LOCUS       NM_007350               5913 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens pleckstrin homology like domain family A member 1
            (PHLDA1), mRNA.
ACCESSION   NM_007350
VERSION     NM_007350.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5913)
  AUTHORS   Song,X., Zhou,L., Yang,W., Li,X., Ma,J., Qi,K., Liang,R., Li,M.,
            Xie,L., Su,T., Huang,D. and Liang,B.
  TITLE     PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis
  JOURNAL   Mol Cell Biochem 479 (3), 653-664 (2024)
   PUBMED   37155089
  REMARK    GeneRIF: PHLDA1 is a P53 target gene involved in P53-mediated cell
            apoptosis.
REFERENCE   2  (bases 1 to 5913)
  AUTHORS   Yousof,T.R., Bouchard,C.C., Alb,M., Lynn,E.G., Lhotak,S., Jiang,H.,
            MacDonald,M., Li,H., Byun,J.H., Makda,Y., Athanasopoulos,M.,
            Maclean,K.N., Cherrington,N.J., Naqvi,A., Igdoura,S.A.,
            Krepinsky,J.C., Steinberg,G.R. and Austin,R.C.
  TITLE     Restoration of the ER stress response protein TDAG51 in hepatocytes
            mitigates NAFLD in mice
  JOURNAL   J Biol Chem 300 (2), 105655 (2024)
   PUBMED   38237682
  REMARK    GeneRIF: Restoration of the ER stress response protein TDAG51 in
            hepatocytes mitigates NAFLD in mice.
REFERENCE   3  (bases 1 to 5913)
  AUTHORS   Wang,J., Yao,N., Hu,Y., Lei,M., Wang,M., Yang,L., Patel,S., Li,X.,
            Liu,K. and Dong,Z.
  TITLE     PHLDA1 promotes glioblastoma cell growth via sustaining the
            activation state of Ras
  JOURNAL   Cell Mol Life Sci 79 (10), 520 (2022)
   PUBMED   36107262
  REMARK    GeneRIF: PHLDA1 promotes glioblastoma cell growth via sustaining
            the activation state of Ras.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5913)
  AUTHORS   Ohnami,S., Maruyama,K., Chen,K., Takahashi,Y., Hatakeyama,K.,
            Ohshima,K., Shimoda,Y., Sakai,A., Kamada,F., Nakatani,S.,
            Naruoka,A., Ohnami,S., Kusuhara,M., Akiyama,Y., Kagawa,H.,
            Shiomi,A., Nagashima,T., Urakami,K. and Yamaguchi,K.
  TITLE     BMP4 and PHLDA1 are plausible drug-targetable candidate genes for
            KRAS G12A-, G12D-, and G12V-driven colorectal cancer
  JOURNAL   Mol Cell Biochem 476 (9), 3469-3482 (2021)
   PUBMED   33982211
  REMARK    GeneRIF: BMP4 and PHLDA1 are plausible drug-targetable candidate
            genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer.
REFERENCE   5  (bases 1 to 5913)
  AUTHORS   R Mangone,F., Av Valoyes,M., G do Nascimento,R., Pf Conceicao,M., R
            Bastos,D., C Pavanelli,A., C Soares,I., S de Mello,E., Nonogaki,S.,
            Ab de T Osorio,C. and A Nagai,M.
  TITLE     Prognostic and predictive value of Pleckstrin homology-like domain,
            family A family members in breast cancer
  JOURNAL   Biomark Med 14 (16), 1537-1552 (2020)
   PUBMED   33179538
  REMARK    GeneRIF: Prognostic and predictive value of Pleckstrin
            homology-like domain, family A family members in breast cancer.
REFERENCE   6  (bases 1 to 5913)
  AUTHORS   Neef,R., Kuske,M.A., Prols,E. and Johnson,J.P.
  TITLE     Identification of the human PHLDA1/TDAG51 gene: down-regulation in
            metastatic melanoma contributes to apoptosis resistance and growth
            deregulation
  JOURNAL   Cancer Res 62 (20), 5920-5929 (2002)
   PUBMED   12384558
  REMARK    GeneRIF: The progressive loss of PHLDA1 expression in melanomas may
            play a role in deregulated cell growth and apoptosis resistance in
            these tumors.
REFERENCE   7  (bases 1 to 5913)
  AUTHORS   Hinz,T., Flindt,S., Marx,A., Janssen,O. and Kabelitz,D.
  TITLE     Inhibition of protein synthesis by the T cell receptor-inducible
            human TDAG51 gene product
  JOURNAL   Cell Signal 13 (5), 345-352 (2001)
   PUBMED   11369516
REFERENCE   8  (bases 1 to 5913)
  AUTHORS   Kuske,M.D. and Johnson,J.P.
