LOCUS       NM_001008489            1121 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens phosphatase, orphan 2 (PHOSPHO2), transcript variant
            2, mRNA.
ACCESSION   NM_001008489
VERSION     NM_001008489.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1121)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1121)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1121)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   4  (bases 1 to 1121)
  AUTHORS   Roberts,S.J., Stewart,A.J., Schmid,R., Blindauer,C.A., Bond,S.R.,
            Sadler,P.J. and Farquharson,C.
  TITLE     Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2
  JOURNAL   Biochim Biophys Acta 1752 (1), 73-82 (2005)
   PUBMED   16054448
  REMARK    GeneRIF: Models of PHOSPHO2 and PHOSPHO1 suggest subtle differences
            in the charge distributions around the putative substrate entry
            site and in the location of potential H-bond donors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC106013.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001008489.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All variants (1-5) encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106013.1, SRR1660805.176816.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359744.8/ ENSP00000352782.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1121              BC106013.1         5-1125
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1121
                     /gene="PHOSPHO2"
                     /note="phosphatase, orphan 2"
                     /db_xref="GeneID:493911"
                     /db_xref="HGNC:HGNC:28316"
     exon            1..154
                     /gene="PHOSPHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            155..187
                     /gene="PHOSPHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..358
                     /gene="PHOSPHO2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..1121
                     /gene="PHOSPHO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1110
                     /gene="PHOSPHO2"
                     /EC_number="3.1.3.74"
                     /codon_start=1
                     /product="pyridoxal phosphate phosphatase PHOSPHO2"
                     /protein_id="NP_001008489.1"
                     /db_xref="CCDS:CCDS33319.1"
                     /db_xref="GeneID:493911"
                     /db_xref="HGNC:HGNC:28316"
                     /translation="MKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFW
                     TEFMGRVFKYLGDKGVREHEMKRAVTSLPFTPGMVELFNFIRKNKDKFDCIIISDSNS
                     VFIDWVLEAASFHDIFDKVFTNPAAFNSNGHLTVENYHTHSCNRCPKNLCKKVVLIEF
                     VDKQLQQGVNYTQIVYIGDGGNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPM
                     EYSVVVWSSGVDIISHLQFLIKD"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHOSPHO2"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="PHOSPHO2"
                     /note="major polyA site"
ORIGIN      
        1 gcagttggcg gtcgggctag agaagagagg cgcctgcgct tgcgagctgg gcttgtgagt
       61 ggggctgccg agagggcagg cgtggggcga ggccaaagga ctgaacccgc aggagcgtca
      121 cgggcgccgg ggcggctgcc gacggcggga ctgggttttc tatcagatgt tccacgtaat
      181 aatgctggag ttaagaagtt tccattattt tgctccaaac cagaagactc tgttccctgt
      241 atatagaata ggagtaatat ttgaaaacaa ctggctgatg tttaaaactg aagattgtca
      301 tgattgttta tcctaatccc aatgctgaag taagattgtc ttggaaatac taagttgggg
      361 taatccaaat ctatttctgg aaccatgaaa attttgctag tttttgactt tgacaataca
      421 atcatagatg acaatagtga cacttggatt gtacaatgtg ctcccaacaa aaagcttcct
      481 attgaactac gtgattctta tcgaaaagga ttttggacag aatttatggg cagagtcttt
      541 aagtatttgg gagataaggg tgtaagagaa catgaaatga aaagagcagt gacatcattg
      601 cctttcactc cagggatggt ggaactcttc aactttataa gaaagaataa ggataaattt
      661 gactgcatta ttatttcaga ttcaaattcg gtcttcatag attgggtttt agaagctgcc
      721 agttttcatg acatatttga taaagtgttt acaaatccag cagcttttaa tagcaatggt
      781 catctcactg ttgaaaatta tcatactcat tcttgcaata gatgcccaaa gaatctttgc
      841 aaaaaggtag ttttgataga atttgtagat aaacagttac aacagggagt gaattataca
      901 caaattgttt atattggtga tggtggaaat gatgtctgtc cagtcacctt tttaaagaat
      961 gatgatgttg ccatgccacg gaaaggatat accttacaga aaactctttc cagaatgtct
     1021 caaaatcttg agcctatgga atattctgtt gtagtttggt cctcaggtgt tgatataatt
     1081 tctcatttac aatttctaat aaaggattaa tatgtcagca a
//
