LOCUS       NM_001369623            3673 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens phosphatidylinositol 4-kinase beta (PI4KB), transcript
            variant 6, mRNA.
ACCESSION   NM_001369623 XM_017001490
VERSION     NM_001369623.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3673)
  AUTHORS   Yang,H., Fan,T., Xun,M., Wu,B., Guo,S., Li,X., Zhao,X., Yao,H. and
            Wang,H.
  TITLE     N-terminal acetyltransferase 6 facilitates enterovirus 71
            replication by regulating PI4KB expression and replication
            organelle biogenesis
  JOURNAL   J Virol 98 (2), e0174923 (2024)
   PUBMED   38189249
  REMARK    GeneRIF: N-terminal acetyltransferase 6 facilitates enterovirus 71
            replication by regulating PI4KB expression and replication
            organelle biogenesis.
REFERENCE   2  (bases 1 to 3673)
  AUTHORS   Stalder,D., Yakunin,I., Pereira,C., Eden,J. and Gershlick,D.C.
  TITLE     Recruitment of PI4KIIIbeta to the Golgi by ACBD3 is dependent on an
            upstream pathway of a SNARE complex and golgins
  JOURNAL   Mol Biol Cell 35 (2), ar20 (2024)
   PUBMED   38134218
  REMARK    GeneRIF: Recruitment of PI4KIIIbeta to the Golgi by ACBD3 is
            dependent on an upstream pathway of a SNARE complex and golgins.
REFERENCE   3  (bases 1 to 3673)
  AUTHORS   Obata,Y., Kurokawa,K., Tojima,T., Natsume,M., Shiina,I.,
            Takahashi,T., Abe,R., Nakano,A. and Nishida,T.
  TITLE     Golgi retention and oncogenic KIT signaling via
            PLCgamma2-PKD2-PI4KIIIbeta activation in gastrointestinal stromal
            tumor cells
  JOURNAL   Cell Rep 42 (9), 113035 (2023)
   PUBMED   37616163
  REMARK    GeneRIF: Golgi retention and oncogenic KIT signaling via
            PLCgamma2-PKD2-PI4KIIIbeta activation in gastrointestinal stromal
            tumor cells.
REFERENCE   4  (bases 1 to 3673)
  AUTHORS   Mizuike,A., Sakai,S., Katoh,K., Yamaji,T. and Hanada,K.
  TITLE     The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide
            trafficking to the distal Golgi
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37195633
  REMARK    GeneRIF: The C10orf76-PI4KB axis orchestrates CERT-mediated
            ceramide trafficking to the distal Golgi.
REFERENCE   5  (bases 1 to 3673)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   6  (bases 1 to 3673)
  AUTHORS   Sorensen,S.D., Linseman,D.A., McEwen,E.L., Heacock,A.M. and
            Fisher,S.K.
  TITLE     A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in
            the endocytosis of muscarinic cholinergic receptors
  JOURNAL   Mol Pharmacol 53 (5), 827-836 (1998)
   PUBMED   9584208
REFERENCE   7  (bases 1 to 3673)
  AUTHORS   Saito,T., Seki,N., Ishii,H., Ohira,M., Hayashi,A., Kozuma,S. and
            Hori,T.
  TITLE     Complementary DNA cloning and chromosomal mapping of a novel
            phosphatidylinositol kinase gene
  JOURNAL   DNA Res 4 (4), 301-305 (1997)
   PUBMED   9405938
REFERENCE   8  (bases 1 to 3673)
  AUTHORS   Suzuki,K., Hirano,H., Okutomi,K., Suzuki,M., Kuga,Y., Fujiwara,T.,
            Kanemoto,N., Isono,K. and Horie,M.
  TITLE     Identification and characterization of a novel human
            phosphatidylinositol 4-kinase
  JOURNAL   DNA Res 4 (4), 273-280 (1997)
   PUBMED   9405935
REFERENCE   9  (bases 1 to 3673)
  AUTHORS   Wong,K., Meyers,dd.R. and Cantley,L.C.
  TITLE     Subcellular locations of phosphatidylinositol 4-kinase isoforms
  JOURNAL   J Biol Chem 272 (20), 13236-13241 (1997)
   PUBMED   9148941
REFERENCE   10 (bases 1 to 3673)
  AUTHORS   Meyers,R. and Cantley,L.C.
  TITLE     Cloning and characterization of a wortmannin-sensitive human
            phosphatidylinositol 4-kinase
  JOURNAL   J Biol Chem 272 (7), 4384-4390 (1997)
   PUBMED   9020160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391069.11 and KF459527.1.
