LOCUS       NM_024297               1978 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PHD finger protein 23 (PHF23), transcript variant 1,
            mRNA.
ACCESSION   NM_024297
VERSION     NM_024297.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Cheng,M., Cao,H., Yao,P., Guan,J., Wu,P., Ji,H., Jiang,S., Yuan,Y.,
            Fu,L., Zheng,Q. and Li,Q.
  TITLE     PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance
            via stabilization of ACTN4 and activation of the ERK pathway
  JOURNAL   Cell Death Dis 14 (8), 558 (2023)
   PUBMED   37626047
  REMARK    GeneRIF: PHF23 promotes NSCLC proliferation, metastasis, and
            chemoresistance via stabilization of ACTN4 and activation of the
            ERK pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Zhang,Y., Guo,Y., Gough,S.M., Zhang,J., Vann,K.R., Li,K., Cai,L.,
            Shi,X., Aplan,P.D., Wang,G.G. and Kutateladze,T.G.
  TITLE     Mechanistic insights into chromatin targeting by leukemic
            NUP98-PHF23 fusion
  JOURNAL   Nat Commun 11 (1), 3339 (2020)
   PUBMED   32620764
  REMARK    GeneRIF: Mechanistic insights into chromatin targeting by leukemic
            NUP98-PHF23 fusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Wang,Z., Hu,J., Li,G., Qu,L., He,Q., Lou,Y., Song,Q., Ma,D. and
            Chen,Y.
  TITLE     PHF23 (plant homeodomain finger protein 23) negatively regulates
            cell autophagy by promoting ubiquitination and degradation of E3
            ligase LRSAM1
  JOURNAL   Autophagy 10 (12), 2158-2170 (2014)
   PUBMED   25484098
  REMARK    GeneRIF: Plant homeodomain finger protein 23 negatively regulates
            cell autophagy by promoting ubiquitination and degradation of E3
            ligase LRSAM1
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Kettunen,J., Tukiainen,T., Sarin,A.P., Ortega-Alonso,A.,
            Tikkanen,E., Lyytikainen,L.P., Kangas,A.J., Soininen,P., Wurtz,P.,
            Silander,K., Dick,D.M., Rose,R.J., Savolainen,M.J., Viikari,J.,
            Kahonen,M., Lehtimaki,T., Pietilainen,K.H., Inouye,M.,
            McCarthy,M.I., Jula,A., Eriksson,J., Raitakari,O.T., Salomaa,V.,
            Kaprio,J., Jarvelin,M.R., Peltonen,L., Perola,M., Freimer,N.B.,
            Ala-Korpela,M., Palotie,A. and Ripatti,S.
  TITLE     Genome-wide association study identifies multiple loci influencing
            human serum metabolite levels
  JOURNAL   Nat Genet 44 (3), 269-276 (2012)
   PUBMED   22286219
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Reader,J.C., Meekins,J.S., Gojo,I. and Ning,Y.
  TITLE     A novel NUP98-PHF23 fusion resulting from a cryptic translocation
            t(11;17)(p15;p13) in acute myeloid leukemia
  JOURNAL   Leukemia 21 (4), 842-844 (2007)
   PUBMED   17287853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA131173.1, BC002509.2 and BC008630.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024297.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1053491.1,
                                           SRR3476690.370932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320316.8/ ENSP00000322579.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA131173.1         50-63
            15-1746             BC002509.2         12-1743
            1747-1978           BC008630.1         1306-1537
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1978
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /note="PHD finger protein 23"
                     /db_xref="GeneID:79142"
                     /db_xref="HGNC:HGNC:28428"
                     /db_xref="MIM:612910"
     exon            1..212
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1390
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /note="isoform 1 is encoded by transcript variant 1; PHD
                     finger protein 23a; PDH-containing protein JUNE-1"
                     /codon_start=1
                     /product="PHD finger protein 23 isoform 1"
