LOCUS       NM_001144758            5445 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens pleckstrin homology like domain family B member 1
            (PHLDB1), transcript variant 2, mRNA.
ACCESSION   NM_001144758
VERSION     NM_001144758.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5445)
  AUTHORS   Tuysuz,B., Uludag Alkaya,D., Geyik,F., Alaylioglu,M., Kasap,B.,
            Kurugoglu,S., Akman,Y.E., Vural,M. and Bilguvar,K.
  TITLE     Biallelic frameshift variants in PHLDB1 cause mild-type
            osteogenesis imperfecta with regressive spondylometaphyseal changes
  JOURNAL   J Med Genet 60 (8), 819-826 (2023)
   PUBMED   36543534
  REMARK    GeneRIF: Biallelic frameshift variants in PHLDB1 cause mild-type
            osteogenesis imperfecta with regressive spondylometaphyseal
            changes.
REFERENCE   2  (bases 1 to 5445)
  AUTHORS   Zhai,J., Zhang,P., Zhang,N., Luo,Y. and Wu,Y.
  TITLE     Analysis of WDFY4 rs7097397 and PHLDB1 rs7389 polymorphisms in
            Chinese patients with systemic lupus erythematosus
  JOURNAL   Clin Rheumatol 41 (7), 2035-2042 (2022)
   PUBMED   35188604
  REMARK    GeneRIF: Analysis of WDFY4 rs7097397 and PHLDB1 rs7389
            polymorphisms in Chinese patients with systemic lupus
            erythematosus.
REFERENCE   3  (bases 1 to 5445)
  AUTHORS   Viana-Pereira,M., Moreno,D.A., Linhares,P., Amorim,J., Nabico,R.,
            Costa,S., Vaz,R. and Reis,R.M.
  TITLE     Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as
            risk factors in Portuguese gliomas patients
  JOURNAL   Mol Biol Rep 47 (2), 877-886 (2020)
   PUBMED   31721021
  REMARK    GeneRIF: The rs6010620 (RTEL1), rs4977756 (CDKN2A/B), and rs498872
            (PHLDB1) are associated with glioma risk in the Portuguese
            population. The GA genotype of the rs498872 (PHLDB1) was associated
            with an increased risk of gliomas (OR 2.92) and glioblastomas (OR
            2.39).  In addition, the genotype AA of the rs498872 (PHLDB1) was
            associated with poor overall survival of gliomas patients (AA vs.
            GA, p = 0.037).
REFERENCE   4  (bases 1 to 5445)
  AUTHORS   Feng,Y., Su,Y., Ma,C., Jing,Z., Yang,X., Zhang,D., Xie,M., Li,W.
            and Wei,J.
  TITLE     3'UTR variants of TNS3, PHLDB1, NTN4, and GNG2 genes are associated
            with IgA nephropathy risk in Chinese Han population
  JOURNAL   Int Immunopharmacol 71, 295-300 (2019)
   PUBMED   30928649
  REMARK    GeneRIF: this paper shows that PHLDB1 gene polymorphism is
            associated with IgA nephropathy risk in Chinese Han population
REFERENCE   5  (bases 1 to 5445)
  AUTHORS   Wei,Y., Wang,X., Zhang,Z., Xie,M., Li,Y., Cao,H. and Zhao,X.
  TITLE     Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast
            Cancer Risk
  JOURNAL   Curr Mol Med 19 (8), 579-588 (2019)
   PUBMED   31215377
  REMARK    GeneRIF: Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in
            Breast Cancer Risk.
REFERENCE   6  (bases 1 to 5445)
  AUTHORS   Sanson,M., Hosking,F.J., Shete,S., Zelenika,D., Dobbins,S.E.,
            Ma,Y., Enciso-Mora,V., Idbaih,A., Delattre,J.Y., Hoang-Xuan,K.,
            Marie,Y., Boisselier,B., Carpentier,C., Wang,X.W., Di Stefano,A.L.,
            Labussiere,M., Gousias,K., Schramm,J., Boland,A., Lechner,D.,
            Gut,I., Armstrong,G., Liu,Y., Yu,R., Lau,C., Di Bernardo,M.C.,
            Robertson,L.B., Muir,K., Hepworth,S., Swerdlow,A., Schoemaker,M.J.,
            Wichmann,H.E., Muller,M., Schreiber,S., Franke,A., Moebus,S.,
            Eisele,L., Forsti,A., Hemminki,K., Lathrop,M., Bondy,M.,
            Houlston,R.S. and Simon,M.