            
            On Oct 19, 2020 this sequence version replaced NM_001369623.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.40075.1,
                                           SRR1803616.91543.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368873.6/ ENSP00000357867.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AL391069.11        64226-64371         c
            147-555             AL391069.11        53056-53464         c
            556-933             KF459527.1         1-378               c
            934-1083            AL391069.11        52528-52677         c
            1084-1128           AL391069.11        47166-47210         c
            1129-1356           AL391069.11        44529-44756         c
            1357-1584           AL391069.11        43091-43318         c
            1585-1694           AL391069.11        40496-40605         c
            1695-1799           AL391069.11        39149-39253         c
            1800-1923           AL391069.11        38799-38922         c
            1924-2189           AL391069.11        35763-36028         c
            2190-2322           AL391069.11        31364-31496         c
            2323-2443           AL391069.11        30973-31093         c
            2444-3673           AL391069.11        28759-29988         c
FEATURES             Location/Qualifiers
     source          1..3673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3673
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /note="phosphatidylinositol 4-kinase beta"
                     /db_xref="GeneID:5298"
                     /db_xref="HGNC:HGNC:8984"
                     /db_xref="MIM:602758"
     exon            1..146
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1083
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2625
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /EC_number="2.7.1.67"
                     /note="isoform 5 is encoded by transcript variant 6;
                     PtdIns 4-kinase beta; phosphatidylinositol 4-kinase,
                     wortmannin-sensitive; type III phosphatidylinositol
                     4-kinase beta; phosphatidylinositol 4-kinase, catalytic,
                     beta"
                     /codon_start=1
                     /product="phosphatidylinositol 4-kinase beta isoform 5"
                     /protein_id="NP_001356552.1"
                     /db_xref="CCDS:CCDS81376.1"
                     /db_xref="GeneID:5298"
                     /db_xref="HGNC:HGNC:8984"
                     /db_xref="MIM:602758"
                     /translation="MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVID
                     PEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEED
                     EMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYI
                     GNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGA
                     YSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSK
                     SDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMA
                     IGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSK
                     DKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVP
                     NYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRR
                     RLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCG
                     DDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKK
                     QSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE
                     GHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAA
                     RKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMR
                     SITTKLYDGFQYLTNGIM"
     exon            1084..1128
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1356
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1584
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1694
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1799
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1923
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2189
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2322
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2443
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..3673
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3326..3331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /note="hexamer: AATAAA"
     polyA_site      3346
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /note="major polyA site"
     regulatory      3656..3661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
                     /note="hexamer: AATAAA"
     polyA_site      3673
                     /gene="PI4KB"
