LOCUS       NM_001395272            4837 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens putative homeodomain transcription factor 2 (PHTF2),
            transcript variant 17, mRNA.
ACCESSION   NM_001395272 XM_005250508
VERSION     NM_001395272.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4837)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   2  (bases 1 to 4837)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   3  (bases 1 to 4837)
  AUTHORS   Manuel,A., Beaupain,D., Romeo,P.H. and Raich,N.
  TITLE     Molecular characterization of a novel gene family (PHTF) conserved
            from Drosophila to mammals
  JOURNAL   Genomics 64 (2), 216-220 (2000)
   PUBMED   10729229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004955.3, AC073520.6 and AC004990.1.
            
            On Jun 21, 2021 this sequence version replaced XM_005250508.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151741,
                              SAMEA2155550 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422959.8/ ENSP00000403042.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC004955.3         107645-107843
            200-279             AC073520.6         28736-28815
            280-336             AC073520.6         82123-82179
            337-348             AC073520.6         82497-82508
            349-418             AC004990.1         4207-4276
            419-577             AC004990.1         5258-5416
            578-743             AC004990.1         12289-12454
            744-908             AC004990.1         13741-13905
            909-1095            AC004990.1         23775-23961
            1096-1251           AC004990.1         26119-26274
            1252-1470           AC004990.1         32605-32823
            1471-1599           AC004990.1         41206-41334
            1600-1872           AC004990.1         43526-43798
            1873-2004           AC004990.1         44024-44155
            2005-2091           AC004990.1         46196-46282
            2092-2247           AC004990.1         53174-53329
            2248-2343           AC004990.1         55113-55208
            2344-2469           AC004990.1         57265-57390
            2470-4837           AC004990.1         58354-60721
FEATURES             Location/Qualifiers
     source          1..4837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23-q21.11"
     gene            1..4837
                     /gene="PHTF2"
                     /note="putative homeodomain transcription factor 2"
                     /db_xref="GeneID:57157"
                     /db_xref="HGNC:HGNC:13411"
                     /db_xref="MIM:616785"
     exon            1..199
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..279
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2490
                     /gene="PHTF2"
                     /note="isoform 1 is encoded by transcript variant 17;
                     protein PHTF2"
                     /codon_start=1
                     /product="protein PHTF2 isoform 1"
                     /protein_id="NP_001382201.1"
                     /db_xref="CCDS:CCDS47621.1"
                     /db_xref="GeneID:57157"
                     /db_xref="HGNC:HGNC:13411"
                     /db_xref="MIM:616785"
                     /translation="MASKVTDAIVWYQKKIGAYDQQIWEKSVEQREIKFIKLGLRNKP
                     KKTAHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFFRWWLQVTSKV
                     IFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKP
                     PLSTGGKRRRKLRKAAHLEVHREGDGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWH
                     AAFFLSGSKKAKNSIDKSTETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIRPEETAW
                     NTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRNRKSHHYKK
                     HYPNEDAPKSGTSCSSRCSSSRQDSESARPESETEDVLWEDLLHCAECHSSCTSETDV