  TITLE     Chromosome 7p11.2 (EGFR) variation influences glioma risk
  JOURNAL   Hum Mol Genet 20 (14), 2897-2904 (2011)
   PUBMED   21531791
REFERENCE   7  (bases 1 to 5445)
  AUTHORS   Hotta,A., Kawakatsu,T., Nakatani,T., Sato,T., Matsui,C.,
            Sukezane,T., Akagi,T., Hamaji,T., Grigoriev,I., Akhmanova,A.,
            Takai,Y. and Mimori-Kiyosue,Y.
  TITLE     Laminin-based cell adhesion anchors microtubule plus ends to the
            epithelial cell basal cortex through LL5alpha/beta
  JOURNAL   J Cell Biol 189 (5), 901-917 (2010)
   PUBMED   20513769
  REMARK    GeneRIF: Signaling from laminin-integrin associations in epithelial
            cells attaches microtubule plus ends to the epithelial basal cell
            cortex via PHLDB1 and PHLDB2.
REFERENCE   8  (bases 1 to 5445)
  AUTHORS   Homma,K., Kikuno,R.F., Nagase,T., Ohara,O. and Nishikawa,K.
  TITLE     Alternative splice variants encoding unstable protein domains exist
            in the human brain
  JOURNAL   J Mol Biol 343 (5), 1207-1220 (2004)
   PUBMED   15491607
REFERENCE   9  (bases 1 to 5445)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human LL5A gene and mouse
            Ll5a gene in silico
  JOURNAL   Int J Oncol 23 (5), 1477-1483 (2003)
   PUBMED   14532993
REFERENCE   10 (bases 1 to 5445)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX489377.1, AB014538.2, AK074918.1, AK125783.1 and AI917888.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001144758.2.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and differs in the 5' UTR, compared to variant 1. Variants
            1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014538.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600882.6/ ENSP00000469820.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BX489377.1         26-36
            12-2700             AB014538.2         13-2701
            2701-2701           AK074918.1         561-561
            2702-4243           AB014538.2         2703-4244
            4244-5442           AK125783.1         3462-4660
            5443-5445           AI917888.1         11-13               c
FEATURES             Location/Qualifiers
     source          1..5445
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..5445
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /note="pleckstrin homology like domain family B member 1"
                     /db_xref="GeneID:23187"
                     /db_xref="HGNC:HGNC:23697"
                     /db_xref="MIM:612834"
     exon            1..85
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            86..166
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..4240
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /note="isoform a is encoded by transcript variant 2;
                     protein LL5-alpha"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family B member
                     1 isoform a"
                     /protein_id="NP_001138230.1"
                     /db_xref="CCDS:CCDS8401.1"
                     /db_xref="GeneID:23187"
                     /db_xref="HGNC:HGNC:23697"
                     /db_xref="MIM:612834"
                     /translation="MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVS
                     LGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNA
                     CTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVP
                     AESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAA
                     TSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQE
                     PGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGLLTDS
                     PAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPAPR
                     NKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
                     LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLT
                     LGARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGD
                     LRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEY
                     SRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERS
                     DEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQ
                     LQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEAL
                     ETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAG
                     QIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEME
                     KLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSP
