LOCUS       NM_001286581            5539 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PHD and ring finger domains 1 (PHRF1), transcript
            variant 1, mRNA.
ACCESSION   NM_001286581 XM_005253024
VERSION     NM_001286581.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5539)
  AUTHORS   Lin,H.W., Shih,T.W., Amanna,A. and Chang,M.S.
  TITLE     PHRF1 Promotes Cell Invasion by Modulating SOX4 Expression in
            Colorectal Cancer HCT116-p53-/- Cells
  JOURNAL   Anticancer Res 43 (12), 5437-5446 (2023)
   PUBMED   38030167
  REMARK    GeneRIF: PHRF1 Promotes Cell Invasion by Modulating SOX4 Expression
            in Colorectal Cancer HCT116-p53[-/-] Cells.
REFERENCE   2  (bases 1 to 5539)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5539)
  AUTHORS   An,C.H., Son,H.J., Yoo,N.J. and Lee,S.H.
  TITLE     Downregulation of a putative tumor suppressor gene PHRF1 in gastric
            and colorectal cancers
  JOURNAL   Pathol Res Pract 216 (6), 152984 (2020)
   PUBMED   32360246
  REMARK    GeneRIF: Downregulation of a putative tumor suppressor gene PHRF1
            in gastric and colorectal cancers.
REFERENCE   4  (bases 1 to 5539)
  AUTHORS   Wang,Y., Wang,H., Pan,T., Li,L., Li,J. and Yang,H.
  TITLE     Overexpression of PHRF1 attenuates the proliferation and
            tumorigenicity of non-small cell lung cancer cells
  JOURNAL   Oncotarget 7 (39), 64360-64370 (2016)
   PUBMED   27608840
  REMARK    GeneRIF: Overexpression of PHRF1 attenuated the proliferation and
            tumorigenicity of non-small cell lung cancer cell lines.
REFERENCE   5  (bases 1 to 5539)
  AUTHORS   Chang,C.F., Chu,P.C., Wu,P.Y., Yu,M.Y., Lee,J.Y., Tsai,M.D. and
            Chang,M.S.
  TITLE     PHRF1 promotes genome integrity by modulating non-homologous
            end-joining
  JOURNAL   Cell Death Dis 6 (4), e1716 (2015)
   PUBMED   25855964
  REMARK    GeneRIF: Results suggest that PHRF1 may combine with H3K36
            methylation and NBS1 to promote NHEJ and stabilize genomic
            integrity upon DNA damage insults.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5539)
  AUTHORS   Webb,R., Kelly,J.A., Somers,E.C., Hughes,T., Kaufman,K.M.,
            Sanchez,E., Nath,S.K., Bruner,G., Alarcon-Riquelme,M.E.,
            Gilkeson,G.S., Kamen,D.L., Richardson,B.C., Harley,J.B. and
            Sawalha,A.H.
  TITLE     Early disease onset is predicted by a higher genetic risk for lupus
            and is associated with a more severe phenotype in lupus patients
  JOURNAL   Ann Rheum Dis 70 (1), 151-156 (2011)
   PUBMED   20881011
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 5539)
  AUTHORS   Sanchez,E., Webb,R.D., Rasmussen,A., Kelly,J.A., Riba,L.,
            Kaufman,K.M., Garcia-de la Torre,I., Moctezuma,J.F.,
            Maradiaga-Cecena,M.A., Cardiel-Rios,M.H., Acevedo,E.,
            Cucho-Venegas,M., Garcia,M.A., Gamron,S., Pons-Estel,B.A.,
            Vasconcelos,C., Martin,J., Tusie-Luna,T., Harley,J.B.,
            Richardson,B., Sawalha,A.H. and Alarcon-Riquelme,M.E.
  TITLE     Genetically determined Amerindian ancestry correlates with
            increased frequency of risk alleles for systemic lupus
            erythematosus
  JOURNAL   Arthritis Rheum 62 (12), 3722-3729 (2010)
   PUBMED   20848568
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 5539)
  AUTHORS   Salloum,R., Franek,B.S., Kariuki,S.N., Rhee,L., Mikolaitis,R.A.,
            Jolly,M., Utset,T.O. and Niewold,T.B.
