LOCUS       NM_198850               2402 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens pleckstrin homology like domain family B member 3
            (PHLDB3), mRNA.
ACCESSION   NM_198850 XM_351201
VERSION     NM_198850.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Chao,T., Zhou,X., Cao,B., Liao,P., Liu,H., Chen,Y., Park,H.W.,
            Zeng,S.X. and Lu,H.
  TITLE     Pleckstrin homology domain-containing protein PHLDB3 supports
            cancer growth via a negative feedback loop involving p53
  JOURNAL   Nat Commun 7, 13755 (2016)
   PUBMED   28008906
  REMARK    GeneRIF: PHLDB3 promotes tumour growth by inactivating p53 in a
            negative feedback fashion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029299.1, BU858992.1, BG403419.1, BC007947.2, AA621318.1,
            CB850627.1 and CA502903.1.
            
            On Aug 14, 2020 this sequence version replaced NM_198850.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292140.10/ ENSP00000292140.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               BC029299.1         88-476
            390-1062            BU858992.1         1-673
            1063-1566           BG403419.1         1-504
            1567-1662           BC007947.2         9-104
            1663-1663           AA621318.1         76-76               c
            1664-2067           BC007947.2         106-509
            2068-2135           CB850627.1         281-348             c
            2136-2402           CA502903.1         17-283              c
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2402
                     /gene="PHLDB3"
                     /note="pleckstrin homology like domain family B member 3"
                     /db_xref="GeneID:653583"
                     /db_xref="HGNC:HGNC:30499"
                     /db_xref="MIM:621041"
     exon            1..158
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            159..385
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2095
                     /gene="PHLDB3"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family B member
                     3"
                     /protein_id="NP_942147.3"
                     /db_xref="CCDS:CCDS12621.2"
                     /db_xref="GeneID:653583"
                     /db_xref="HGNC:HGNC:30499"
                     /db_xref="MIM:621041"
                     /translation="MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEP
                     SSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ
                     GQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRE
                     LLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQG
                     VQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRR
                     GALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGG
                     DFSEPNPALTKLLFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTG
                     SLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGA
                     IHPDIAHMERLLQQAMAERERLLKAREGTRRGTEGSSGPAVPAITAPPTPPHPPGPRI
                     LDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYY
                     ADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMVAPSPEAMR
                     IWMDVIVTAADENHAP"
     exon            386..568
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..706
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..835
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            836..997
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1123
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1207
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1321
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1421
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1512
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1600
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1657
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1874
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1960
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2402
                     /gene="PHLDB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDB3"
                     /note="hexamer: ATTAAA"
     polyA_site      2402
                     /gene="PHLDB3"
                     /note="major polyA site"
ORIGIN      
        1 agaagcggcc gtgcccagcg cgcagagcgg agcgcgccga agcctgagct cgtgaggggg
       61 ccgaggctgt ggggaggtgg cagttggact tcggaatctc aaggactccg actcctggct
      121 tgttcagaga aggagagccc cgactcctgg atccctggga gtcccagcgg ccatggggac
      181 gcgaagcagc cccgaggagg ggaccccgcc gccgctggtc ccggaatgcg acgtggaggt
      241 ccagccccag ggccatcccg aggagtcccg ggaacaggag gcatccgaag tcctggcgga
      301 accttcgagc cgcgggggag ctgagcagca ggcagaggaa gaagaagtgg gagaaggcag
      361 cagcactgag agcagccgcg acgcgcccga ggctacgcct ccgatagcta tggcggccac
      421 acctcccgca tccacctctt cgcgggaagg ggtgcgaggg gcggcgcggc gcctgcaagg
      481 acagcagctg gaggcattga ctcgtgtggc cctgatggag cagcgagtga aggagctaca
      541 gcgccagagg aaggagctga ggatcgagat ggaggtggag gtggccttgc tgcggggtga
      601 gctggctggg gagcgagtgg ccgctcgccg ggaggaggag cagctgcggg agctgctgga
      661 gcagcaggcg gcctcggagc agcgcggccg ccagcagcgg gaacaggaac agaggcggct
      721 gagccaggaa cgggatcgcc tagagggtct tcgccagaga ctccgcaagg cccagggaca
      781 gctcgactca cagccagagg accaacgcga gcggcttctg cagggtgtgc aggagatgag
      841 ggaacaactg gatgtggccc aacgtgccta tgaggacctg gagttccagc aactggagcg
      901 ggagagccgg caggaggagg aggatcggga cagccctggg ccccaggtgc cagaccccaa
      961 ggtccaggaa ctccaggcca gcatggcgca gcacagaagg ggtgctctgc agcaccggat
     1021 ccgggtcctg gaagagcagc tcaagtcact gggggagcag atggcagccg agagccgggg
     1081 gttgagccgg aagaaggagg aggcccttca ggccctgtca caggaacgga gccggctgct
     1141 cgagctcaat tgccttcagg gaacacctgg cggggacttc tctgagccca acccggccct
     1201 cactaagctg ctgttcaccc agaagacaga ccgccagctg ctggtgctcc aggatgccgt
     1261 ggcccactcc gctgccaccc ctacttcttc ctgcctcttt tctgtccaca gctccctgca
     1321 gggctccatt ggcctccaga ggactgggag cctgccccgg aaaagggggg agagggggag
     1381 ccagagagga tccccccgac ctctgtcctt ccattgtact gaatccctgg aggcctcagc
     1441 tctcccgcca gcagtggggg actccggcag ataccccctc taccagctgc tgaactgtgg
     1501 ccgtgggaat agctgtgggg ccatccatcc agacattgcc cacatggagc ggctcctgca
     1561 gcaggccatg gcggagaggg agcggctgct caaggcccgg gaaggaacaa gaaggggcac
     1621 ggaaggttcc tcaggccctg ctgttcctgc catcacggcc ccacccaccc caccccaccc
     1681 tccaggcccg cgaatcttgg atctccggca gcatctggag ggatggggcc acaacccgga
     1741 aaactgccca catgtgcagg tgtctgggtg ctgctgccgt ggacccctgg tgaagatggg
     1801 cggccgcatc aagacctgga ggaagcgatg gttctgcttt gaccgccaag cccgccgctt
     1861 ggcctactat gcggacaagg aagagaccaa gctcaaaggt gtcatctact tccaggccat
     1921 tgaggaagtc tattatgacc acttacgctg tgccttcaag agccccaacc cccgcctgac
     1981 cttctgcgtc aaaacctacg aacgcctttt ctacatggtg gctccgagcc ccgaagccat
     2041 gcgcatttgg atggacgtca tcgtgaccgc cgctgacgaa aaccacgccc cctgagtggc
     2101 cccgccctct tggggggaag tcccttcgag gctccgccgg cgcggggcgc gggggcgttc
     2161 ctaggccccg cccactgccg gaaaacttgg acgcaccgct ttggaactct cccgggaatt
     2221 ccgcaggcgc ggcagttcag ctggcctgag ctgctgcgtt ctgggttgca ggtgccttgc
     2281 ccccgacggg atcgccggcc cctaaggccc tgcccggggc aggaggaaga ttgcaggggc
     2341 gggaagaaac tatttattgg tgctcctgtg ataccgaatt aaatacggag gaaaaacagg
     2401 aa
//
