LOCUS       NP_060404               1821 aa            linear   PRI 23-MAR-2025
DEFINITION  PH-interacting protein [Homo sapiens].
ACCESSION   NP_060404
VERSION     NP_060404.4
DBSOURCE    REFSEQ: accession NM_017934.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1821)
  AUTHORS   Tirado-Class,N., Hathaway,C., Chung,W.K. and Dungrawala,H.
  TITLE     PHIP variants associated with Chung-Jansen syndrome disrupt
            replication fork stability and genome integrity
  JOURNAL   Cold Spring Harb Mol Case Stud 8 (5) (2022) In press
   PUBMED   35863899
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 1821)
  AUTHORS   Morgan,M.A.J., Popova,I.K., Vaidya,A., Burg,J.M., Marunde,M.R.,
            Rendleman,E.J., Dumar,Z.J., Watson,R., Meiners,M.J., Howard,S.A.,
            Khalatyan,N., Vaughan,R.M., Rothbart,S.B., Keogh,M.C. and
            Shilatifard,A.
  TITLE     A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in
            neurodevelopmental disorders and cancer
  JOURNAL   Genes Dev 35 (23-24), 1642-1656 (2021)
   PUBMED   34819353
  REMARK    GeneRIF: A trivalent nucleosome interaction by PHIP/BRWD2 is
            disrupted in neurodevelopmental disorders and cancer.
REFERENCE   3  (residues 1 to 1821)
  AUTHORS   Kim,D.K., Redon,C.E., Aladjem,M.I., Kim,H.K. and Jang,S.M.
  TITLE     Molecular double clips within RepID WD40 domain control chromatin
            binding and CRL4-substrate assembly
  JOURNAL   Biochem Biophys Res Commun 567, 208-214 (2021)
   PUBMED   34171797
  REMARK    GeneRIF: Molecular double clips within RepID WD40 domain control
            chromatin binding and CRL4-substrate assembly.
REFERENCE   4  (residues 1 to 1821)
  AUTHORS   Townsend,A., Lora,G., Engel,J., Tirado-Class,N. and Dungrawala,H.
  TITLE     DCAF14 promotes stalled fork stability to maintain genome integrity
  JOURNAL   Cell Rep 34 (4), 108669 (2021)
   PUBMED   33503431
  REMARK    GeneRIF: DCAF14 promotes stalled fork stability to maintain genome
            integrity.
REFERENCE   5  (residues 1 to 1821)
  AUTHORS   Raich,L., Meier,K., Gunther,J., Christ,C.D., Noe,F. and Olsson,S.
  TITLE     Discovery of a hidden transient state in all bromodomain families
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33468647
  REMARK    GeneRIF: Discovery of a hidden transient state in all bromodomain
            families.
REFERENCE   6  (residues 1 to 1821)
  AUTHORS   Filippakopoulos,P., Picaud,S., Mangos,M., Keates,T., Lambert,J.P.,
            Barsyte-Lovejoy,D., Felletar,I., Volkmer,R., Muller,S., Pawson,T.,
            Gingras,A.C., Arrowsmith,C.H. and Knapp,S.
  TITLE     Histone recognition and large-scale structural analysis of the
            human bromodomain family
  JOURNAL   Cell 149 (1), 214-231 (2012)
   PUBMED   22464331
REFERENCE   7  (residues 1 to 1821)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 1821)
  AUTHORS   Podcheko,A., Northcott,P., Bikopoulos,G., Lee,A., Bommareddi,S.R.,
            Kushner,J.A., Farhang-Fallah,J. and Rozakis-Adcock,M.
  TITLE     Identification of a WD40 repeat-containing isoform of PHIP as a
            novel regulator of beta-cell growth and survival
  JOURNAL   Mol Cell Biol 27 (18), 6484-6496 (2007)
   PUBMED   17636024
REFERENCE   9  (residues 1 to 1821)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   10 (residues 1 to 1821)
  AUTHORS   Farhang-Fallah,J., Yin,X., Trentin,G., Cheng,A.M. and
            Rozakis-Adcock,M.
  TITLE     Cloning and characterization of PHIP, a novel insulin receptor
            substrate-1 pleckstrin homology domain interacting protein
  JOURNAL   J Biol Chem 275 (51), 40492-40497 (2000)
   PUBMED   11018022
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA500781.1, DQ924532.1,
            BF934406.1, AL450327.12 and BQ006356.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 18, 2016 this sequence version replaced NP_060404.3.
            
            Summary: This gene encodes a protein that binds to the insulin
            receptor substrate 1 protein and regulates glucose transporter
            translocation in skeletal muscle cells. The encoded protein may
            also regulate growth and survival of pancreatic beta cells.
