LOCUS       NM_003311                920 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens pleckstrin homology like domain family A member 2
            (PHLDA2), mRNA.
ACCESSION   NM_003311
VERSION     NM_003311.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 920)
  AUTHORS   Feng,K., Peng,H., Lv,Q. and Zhang,Y.
  TITLE     PHLDA2 reshapes the immune microenvironment and induces drug
            resistance in hepatocellular carcinoma
  JOURNAL   Oncol Res 32 (6), 1063-1078 (2024)
   PUBMED   38827322
  REMARK    GeneRIF: PHLDA2 reshapes the immune microenvironment and induces
            drug resistance in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 920)
  AUTHORS   Chia,W.K., Chia,P.Y., Abdul Aziz,N.H., Shuib,S., Mustangin,M.,
            Cheah,Y.K., Khong,T.Y., Wong,Y.P. and Tan,G.C.
  TITLE     Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in
            Hydatidiform Mole
  JOURNAL   Int J Mol Sci 24 (11), 9656 (2023)
   PUBMED   37298606
  REMARK    GeneRIF: Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry
            in Hydatidiform Mole.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 920)
  AUTHORS   Liu,G., Wang,H., Ran,R., Wang,Y. and Li,Y.
  TITLE     FOSL1 transcriptionally regulates PHLDA2 to promote 5-FU resistance
            in colon cancer cells
  JOURNAL   Pathol Res Pract 246, 154496 (2023)
   PUBMED   37178619
  REMARK    GeneRIF: FOSL1 transcriptionally regulates PHLDA2 to promote 5-FU
            resistance in colon cancer cells.
REFERENCE   4  (bases 1 to 920)
  AUTHORS   Song,G. and Jin,F.
  TITLE     RhoGDI1 interacts with PHLDA2, suppresses the proliferation,
            migration, and invasion of trophoblast cells, and participates in
            the pathogenesis of preeclampsia
  JOURNAL   Hum Cell 35 (5), 1440-1452 (2022)
   PUBMED   35841528
  REMARK    GeneRIF: RhoGDI1 interacts with PHLDA2, suppresses the
            proliferation, migration, and invasion of trophoblast cells, and
            participates in the pathogenesis of preeclampsia.
REFERENCE   5  (bases 1 to 920)
  AUTHORS   Guo,C., Liu,S., Zhang,T., Yang,J., Liang,Z. and Lu,S.
  TITLE     Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma
            cells through the AKT/mTOR pathway
  JOURNAL   J Neurogenet 36 (2-3), 74-80 (2022)
   PUBMED   35894264
  REMARK    GeneRIF: Knockdown of PHLDA2 promotes apoptosis and autophagy of
            glioma cells through the AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 920)
  AUTHORS   Feinberg,A.P.
  TITLE     Imprinting of a genomic domain of 11p15 and loss of imprinting in
            cancer: an introduction
  JOURNAL   Cancer Res 59 (7 Suppl), 1743s-1746s (1999)
   PUBMED   10197590
  REMARK    Review article
REFERENCE   7  (bases 1 to 920)
  AUTHORS   Schwienbacher,C., Sabbioni,S., Campi,M., Veronese,A., Bernardi,G.,
            Menegatti,A., Hatada,I., Mukai,T., Ohashi,H., Barbanti-Brodano,G.,
            Croce,C.M. and Negrini,M.
  TITLE     Transcriptional map of 170-kb region at chromosome 11p15.5:
            identification and mutational analysis of the BWR1A gene reveals
            the presence of mutations in tumor samples
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3873-3878 (1998)
   PUBMED   9520460
REFERENCE   8  (bases 1 to 920)
  AUTHORS   Lee,M.P. and Feinberg,A.P.
  TITLE     Genomic imprinting of a human apoptosis gene homologue, TSSC3
  JOURNAL   Cancer Res 58 (5), 1052-1056 (1998)
   PUBMED   9500470
REFERENCE   9  (bases 1 to 920)
  AUTHORS   Hu,R.J., Lee,M.P., Connors,T.D., Johnson,L.A., Burn,T.C., Su,K.,
            Landes,G.M. and Feinberg,A.P.
  TITLE     A 2.5-Mb transcript map of a tumor-suppressing subchromosomal
            transferable fragment from 11p15.5, and isolation and sequence
            analysis of three novel genes
  JOURNAL   Genomics 46 (1), 9-17 (1997)
   PUBMED   9403053
REFERENCE   10 (bases 1 to 920)
  AUTHORS   Qian,N., Frank,D., O'Keefe,D., Dao,D., Zhao,L., Yuan,L., Wang,Q.,
            Keating,M., Walsh,C. and Tycko,B.