  TITLE     Genetic variation at the IRF7/PHRF1 locus is associated with
            autoantibody profile and serum interferon-alpha activity in lupus
            patients
  JOURNAL   Arthritis Rheum 62 (2), 553-561 (2010)
   PUBMED   20112359
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5539)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 5539)
  AUTHORS   Harley,J.B., Alarcon-Riquelme,M.E., Criswell,L.A., Jacob,C.O.,
            Kimberly,R.P., Moser,K.L., Tsao,B.P., Vyse,T.J., Langefeld,C.D.,
            Nath,S.K., Guthridge,J.M., Cobb,B.L., Mirel,D.B., Marion,M.C.,
            Williams,A.H., Divers,J., Wang,W., Frank,S.G., Namjou,B.,
            Gabriel,S.B., Lee,A.T., Gregersen,P.K., Behrens,T.W., Taylor,K.E.,
            Fernando,M., Zidovetzki,R., Gaffney,P.M., Edberg,J.C., Rioux,J.D.,
            Ojwang,J.O., James,J.A., Merrill,J.T., Gilkeson,G.S., Seldin,M.F.,
            Yin,H., Baechler,E.C., Li,Q.Z., Wakeland,E.K., Bruner,G.R.,
            Kaufman,K.M. and Kelly,J.A.
  CONSRTM   International Consortium for Systemic Lupus Erythematosus Genetics
            (SLEGEN)
  TITLE     Genome-wide association scan in women with systemic lupus
            erythematosus identifies susceptibility variants in ITGAM, PXK,
            KIAA1542 and other loci
  JOURNAL   Nat Genet 40 (2), 204-210 (2008)
   PUBMED   18204446
  REMARK    GeneRIF: study presents four new regions having genetic
            associations with systemic lupus erythematosus in women of European
            descent: ITGAM, KIAA1542, PXK and rs10798269
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA656880.1, BC146771.1 and AP006284.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001286581.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146771.1, AB040975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264555.10/ ENSP00000264555.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA656880.1         25-40
            17-643              BC146771.1         1-627
            644-644             AP006284.2         50180-50180
            645-4489            BC146771.1         629-4473
            4490-4490           AP006284.2         68994-68994
            4491-5539           BC146771.1         4475-5523
FEATURES             Location/Qualifiers
     source          1..5539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..5539
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /note="PHD and ring finger domains 1"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
     exon            1..123
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            124..238
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..5094
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /note="isoform 1 is encoded by transcript variant 1; PHD
                     and RING finger domain-containing protein 1; CTD-binding
                     SR-like protein rA9; protein phosphatase 1, regulatory
                     subunit 125"
                     /codon_start=1
                     /product="PHD and RING finger domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001273510.1"
                     /db_xref="CCDS:CCDS65988.1"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
                     /translation="MDDDSLDELVARSPGPDGHPQVGPADPAGDFEESSVGSSGDSGD
                     DSDSEHGDGTDGEDEGASEEEDLEDRSGSEDSEDDGETLLEVAGTQGKLEAAGSFNSD
                     DDAESCPICLNAFRDQAVGTPENCAHYFCLDCIVEWSKNANSCPVDRTLFKCICIRAQ
