LOCUS       NM_058004               6751 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens phosphatidylinositol 4-kinase alpha (PI4KA),
            transcript variant 1, mRNA.
ACCESSION   NM_058004 XM_001131210
VERSION     NM_058004.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6751)
  AUTHORS   Suresh,S. and Burke,J.E.
  TITLE     Structural basis for the conserved roles of PI4KA and its
            regulatory partners and their misregulation in disease
  JOURNAL   Adv Biol Regul 90, 100996 (2023)
   PUBMED   37979461
  REMARK    GeneRIF: Structural basis for the conserved roles of PI4KA and its
            regulatory partners and their misregulation in disease.
            Review article
REFERENCE   2  (bases 1 to 6751)
  AUTHORS   Govindarajan,B., Sbrissa,D., Pressprich,M., Kim,S., Rishi,A.K.,
            Vaishampayan,U., Cher,M.L. and Chinni,S.R.
  TITLE     Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate
            cancer cells and the significance of PI4KA in bone tumor growth
  JOURNAL   Sci Rep 13 (1), 20634 (2023)
   PUBMED   37996444
  REMARK    GeneRIF: Adaptor proteins mediate CXCR4 and PI4KA crosstalk in
            prostate cancer cells and the significance of PI4KA in bone tumor
            growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6751)
  AUTHORS   Sun,H., Xu,F. and You,D.
  TITLE     CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis
            Metabolism in Papillary Thyroid Carcinoma by Causing the
            miR-1287-5p-Mediated NRP2 Expression Elevation
  JOURNAL   Horm Metab Res 55 (10), 701-710 (2023)
   PUBMED   37813099
  REMARK    GeneRIF: CircPI4KA Overexpression Enhances Carcinogenesis and
            Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the
            miR-1287-5p-Mediated NRP2 Expression Elevation.
REFERENCE   4  (bases 1 to 6751)
  AUTHORS   Gajardo,T., Bernard,M., Lo,M., Turck,E., Leveau,C., El-Daher,M.T.,
            Deslys,A., Panikulam,P., Menche,C., Kurowska,M., Le Lay,G.,
            Barbier,L., Moshous,D., Neven,B., Farin,H.F., Fischer,A.,
            Menasche,G., de Saint Basile,G., Vargas,P. and Sepulveda,F.E.
  TITLE     Actin dynamics regulation by TTC7A/PI4KIIIalpha limits DNA damage
            and cell death under confinement
  JOURNAL   J Allergy Clin Immunol 152 (4), 949-960 (2023)
   PUBMED   37390900
  REMARK    GeneRIF: Actin dynamics regulation by TTC7A/PI4KIIIalpha limits DNA
            damage and cell death under confinement.
REFERENCE   5  (bases 1 to 6751)
  AUTHORS   Barlow-Busch,I., Shaw,A.L. and Burke,J.E.
  TITLE     PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes
            involved in myriad human diseases
  JOURNAL   Curr Opin Cell Biol 83, 102207 (2023)
   PUBMED   37453227
  REMARK    GeneRIF: PI4KA and PIKfyve: Essential phosphoinositide signaling
            enzymes involved in myriad human diseases.
            Review article
REFERENCE   6  (bases 1 to 6751)
  AUTHORS   Kauffmann-Zeh,A., Thomas,G.M., Ball,A., Prosser,S., Cunningham,E.,
            Cockcroft,S. and Hsuan,J.J.
  TITLE     Requirement for phosphatidylinositol transfer protein in epidermal
            growth factor signaling
  JOURNAL   Science 268 (5214), 1188-1190 (1995)
   PUBMED   7761838
REFERENCE   7  (bases 1 to 6751)
  AUTHORS   Wong,K. and Cantley,L.C.
  TITLE     Cloning and characterization of a human phosphatidylinositol
            4-kinase
  JOURNAL   J Biol Chem 269 (46), 28878-28884 (1994)
   PUBMED   7961848
REFERENCE   8  (bases 1 to 6751)
  AUTHORS   Prasad,K.V., Kapeller,R., Janssen,O., Repke,H., Duke-Cohan,J.S.,
            Cantley,L.C. and Rudd,C.E.
