LOCUS       NM_032439               3521 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phytanoyl-CoA 2-hydroxylase interacting protein like
            (PHYHIPL), transcript variant 1, mRNA.
ACCESSION   NM_032439 XM_166146
VERSION     NM_032439.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3521)
  AUTHORS   Sugimoto,H., Horii,T., Hirota,J.N., Sano,Y., Shinoda,Y., Konno,A.,
            Hirai,H., Ishizaki,Y., Hirase,H., Hatada,I., Furuichi,T. and
            Sadakata,T.
  TITLE     The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL
            affects the cerebellum in mice
  JOURNAL   Mol Brain 14 (1), 52 (2021)
   PUBMED   33712038
  REMARK    GeneRIF: The Ser19Stop single nucleotide polymorphism (SNP) of
            human PHYHIPL affects the cerebellum in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3521)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3521)
  AUTHORS   Fu,H., Ge,B., Chen,D., Wu,Y., Luo,Q., Li,X., Zheng,C. and Tang,Q.
  TITLE     Phytanoyl-CoA 2-Hydroxylase-Interacting Protein-Like Gene Is a
            Therapeutic Target Gene for Glioblastoma Multiforme
  JOURNAL   Med Sci Monit 25, 2583-2590 (2019)
   PUBMED   30962415
  REMARK    GeneRIF: Protein-protein interactions (PPI) net indicated that
            PHYHIPL may play a vital role in cell metabolism, and authors
            hypothesize that the downregulation mechanism may be the result of
            mutations of the ss-catenin gene and the endogenous siRNA, as shown
            in previous studies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3521)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3521)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3521)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 3521)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016398.6 and AC025038.6.
            
            On Nov 23, 2018 this sequence version replaced NM_032439.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.214166.1,
                                           SRR1660803.109271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373880.9/ ENSP00000362987.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC016398.6         123859-124175
            318-514             AC025038.6         111449-111645       c
            515-689             AC025038.6         109292-109466       c
            690-807             AC025038.6         107244-107361       c
            808-3521            AC025038.6         98179-100892        c
FEATURES             Location/Qualifiers
     source          1..3521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..3521
                     /gene="PHYHIPL"
                     /note="phytanoyl-CoA 2-hydroxylase interacting protein
                     like"
                     /db_xref="GeneID:84457"
                     /db_xref="HGNC:HGNC:29378"
     exon            1..317
                     /gene="PHYHIPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1342
                     /gene="PHYHIPL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phytanoyl-CoA hydroxylase-interacting protein-like"
                     /codon_start=1
                     /product="phytanoyl-CoA hydroxylase-interacting
                     protein-like isoform 1"
                     /protein_id="NP_115815.2"
                     /db_xref="CCDS:CCDS7254.1"
                     /db_xref="GeneID:84457"
                     /db_xref="HGNC:HGNC:29378"
                     /translation="MEVPRLDHALNSPTSPCEEVIKNLSLEAIQLCDRDGNKSQDSGI
                     AEMEELPVPHNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKD
                     VPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTAD
                     YSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYVREHHGNAMQPSVKDNSGSHG
                     SPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYT
                     AYHYVILVIAPVGSPGDEFCKQRLPQLNSKDNKFLTCTEEDGVLVYHHAQDVILEVIY
                     TDPVDLSVGTVAEITGHQLMSLSTANAKKDPSCKTCNISVGR"
     exon            318..514
                     /gene="PHYHIPL"
                     /inference="alignment:Splign:2.1.0"
     exon            515..689
                     /gene="PHYHIPL"
                     /inference="alignment:Splign:2.1.0"
     exon            690..807
                     /gene="PHYHIPL"
                     /inference="alignment:Splign:2.1.0"
     exon            808..3521
                     /gene="PHYHIPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHYHIPL"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="PHYHIPL"
                     /note="major polyA site"
     regulatory      2064..2069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHYHIPL"
                     /note="hexamer: ATTAAA"
     polyA_site      2084
                     /gene="PHYHIPL"
     regulatory      3214..3219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHYHIPL"
                     /note="hexamer: ATTAAA"
     polyA_site      3255