  TITLE     Assignment of the human PHLDA1 gene to chromosome 12q15 by
            radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 1 (2000)
   PUBMED   10894922
REFERENCE   9  (bases 1 to 5913)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   10 (bases 1 to 5913)
  AUTHORS   Park,C.G., Lee,S.Y., Kandala,G., Lee,S.Y. and Choi,Y.
  TITLE     A novel gene product that couples TCR signaling to Fas(CD95)
            expression in activation-induced cell death
  JOURNAL   Immunity 4 (6), 583-591 (1996)
   PUBMED   8673705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR002699.1 and AC011611.26.
            
            On Dec 23, 2005 this sequence version replaced NM_007350.2.
            
            Summary: This gene encodes an evolutionarily conserved
            proline-histidine rich nuclear protein. The encoded protein may
            play an important role in the anti-apoptotic effects of
            insulin-like growth factor-1. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.47391.1,
                                           SRR1660807.230274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266671.10/ ENSP00000266671.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DR002699.1         7-195
            190-1267            AC011611.26        119365-120442       c
            1268-1789           AC011611.26        118426-118947       c
            1790-5913           AC011611.26        114302-118425       c
FEATURES             Location/Qualifiers
     source          1..5913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..5913
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="pleckstrin homology like domain family A member 1"
                     /db_xref="GeneID:22822"
                     /db_xref="HGNC:HGNC:8933"
                     /db_xref="MIM:605335"
     exon            1..1267
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1241
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="PQ-rich protein; apoptosis-associated nuclear
                     protein; proline-histidine rich protein; PQR protein;
                     proline- and glutamine-rich protein; proline- and
                     histidine-rich protein; T-cell death-associated gene 51
                     protein"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family A member
                     1"
                     /protein_id="NP_031376.3"
                     /db_xref="CCDS:CCDS31861.1"
                     /db_xref="GeneID:22822"
                     /db_xref="HGNC:HGNC:8933"
                     /db_xref="MIM:605335"
                     /translation="MRRAPAAERLLELGFPPRCGRQEPPFPLGVTRGWGRWPIQKRRE
                     GARPVPFSERSQEDGRGPAARSSGTLWRIRTRLSLCRDPEPPPPLCLLRVSLLCALRA
                     GGRGSRWGEDGARLLLLPPARAAGNGEAEPSGGPSYAGRMLESSGCKALKEGVLEKRS
                     DGLLQLWKKKCCILTEEGLLLIPPKQLQHQQQQQQQQQQQQQQQPGQGPAEPSQPSGP
                     AVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEI
                     TLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQ
                     PQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHR
                     LLRSTSNSA"
     exon            1268..5913
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="hexamer: ATTAAA"
     polyA_site      1792
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="major polyA site"
     regulatory      5167..5172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="hexamer: AATAAA"
     regulatory      5186..5191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="hexamer: AGTAAA"
     polyA_site      5198
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
     polyA_site      5206
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
     regulatory      5887..5892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