  TITLE     Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the
            CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but
            not PI 4-kinase
  JOURNAL   Mol Cell Biol 13 (12), 7708-7717 (1993)
   PUBMED   8246987
REFERENCE   9  (bases 1 to 6751)
  AUTHORS   Baple,E.L., Salter,C., Uhlig,H., Wolf,N.I. and Crosby,A.H.
  TITLE     PI4KA-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35951779
REFERENCE   10 (bases 1 to 6751)
  AUTHORS   Graziani,A., Ling,L.E., Endemann,G., Carpenter,C.L. and
            Cantley,L.C.
  TITLE     Purification and characterization of human erythrocyte
            phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and
            phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes
  JOURNAL   Biochem J 284 (Pt 1) (Pt 1), 39-45 (1992)
   PUBMED   1318025
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA959365.1, AK302424.1,
            AL048955.1, AB210002.1 and BU685224.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_058004.3.
            
            Summary: This gene encodes a phosphatidylinositol (PI) 4-kinase
            which catalyzes the first committed step in the biosynthesis of
            phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases
            have been classified into two types, II and III, based on their
            molecular mass, and modulation by detergent and adenosine. The
            protein encoded by this gene is a type III enzyme that is not
            inhibited by adenosine. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Apr 2018].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210002.1, SRR1803612.268013.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000255882.11/
                                                ENSP00000255882.6
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                DA959365.1         2-72
            72-949              AK302424.1         1-878
            950-963             AL048955.1         455-468
            964-5764            AK302424.1         893-5693
            5765-6740           AB210002.1         5736-6711
            6741-6751           BU685224.1         17-27               c
FEATURES             Location/Qualifiers
     source          1..6751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..6751
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /note="phosphatidylinositol 4-kinase alpha"
                     /db_xref="GeneID:5297"
                     /db_xref="HGNC:HGNC:8983"
                     /db_xref="MIM:600286"
     exon            1..242
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..6395
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /EC_number="2.7.1.67"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol 4-kinase, type III, alpha;
                     phosphatidylinositol 4-kinase 230; PI4-kinase alpha;
                     ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase,
                     catalytic, alpha; testicular secretory protein Li 35;
                     phosphatidylinositol 4-kinase III alpha;
                     phosphatidylinositol 4-kinase IIII+/-"
                     /codon_start=1
                     /product="phosphatidylinositol 4-kinase alpha isoform 1"
                     /protein_id="NP_477352.3"
                     /db_xref="CCDS:CCDS33603.2"
                     /db_xref="GeneID:5297"
                     /db_xref="HGNC:HGNC:8983"
                     /db_xref="MIM:600286"
                     /translation="MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAV
                     QRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLR
                     LLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQV
                     LHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLR
                     VLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSP
                     GGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLN
                     LVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLP
                     TSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVK
                     DEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLR
                     DFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLR
                     DIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIA
                     VALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQI
                     SVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQL
                     GLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDF
