LOCUS       XM_011542703            6673 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens pleckstrin homology like domain family B
            member 1 (PHLDB1), transcript variant X1, mRNA.
ACCESSION   XM_011542703
VERSION     XM_011542703.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011542703.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..6673
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /note="pleckstrin homology like domain family B member 1;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 92 ESTs, 363 long SRA reads, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:23187"
                     /db_xref="HGNC:HGNC:23697"
                     /db_xref="MIM:612834"
     CDS             708..5468
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family B member
                     1 isoform X1"
                     /protein_id="XP_011541005.1"
                     /db_xref="GeneID:23187"
                     /db_xref="HGNC:HGNC:23697"
                     /db_xref="MIM:612834"
                     /translation="MCAWRAKAAAERTPARPGGPLATAMHRLGRGRGRPPGTQELWSL
                     RTMDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITL
                     LPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPT
                     RLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHT
                     PQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGR
                     YLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPAR
                     SSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRA
                     TESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPS
                     PFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSP
                     SLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPS
                     PTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNS
                     ITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGEL
                     PSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSST
                     ESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMER
                     ALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKERAELAAGRRHLEARQA
                     LYAELQTQLDNCPESVREQLQEQLRREAEALETETKLFEDLEFQQLERESRVEEEREL
                     AGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKE
                     KEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKALGLFPGSSQAGA
                     SSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASASRDLVPTTC
                     LPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPA
                     KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL
                     TQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRRRLA
                     ELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDT
                     LSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR
                     EREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLP
                     IRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKR
                     TLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKT
                     HDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN"
ORIGIN      
        1 aaagaaaggc cgcttgtcag gggcgggcgg gcaggcggca gcggcaggcg cccaacactg
       61 cggccttgtc ccacgcgggc agcctgggca ggagcaggcc gaggggtgca aggggccgct
      121 accttgcgga aacctccctc cctcggccct gcggaccgcg gagaggcacc tttccaccac
      181 cggacaccca agcaacagcc ctcgctccat ccgcgctctc ccggctcccc ctctcctcgg
      241 gccgcccatc tctcctctct tccgcctttg gggtcccggt gggccccagc ctccctctcc
      301 ttcgccccat ctccccgccc gtcagcctcc cctccgctgc cctcgcgcat ccccagtgtt
      361 cccgtctgtc gtcgcctcca cttgaggacc cgcctgtcct ttcttccccc gacccctcca
      421 cctctgtgtt cttcagtctc cccgcatcct ctgccctcgg tcttcccctc cccagcttgc