                     FGGKILRKIPVENTKASEEEEDPTFCEVCGRSDREDRLLLCDGCDAGYHMECLDPPLQ
                     EVPVDEWFCPECAAPGVVLAADAGPVSEEEVSLLLADVVPTTSRLRPRAGRTRAIART
                     RQSERVRATVNRNRISTARRVQHTPGRLGSSLLDEAIEAVATGLSTAVYQRPLTPRTP
                     ARRKRKTRRRKKVPGRKKTPSGPSAKSKSSATRSKKRQHRVKKRRGKKVKSEATTRSR
                     IARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDPFDSSEELS
                     ANPLSPLSAKRRALSRSALQSHQPVARPVSVGLSRRRLPAAVPEPDLEEEPVPDLLGS
                     ILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVSFQRNSGSLSRGEEGFKGCLQPRALPS
                     GSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPVRLDLPAAPGAVQARNLSNGSVPGF
                     RQSHSPWFNGTNKHTLPLASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDISELPRI
                     PKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGTRAESEASSRVPRE
                     PGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCN
                     TFRPVDDKEQRKENPSPLFSIKKTKQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLP
                     SEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAAEGA
                     SDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPP
                     SPDVLQAATHRVVELRPPSRSRSTSSSRSRKKAKRKRVSREHGRTRSGTRSESRDRSS
                     RSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRT
                     SRSRSGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRERSHERP
                     DRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSREKWPQTRSHSPERKGAVREASPA
                     PLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLDYG
                     DSVEAGHVFDDFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQ
                     REVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSPDVAPAGKEDSPSASGRV
                     QEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAW
                     DMEDVAPTGVRQVFSELPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALV
                     SQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNSEEKTPAPRLAA
                     EKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGE
                     INPVKVANLVKAYVDKYRHMRRHKKPEAGEEPPTQGAEG"
     exon            239..358
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            359..564
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            565..648
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            649..764
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            765..862
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1038
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1168
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1296
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1478
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1598
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1753
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..4408
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            4409..4560
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4821
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            4822..4950
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            4951..5539
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5377
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /note="major polyA site"
     polyA_site      5539
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /note="major polyA site"
ORIGIN      