                     WLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTV
                     TPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQ
                     VMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLL
                     VNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQP
                     YYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQ
                     NWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLR
                     NRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSK
                     DCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQ
                     KFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIF
                     SSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKI
                     YSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRS
                     NLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLS
                     LLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISP
                     YLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVL
                     CWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY
                     VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGP
                     AKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIV
                     LDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKI
                     SWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIP
                     DCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDR
                     HNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWF
                     MEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFI
                     MKVIQSCFLSNRSRTYDMIQYYQNDIPY"
     exon            243..359
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            360..453
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            454..542
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            543..615
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            616..875
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            876..942
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1091
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1157
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1254
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1446
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1547
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1677
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1810
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1906
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2090
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2194
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2363
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2414
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2523
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2660
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2794
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2877
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2948
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3073
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3155
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3239
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3329
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3449
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3542
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3699
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3827
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3986
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4138
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4246
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4374
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4375..4494
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4574
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4768
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4859
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..5027
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5028..5081
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5202
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5203..5332
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5333..5403
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5404..5476
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5477..5547
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5548..5657
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5658..5762
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5888
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            5889..6009
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            6010..6169
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            6170..6259
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6343
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
     exon            6344..6751
                     /gene="PI4KA"
                     /gene_synonym="GIDID2; PI4K-ALPHA; pi4K230; PIK4CA;
                     PMGYCHA; SPG84"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatgcacct acgcctgcgc cctgaggtcg ggcgctcgcg ggccaggagc ggggagccgg
       61 cgggcagcgc cgcggctcgt gaggtgatgg cggcggcccc ggcccgggga ggcggaggcg
      121 gaggcggagg cggcggcggc tgctccggct ccggctccag cgcctcgcgg ggcttctatt
      181 tcaacacggt cctgtcactg gcccgctccc tggcggtgca gagaccagca tccttggaga
      241 aggtccaaaa gcttctttgc atgtgtccag tggatttcca tgggatcttc cagttagatg
      301 aaagacggag agatgcagtg attgcattgg gcatttttct gattgaatct gatcttcagc
      361 acaaagattg tgtggttcct taccttcttc gacttctcaa aggtcttcca aaagtgtatt
      421 gggtagaaga aagcacagct cggaaaggca gaggtgccct cccggttgca gagagcttca
      481 gcttctgctt ggtaactctg ctgtctgatg tggcctatag ggatccttca cttagggatg
      541 agattttaga ggtgcttttg caggttttgc atgtcctctt ggggatgtgc caggccttgg
      601 agattcaaga caaagaatac ctttgcaagt atgctatccc atgcctgata ggaatctcgc
      661 gagcatttgg gcgttacagc aacatggaag agtctctcct ctcaaagctc tttcccaaaa
      721 tccctcctca ttccctccgt gtcctggaag agcttgaagg tgttcgaagg cgttccttta
      781 atgacttccg ctccatcctc cccagcaatc tgctgactgt ctgtcaggag ggtaccctga
      841 agaggaaaac cagcagtgtg tccagcatct ctcaggtcag ccctgaacgc ggcatgcccc
      901 ctcccagttc ccctggagga tctgcctttc actactttga agcctcctgc ttgcccgatg
      961 ggactgccct agagcctgag tactactttt caaccatcag ctccagcttc tcagtctctc
     1021 cccttttcaa cggtgtcaca tataaggagt ttaacattcc attggaaatg cttcgggaac
     1081 tcttaaacct ggtgaagaag atcgttgagg aggctgttct caaatctttg gatgccattg
     1141 tagccagtgt gatggaggcc aaccccagtg ctgatctcta ctacacttcc ttcagtgacc
     1201 ctctctacct gaccatgttc aagatgctgc gtgacactct gtactacatg aaggacctcc
     1261 cgacctcttt tgtgaaggag atccatgatt ttgtgctgga gcagttcaac acgagccagg
     1321 gggagctcca gaagattcta catgacgcag accggatcca caatgagctg agccccctca
     1381 aactgcgctg tcaggcgaat gctgcctgtg tggacctcat ggtgtgggct gtgaaggacg
     1441 agcagggtgc agaaaacctt tgcatcaagc tatctgagaa gctgcagtcc aagacgtcca
     1501 gcaaagtcat tattgctcac ttgcccctgc tgatctgctg tctgcagggt ttgggccgcc
     1561 tgtgcgagag gttcccggtg gtggtgcact ctgtgacacc gtccttgcga gacttcctgg
     1621 tcatcccgtc cccagttctg gtgaagctct acaagtacca cagtcagtac cacacagttg
     1681 ctggcaatga tataaaaatc agtgtgacca atgagcattc cgagtcaacc ctgaacgtca
     1741 tgtcgggtaa gaagagccag ccctccatgt acgagcagct ccgagacatc gctattgaca
     1801 acatctgcag gtgcctgaag gctggattga cggtggaccc agtgattgtg gaggcgttct
     1861 tggccagcct gtccaaccgg ctctacatct ctcaggagag cgacaaggac gctcacttga
     1921 ttcccgacca cacaatccga gccttgggac acattgcggt ggccttgagg gacaccccga
     1981 aggtcatgga gcccattctg cagatcctac agcagaaatt ctgccagcca ccctcccccc
     2041 tcgatgtgct gattattgac cagctgggct gcctggttat caccggaaat caatacatct
     2101 atcaggaagt gtggaacctc ttccagcaga tcagtgtgaa ggccagctcc gttgtatact
     2161 cagccaccaa agattacaag gaccacggct ataggcattg ctccctggca gtgattaatg
     2221 ccctggccaa catcgcggcc aacatccaag acgagcacct ggtggatgag ctgctcatga
     2281 acctgttgga gttgtttgtg cagctggggc tggaggggaa gcgagccagc gagagggcaa
     2341 gcgagaaggg ccctgcccta aaggcttcta gcagtgcagg gaacttggga gtactcattc
     2401 ctgtaatagc tgtgctcacc cgacgactgc cacccatcaa agaagctaag cctcggttac
     2461 agaagctctt ccgagacttc tggctgtatt ccgttctgat gggattcgct gtggagggct
     2521 caggactctg gccagaagaa tggtacgagg gggtctgtga aatagccact aagtccccct
     2581 tgctcacctt tcccagcaag gagccactgc ggtccgtcct ccagtataac tcagccatga
     2641 agaatgacac ggtcaccccc gctgagctga gtgagctccg cagcactatc atcaacctgc
     2701 tggacccccc tcccgaggtg tccgcactca tcaacaagct ggacttcgcc atgtccacct
     2761 acctcctctc tgtgtaccgg ctggagtaca tgagggtact gcgttcaaca gatcctgatc
     2821 gcttccaggt aatgttctgc tactttgagg ataaagctat tcagaaagac aaatctggga
     2881 tgatgcagtg tgtgattgca gtcgcggaca aagtattcga tgccttcctg aacatgatgg
     2941 cggataaagc caagaccaag gagaacgagg aggagctgga gcggcacgct cagttcctgt
     3001 tggtgaactt caaccacatc cacaagagga taaggagggt ggcagacaag tatctatctg
     3061 gtctggtgga taagtttccc cacttgctct ggagcgggac tgtgctgaag accatgctgg
