LOCUS       NM_015297               5757 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens PHD finger protein 24 (PHF24), transcript variant 1,
            mRNA.
ACCESSION   NM_015297 XM_048592 XM_939621
VERSION     NM_015297.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5757)
  AUTHORS   Park,J.C., Luebbers,A., Dao,M., Semeano,A., Nguyen,A.M.,
            Papakonstantinou,M.P., Broselid,S., Yano,H., Martemyanov,K.A. and
            Garcia-Marcos,M.
  TITLE     Fine-tuning GPCR-mediated neuromodulation by biasing signaling
            through different G protein subunits
  JOURNAL   Mol Cell 83 (14), 2540-2558 (2023)
   PUBMED   37390816
REFERENCE   2  (bases 1 to 5757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5757)
  AUTHORS   Miyamoto,K., Yamashita,A. and Saito,K.
  TITLE     Solution structure of the PHD finger from the human KIAA1045
            protein
  JOURNAL   Protein Sci 27 (5), 987-992 (2018)
   PUBMED   29430827
  REMARK    GeneRIF: Cross-brace structural motifs are required as a scaffold
            to design artificial RING fingers (ARFs) that function as ubiquitin
            ligase (E3) in ubiquitination and have specific
            ubiquitin-conjugating enzyme (E2)-binding capabilities.
REFERENCE   4  (bases 1 to 5757)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355377.25, AB028968.1 and BC041169.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_015297.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR, and
            uses an alternate in-frame splice site in the 3' coding region,
            compared to variant 5. The encoded isoform (1) is shorter than
            isoform 2. Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041169.1, AB028968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242315.4/ ENSP00000242315.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL355377.25        83043-83081
            40-1458             AB028968.1         1-1419
            1459-5559           AL355377.25        103004-107104
            5560-5757           BC041169.1         5649-5846
FEATURES             Location/Qualifiers
     source          1..5757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..5757
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /note="PHD finger protein 24"
                     /db_xref="GeneID:23349"
                     /db_xref="HGNC:HGNC:29180"
                     /db_xref="MIM:619928"
     exon            1..117
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     exon            118..499
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1324
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Galpha inhibitory interacting protein"
                     /codon_start=1
                     /product="PHD finger protein 24 isoform 1"
                     /protein_id="NP_056112.1"
                     /db_xref="CCDS:CCDS43796.1"
                     /db_xref="GeneID:23349"
                     /db_xref="HGNC:HGNC:29180"
                     /db_xref="MIM:619928"
                     /translation="MGVLMSKRQTVEQVQKVSLAVSAFKDGLRDRPSIRRTGELPGSR
                     RGTVEGSVQEVQEEKEAEAGTSVVQEESSAGRAAWERLRDGRGVEPEEFDRTSRFTPP
                     AFIRPTRKLDDDKPPEICLEPREPVVNDEMCDVCEVWTAESLFPCRVCTRVFHDGCLR
                     RMGYIQGDSAAEVTEMAHTETGWSCHYCDNINLLLTEEEMYSLTETFQRCKVIPDCSL
                     TLEDFLRYRHQAAKRGDRDRALSEEQEEQAARQFAALDPEHRGHIEWPDFLSHESLLL
                     LQQLRPQNSLLRLLTVKERERARAAFLARGSGSTVSEAECRRAQHSWFCKRFPEAPSC
                     SVSISHVGPIADSSPASSSSKSQDKTLLPTEQESRFVDWPTFLQENVLYILAARPNSA
                     AIHLKPPG"
     exon            500..685
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     exon            686..764
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     exon            765..970
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1131
