LOCUS       XM_047417680            2410 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphoglycerate dehydrogenase (PHGDH),
            transcript variant X4, mRNA.
ACCESSION   XM_047417680
VERSION     XM_047417680.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..2410
                     /gene="PHGDH"
                     /gene_synonym="3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG;
                     PGAD; PGD; PGDH; PHGDHD; SERA"
                     /note="phosphoglycerate dehydrogenase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 135 ESTs, 1270 long SRA reads, 3 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 7 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:26227"
                     /db_xref="HGNC:HGNC:8923"
                     /db_xref="MIM:606879"
     CDS             697..2235
                     /gene="PHGDH"
                     /gene_synonym="3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG;
                     PGAD; PGD; PGDH; PHGDHD; SERA"
                     /codon_start=1
                     /product="D-3-phosphoglycerate dehydrogenase isoform X4"
                     /protein_id="XP_047273636.1"
                     /db_xref="GeneID:26227"
                     /db_xref="HGNC:HGNC:8923"
                     /db_xref="MIM:606879"
                     /translation="MNTPNGNSLSAAELTCGMIMCLARPETFRDQEITFPMARPAFPP
                     AGGGSGGIYLCSNSSLQFPSELSGPALFKGIGEMLWFKRSSPLSTAHHDLTHQRQIPQ
                     ATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPE
                     VSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGI
                     VDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGE
                     EIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQ
                     VITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAP
                     GEQGFGECLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQ
                     TSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAF
                     QFHF"
ORIGIN      
        1 tttatcgctg gttgggagtg accagactcg actagaatcc gatcccaaac gctcccagat
       61 gatttatagt cttagcaaat ttttatctcc ttttgttgtg atatataatt aatctacttc
      121 aaatctttat ccaccgtgtt tgaaaaggcc tgctgggcct ggtggccttg tccggaatat
      181 ttattttgtg aactcttcac tccagtgcct gcactttcga cctctgtagt cgacccagct
      241 gcccagtctc tacctcacct gatccagtat attctccccc accctccaaa tcgcacaacc
      301 gccttctgcc cgcctcagcc ctgtccacca ccttcagccg tctcctcctc cgaggacccc
      361 ttagaccgca gaggctgctg ttgttgcttt agttgtgcca caaccacgtg gtcctggaaa
      421 ctgcctcgct cactttgtct gcctttgtat ctgctggcgt ggatcttgtc accatggcat
      481 gacactatat ccaagtatcc agctctgccc tgtactcaga agaatttggt ccctgccttc
      541 aagaagtttg actgtgaagg ccttattgtt cgctctgcca ccaaggtgac cgctgatgtc
      601 atcaacgcag ctgagaaact ccaggtggtg ggcagggctg gcacaggtgt ggacaatgtg
      661 gatctggagg ccgcaacaag gaagggcatc ttggttatga acacccccaa tgggaacagc
      721 ctcagtgccg cagaactcac ttgtggaatg atcatgtgcc tggccaggcc tgaaaccttc
      781 cgggaccaag aaattacttt tcccatggcg agacctgctt tccctcctgc tggaggagga
      841 tctgggggaa tttacctctg ctctaactcc tccctgcagt ttccatctga gctctctgga
      901 ccagctttgt ttaaaggaat cggtgaaatg ctgtggttta aaagaagctc cccattgtca
      961 actgctcacc atgacctcac tcatcaaagg cagattcccc aggcgacggc ttcgatgaag
     1021 gacggcaaat gggagcggaa gaagttcatg ggaacagagc tgaatggaaa gaccctggga
     1081 attcttggcc tgggcaggat tgggagagag gtagctaccc ggatgcagtc ctttgggatg
     1141 aagactatag ggtatgaccc catcatttcc ccagaggtct cggcctcctt tggtgttcag
     1201 cagctgcccc tggaggagat ctggcctctc tgtgatttca tcactgtgca cactcctctc
     1261 ctgccctcca cgacaggctt gctgaatgac aacacctttg cccagtgcaa gaagggggtg
     1321 cgtgtggtga actgtgcccg tggagggatc gtggacgaag gcgccctgct ccgggccctg
     1381 cagtctggcc agtgtgccgg ggctgcactg gacgtgttta cggaagagcc gccacgggac
     1441 cgggccttgg tggaccatga gaatgtcatc agctgtcccc acctgggtgc cagcaccaag
     1501 gaggctcaga gccgctgtgg ggaggaaatt gctgttcagt tcgtggacat ggtgaagggg
     1561 aaatctctca cgggggttgt gaatgcccag gcccttacca gtgccttctc tccacacacc
     1621 aagccttgga ttggtctggc agaagctctg gggacactga tgcgagcctg ggctgggtcc
     1681 cccaaaggga ccatccaggt gataacacag ggaacatccc tgaagaatgc tgggaactgc
     1741 ctaagccccg cagtcattgt cggcctcctg aaagaggctt ccaagcaggc ggatgtgaac
     1801 ttggtgaacg ctaagctgct ggtgaaagag gctggcctca atgtcaccac ctcccacagc
     1861 cctgctgcac caggggagca aggcttcggg gaatgcctcc tggccgtggc cctggcaggc
     1921 gccccttacc aggctgtggg cttggtccaa ggcactacgc ctgtactgca ggggctcaat
     1981 ggagctgtct tcaggccaga agtgcctctc cgcagggacc tgcccctgct cctattccgg
     2041 actcagacct ctgaccctgc aatgctgcct accatgattg gcctcctggc agaggcaggc
     2101 gtgcggctgc tgtcctacca gacttcactg gtgtcagatg gggagacctg gcacgtcatg
     2161 ggcatctcct ccttgctgcc cagcctggaa gcgtggaagc agcatgtgac tgaagccttc
     2221 cagttccact tctaaccttg gagctcactg gtccctgcct ctggggcttt tctgaagaaa
     2281 cccacccact gtgatcaata gggagagaaa atccacattc ttgggctgaa cgcgggcctc
     2341 tgacactgct tacactgcac tctgaccctg tagtacagca ataaccgtct aataaagagc
     2401 ctacccccaa
//