                     /protein_id="NP_077273.2"
                     /db_xref="CCDS:CCDS42250.1"
                     /db_xref="GeneID:79142"
                     /db_xref="HGNC:HGNC:28428"
                     /db_xref="MIM:612910"
                     /translation="MLEAMAEPSPEDPPPTLKPETQPPEKRRRTIEDFNKFCSFVLAY
                     AGYIPPSKEESDWPASGSSSPLRGESAADSDGWDSAPSDLRTIQTFVKKAKSSKRRAA
                     QAGPTQPGPPRSTFSRLQAPDSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRP
                     PAALTPVPLSQGDLSHPPRKKDRKNRKLGPGAGAGFGVLRRPRPTPGDGEKRSRIKKS
                     KKRKLKKAERGDRLPPPGPPQAPPSDTDSEEEEEEEEEEEEEEMATVVGGEAPVPVLP
                     TPPEAPRPPATVHPEGVPPADSESKEVGSTETSQDGDASSSEGEMRVMDEDIMVESGD
                     DSWDLITCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKCKELRPEAR
                     RLGGPPKSGEP"
     exon            213..244
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            245..337
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            338..1175
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1978
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /note="hexamer: TATAAA"
     polyA_site      1730
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /note="major polyA site"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
                     /note="hexamer: AATAAA"
     polyA_site      1978
                     /gene="PHF23"
                     /gene_synonym="hJUNE-1b"
ORIGIN      
        1 agtgcgggag gcagtggtag agggaggtgg cggcagcggc tagcggactc gagtctcaac
       61 cgggctgagg cggacacttc tgtggagcga agcagtggga gcatcgagca ctagaggcgg
      121 caccgggatc cccggctccg gggagggggg cgccggaccg ggaggagggg agggggcgat
      181 gctggaagcc atggcggagc ccagtcccga agatccacct ccgaccctta agccagagac
      241 tcagccacca gagaaacggc ggagaacaat tgaggatttc aacaaattct gcagttttgt
      301 tttggcatat gctggttaca ttccccctag caaagaggaa agtgactggc cagcctctgg
      361 ctccagctct ccattgcgag gagagagtgc ggccgacagt gatggctggg actcggcccc
      421 ctcagatctt cgaaccatcc agacttttgt taagaaagca aagtcatcca agagaagggc
      481 agctcaagca ggtcccaccc agccaggacc cccaaggtcc actttctctc gtctgcaggc
      541 ccccgacagt gctaccttgc ttgagaagat gaagctcaag gactctctct ttgatctgga
      601 tgggcccaaa gtggcatctc ctttgtcccc cacatccctg acacatacct cccggccccc
      661 tgctgctctt acccccgtgc ccctttccca gggggacctc tcccatcctc ctcgaaagaa
      721 ggaccgaaag aaccgaaagt tggggccagg agctggggct ggctttgggg tgcttcggag
      781 gcctcggcca actcctgggg atggggaaaa gagatctcga atcaagaaga gcaagaagcg
      841 gaagttaaaa aaggcagaac ggggggatag actcccacct cctgggcctc cccaggcacc
      901 ccccagtgat acagactctg aagaggagga ggaagaggag gaagaggaag aagaagaaga
      961 gatggcaaca gtggtagggg gtgaagcccc agtccctgtg ctgccaacac cccctgaggc
     1021 tcctaggccc cctgccacag tgcaccctga aggagtccct cctgctgaca gtgaaagcaa
     1081 ggaggtgggc agcactgaaa caagccaaga tggagatgcc agctccagtg aaggcgagat
     1141 gcgggtcatg gacgaggaca tcatggtaga atcaggtgat gactcatggg atctgatcac
     1201 atgttactgt cgaaagccct ttgcagggcg gcccatgatt gagtgcagcc tgtgtgggac
     1261 gtggatccac ctctcctgtg ctaagattaa gaagaccaac gtccccgact tcttttattg
     1321 ccagaaatgc aaggaactga ggccagaggc ccggcggtta ggggggcctc ccaaatctgg
     1381 agagccctga tggcaccaac tttagcctgg aacttccaaa tgacaacatg atttgggaac
     1441 tgagcctcag ggtcctcagc ctatcccctg gagcttggat actgtctgca cttcaaggca
     1501 ggaattctca agggagactt gtttgaaaat gagtgtctca ctttcccacc ctatccttcc
     1561 tccccactct gtggacttga aattgaatcc attacggttg gggatgggag gctgtctgtg
     1621 tcccgacaca taatctctgt ctcttggacc tgccaccatc actttctggg tcaggattgg
     1681 aattgggatg gaatgggaca gttgtctata aaactctagt gtaaatatta gcactcccct
     1741 ccctcatctt ttcttctatt tcactcccca tttattttct tctacaccgg ttgtattttt
     1801 aattttggac ttcccctatt gggcatggca gctcaaaggt ggagtactag agcctggcca
     1861 agtgaggaag gaaagcagaa aggtgacgat tctcactcac ctcttttgtt tttaataata
     1921 tcggccgctg tttgtacaga cagcctgcgt gttgtaaata aagcagagtg ggctcttt
//