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1227
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..5757
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5737..5742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /note="hexamer: AATAAA"
     polyA_site      5757
                     /gene="PHF24"
                     /gene_synonym="GINIP"
                     /note="major polyA site"
ORIGIN      
        1 gcctgctgcc ggcgctcggc ccagcacgcc ggctctcggg ctgccgtggg ctgcgcgggg
       61 cccgcggtgt gtagagtccg ccgccccgga gccgcgtccc gcacccggac ggtcccgagc
      121 catgggggtg ttgatgtcca agcggcagac agtggagcag gtgcagaagg tgagtctggc
      181 tgtgtctgct ttcaaggatg ggctgcggga caggccttcc atccgacgca caggtgagct
      241 gccagggtcc cgccgtggca ctgtagaggg ctccgtccag gaggtacagg aggagaagga
      301 agcagaagca ggaacctcgg tggtccagga agagagtagt gccggccgcg cagcctggga
      361 gcggctccga gatgggcgcg gcgtggagcc tgaggagttt gacaggacaa gtcgattcac
      421 accccctgcg ttcatccgcc ccacccggaa gctggatgat gacaaacctc cagaaatctg
      481 cctggagccc agagagcctg ttgtcaacga tgagatgtgt gatgtttgtg aggtctggac
      541 agctgagagc ctcttcccgt gcagggtctg caccagggtt ttccatgatg gctgcctgcg
      601 ccgcatgggc tacatccaag gagacagtgc agcggaggtg acggagatgg cccacacaga
      661 aacaggctgg agctgccact actgtgacaa catcaacttg ctgcttactg aggaggaaat
      721 gtatagcctc acggagacct ttcagcggtg taaagtcatc cctgattgct ccctgacact
      781 ggaggacttt ctgcgttacc gccaccaagc agccaagcgg ggggaccgtg acagggccct
      841 gagtgaggag caagaagagc aggcggcccg ccagtttgct gccctggacc ctgaacatcg
      901 aggccacata gagtggcctg acttcttgtc ccatgagtcc ctcctgcttc tgcagcagtt
      961 gcgtccccag aactctctgt tgaggcttct gacagtgaag gagcgggagc gagcccgagc
     1021 cgccttcctg gctcggggca gtgggagcac cgtcagtgag gcagagtgcc gccgggccca
     1081 gcactcttgg ttttgcaaac ggttcccaga ggctccttcc tgcagtgtca gcatcagcca
     1141 tgtgggtccc atcgcagata gcagcccagc cagcagcagc agcaagagtc aggacaagac
     1201 cctgctgccc acagagcagg agtccagatt tgtggactgg cctaccttcc tgcaagagaa
     1261 tgtcctctac atcctggctg ctcgccccaa cagcgcagcc attcacctga agcccccagg
     1321 atagcatgga gcagagaagc tcggtttgag gacagtgaca tcctctccct cctttccttt
     1381 ctcccttccc ccaccaacct ctggcacaga gactcatggg gttgggacac tgccagcgtc
     1441 ttaacttgtc actaagcttt aaggcactga aatcaccatt cccctcacaa tagaggcagt
     1501 gaatgcattg ccacaaggag aagccctggg agctgtggca gcatcctctc ctggaccgcc
     1561 cctgccccac atcatagacg ggacctgcca ccacacttat atacatgtgc acatgctgcc
     1621 cagctgtcca tgccttcaga agcctggttc tttttggttg agaaaggacc aaagtccctt
     1681 tgtgaagccc ctggtataga ggagggggtc tctactcacc ccttctatag gcaggccagt
     1741 tctaatttcc aatagataag tctctggcca agtgattctt aggaaggggg catgtcagac
     1801 tcgcatgcct gcctagagct cctggagatc ctaatgggcc ccgctttctc caccaaaaat
     1861 cccttctgca gtcagctgct gttactagta ggtgtgcatt atgtacctcg gctgtactga
     1921 gttgggaaaa gagttaaaca tcaccactga aattcagccc tttatttatt taaattccaa
     1981 ttcctggtga cagaaaaggc aactagcctg gagaatcctg actggaagag ggggaggcag
     2041 cccttcccag ggactcggga ttctaggaac ctctcagtca ggtcacctga gtccaaaagt
     2101 ctttagcagg gtagtcaaaa atcaaggtga gccttcttgg ccccattttt cagatggtag
     2161 ctcatggcct agggccaagg gggcctgaat ggagcaaaca cactggcagg agccacagcc
     2221 ctctgtgtta gatgcttcac ccaagtcacc gaccacagag actgacgaga gcacactctg
     2281 gaggaagagg agagaacggg gctctgcttc ctcatcattc cagctcaact caactgtaga
     2341 caccttccac agcccaagaa agatctgcag agccctgagc agggactctt tcagccatcc
     2401 tgacaaacag gataagaggc tggggcttaa gaagaggctc tgcagagaag gtcctgggaa
     2461 agccttacag aagaagtttt ccgcttctcc ctatcactga gactcggctt gagtggctgc
     2521 ttctcctcac tgctcatcac atgtccttcc ccagcaggct agggcttggg cctggcatgg
     2581 aaggcctttt ggggcaatca gaggctgcca caagagcacc aagcctggcc tccaagcccc
     2641 agccctcctt cctaagtact catcaaattc aaattcttca gtccgtgtgt tatggctcat