                     /gene_synonym="DFNA87; NPIK; PI4K-BETA; PI4K92; PI4KBETA;
                     PI4KIII; PI4KIIIBETA; PIK4CB"
ORIGIN      
        1 agccggggcc tggtgcagcc tccgcggccg ctgtcaggga agcgcaggcg gccaatggaa
       61 cccgggagcg gtcgctgctg ctgaggcggc agtgtcggca gtccaaccgc gactgcccgc
      121 accccctccg cgggggtccc ccagagcttg gaagctcgaa gtctggctgt ggccatggga
      181 gatacagtag tggagcctgc ccccttgaag ccaacttctg agcccacttc tggcccacca
      241 gggaataatg gggggtccct gctaagtgtc atcacggagg gggtcgggga actatcagtg
      301 attgaccctg aggtggccca gaaggcctgc caggaggtgt tggagaaagt caagcttttg
      361 catggaggcg tggcagtctc tagcagaggc accccactgg agttggtcaa tggggatggt
      421 gtggacagtg agatccgttg cctagatgat ccacctgccc agatcaggga ggaggaagat
      481 gagatggggg ccgctgtggc ctcaggcaca gccaaaggag caagaagacg gcggcagaac
      541 aactcagcta aacagtcttg gctgctgagg ctgtttgagt caaaactgtt tgacatctcc
      601 atggccattt catacctgta taactccaag gagcctggag tacaagccta cattggcaac
      661 cggctcttct gctttcgcaa cgaggacgtg gacttctatc tgccccagtt gcttaacatg
      721 tacatccaca tggatgagga cgtgggtgat gccattaagc cctacatagt ccaccgttgc
      781 cgccagagca ttaacttttc cctccagtgt gccctgttgc ttggggccta ttcttcagac
      841 atgcacattt ccactcaacg acactcccgt gggaccaagc tacggaagct gatcctctca
      901 gatgagctaa agccagctca caggaagagg gagctgccct ccttgagccc ggcccctgac
      961 acagggctgt ctccctccaa aaggactcac cagcgctcta agtcagatgc cactgccagc
     1021 ataagtctca gcagcaacct gaaacgaaca gccagcaacc ctaaagtgga gaatgaggat
     1081 gaggagctct cctccagcac cgagagtatt gataattcat tcagttcccc tgttcgactg
     1141 gctcctgaga gagaattcat caagtccctg atggcgatcg gcaagcggct ggccacgctc
     1201 cccaccaaag agcagaaaac acagaggctg atctcagagc tctccctgct caaccataag
     1261 ctccctgccc gagtctggct gcccactgct ggctttgacc accacgtggt ccgtgtaccc
     1321 cacacacagg ctgttgtcct caactccaag gacaaggctc cctacctgat ttatgtggaa
     1381 gtccttgaat gtgaaaactt tgacaccacc agtgtccctg cccggatccc cgagaaccga
     1441 attcggagta cgaggtccgt agaaaacttg cccgaatgtg gtattaccca tgagcagcga
     1501 gctggcagct tcagcactgt gcccaactat gacaacgatg atgaggcctg gtcggtggat
     1561 gacataggcg agctgcaagt ggagctcccc gaagtgcata ccaacagctg tgacaacatc
     1621 tcccagttct ctgtggacag catcaccagc caggagagca aggagcctgt gttcattgca
     1681 gcaggggaca tccgccggcg cctttcggaa cagctggctc ataccccgac agccttcaaa
     1741 cgagacccag aagatccttc tgcagttgct ctcaaagagc cctggcagga gaaagtacgg
     1801 cggatcagag agggctcccc ctacggccat ctccccaatt ggcggctcct gtcagtcatt
     1861 gtcaagtgtg gggatgacct tcggcaagag cttctggcct ttcaggtgtt gaagcaactg
     1921 cagtccattt gggaacagga gcgagtgccc ctttggatca agccatacaa gattcttgtg
     1981 atttcggctg atagtggcat gattgaacca gtggtcaatg ctgtgtccat ccatcaggtg
     2041 aagaaacagt cacagctctc cttgctcgat tacttcctac aggagcacgg cagttacacc
     2101 actgaggcat tcctcagtgc acagcgcaat tttgtgcaaa gttgtgctgg gtactgcttg
     2161 gtctgctacc tgctgcaagt caaggacaga cacaatggga atatcctttt ggacgcagaa
     2221 ggccacatca tccacatcga ctttggcttc atcctctcca gctcaccccg aaatctgggc
     2281 tttgagacgt cagcctttaa gctgaccaca gagtttgtgg atgtgatggg cggcctggat
     2341 ggcgacatgt tcaactacta taagatgctg atgctgcaag ggctgattgc cgctcggaaa
     2401 cacatggaca aggtggtgca gatcgtggag atcatgcagc aaggttctca gcttccttgc
     2461 ttccatggct ccagcaccat tcgaaacctc aaagagaggt tccacatgag catgactgag
     2521 gagcagctgc agctgctggt ggagcagatg gtggatggca gtatgcggtc tatcaccacc
     2581 aaactctatg acggcttcca gtacctcacc aacggcatca tgtgacacgc tcctcagccc
     2641 aggagtggtg gggggtccag ggcaccctcc ctagagggcc cttgtctgag aaaccccaaa
     2701 ccaggaaacc ccacctaccc aaccatccac ccaagggaaa tggaaggcaa gaaacacgaa
     2761 ggatcatgtg gtaactgcga gagcttgctg aggggtggga gagccagctg tggggtccag
     2821 acttgttggg gcttccctgc ccctcctggt ctgtgtcagt attaccacca gactgactcc
     2881 aggactcact gccctccaga aaacagaggt gacaaatgtg agggacactg gggcctttct
     2941 tctccttgta ggggtctctc agaggttctt tccacaggcc atcctcttat tccgttctgg
     3001 ggcccaggaa gtggggaaga gtaggttctc ggtacttagg acttgatcct gtggttggcc
     3061 actggccatg ctgctgccca gctctacccc tcccagggac ctacccctcc cagggaccga
     3121 cccctggccc aagctcccct tgctggcggg cgctgcgtgg gccctgcact tgctgaggtt
     3181 ccccatcatg ggcaaggaag ggaattccca cagccctcca gtgtactgag ggtactggcc
     3241 tagccatgtg gaattcccta ccctgactcc ttccccaaac ccagggaaaa gagctctcaa
     3301 ttttttattt ttaatttttg tttgaaataa agtccttagt tagccacttg tgtcatttcc
     3361 aggttttctg ggggagtgca gggggagatg ggtgatgagg tatgaacgga tgcctcagtg
     3421 tccaagatac aaaaggcact acatagaagt ttgctttttc cctgcctgtc ttggtcacta
     3481 ccacctcttc cctgagaagg gcgggccttc catgttctct cacccgcttc aactccacat
     3541 tgtccaagtc acagaaaaag agaggcctga atggagattc gaccacaaac agttttaatg
     3601 gtctggtttt ctccctagtt ccccaactgt ttgttagtat tattattact acaagaataa
     3661 aggattcctg aga
//