                     /note="hexamer: AATAAA"
     polyA_site      5913
                     /gene="PHLDA1"
                     /gene_synonym="DT1P1B11; PHRIP; TDAG51"
ORIGIN      
        1 gtggacgcag cgggctttgg aaaggcccca agttaatgag gcgtgcgccg gctgccgagc
       61 gcctcttgga gctgggcttt cccccgcggt gcgggcgcca ggagccgcct tttccgctgg
      121 gtgtcactcg ggggtgggga agatggccca ttcaaaagcg ccgcgagggg gcccggccag
      181 tgcccttcag tgagcgctcg caagaggacg gcagaggccc ggcagctcgg agctccggga
      241 ccttgtggcg catcaggacg cggctgtccc tctgccggga cccagagccg ccgccgccgc
      301 tctgcctcct gcgtgttagc ctcctctgcg cgctccgggc aggcggccgt gggagccgct
      361 ggggcgagga cggcgcgagg ctgctgctgc tgcccccggc ccgcgcggct ggaaacggag
      421 aggccgagcc aagcggcggc ccctcttatg ctgggaggat gctggagagt agcggctgca
      481 aagcgctgaa ggagggcgtg ctggagaagc gcagcgacgg gttgttgcag ctctggaaga
      541 aaaagtgttg catcctcacc gaggaagggc tgctgcttat cccgcccaag cagctgcaac
      601 accagcagca gcagcagcaa cagcagcagc agcagcagca acaacagccc gggcaggggc
      661 cggccgagcc gtcccaaccc agtggccccg ctgtcgccag cctcgagccg ccggtcaagc
      721 tcaaggaact gcacttctcc aacatgaaga ccgtggactg tgtggagcgc aagggcaagt
      781 acatgtactt cactgtggtg atggcagagg gcaaggagat cgactttcgg tgcccgcaag
      841 accagggctg gaacgccgag atcacgctgc agatggtgca gtacaagaat cgtcaggcca
      901 tcctggcggt caaatccacg cggcagaagc agcagcacct ggtccagcag cagcccccct
      961 cgcagccgca gccgcagccg cagctccagc cccaacccca gcctcagcct cagccgcaac
     1021 cccagcccca atcacaaccc cagcctcagc cccaacccaa gcctcagccc cagcagctcc
     1081 acccgtatcc gcatccacat ccacatccac actctcatcc tcactcgcac ccacaccctc
     1141 acccgcaccc gcatccgcac caaataccgc acccacaccc acagccgcac tcgcagccgc
     1201 acgggcaccg gcttctccgc agcacctcca actctgcctg aaaggggcag ctcccgggca
     1261 agacaaggtt ttgaggactt gaggaagtgg gacgagcaca tttctattgt cttcacttgg
     1321 atcaaaagca aaacagtctc tccgccccgc accagatcaa gtagtttgga catcacccta
     1381 ctgaaaactt gcgattcttc ttagttttct gcatactttt catcacgatg caggaaacga
     1441 tttcgagtca agaagacttt tatttatgaa cctttgaaag gatcgtcttg tatggtgaat
     1501 tttctaggag cgatgatgta ctgtaatttt attttaatgt attttgattt atgattattt
     1561 attagttttt ttttaaatgc ttgttctaag acatttctga atgtagacca ttttccaaaa
     1621 aggaaacttt attttcaaaa acctaatccg tagtaattcc taatcttgga gaataaaaaa
     1681 gggcggtgga ggggaaaaca ttaagaattt attcattatt tctcgagtac tttcagaaag
     1741 tctgacactt tcattgttgt gccagctggt tgaaattaaa actctgatat tacttttttt
     1801 gaggattttt atttttgttt ttgcttaaac atatagtttg tctagaagtt taaaaagcta
     1861 aaagttaaaa atggtgtaat tatgaaaatc taacactcaa gatagtttct aaaaggaaat
     1921 cagtagttaa ggatacctga tttcaaaata tttaaagcat aacctaactg atggtaggat
     1981 gattgtatct tgaatatgtg gtagggccac atctattgta ggaaaacctt gcttttatca
     2041 tctgtgtgta aagggcttaa taaggagaag aggccttttg actgatttgt gagtataaat
     2101 gcatttgctg tttcatttca aaaatgttgt ggaggaaaag agtacattta acttgtataa
     2161 gagaatattt gtactcctgt ccaggctgca ggacctttct tcgagagctt tgcacacttg
     2221 acttgaacca cattttctga tccctttact ttgttttaga agcacactga aaaatctcgt
     2281 tgtttaaagt acaatttgta aatatttcaa aggtctagga gtcataactt ttgttttcat
     2341 actgaaaatg atgttgatca gagaaaccaa ctgttttgct tttcattgct ctgtgagaaa
     2401 tttgaggatt ctgttttgct gttaggtaag ctaaactcag aaattgaaaa ggaaaagact
     2461 ggataaacac aggattttca gtaagaaaac aaccccagtc ttgtcttaga agccacttgt
     2521 tgaggagtct gttgggggaa aaaagaggat atgcttttaa aggtagaaca aaccttcttc
     2581 tgtgttaaat caaaaggatg ttcaaaatcc accaggacag atgctacttg ggtttaaatg
     2641 gagccataga tgatacaaag tcctcttggg gctgaaaatc acttcctatt tgcatggctt
     2701 tactaactgg tttctgtttt ccattatctt tttcacagaa agtcttggtc agtatttttc
     2761 cagcatttaa attgaaacgg tcagtattag accactgcta ggttatgtag tcaagaaata
     2821 aaaatagaat tacatgctac agatgtcttt attctccttc catctagaaa ggagttccaa