      481 attttttccc atctcttagt ctgcctttca ttttcccctt cacatcccgg tggctcccct
      541 tccccgcccc gtccctctgc acacccccat tcatctctgt caggtttttc tcatccttaa
      601 gttctctcgt ccccctcccc actcgggcgt cccccgctgg gctccccgcc tcagtttcct
      661 tcccttcctg actccttcct ctgacggcgg ccctttctcg agggcggatg tgcgcctgga
      721 gggcgaaggc ggcggccgag aggaccccag ctcggcctgg cgggcctctg gccacagcca
      781 tgcaccgctt gggccgaggc cgaggccgac ccccagggac acaggagctc tggagcctta
      841 ggaccatgga cgctctcaat aggaaccaaa taggccctgg atgccagacc cagaccatgg
      901 tgcagaaagg acccttggac ctgatcgaga caggcaaagg gctgaaagtg caaacggaca
      961 aaccccacct ggtgagcctg ggcagtgggc gactcagcac agccatcacc ctcctgccgc
     1021 tggaggaagg gaggacggtg attggctctg cagccagaga catctcacta cagggcccag
     1081 gcctggctcc agagcactgc tacatcgaga acctgcgggg caccctcacc ctctacccct
     1141 gtggcaatgc ctgcactatt gatgggctcc ctgtccggca gcctacccgg ctcactcagg
     1201 gctgcatgtt gtgcctgggt cagtccacct tccttcgctt taaccacccg gctgaagcca
     1261 agtggatgaa aagcatgatt ccagcagggg gccgagcccc tgggcccccc tacagccctg
     1321 ttcctgcaga atcagaaagt ctggtaaatg ggaaccacac cccacagact gcaacacggg
     1381 gaccctctgc ctgtgccagc cacagttccc tggtgagctc tattgagaag gacctgcaag
     1441 agatcatgga ctcactggtg ctagaggagc ctggagctgc tggcaagaag cctgccgcaa
     1501 cctctccact gtcaccgatg gctaatggtg ggcgctacct gctgtctccc ccaaccagcc
     1561 ccggcgccat gtctgtgggc tccagctatg agaacacctc tccagccttc tctccactct
     1621 cttcaccagc cagcagtgga agctgtgcca gtcactcacc cagtgggcaa gagccaggac
     1681 cttctgtgcc cccgctggta cctgcccgtt cctccagcta ccatctggcc ctacagcccc
     1741 cacagtcccg cccaagtggt gctcgctccg agagtcctcg gctgagcagg aaagggggcc
     1801 atgagaggcc tcccagccct ggcctccggg gtctgctgac agacagccct gcagctactg
     1861 tcttggcgga ggcccggaga gccactgaga gcccccggct gggtgggcag ctgcctgtgg
     1921 tggccatcag cctgagtgaa tacccagctt ctggtgctct cagtcaaccc accagcattc
     1981 ctggcagccc caagtttcag cctccagtcc ctgctccccg aaacaagatt ggcacactcc
     2041 aggaccgccc tcccagccct ttccgtgagc ctccaggcag tgagcgggtg ctaacaacca
     2101 gcccctcacg ccaactggtg ggccgaacat tttcagatgg gttagccacc cgtaccctgc
     2161 agcctcctga gagtccccgc ctgggccggc ggggcctgga cagtatgcga gaactacccc
     2221 ccttaagtcc atctctgtcc cggcgagctc tctccccgct gcccacccgg accaccccag
     2281 atcccaagct aaacagggaa gtggcagaga gtcctcggcc ccggcgctgg gcagcccatg
     2341 gggcttcacc agaggacttc tccctgacgc tgggggcacg gggccgtagg acacggagcc
     2401 cctcacccac actgggtgag tctctggcac cccacaaggg cagcttcagt ggcaggctga
     2461 gcccagccta cagtctgggc tctcttactg gggcttcacc ctgccagagt ccctgtgtcc
     2521 agaggaagct ctccagcggg gacttgcggg tgcctgtcac aagggagcgg aaaaatagca
     2581 tcacagagat cagtgacaat gaggacgacc tcctggagta ccaccggcga cagcgccaag
     2641 agcggctccg ggagcaggag atggagaggc tggaacgcca gcgcctggag accatcctga
     2701 acctgtgtgc cgaatacagc cgggctgatg ggggacctga ggctggggag cttcccagca
     2761 ttggggaggc caccgcagca ttggcactgg caggccggag gccctcacga ggccttgcag
     2821 gggcctctgg gcggagcagc gaggagcctg gcgttgccac ccaacgccta tgggagagta
     2881 tggagcgctc agatgaggaa aatctcaagg aggagtgcag cagcactgag agcacccagc
     2941 aggagcacga agatgcacct agcaccaagc tccagggaga ggtgctagcc ctggaagaag
     3001 agcgggctca ggtgctgggg cacgtggagc agctcaaggt ccgtgtgaag gagctagagc
     3061 agcagctgca ggagtcagcc cgagaggccg aaatggagcg ggcactgctg cagggagaga
     3121 gggaggcaga gcgggcactg ctgcagaagg agcagaaggc agtggatcag ctgcaggaga
     3181 agctggtggc cttggagaca ggcatccaga aggagaggga caaggagagg gcggagctgg
     3241 ccgcgggacg gaggcacctg gaggcccgcc aggcgctcta cgccgagctc cagacgcagc
     3301 tcgataactg ccccgagtca gtgcgggaac agttacagga gcagctgaga agggaggcag
     3361 aggccctgga gactgagaca aagctctttg aggacttgga gttccagcag ttggagcggg
     3421 agagccgcgt ggaggaggag cgcgagctgg ccggccaggg gctgctccgg agcaaggctg
     3481 agctgctccg cagcatcgcc aagaggaagg agcgcctggc catcctggac agtcaggctg
     3541 ggcagatccg ggctcaggcc gtgcaggaat cagaacgcct ggcccgggac aagaatgcct