                     LPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIE
                     TKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMH
                     HSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMG
                     KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQL
                     VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGY
                     LVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
                     KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN"
     exon            167..290
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            291..461
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            462..587
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1933
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2206
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2347
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2485
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2641
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2752
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2842
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2983
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3124
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3227
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3522
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3613
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3760
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3877
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..3980
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4066
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4099
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..5445
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5423..5428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /note="hexamer: AATAAA"
     polyA_site      5445
                     /gene="PHLDB1"
                     /gene_synonym="LL5A; LL5alpha; OI23"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtcctcc taagcctgag gccaccgcga ccgagccgag ccaggctaag ggaccagtgt
       61 ctccctgccc cccccccacc tctaggagct ctggagcctt aggaccatgg acgctctcaa
      121 taggaaccaa ataggccctg gatgccagac ccagaccatg gtgcagaaag gacccttgga
      181 cctgatcgag acaggcaaag ggctgaaagt gcaaacggac aaaccccacc tggtgagcct
      241 gggcagtggg cgactcagca cagccatcac cctcctgccg ctggaggaag ggaggacggt
      301 gattggctct gcagccagag acatctcact acagggccca ggcctggctc cagagcactg
      361 ctacatcgag aacctgcggg gcaccctcac cctctacccc tgtggcaatg cctgcactat
      421 tgatgggctc cctgtccggc agcctacccg gctcactcag ggctgcatgt tgtgcctggg
      481 tcagtccacc ttccttcgct ttaaccaccc ggctgaagcc aagtggatga aaagcatgat
      541 tccagcaggg ggccgagccc ctgggccccc ctacagccct gttcctgcag aatcagaaag
      601 tctggtaaat gggaaccaca ccccacagac tgcaacacgg ggaccctctg cctgtgccag
      661 ccacagttcc ctggtgagct ctattgagaa ggacctgcaa gagatcatgg actcactggt
      721 gctagaggag cctggagctg ctggcaagaa gcctgccgca acctctccac tgtcaccgat
      781 ggctaatggt gggcgctacc tgctgtctcc cccaaccagc cccggcgcca tgtctgtggg
      841 ctccagctat gagaacacct ctccagcctt ctctccactc tcttcaccag ccagcagtgg
      901 aagctgtgcc agtcactcac ccagtgggca agagccagga ccttctgtgc ccccgctggt
      961 acctgcccgt tcctccagct accatctggc cctacagccc ccacagtccc gcccaagtgg
     1021 tgctcgctcc gagagtcctc ggctgagcag gaaagggggc catgagaggc ctcccagccc
     1081 tggcctccgg ggtctgctga cagacagccc tgcagctact gtcttggcgg aggcccggag
     1141 agccactgag agcccccggc tgggtgggca gctgcctgtg gtggccatca gcctgagtga
     1201 atacccagct tctggtgctc tcagtcaacc caccagcatt cctggcagcc ccaagtttca
     1261 gcctccagtc cctgctcccc gaaacaagat tggcacactc caggaccgcc ctcccagccc
     1321 tttccgtgag cctccaggca gtgagcgggt gctaacaacc agcccctcac gccaactggt
     1381 gggccgaaca ttttcagatg ggttagccac ccgtaccctg cagcctcctg agagtccccg
     1441 cctgggccgg cggggcctgg acagtatgcg agaactaccc cccttaagtc catctctgtc
     1501 ccggcgagct ctctccccgc tgcccacccg gaccacccca gatcccaagc taaacaggga
     1561 agtggcagag agtcctcggc cccggcgctg ggcagcccat ggggcttcac cagaggactt
     1621 ctccctgacg ctgggggcac ggggccgtag gacacggagc ccctcaccca cactgggtga
     1681 gtctctggca ccccacaagg gcagcttcag tggcaggctg agcccagcct acagtctggg
     1741 ctctcttact ggggcttcac cctgccagag tccctgtgtc cagaggaagc tctccagcgg
     1801 ggacttgcgg gtgcctgtca caagggagcg gaaaaatagc atcacagaga tcagtgacaa
     1861 tgaggacgac ctcctggagt accaccggcg acagcgccaa gagcggctcc gggagcagga