     2881 ggtcaaatta ctttttagtg caatagttaa atgacatttt gagatcataa ctcatatcca
     2941 aaaagttgca gggaaaatta aaatagcttt cccctattaa gctaatggca aacaaaactt
     3001 aagtggaccc ccacttccag tggttgttta ggttgcagtt gtgaaaatat gctgccaaca
     3061 tttaaaaact tgtttcatat gtatatatgt atacacatat atgaatatgt atgtatatat
     3121 acatatatga gaacatgtgt gtacacatat atgaatatgt atatatgtgt atgtatgtat
     3181 atatgtatat gaaatgagag ccacatctaa agatttctta aatcaagttt ggttcagctt
     3241 ccttagaact gtggctgtac tttttgagga gtacctcata gtactatatt tttaatgcat
     3301 gcaaatcata atagctccaa atgaaccaca gttttttccc aatggaggat ttttttttaa
     3361 ttcttgtact aaaaaaaaaa aatccatacc aaatattttt acaaattaag attgatgtag
     3421 gttttaaaaa aggcatttgt atgttgttag cttacatatg gggctaggta atttcattgc
     3481 ttaaaaagat gcgcctaggc tccctcttgg tggctggatt tctttttctt cgcccgtggt
     3541 ggccatggtt cttaataggg ccaccggaat catggtttct tttttttttt ttttttttga
     3601 gatggagtct cgccctgtga cccaggctgg agtgcagtgg cacgatctcg gctcactgca
     3661 acctctgcct cctgggttca cgccattctc ctgtctcagc ctcctgagta gctgggacta
     3721 caggtgaatg ccaccacgcc cggctgattt ttgtattttt agtagagatg gggtttcacc
     3781 atagtggtca ggctgttctc gaactcctga cctcaggtga tccacctgcc ttggcctccc
     3841 aaagtgctag gattacaggt gtgagccacc acacccggcc ccagaataat ggtttcttga
     3901 ctttctgtag cccttgttcc ttagtctgct gtgatattta tgttgacctt tatcattttc
     3961 tattctgaac ccctcttagc atttaatgtg aaatctaaga aattagaagt agaatggctt
     4021 ttattgtttt gacacctttg aaattattat taataatttt tccagagcaa aaaagcaaac
     4081 acgctcaata agactaaaca aaacaaaata taaatgtaca tcatttaatg tcccagtggc
     4141 tctattctac ctgtaagaaa atgatacaaa accacctaag atattttgaa gcctgacaaa
     4201 tcagcttcat ggaaaaaggt aaaaaatgca tttttcaacc gaaagggcag atccaataga
     4261 agacccgctc cttaaataaa cataaaatgt aaaaagttgg aaaattaaga gtaatgttcc
     4321 atctggaaac tgaacttttg tccttgaact tgtgttggca ccaagcctca tacacagtga
     4381 gctcaataac tgttgggaca aaggaaggaa ggacaaaatg tgtaacttcc cagcatctgg
     4441 gagatgctgt ctcttgcctc actgagtgtt ccttttcttt gctctcatgt cattccctga
     4501 gaacaatgaa ttctgggaca ggctaaacat catgatgaag tttcttaaac agactttctt
     4561 agtggaaatc catttagatc tgggtgtgct ctatggggag tgctgacgtc aaagagcaaa
     4621 tgtctataag gggccctttt aaaatgaaca ttttcctcat tgagcaagct gggattctct
     4681 aatgtagaaa tcaagccatc tttataattt cacttcagat gtttatgttt ttgttttttt
     4741 tgtctccaat gatggtaaaa ataaaaacta cgcattactt aaaggagttt ccctcacatg
     4801 taaacactgt taggaagtct ggattaagtt gaaagtcctg ttttaacttt ttttctctca
     4861 tataccaaac actctgtatt tctcttaaag aagcccttta agagaaagcc ctaattttat
     4921 atctgacagt aaagtttgct gcaagtgtat gagttcaaac acatcccttg ttttctgtcc
     4981 ctaggggaaa agtcatgtag ttttagcttg gctccagtgt taatattata ttcagtagca
     5041 gccttagaag agtggtctaa gacttgaacc tggagcaatt ttatagcaca gaatcctacg
     5101 aagataggac tgtgaacatt tgttttcttt ttcgtgtgtg tcaaactaac tggtttttgc
     5161 tttaccaata aaatgtcctc ggcagagtaa attttaaacg tgaaaattat agatcttgat
     5221 attgaatcca tcagtgattc aagagataca cctatttgcc taaaacaacc taagatgtat
     5281 tggttatgga atcatgtgtt ggataggttc ttaagacctg tttcctcaaa tcttgacaca
     5341 gttttcaagg gtggcttatt gacttgcacg gttgggcaga taatccagat ttacctaaga
     5401 ttgggtaaaa aagtcatctg tgactttgct ggcagggcat ttgctaagtg gagtacagga
     5461 tctaaaaggg ttttcttaga aagggcaata ttgtccaatg aagtaagcag aaggactctg
     5521 ggttagaagc atctgcacaa aaactggtga gacctactct ccactgctct gcagctggat
     5581 ggctgatggc aggctgagca gtggggaagc aggttttaac aacagggagt ccttccaggt
     5641 cactgtatat tgagaagaaa cataaaacta ttgtctgtta cattccgagg tcagccttct
     5701 tcttaacgtt ttataatatg caaatgccag cttctggaaa gcaagtatca tcatgtacca
     5761 aatgctttat acaccatcac attcatgaat tttttagcat ggtcagaact tgtgtaaata
     5821 tgtctcttag atgattttgg ggagatgtga tttatttttc atattttcaa aatgcatttc
     5881 atttcaaata aagttatcta ttgagacaac cga
//