                     ENHQINPCVKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISG
                     MIMNRVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFG
                     SNEDVIVLSMVIISFVVRVSLVWIFFFLLCVAERTYKQRLLFAKLFGHLTSARRARKS
                     EVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHVH
                     EIFLDCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKP
                     NKKEELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLLYNITQVVILSAVSGVISDLL
                     GFNLKLWKIKS"
     exon            280..336
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..348
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..418
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..577
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..743
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..908
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1095
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1251
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1470
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1599
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1872
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2004
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2091
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2247
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2343
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2469
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..4837
                     /gene="PHTF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4817..4822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHTF2"
                     /note="hexamer: AATAAA"
     polyA_site      4837
                     /gene="PHTF2"
                     /note="major polyA site"
ORIGIN      
        1 atcctccctg cccgcgcgca gtgactgcag gctccggcgc aaaatcctgc gggagagggg
       61 gtggggcaac cctctggagg cagcgcgccc gcgggcagcc tcgttgtggc tccttgggct
      121 ctgttggcgg cggcgctagc ttcggagtct cccgcgcgca cctcagccgc ctcctagcgg
      181 cgcggcgctc gctcctacgc ctaaaatgac caatgtgtga tttcagtgga ataaatggcg
      241 tccaaagtca cagatgctat agtctggtat caaaagaaga ttggagcata tgatcaacaa
      301 atatgggaaa aatctgttga acagagagaa atcaagttta ttaaactggg gctaaggaat
      361 aaaccaaaga aaacagcaca tgtgaaacca gacctcatag atgttgatct tgtaagaggg
      421 tctgcatttg caaaggcaaa gcctgaaagt ccttggactt ctctgaccag aaagggaatt
      481 gttcgagttg tatttttccc ctttttcttc cggtggtggt tacaagtaac atcaaaggtc
      541 atctttttct ggcttcttgt cctttatctt cttcaagttg ctgcaatagt attattctgc
      601 tccacttcta gcccacacag catacctctg acagaggtga ttgggccgat atggctgatg
      661 ctgctcctgg gaactgtgca ttgccagatt gtttccacaa gaacacccaa acctcctcta
      721 agtacagggg gtaaaagaag aaggaaatta agaaaagcag cccatttgga agtacatagg
      781 gaaggagatg gttctagtac cacagataac acacaagagg gagcagttca gaaccacggt
      841 acaagcacct ctcacagcgt tggcactgtc ttcagagatc tctggcatgc tgctttcttt
      901 ttatcaggat caaagaaagc aaagaattca attgataaat caactgaaac tgacaatggc
      961 tatgtatccc ttgatgggaa gaagactgtt aaaagcggtg aagatggaat acaaaaccat
     1021 gaacctcagt gtgaaactat tcgaccagaa gagacagcct ggaacacagg aacactgagg
     1081 aatggtccta gcaaagatac ccaaaggaca ataacaaatg tctctgatga agtctccagt
     1141 gaggaaggtc ctgaaacagg atactcatta cgtcgtcatg tggacaggac ttctgaaggt
     1201 gttcttcgga atagaaagtc acaccattat aagaaacatt accctaatga ggacgcccct
     1261 aaatcgggta ctagttgcag ctctcgctgt tcaagttcca gacaggattc tgagagtgca
     1321 aggccagaat ctgaaacaga agatgtgtta tgggaagact tgttacattg tgcagaatgc
     1381 cattcatctt gtaccagtga gacagatgtg gaaaatcatc agattaatcc atgtgtgaaa
     1441 aaagaatata gagatgaccc ttttcatcag agtcatttgc cctggctcca tagttcccac
     1501 ccaggattag aaaaaataag tgctatagta tgggaaggta atgattgtaa gaaagcagac
     1561 atgtctgtac ttgaaatcag tggaatgata atgaacagag tgaacagcca tataccagga
     1621 ataggatacc agatttttgg aaatgcagtc tctctcatac tgggtttaac tccatttgtt
     1681 ttccgacttt ctcaagctac agacttggaa caactcacag cacattctgc ttcagaactt