     2701 cttggccggc cgtggggtcc atgttctagg cttctgtttc caacttaatg acttaggcat
     2761 agcgagatct gactaccaag agttattcaa aagggagtgg agtgcagtca tgcagaagca
     2821 aacacgtctt cattgctcga ggcccttgtg ctaaatcggg tgcgtacaga agaacacaca
     2881 ccgctcggtg ctgaatgttt cgaggaaagc aaggagctgc ggccaggggc ttcttgagag
     2941 ccctgtgtag tctcctcctg taggaaccac cttagctgga agcagggtgg tgagctgctg
     3001 gggttggatt atttgggact gaaatgaagc agacaggaga caaatctggg ctcaggtgta
     3061 tggcccacag cttttagaaa tgctcttcag ccgtccccca ggattgatcc ataggagggg
     3121 ccattattca gtctagtcaa aacaagaaag cgcaggactc ctgggcctaa gaactgcatc
     3181 tgaagcagcc aggcctgggg ttttgcactg agatgaaagc acattaagca caggggctct
     3241 tacctactct cctggcaaat catctcctgt gccactggcc ttgggctgct cgatctcaca
     3301 gacggggcat tttgagtaga gacaagctct gggctttgag agctgaatag catttttctc
     3361 ctgcctcatc agtcacaggg actggaagtc catcttgttc cctgatcctt cacagatcaa
     3421 ggtgatgcct acctctttgg agctgctgcc tctagctctc cacgggtgag tgaggagagt
     3481 tggtgggcca ggtcaggcct gccgtattcc agggcctggc aaagcagccc cagagttctt
     3541 ccacaacagg aacaggccca tttggatcac gcttctccct attccagaac agcaaacttc
     3601 ctgggtgagg gcctgctaca gagatcccag gggacacttc cctcagcaaa gagtagagtt
     3661 cccatcccac aagagtccta ggaagcagga aagcacgaag gagcagccag cctcttctcc
     3721 acaggcagtc atctagcttt ttaccaaagg ggaagtgccg ttgctcccca agtccagagt
     3781 tgcagacgcc ctgccccaac ccccgtccag aatctccctt tgcagtgttc taatccccag
     3841 agcccctctg cggtatgtat agagttgtta aaaacgttca gaaacccagt gaagcccatt
     3901 tcgttttcaa gccctcccat cactgtgact ctgaaattct gccaagtaca aatattagcg
     3961 tttggctcta ataagggtat gagaaaatgt ttcagtcttt tctttgtggc tacccaaaat
     4021 tgagatcagt gtttctaacc aaggaaggcc tgggttatag acaggctcct ctgaagccca
     4081 cttgccctaa gcatttttca cctagcattc ctcttcctca tgttcagatg tgaatgaagg
     4141 ggcagctgga ggatgtggtg gagctgcagg gaccgagggt cagctgagca gtggccctgg
     4201 ccacaaaacc actccaagtc tgctccttgg cttcctctcc tgagcccagc cttccccaac
     4261 agaacacttg agcaagggcc cctagagtat cccagggatg gagcagtccc ctcactctag
     4321 gtactgatct aaccttcaag tgctcctctt catttgagga cacctacagt agaaaccatg
     4381 aggacattgc ctctttctgc cctcagccca agtacctggg gctagcaggg cagataccag
     4441 cctttctggt cctgctgctc cctatgggat gtcaccctga ccttgcttaa gtggccaagt
     4501 cttagggtcc ccttattcct gtcaccatta tgaaaaacac agcattaaac tgcctgggaa
     4561 gaggacacct ccttggggga gtgagcccca aggttatacc caggactcat agcccaaagc
     4621 acaacctcgg ccattgcagg tttcacagct tcagtcagag tggtgccagg aagcccaaaa
     4681 gccaagaggg aaggtcagca gaagctgcct ggcaaggccc caggccagcc aggcccaccc
     4741 cagagccaag agaaacttca agcaggactg agaactggta gctggctcta gtgatcctga
     4801 aagcatgttc ccttcagacc agcagagtga agacagacag atgtgtggcc ctaaaaggca
     4861 gaacagtttt gatgccagaa cttcaggact gtcaccacag tcccttttta cccctcctct
     4921 atttacagtg aaataaaatt cctattttct tttttttttt tttttaattt tccttatttc
     4981 aagctcttat ctgaaaaaat gctactttct cctaccactt agtttgaatt tgcccaggat
     5041 atctgtctgg gcccctggct gcaacccaga caatggcgag atctcctgga gtgggggata
     5101 ttcacgcatc gtgcctgttc ctgacagctc agccctggtg tagggtggga ctgggcattt
     5161 tctctgctgt tacttttctg ctaccactat ttttggcaac cttggaaaga aaataaacag
     5221 gttacagaat ttcggctagc actaagggaa agctttttcc tctgggccac atgccccagt
     5281 gacccagagc atggaaaggg ggtcagctct ggtctgggcc agtgactaag aagcccaatc
     5341 acattccagt ttctatagca ctgggtaggc acaacccaca gttaagaaca tcaagttata
     5401 agtagccagg ccttttcata gccatggtga cacaaaggcc ctcaagatta gcctcctgcc
     5461 atcatgggtt ggcctgtgat ctgtccccca gccaaaccca agtttgtgag agggactctg
     5521 agaacacttg agcaacactt gggaatccaa tgcgctctgg tccctcatgc ccttcccatg
     5581 tgcttttctg cagaaggtaa cttgacagca agctgagggg aacgtcccca agccctgtct
     5641 ccctgtctct acagctgcat gctcctctgc gtggcccagc cttcacagcg ctccagaaga
     5701 agctgatgcc ctgaggctgg gcacagtgga aatcataata aagcgattgc gatgctc
//