                     /gene="PHYHIPL"
     polyA_site      3260
                     /gene="PHYHIPL"
     regulatory      3312..3317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHYHIPL"
                     /note="hexamer: AATAAA"
     polyA_site      3341
                     /gene="PHYHIPL"
     regulatory      3501..3506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHYHIPL"
                     /note="hexamer: AATACA"
     polyA_site      3521
                     /gene="PHYHIPL"
ORIGIN      
        1 agagccgcac actccgcgga gctcctgcca cagccgtcgc cttcgcggcg gctctccagc
       61 cccgcgcctc agcctcggcg ccgcatcacc gcgtcccagg cctccttccc tccctctgcc
      121 actccccctc cctttcccgc tcttcttgcc cacccggccg gcagagagag cctggatacg
      181 aagcaggcgg gcttcagagt gggttggaaa aatggaggtg ccgcgcctgg atcatgccct
      241 caacagcccc accagcccct gtgaggaggt gatcaaaaac ctcagcctgg aggccattca
      301 gctgtgcgac cgggacggga acaaatcaca agacagtggc atagcagaga tggaagaact
      361 tcctgtacca cataacatca aaataagcaa tataacgtgt gactcattca agatttcatg
      421 ggaaatggat tcaaaatcaa aggatcgcat tacacactat tttattgacc tcaacaagaa
      481 agagaacaag aactccaata aatttaaaca caaggatgtt cccacaaaat tggtggcaaa
      541 agctgttccc ttgcctatga ctgtccgtgg acactggttt ttaagcccaa gaactgaata
      601 tacagtagca gtgcagactg cctcaaaaca agttgatggt gattatgttg tgtctgaatg
      661 gagtgaaatt atagaattct gcaccgcaga ctattcaaaa gttcatctaa cacaattgtt
      721 ggagaaggct gaagtgattg caggacgcat gcttaagttt tctgtttttt atcgtaatca
      781 gcacaaagaa tattttgact atgttcgaga acatcatggg aatgctatgc agccatctgt
      841 caaggataac agtggtagcc atggctctcc tatcagtgga aaattagaag gcatcttctt
      901 cagctgcagc actgaattca atactggaaa gccaccccag gattcacctt atggaagata
      961 caggtttgag attgccgcag aaaaactttt taaccccaat actaacttat actttgggga
     1021 cttctactgt atgtacactg cttatcatta tgtgattctt gttattgctc ctgtgggatc
     1081 accaggagat gaattttgta agcagcgcct tcctcaacta aattctaagg ataataaatt
     1141 tttgacctgt acagaagaag atggggtgct ggtttaccac catgcccagg atgtcatttt
     1201 agaagtcatt tacactgacc ctgtggatct ttctgtgggc accgtggcag aaatcactgg
     1261 tcatcagctc atgagtttgt ctactgcaaa tgcaaagaaa gatcccagct gcaaaacctg
     1321 taatatcagt gttggacgtt aatgcccact tttcttattc ttactcagcc ccttttcctc
     1381 ccttaggagc attggtcctc tgttgtccat ttttatcacc agatgttttc cactgaagca
     1441 tgcacatgcc actgtcacca aaacaaacaa ctaccacttt ccaaatttca ttcagaacca
     1501 ttttagtgtt ttcctattcc ctacccctcc cactactttc aatgatgaaa taccctaagt
     1561 taagttctcc ttttgacact ttattgccta gatgctgcaa tgtttttatg tttcctttat
     1621 gccaaacata acaaaacagt tatatagact gctttagcaa agtacacaat aatggcttat
     1681 aaatggtgtt taaatatgca ttcattttaa tctactgaac aaatattggg ataactccaa
     1741 accgcatgaa agggtgtaat tgcagcatga gttaaatctt gaagcctaga attgtcagca
     1801 cttccaactt cttgtttgac agtgttattt atgttattta tattagctaa caggaaacaa
     1861 ctactgtgtt tcaacataat aaatataata gaaaaatatt ttatttgtat tgttgtataa
     1921 aatatttaca atcatataga atatatagag ttacatttta atagcaactg tgtacatgtc
     1981 acgaaaccat ttcccttatc aaagatgtaa tttgtaaacc tcaaatagtt gtgtatctgt
     2041 cctgttagaa gtagatgact tcaattaaac aaatttatga aggacattat tctgattcat
     2101 aaaagttata aaatattagg taaatacaga gaaaacaata agcctctgaa ataagtctgt
     2161 ttctgaaata gtcaatagtc ttcccatcca aactataaga gaatgtgaat ttcttcaaca
     2221 tcatacttaa acattacaga aaatagaaat acaaacaagg ttggtacatg agagaaaatg
     2281 ttgacctttt acttcctttt acaaaaatga aaataataaa catgttttcg tataaaataa
     2341 cacaaaatga tatacactga agttgatgaa gcaaataaat attctggctt ctttttcaag
     2401 gtatcagggc aaacaatttc caaacttttc attttgtaca gaaggatgaa taactacagc
     2461 tcatgggaaa tgttttgact ttacaaagta tagatgttgg aacattaaga aaaatgtata
     2521 ttcccaatga aaaaatagtt atatcatctt atagtaaacc aaaagattag caataatact
     2581 atggacacat tagattatat actacagaca catatctatc caaaatacct attttaaatt
     2641 tttaatacaa tattttattt taatataaac atctgtcagt tatagacaaa gataataatt
     2701 cacaaagtac atgctatcag aatgaacttt ggtaaccaga aatgtaaaat ttcaaataac
     2761 ggataaaata atgtgttatt tttatagaga aagaaaaaaa tagcaacaca atctagttta
     2821 ttttagggta ctgagagcct agcagactta aaggacaagg tagtaaatgt tttatcactc
     2881 aaaaatccat tagaagtttc aaataaattg ctttcttgct agctgtattc cttcctactt
     2941 gaaaagcgaa tttcttttcc tcctatgatt gattttttaa aatcatgctc ttttccatac
     3001 atcaacataa acagtctttg gatactaaat aaactttccc taacaagtgt cctagctatg
     3061 ttatttagat ttgataaaat attagacatt tttaaaaata cttgtattga ctatgagttt
     3121 tctgcttggc atggaggaca ctgaattttt tcccaattat atggctacct gttgtattct
     3181 tccccccgtt taaatccctt ctccttgtat ataattaaac ttgctattcc ttcttaaaaa
     3241 cagctaatac taccactaaa gtgcttccat tttcattgtg tcaaaactac ttagcaagga
     3301 tggcagagga aaataaactt tactttatat catgggtgaa agtgatcata acatttcctg
     3361 aacctcaaat agttttggcc acatcttgct tgctgatgag gacctctaat agtctcagtt
     3421 tggcttttat gtgcttatat tcataatact catctgccat tggtatccta tcttcctttt
     3481 gtggacttct gcaaaacaaa aatacatttg ttagttcaca a
//