     1921 gatggagagg ctggaacgcc agcgcctgga gaccatcctg aacctgtgtg ccgaatacag
     1981 ccgggctgat gggggacctg aggctgggga gcttcccagc attggggagg ccaccgcagc
     2041 attggcactg gcaggccgga ggccctcacg aggccttgca ggggcctctg ggcggagcag
     2101 cgaggagcct ggcgttgcca cccaacgcct atgggagagt atggagcgct cagatgagga
     2161 aaatctcaag gaggagtgca gcagcactga gagcacccag caggagcacg aagatgcacc
     2221 tagcaccaag ctccagggag aggtgctagc cctggaagaa gagcgggctc aggtgctggg
     2281 gcacgtggag cagctcaagg tccgtgtgaa ggagctagag cagcagctgc aggagtcagc
     2341 ccgagaggcc gaaatggagc gggcactgct gcagggagag agggaggcag agcgggcact
     2401 gctgcagaag gagcagaagg cagtggatca gctgcaggag aagctggtgg ccttggagac
     2461 aggcatccag aaggagaggg acaaggaggc agaggccctg gagactgaga caaagctctt
     2521 tgaggacttg gagttccagc agttggagcg ggagagccgc gtggaggagg agcgcgagct
     2581 ggccggccag gggctgctcc ggagcaaggc tgagctgctc cgcagcatcg ccaagaggaa
     2641 ggagcgcctg gccatcctgg acagtcaggc tgggcagatc cgggctcagg ccgtgcagga
     2701 atcagaacgc ctggcccggg acaagaatgc ctccttacag ctgctgcaaa aggagaagga
     2761 gaagctgact gtgctggaaa ggagatacca ctcactcaca gggggcaggc ctttcccgaa
     2821 gaccacatcg accctcaaag agatggagaa gctgctgctc cctgctgtag acttagagca
     2881 gtggtaccag gagctgatgg ccgggctggg gactggcccc gctgcagcct cccctcactc
     2941 ttctcccccg cctctgcccg ccaaagcttc ccgtcagctg caggtttacc gctccaagat
     3001 ggatggcgag gccaccagcc cccttccccg gacccgcagc ggccccctcc cctcctcctc
     3061 tggctcttcc tcctcctcct cccagctcag cgtggctacc ctggggcgta gcccctcccc
     3121 aaagagcgct ctactcaccc agaatggcac gggcagcctt cctcgcaacc tggcagccac
     3181 actgcaggac atcgagacca agcgccaact agctctgcag cagaagggac aacaagtgat
     3241 tgaagagcag cggcggcgac tggctgagct gaagcagaaa gcggcagctg aggcacagtg
     3301 ccagtgggat gcccttcacg gggcagcacc cttcccagcg ggcccctcgg gcttcccccc
     3361 tctcatgcac cactctatcc tacaccacct gcctgcgggg cgggagcgtg gggaggaggg
     3421 tgagcacgcc tatgatacgc tgagtctgga gagctctgac agcatggaga ccagcatctc
     3481 caccgggggc aactcggcct gctcccctga caacatgtcc agcgcgagtg gtctggacat
     3541 ggggaagatc gaggagatgg agaagatgct gaaagaggct catgcagaga agaaccggct
     3601 catggagtcg agggagcggg agatggagct gcggcggcag gccctggagg aggagcggcg
     3661 gaggcgtgag caggtagaac ggaggctgca gagtgagagt gcccggaggc agcagctggt
     3721 cgagaaggag gtcaagatgc gggagaaaca attttcccag gcacgacccc tgacccgcta
     3781 cctgccaatc cggaaggagg actttgacct gaagacacat attgagtcat cgggccatgg
     3841 tgttgatacc tgcctgcacg tggtgctcag cagcaaggtc tgccgtggct acttggtcaa
     3901 gatgggcggc aagattaaat catggaagaa gcgctggttt gtcttcgacc ggctcaagcg
     3961 caccctttcc tattatgtgg acaagcatga gacgaagctg aagggagtca tctatttcca
     4021 ggccattgag gaagtgtact acgaccacct gcgcagtgca gccaagaaga ggtttttccg
     4081 cttcactatg gtgactgaga gcccgaaccc agccctcacc ttctgcgtaa agacccatga
     4141 ccggctgtac tacatggtgg ccccatctgc agaggccatg cgtatctgga tggatgtcat
     4201 tgtcacaggg gctgagggct acactcagtt catgaactaa ctgccgtggg cctcctggca
     4261 gagcacaact ggggcttttg tataagaaga ctttaatatt ctgtaaggag cttggtcctg
     4321 tgagtttctg ggctctggcc tcctgaagaa ccagccagaa gaagaaaagt agaggtggct
     4381 ttgctgcctc ctgggagccc agaacttgca gtaacccttt agggtcctgc cccaggccca
     4441 gccagggctg aggagctgtc acagagaggg cctcagctct gacctgacac ctgctctccc
     4501 cagcctgttt tctcttttct aaaagacaaa ttatggtacc ataagctgcc aaagatcccc
     4561 tcctgcctca gacccctttg ccaggggctt tgggggctga gcagagccac atccagagtg
     4621 gggtaatagc tcaggcggcc cgcttcccat ttctcaaacc ccgctctgcc ccattgttct
     4681 cctttccctt atacttttta ttaccttgct caagggccag agatctcaag tgtcaacctt
     4741 gaggtcccag ctccatcccc tagttgcaga ctcatcacca tggttaccat agtgactgct
     4801 tcattgccat ggttacatac taattgctgc agctctgtgg cccagcccac tgcttcagct
     4861 gtgggccatc tgagggtacg tgccatcatc tctccagccc aggcccctgg gcatctcatg
     4921 ctggggggaa gggactgaat acctttttcc ttccccctgc ctgtgtcttc agccctgatg
     4981 cacaggctgc cagcccccca gtccagccct ctcccttcca ctggtgcctt gcttagagcc
     5041 agaagggatg aagccggggg atctatggaa cagaggagga gcgatgcagt tgggagagga
     5101 agctagaagg gttatggttg gagttctgta cagtgttgag tttccgacag ggaaagagga
     5161 ttcctccaat gctcctagag agaaagcctg agcaggagat gatgcagcag aggggaaggg
     5221 ccctgtggtg ccgccgccct tccttcagcc tccgaagggt gatggaaatg gagagtggag
     5281 gaccaggcct ccagctgtct ggcctcgccc ttcacgcctt aacactaagc ccacctcccc
     5341 tgctctcctt cccagcattg agcccttggt tgcctgggcc caggctgggg gttttcagta
     5401 tttgtaagca tttcagcaga acaataaagc ctttggacta cggaa
//