        1 gcacttccgg gtcgaagagc gcacggcggc ggcagaggcg gcggcggccg ggcctaggag
       61 cgactctcgg tcgtgcagcg gcggcgagcg ctcgcgagcg gctgcgggac gcgaggtttc
      121 cggagctgag ctcaatgtgc agcaatggat gacgacagcc tggatgagct tgtggcccgg
      181 agcccagggc cggatggaca cccacaggtc ggccctgcgg acccggcagg tgactttgaa
      241 gaaagcagcg tgggcagcag tggggactct ggggacgaca gtgacagcga gcatggagat
      301 ggcacagacg gagaagacga gggggcgtct gaggaggaag acctggaaga cagatctggt
      361 tccgaggatt ctgaagacga cggggagaca ttgctggagg tagcgggtac tcaggggaaa
      421 ctggaagccg ctggctcttt caattctgat gatgatgcag agagctgccc aatctgtctc
      481 aacgcattca gagaccaggc cgtggggacg ccggagaact gtgcccatta cttctgcctg
      541 gactgcattg tcgaatggtc caagaatgcc aattcctgtc cagttgatcg aactctattt
      601 aagtgcattt gtattcgagc tcaatttggt ggtaaaatct taagaaagat cccagtggag
      661 aacaccaaag cgagcgagga ggaggaggac ccgaccttct gtgaggtgtg cggcaggagc
      721 gaccgtgagg acaggctttt gctctgcgac ggctgcgatg cggggtacca catggaatgc
      781 ttggaccccc ctctccagga ggtgccggtg gacgagtggt tctgcccgga atgtgctgcg
      841 cctggtgttg tccttgccgc tgatgcgggt cccgtgagtg aggaggaggt ctccctgctc
      901 ttggctgatg tggtgcccac caccagcagg cttcggcctc gagcaggtag gacccgggcg
      961 atagccagga cacggcagag tgagagagtg agagcaaccg tgaaccggaa ccggatctcc
     1021 acggccagga gggtccagca cacaccaggg cgcctcgggt cttccctgct ggatgaagcc
     1081 atcgaggctg tggcgactgg cctgagcact gccgtgtatc agcgccccct gacgccgcgc
     1141 actcccgccc gacggaagag gaagacaaga agacggaaga aagtgccggg aagaaagaaa
     1201 accccgtccg gaccatccgc aaaaagtaag agctcagcga caagatctaa gaaacgccaa
     1261 catcgagtga agaagagaag agggaagaag gtaaagagtg aagccaccac tcgctctcga
     1321 atcgcgcgga cgctgggcct gcgcaggcct gttcacagca gctgcatccc gtcagtgttg
     1381 aagccagtgg agccctcttt ggggctgctg agagcggata ttggagctgc ctctctgtct
     1441 ctgtttggag atccttatga gctggatccc ttcgacagca gtgaagagct ttctgcaaac
     1501 cctctttccc ctctgagtgc caagagacgg gctctgtccc ggtcagccct gcagtcccac
     1561 cagcccgtgg ccaggcccgt ctccgtgggg ctttccagga ggcgcctccc tgccgcggtg
     1621 ccagagccag acttggagga ggagccagtg cctgacctgc tgggcagcat cctgtcgggc
     1681 cagagcctcc tgatgctggg cagcagtgat gtcatcatcc accgcgacgg ctccctcagc
     1741 gccaagaggg cggctccagt ttcttttcag cgaaactcag gcagtctgtc cagaggggaa
     1801 gaaggattca agggctgcct gcagccccga gcactgccct ccgggagccc ggcccaaggc
     1861 ccgtcaggaa acaggccaca gagcacaggg ctcagctgtc aaggcaggtc ccgcaccccc
     1921 gcccgcaccg cgggggcgcc tgtgaggctg gacttgccag cagcccctgg ggcggttcag
     1981 gctcggaact tgtcaaatgg gagtgtgcct ggcttcagac agagccacag cccctggttc
     2041 aacggcacca acaagcacac cttgcccctt gcctctgccg cgtctaagat ctcaagcaga
     2101 gattctaagc ccccatgtcg cagtgtggtg ccggggcctc ccctgaagcc agcgcccaga
     2161 agaacagaca tctctgagct acccaggata ccaaagatca ggagagatga cggtggtggc
     2221 agacgggatg cggccccggc ccacgggcag agcattgaga tccccagtgc ctgcatcagc
     2281 cgactgactg gcagggaggg caccgggcag ccagggcgag gcacacgggc agagagcgag
     2341 gccagcagca gggtgccccg ggagcccggg gtgcacacgg gcagctcccg gcccccagcc
     2401 cccagctccc atggcagttt ggccccactg ggaccatcaa gagggaaagg ggtcgggtcg
     2461 acctttgaga gcttccggat caatattcct ggaaacatgg cacattccag ccagctctcc
     2521 agccctggct tctgtaacac gttccggcct gtggacgata aggagcagag gaaggagaac
     2581 ccctcacccc tcttctccat caagaagacg aagcagctgc ggagcgaggt ctacgaccca
     2641 tccgacccca ccggctccga ctccagcgcc cctggcagca gccccgagag gtctggcccc
     2701 ggcctcctgc cctctgagat cacacgaacc atctccatca acagcccgaa ggcccagacg