  TITLE     The IPL gene on chromosome 11p15.5 is imprinted in humans and mice
            and is similar to TDAG51, implicated in Fas expression and
            apoptosis
  JOURNAL   Hum Mol Genet 6 (12), 2021-2029 (1997)
   PUBMED   9328465
  REMARK    GeneRIF: PHLDA2 gene is imprinted, with preferential expression
            from the maternal allele in placenta and liver.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF035444.1 and AI659266.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_003311.3.
            
            Summary: This gene is located in a cluster of imprinted genes on
            chromosome 11p15.5, which is considered to be an important tumor
            suppressor gene region. Alterations in this region may be
            associated with the Beckwith-Wiedemann syndrome, Wilms tumor,
            rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and
            breast cancer. This gene has been shown to be imprinted, with
            preferential expression from the maternal allele in placenta and
            liver. [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF035444.1, BU500509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 9328465
            MANE Ensembl match     :: ENST00000314222.5/ ENSP00000319231.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               AF035444.1         1-854
            855-920             AI659266.1         18-83               c
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..920
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /note="pleckstrin homology like domain family A member 2"
                     /db_xref="GeneID:7262"
                     /db_xref="HGNC:HGNC:12385"
                     /db_xref="MIM:602131"
     exon            1..525
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..515
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /note="tumor suppressing subtransferable candidate 3;
                     tumor suppressing subchromosomal transferable fragment
                     cDNA 3; p17-Beckwith-Wiedemann region 1C; tumor-supressing
                     STF cDNA 3; p17-BWR1C; p17-Beckwith-Wiedemann region 1 C;
                     imprinted in placenta and liver protein;
                     beckwith-Wiedemann syndrome chromosomal region 1 candidate
                     gene C protein; tumor-suppressing subchromosomal
                     transferable fragment candidate gene 3 protein"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family A member
                     2"
                     /protein_id="NP_003302.1"
                     /db_xref="CCDS:CCDS7741.1"
                     /db_xref="GeneID:7262"
                     /db_xref="HGNC:HGNC:12385"
                     /db_xref="MIM:602131"
                     /translation="MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPR
                     ARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQ
                     NRRALQDFRSRQERTAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP"
     exon            526..920
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      744..749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /note="hexamer: AATAAA"
     polyA_site      776
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /note="major polyA site"
     regulatory      898..903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
                     /note="hexamer: AATAAA"
     polyA_site      920
                     /gene="PHLDA2"
                     /gene_synonym="BRW1C; BWR1C; HLDA2; IPL; TSSC3"
ORIGIN      
        1 agagccggcg ccgtcaccgc ccgcattgcc gctcccagtc ccgcgctcgg cacgacatga
       61 aatcccccga cgaggtgcta cgcgagggcg agttggagaa gcgcagcgac agcctcttcc
      121 agctatggaa gaagaagcgc ggggtgctca cctccgaccg cctgagcctg ttccccgcca
      181 gcccccgcgc gcgccccaag gagctgcgct tccactccat cctcaaggtg gactgcgtgg
      241 agcgcacggg caagtacgtg tacttcacca tcgtcaccac cgaccacaag gagatcgact
      301 tccgctgcgc gggcgagagc tgctggaacg cggccatcgc gctggcgctc atcgatttcc
      361 agaaccgccg cgccctgcag gactttcgca gccgccagga acgcaccgca cccgccgcac
      421 ccgccgagga cgccgtggct gccgcggccg ccgcaccctc cgagccctcg gagccctcca
      481 ggccatcccc gcagcccaaa ccccgcacgc catgagcccg ccgcgggcca tacgctggac
      541 gagtcggacc gaggctagga cgtggccggc gctctccagc cctgcagcag aagaacttcc
      601 cgtgcgcgcg gatcctcgct ccgttgcacg ggcgccttaa gttattggac tatctaatat
      661 ctatgtattt atttcgctgg ttctttgtag tcacatattt tatagtctta atatcttgtt
      721 tttgcatcac tgtgcccatt gcaaataaat cacttggcca gtttgctttt ctaccatccg
      781 gctgtggctc agtgagactc ctgctgggag ggtggaggcc caggaatggg cgggcaggac
      841 accctcatcc agtcctgcgg ggctggtgtg aaaggcgctg ggaaccggct ttgaatgaat
      901 aaatgaatcg tgtcatctgc
//