     1741 tatgtgattg catttggttc taatgaagat gtcatagttc tttctatggt tataataagt
     1801 tttgtggttc gcgtgtctct tgtgtggatt ttcttttttt tgctctgtgt agcagaaaga
     1861 acttataaac agcgattact ttttgcaaaa ctctttggac atttaacatc tgcaaggagg
     1921 gctcgaaaat ctgaggttcc tcatttccgg ttgaagaaag tacagaatat aaaaatgtgg
     1981 ctatctctcc gttcctatct taagcgtcga ggtcctcagc gatcagttga tgtaatagtt
     2041 tcatctgctt tcttattgac tatctcagtt gtatttatct gttgtgccca gctacttcat
     2101 gtacacgaga tcttccttga ttgtcactac aattgggaat tggtaatctg gtgcatctcg
     2161 ttaacacttt ttctcctaag atttgttacc cttggatcag aaacaagtaa aaaatatagt
     2221 aatacctcaa tattacttac tgaacagata aacctctact tgaaaatgga gaaaaaacct
     2281 aacaaaaagg aggaactgac actagtgaat aatgttttaa aactggctac taaactgcta
     2341 aaggagttgg acagtccttt tagattatat gggcttacaa tgaatccgct gctttataac
     2401 atcacccagg ttgttatcct gtcagctgtt tctggtgtta tcagtgactt gcttggattt
     2461 aatttaaagc tatggaagat taagtcatga caattcaaag aaaagaagat gtagcctctt
     2521 ttccagaata agagtactga ctaagctgcc tgaaagcttg tcactgattc tttgcttcag
     2581 gagtctcagc tagggagttg aagtgtttac atcagactgt cttgtgcaat tcttatattt
     2641 attttactgg ttcacttttt tttacattta ttttagtctt tatattttta tttttaagca
     2701 ttgatgtact tagttgttga aagggtgatg aaactgatat ccagatactt gagatcctgg
     2761 taattggtca taaataattg gcaaaataac aaattgtgaa aatagaagcc attgctcagc
     2821 accgtttctc catcaatgcc gtgaacttgc cttacttgag gaaaaattct ttaactttgg
     2881 aatattgcat tgaactcagc tatacacata aaacattttc tttggtaaat caagatccag
     2941 tcagggtttc tcttgaatta ttttggaaca atgccaggat ccaaactgat taagttacag
     3001 tttaagcacc cttcagtatt aatatatacg gtattatata acaggtcaac aagtgctctt
     3061 tgatgataaa acttgtaata gagcaataat tgtaaatggt taccatactg taagatattt
     3121 tgataaaaat taactagtaa tacttgtatt tatttgaaac actgggctgt ttgcacagct
     3181 ccaactgtgc atgctcaaaa tgtgcacttt ttaaaattgt tacttttaat gcgtatcttt
     3241 atatgggatc tgttatagta tactagggca tgatatggta tccttttgag tgaggtatat
     3301 actcatctca caagtgaagt gcctactgat attactaaag tacattatgt ttactcaagt
     3361 aaataatttt ctccccatgg tacactctag tgtaggctat tcataccaca ctgaaatgaa
     3421 caactgaaga ataaggctaa gaaccaataa aatatttctc taattgctag ttgtaaaact
     3481 gtatccaaat tttcagaaaa gacagcttca gcttgcaaat tctatcctct aaacttatct
     3541 ggtgcattct ccccacccca cccccattat ataagggcta ttttagatgc ttttaacctc
     3601 cccaacaaat aatttgccaa gtgtccaatg agaacttatc atgttggtgt gttaggtaaa
     3661 tcgggcaaat atgatagtgt cttacattgg gccttgattt taagttgtta tatttgtaca
     3721 atcgagtatt ttagaaatta catgaaacat gaaacagttt ttgcaatttt ttttaaactg
     3781 ggcatctggt ttctaaaaat ttatttgaaa caatctagaa ttttcttggt gcaaagtgta
     3841 tcatgtggaa tatcctcata tttttaccat attttaagaa ctttaagacg attaattgta
     3901 aataatttat ttgattggtg cagttctaat ccctaaatca taatcttaaa atcaggaatg
     3961 tgtggagaac agagccatgt catatcactt tgctcttacc attccttttg atcagcctca
     4021 attcagcctc attgtgtagt atgttttttc tttctatgaa aaacaacaga aagcatttca
     4081 ttttatttgc ctatgttcaa atatgtttaa taatgaccaa agtgcattct gagttttttc
     4141 aaggaatgta atactggagc tttaagaaca tacttagttt ctcatgtgaa aacttaggct
     4201 ttgtctgatg tttttccttc ctctattgtc taatgttgag gttgttttta ggaattatgt
     4261 tttataaact ttttcaatat aaggtacatg cctatacaga acttaacatt ttgcacagaa
     4321 tatatcaaat atattttgag aaaaaaagta cggcatgagt tctgttagga ataaaagatg
     4381 aaactattgt atctcacaaa aaatcttatt tcagaatgga aatatttttg agaaaagtag
     4441 ctgagtatac tggtttaaga aaatgcttgt tttagattga ggttaactta gagttgggag
     4501 ttgatttatt aagtacagta tacctctcaa cagtttataa ataatatgtt gaattatgtc
     4561 agtgtgggca gcagtagaat actaaaagga aaatgtcatg ttaagcaatt tcagaacatt
     4621 aactgaacta ttttcaaagc agaaaaattg acattgctgc ctttaagaat accatgaatg
     4681 taagaaattg aaagaaattg taaaatatca cataatatag aaatggcagt tcaaagagaa
     4741 ttgtggcaga tgttgtgtgt gaactgttgt ttctttgcca catgtgttgt atttgaaagt
     4801 tttacagtaa gtttaaaata aaacattctg tgactga
//