            Elevated copy number of this gene may be associated with melanoma
            severity and the encoded protein may promote melanoma metastasis in
            human patients. [provided by RefSeq, Oct 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.83153.1,
                                           SRR1803615.80009.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275034.5/ ENSP00000275034.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     Protein         1..1821
                     /product="PH-interacting protein"
                     /note="DDB1 and CUL4 associated factor 14; pleckstrin
                     homology domain interacting protein; IRS-1 PH
                     domain-binding protein; WD repeat-containing protein 11"
                     /calculated_mol_wt=206559
     Region          118..497
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          181..222
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          186..223
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          224..262
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          229..265
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          265..310
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          270..315
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          319..360
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          323..362
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          363..402
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          368..416
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          422..461
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          464..504
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          469..494
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          512..551
                     /region_name="WD 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            641
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          658..689
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            659
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            674
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            677
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            683
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18220336,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            692
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          751..927
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            879
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            880
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            881
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            911
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          924..1129
                     /region_name="Mediates interaction with IRS1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          1148..1263
                     /region_name="Bromo_WDR9_I_like"
                     /note="Bromodomain; WDR9 repeat I_like subfamily. WDR9 is
                     a human gene located in the Down Syndrome critical
                     region-2 of chromosome 21. It encodes for a nuclear
                     protein containing WD40 repeats and two bromodomains,
                     which may function as a transcriptional...; cd05529"
                     /db_xref="CDD:99958"
     Site            order(1188,1193,1196,1235,1239,1245)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99958"
     Region          1280..1310
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1281
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1296
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          1316..1434
                     /region_name="Bromo_WDR9_II"
                     /note="Bromodomain; WDR9 repeat II_like subfamily. WDR9 is
                     a human gene located in the Down Syndrome critical
                     region-2 of chromosome 21. It encodes for a nuclear
                     protein containing WD40 repeats and two bromodomains,
                     which may function as a transcriptional...; cd05496"
                     /db_xref="CDD:99928"
     Site            order(1345,1350,1353,1392,1396,1403)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99928"
     Site            1359
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1405
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          1435..1507
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1479
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1497
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1525
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1533
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          1555..1597
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1560
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          1623..1646
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1651
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Region          1751..1784
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1762
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     Site            1783
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q8WWQ0.2)"
     CDS             1..1821
                     /gene="PHIP"
                     /gene_synonym="BRWD2; CHUJANS; DCAF14; DIDOD; ndrp; RepID;
                     WDR11"
                     /coded_by="NM_017934.7:187..5652"
                     /db_xref="CCDS:CCDS4987.1"
                     /db_xref="GeneID:55023"
                     /db_xref="HGNC:HGNC:15673"
                     /db_xref="MIM:612870"
ORIGIN      
        1 mscerkglse lrselyflia rfledgpcqq aaqvlireva ekellprrtd wtgkehprty
       61 qnlvkyyrhl apdhllqich rlgplleqei pqsvpgvqtl lgagrqsllr tnksckhvvw
      121 kgsalaalhc grppespvny gsppsiadtl fsrklngkyr lerlvptavy qhmkmhkril
      181 ghlssvycvt fdrtgrrift gsddclvkiw atddgrllat lrghaaeisd mavnyentmi
      241 aagscdkmir vwclrtcapl avlqghsasi tslqfsplcs gskrylsstg adgticfwlw
      301 dagtlkinpr pakfterprp gvqmicssfs aggmflatgs tdhiirvyff gsgqpekise
      361 lefhtdkvds iqfsntsnrf vsgsrdgtar iwqfkrrewk silldmatrp agqnlqgied
      421 kitkmkvtmv awdrhdntvi tavnnmtlkv wnsytgqlih vlmghedevf vlephpfdpr
      481 vlfsaghdgn vivwdlargv kirsyfnmie gqghgavfdc kcspdgqhfa ctdshghlli
      541 fgfgssskyd kiadqmffhs dyrplirdan nfvldeqtqq aphlmpppfl vdvdgnphps
      601 ryqrlvpgre ncreeqlipq mgvtssglnq vlsqqanqei spldsmiqrl qqeqdlrrsg
      661 eavisntsrl srgsisstse vhsppnvglr rsgqiegvrq mhsnaprsei aterdlvaws
      721 rrvvvpelsa gvasrqeewr takgeeeikt yrseekrkhl tvpkenkipt vsknhahehf
      781 ldlgeskkqq tnqhnyrtrs aleetprpse eiengssssd egevvavsgg tseeeerawh
      841 sdgsssdyss dysdwtadag inlqppkkvp knktkkaess sdeeeesekq kqkqikkekk
      901 kvneekdgpi spkkkkpker kqkrlavgel tengltleew lpstwitdti prrcpfvpqm
      961 gdevyyfrqg heayvemark nkiysinpkk qpwhkmelre qelmkivgik yevglptlcc
     1021 lklafldpdt gkltggsftm kyhdmpdvid flvlrqqfdd akyrrwnigd rfrsviddaw
     1081 wfgtiesqep lqleypdslf qcynvcwdng dtekmspwdm elipnnavfp eelgtsvplt
     1141 dgecrsliyk pldgewgtnp rdeeceriva ginqlmtldi asafvapvdl qaypmyctvv
     1201 ayptdlstik qrlenrfyrr vsslmwevry iehntrtfne pgspivksak fvtdlllhfi
     1261 kdqtcyniip lynsmkkkvl sdsedeekda dvpgtstrkr kdhqprrrlr nraqsydiqa
     1321 wkkqceelln lifqcedsep frqpvdlley pdyrdiidtp mdfatvretl eagnyespme
     1381 lckdvrlifs nskaytpskr sriysmslrl saffeehiss vlsdyksalr fhkrntitkr
     1441 rkkrnrsssv sssaassper kkrilkpqlk sesstsafst ptrsipprhn aaqingktes
     1501 ssvvrtrsnr vvvdpvvteq pstssaaktf itkanasaip gktilensvk hskalntlss
     1561 pgqssfshgt rnnsakenme kekpvkrkmk ssvlpkastl skssavieqg dcknnalvpg
     1621 tiqvnghggq psklvkrgpg rkpkvevntn sgeiihkkrg rkpkklqyak pedleqnnvh
     1681 pirdevlpss tcnflsetnn vkedllqkkn rggrkpkrkm ktqkldadll vpasvkvlrr
     1741 snrkkiddpi deeeefeelk gsephmrtrn qgrrtafyne ddseeeqrql lfedtsltfg
     1801 tssrgrvrkl tekakanlig w
//