     2761 gtgcaggctg tgcgctgcgt cacctcctac acggtggaga gcatctttgg tacagagccc
     2821 gaaccccctc tcggaccgtc ctccgccatg tccaagctcc ggggtgcagt ggctgccgag
     2881 ggggcctctg acacggagcg agaggagccc acagagagcc agggcctggc tgcccggctg
     2941 cggaggccat cccccccaga gccctgggat gaggaggatg gggcgtcttg cagcaccttc
     3001 tttggctctg aggagcggac ggtgacctgt gtgactgtcg tggagccgga agccccaccc
     3061 agcccggacg tgctgcaggc tgccacccac agagtcgtgg agctcaggcc cccttcccgg
     3121 tcccgctcca catccagctc ccgcagcagg aagaaggcca agaggaagag ggtgtccagg
     3181 gagcacggac ggacgcgctc tgggacgcgc tctgaatcca gggacaggag ctcgaggtca
     3241 gcgtcaccat cagtgggtga ggagcgcccc aggaggcagc ggtccaaggc caagagccgg
     3301 cggtcctcca gtgaccgctc cagcagccga gagcgagcta agaggaagaa agccaaggac
     3361 aagagcaggg agcacaggcg gggcccctgg ggccacagcc ggaggacgtc ccggtcgcgg
     3421 tcggggagcc ctggcagctc ttcctatgag cactatgaga gtaggaagaa gaagaaaagg
     3481 agatcagcgt ccagacctcg gggaagggag tgctccccca ccagcagcct ggagaggctc
     3541 tgcaggcaca agcatcagcg ggaacgcagc cacgagcggc cagacaggaa ggagagtgtg
     3601 gcgtggcccc gagaccggag gaagcggagg tcccggtccc caagctcgga gcacagggca
     3661 cgggagcaca ggcggcctcg gtcccgtgag aagtggccgc agacccggtc ccattcccca
     3721 gagaggaagg gggctgtgag ggaggcttcc ccagcgcccc ttgcacaggg ggagccaggg
     3781 cgggaagacc tccccaccag gttgccagcc ttgggggaag cacatgtctc gccggaggtg
     3841 gctacggccg acaaggcccc cctgcaggct ccccctgtcc tggaggtggc agctgagtgt
     3901 gagccggacg acctggacct ggattatggc gactccgtgg aggccggaca cgtctttgat
     3961 gatttctcaa gcgacgccgt tttcatccag ctcgatgaca tgagctcgcc accttctccc
     4021 gaaagcacag actcttcccc ggagcgagac ttcccactga agcctgcgtt gcccccagcc
     4081 agcctggccg tggccgccat ccagagggag gtgtcattga tgcacgatga agacccttcg
     4141 cagcccccac ccctgccaga gggcacccag gagccacatt tgctcaggcc ggacgcggct
     4201 gagaaggctg aggcacccag ttccccggat gtggcgcctg cggggaagga agacagcccc
     4261 tctgcgagtg ggagggtaca ggaggcagcc cggcctgagg aggtggtttc gcagaccccc
     4321 ctgctgcggt ccagagccct ggtgaagcgg gtcacctgga acctgcagga gtcggagagc
     4381 agcgcccccg ccgaggacag agccccccgg gcaccacttc acaggccaca gaagccccga
     4441 gaaggagcct gggacatgga ggatgtggcc cccacagggg tcaggcaggt gttctccgag
     4501 ctgccctttc ccagtcacgt gcttccggaa cccgggttcc cagacacaga cccctctcag
     4561 gtttacagcc ccggcctgcc gcctgccccg gcccagccct caagcatccc accctgcgca
     4621 ctggtcagcc agcccacggt ccagttcatc cttcagggga gcctgccgct agtgggctgt
     4681 ggggcagcac agaccctggc cccagtgccc gctgccctga ccccagcctc agagccagcc
     4741 agtcaagcca ctgcagccag caactcggag gagaagaccc cggcccccag gctagctgcg
     4801 gagaaaacca agaaggagga gtacatgaag aagctgcaca tgcaggagcg tgctgtggag
     4861 gaggtgaagc tggccatcaa gcccttctac cagaagaggg aggtgaccaa ggaggagtac
     4921 aaggacatcc tgcgcaaggc cgtgcagaag atctgccaca gcaagagtgg agagatcaac
     4981 cccgtgaagg tggccaacct ggtgaaggcg tacgtggaca agtacaggca catgcgcagg
     5041 cacaagaaac cagaggccgg ggaggagccg cccacgcagg gggccgaggg ctgaggccag
     5101 gcaatcacgg gctatgcccg gggagctgtc gggagtggcg ggaatcgggg ccatgcccgg
     5161 ggagctgtcg ggagtggcgg gaatcggggc catgcccggg gagctgtcgg gagtggcggg
     5221 aaatgggggg catcaccatg cctgccgtcg ggttcctgcg ctgacacctg gtctgtgcac
     5281 ctgtgttgct cacagttgaa aactggacac ttttgtatgt atattataga gacactgttt
     5341 ccattctaat ttatcaaaaa tggattatct ttagaaacct cttgattgac ttactacttg
     5401 gaagataaag cacttggtga tcaagagggg ctcctggtgg ggtggcgcgt ccttgataaa
     5461 tctctaggtg gcctcccgcc aacagctgct gtgtaccttt ggctctgaat taggaatatc
     5521 tttactttct cttttccaa
//