     3601 ccttacagct gctgcaaaag gagaaggaga agctgactgt gctggaaagg agataccact
     3661 cactcacagg gggcaggcct ttcccgaaga ccacatcgac cctcaaagag gccgagctgc
     3721 tcatctccga gtcctcagag atggggctgg ggactaaggc tctgggcctt ttcccagggt
     3781 cttctcaggc tggggcctcc tctgtctctt taaccccacc tgcttccact cttctctgcc
     3841 ccaaagcaca agagtacgtg atgcttgagc agctaaaggt gatgcggggc acctcgccca
     3901 tgcccccagc ccctgtgcca ggcctttctc cctgggcctc cgcctcccgg gacctggttc
     3961 ccaccacctg ccttcctccc atgctgccct cctcctcgtt cgcttccatc acgccttcac
     4021 ctaagatgga gaagctgctg ctccctgctg tagacttaga gcagtggtac caggagctga
     4081 tggccgggct ggggactggc cccgctgcag cctcccctca ctcttctccc ccgcctctgc
     4141 ccgccaaagc ttcccgtcag ctgcaggttt accgctccaa gatggatggc gaggccacca
     4201 gcccccttcc ccggacccgc agcggccccc tcccctcctc ctctggctct tcctcctcct
     4261 cctcccagct cagcgtggct accctggggc gtagcccctc cccaaagagc gctctactca
     4321 cccagaatgg cacgggcagc cttcctcgca acctggcagc cacactgcag gacatcgaga
     4381 ccaagcgcca actagctctg cagcagaagg tcgagtcgct tcccgccgag cccctcccaa
     4441 ccgacgaccc agcaggacaa caagtgattg aagagcagcg gcggcgactg gctgagctga
     4501 agcagaaagc ggcagctgag gcacagtgcc agtgggatgc ccttcacggg gcagcaccct
     4561 tcccagcggg cccctcgggc ttcccccctc tcatgcacca ctctatccta caccacctgc
     4621 ctgcggggcg ggagcgtggg gaggagggtg agcacgccta tgatacgctg agtctggaga
     4681 gctctgacag catggagacc agcatctcca ccgggggcaa ctcggcctgc tcccctgaca
     4741 acatgtccag cgcgagtggt ctggacatgg ggaagatcga ggagatggag aagatgctga
     4801 aagaggctca tgcagagaag aaccggctca tggagtcgag ggagcgggag atggagctgc
     4861 ggcggcaggc cctggaggag gagcggcgga ggcgtgagca ggtagaacgg aggctgcaga
     4921 gtgagagtgc ccggaggcag cagctggtcg agaaggaggt caagatgcgg gagaaacaat
     4981 tttcccaggc acgacccctg acccgctacc tgccaatccg gaaggaggac tttgacctga
     5041 agacacatat tgagtcatcg ggccatggtg ttgatacctg cctgcacgtg gtgctcagca
     5101 gcaaggtctg ccgtggctac ttggtcaaga tgggcggcaa gattaaatca tggaagaagc
     5161 gctggtttgt cttcgaccgg ctcaagcgca ccctttccta ttatgtggac aagcatgaga
     5221 cgaagctgaa gggagtcatc tatttccagg ccattgagga agtgtactac gaccacctgc
     5281 gcagtgcagc caagaagagg tttttccgct tcactatggt gactgagagc ccgaacccag
     5341 ccctcacctt ctgcgtaaag acccatgacc ggctgtacta catggtggcc ccatctgcag
     5401 aggccatgcg tatctggatg gatgtcattg tcacaggggc tgagggctac actcagttca
     5461 tgaactaact gccgtgggcc tcctggcaga gcacaactgg ggcttttgta taagaagact
     5521 ttaatattct gtaaggagct tggtcctgtg agtttctggg ctctggcctc ctgaagaacc
     5581 agccagaaga agaaaagtag aggtggcttt gctgcctcct gggagcccag aacttgcagt
     5641 aaccctttag ggtcctgccc caggcccagc cagggctgag gagctgtcac agagagggcc
     5701 tcagctctga cctgacacct gctctcccca gcctgttttc tcttttctaa aagacaaatt
     5761 atggtaccat aagctgccaa agatcccctc ctgcctcaga cccctttgcc aggggctttg
     5821 ggggctgagc agagccacat ccagagtggg gtaatagctc aggcggcccg cttcccattt
     5881 ctcaaacccc gctctgcccc attgttctcc tttcccttat actttttatt accttgctca
     5941 agggccagag atctcaagtg tcaaccttga ggtcccagct ccatccccta gttgcagact
     6001 catcaccatg gttaccatag tgactgcttc attgccatgg ttacatacta attgctgcag
     6061 ctctgtggcc cagcccactg cttcagctgt gggccatctg agggtacgtg ccatcatctc
     6121 tccagcccag gcccctgggc atctcatgct ggggggaagg gactgaatac ctttttcctt
     6181 ccccctgcct gtgtcttcag ccctgatgca caggctgcca gccccccagt ccagccctct
     6241 cccttccact ggtgccttgc ttagagccag aagggatgaa gccgggggat ctatggaaca
     6301 gaggaggagc gatgcagttg ggagaggaag ctagaagggt tatggttgga gttctgtaca
     6361 gtgttgagtt tccgacaggg aaagaggatt cctccaatgc tcctagagag aaagcctgag
     6421 caggagatga tgcagcagag gggaagggcc ctgtggtgcc gccgcccttc cttcagcctc
     6481 cgaagggtga tggaaatgga gagtggagga ccaggcctcc agctgtctgg cctcgccctt
     6541 cacgccttaa cactaagccc acctcccctg ctctccttcc cagcattgag cccttggttg
     6601 cctgggccca ggctgggggt tttcagtatt tgtaagcatt tcagcagaac aataaagcct
     6661 ttggactacg gaa
//
