc ccttcccttt ctcctacagt cccttttgtc
     2281 ttgtctgtcc tggctgtctg tgtgtgtgcc attctctgga cttcagagcc ccctgagcca
     2341 gtcctccctt cccagcctcc ctttgggcct ccctaactcc acctaggctg ccagggaccg
     2401 gagtcagctg gttcaaggcc atcgggagct ctgcctccaa gtctaccctt cccttcccgg
     2461 actccctcct gtcccctcct ttcctccctc cttccttcca ctctccttcc ttttgcttcc
     2521 ctgccctttc cccctcctca ggttcttccc tccttctcac tggtttttcc accttcctcc
     2581 ttcccttctt ccctggctcc taggctgtga tatatatttt tgtattatct ctttcttctt
     2641 cttgtggtga tcatcttgaa ttactgtggg atgtaagttt caaaattttc aaataaagcc
     2701 tttgcaagat a
//