     3121 acatcctgca gaccctgtca ctgtcactga gcgctgatat tcacaaggat cagccttact
     3181 atgacatccc cgacgccccc taccggatca cggttcctga cacgtacgaa gcccgtgaga
     3241 gcattgtgaa ggacttcgct gcacgctgtg ggatgatcct ccaggaggcc atgaagtggg
     3301 cacctaccgt caccaagtcc cacctgcagg aatatctgaa caaacatcag aactgggtat
     3361 cgggactgtc ccagcacacg gggctggcca tggccactga gagcatcctt cactttgctg
     3421 gctacaacaa gcagaacaca actcttgggg caactcagct gagcgagcgc ccggcctgtg
     3481 tgaagaaaga ctactccaac ttcatggcat ccctgaatct gcgcaaccgc tacgcgggcg
     3541 aggtgtatgg aatgattcgg ttctcaggca ccacaggcca gatgtctgac ctgaacaaaa
     3601 tgatggtcca ggatctacat tcagctttag accgcagtca tcctcagcac tacacgcagg
     3661 ccatgttcaa gctgaccgca atgctcatta gcagtaaaga ttgtgacccg cagctccttc
     3721 atcatctgtg ctggggtccc ctccggatgt tcaatgagca tggcatggag acggccctgg
     3781 cctgctggga gtggctgctg gctggcaagg atggagtgga agtgccgttc atgcgggaga
     3841 tggcaggggc ctggcacatg acggtggagc agaaatttgg cctgttttct gctgagataa
     3901 aggaagcaga ccccctggct gcctcggaag caagtcaacc caaaccctgt ccccccgaag
     3961 tgacccccca ctacatctgg atcgacttcc tggtgcagcg gtttgagatc gccaagtact
     4021 gcagctctga ccaagtggag atcttctcca gcctgctgca gcgctccatg tccctgaaca
     4081 tcggcggggc caaggggagc atgaaccggc acgtggcggc catcgggccc cgcttcaagc
     4141 tgctgaccct ggggctgtcc ctcctgcatg ccgatgtggt tccaaatgca accatccgca
     4201 atgtgcttcg cgagaagatc tactccactg cctttgacta cttcagctgt cccccaaagt
     4261 tccctactca aggagagaag cggctgcgtg aagacataag catcatgatt aaattttgga
     4321 ccgccatgtt ctcagataag aagtacctga ccgccagcca gcttgttccc ccagataatc
     4381 aggacacccg gagcaacctg gacataactg tcggctctcg gcaacaagcc acccaaggct
     4441 ggatcaacac ataccccctg tccagcggca tgtccaccat ctccaagaaa tcaggcatgt
     4501 ctaagaaaac caaccggggc tcccagctgc acaaatacta catgaagcgc aggacgctgc
     4561 tgctgtccct gctggccact gagatcgagc gtctcatcac atggtacaac ccgctgtcag
     4621 ccccggaact ggaactagac caggccggag agaacagcgt ggccaactgg agatctaagt
     4681 acatcagcct gagtgagaag cagtggaagg acaacgtgaa cctcgcctgg agcatctctc
     4741 cctacctagc cgtgcagctg cctgccaggt ttaagaacac agaagccatt gggaacgaag
     4801 tgacccgtct cgttcggttg gacccgggag ccgttagtga tgtgcctgaa gcaatcaagt
     4861 tcctggtcac ctggcacacc atcgacgccg atgctccaga gctcagccat gtgctgtgct
     4921 gggcgcccac ggacccaccc acaggcctct cctacttctc cagcatgtac ccgccgcacc
     4981 ctctcacggc gcagtacggg gtgaaagtcc tgcggtcctt ccctccggac gccatcctct
     5041 tctacatccc ccagattgtg caggccctca ggtacgacaa gatgggctat gtgcgggagt
     5101 atattctgtg ggcagcgtct aaatcccagc ttctggcaca ccagttcatc tggaacatga
     5161 agactaacat ttatctagat gaagagggcc accagaaaga ccctgacatc ggcgacctcc
     5221 tggatcagtt ggtagaggag atcacaggct ccttgtccgg cccagcgaag gacttttacc
     5281 agcgggagtt tgatttcttt aacaagatca ccaacgtgtc ggctatcatc aagccctacc
     5341 ctaaaggcga cgagagaaag aaggcttgtc tgtcggccct gtctgaagtg aaggtgcagc
     5401 cgggctgcta cctgcccagc aaccctgagg ccattgtgct ggacatcgac tacaagtctg
     5461 ggaccccgat gcagagtgct gcaaaagccc catatctggc caagttcaag gtgaagcgat
     5521 gtggagttag tgaacttgaa aaagaaggtc tgcggtgccg ctcagactcc gaggatgagt
     5581 gcagcacgca ggaggccgac ggccagaaga tctcctggca ggcagccatc ttcaaggtgg
     5641 gagacgactg ccggcaggac atgctggccc tgcagatcat cgacctcttc aagaacatct
     5701 tccagctggt cggcctggac ctctttgttt ttccctaccg cgtggtggcc actgcccctg
     5761 ggtgcggggt gatcgagtgc atccccgact gcacctcccg ggaccagctg ggccgccaga
     5821 cagacttcgg catgtacgac tacttcacac gccagtacgg ggatgagtcc actctggcct
     5881 tccagcaggc ccgctacaac ttcatccgaa gcatggccgc ctacagcctc ctgctgttcc
     5941 tgctgcagat caaggacaga cacaacggca acattatgct ggacaagaag ggtcatatca
     6001 tccacatcga ctttggcttc atgtttgaaa gctcgccggg cggcaatctc ggctgggaac
     6061 ccgacatcaa gctgacggat gagatggtga tgatcatggg gggcaagatg gaggccacac
     6121 ccttcaagtg gttcatggag atgtgtgtcc gaggctacct ggctgtgcgg ccctacatgg
     6181 acgcggtcgt ctccctggtc actctcatgt tggacacggg cctgccctgt tttcgcggcc
     6241 agacaatcaa gctcttgaag cacaggttta gccccaacat gactgagcgc gaggctgcaa
     6301 atttcatcat gaaggtcatc cagagctgct tcctcagcaa caggagccgg acctacgaca
     6361 tgatccagta ctatcagaat gacatcccct actgaggagg ggaccttcga gggcctctgc
     6421 cccatgtgcc ctcaaagctg tcccacaatc atggagccct gcgacctccc tgccctgccg
     6481 ccacatgcag tggaggagag gcctgtggcc caaagaacct ggtagcgcct cctggggcag
     6541 cacgtgggtg gcgcagcctt ggtaacgcca tggactgcag cgacaatcaa tggatggtgc
     6601 tgtctatgca caggtgtgag tcctctgttt gcactggaca tattccctac ctgtcttatt
     6661 tcataggtac atgaagtatt gtgtataaaa aaagagataa gatttaacca acatcaacaa
     6721 aataaaaacc caaaatagtg ctgtgttgga a
//
