LOCUS       NM_138415               3976 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens PHD finger protein 21B (PHF21B), transcript variant 1,
            mRNA.
ACCESSION   NM_138415
VERSION     NM_138415.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3976)
  AUTHORS   Wong,M.L., Arcos-Burgos,M., Liu,S., Velez,J.I., Yu,C., Baune,B.T.,
            Jawahar,M.C., Arolt,V., Dannlowski,U., Chuah,A., Huttley,G.A.,
            Fogarty,R., Lewis,M.D., Bornstein,S.R. and Licinio,J.
  TITLE     The PHF21B gene is associated with major depression and modulates
            the stress response
  JOURNAL   Mol Psychiatry 22 (7), 1015-1025 (2017)
   PUBMED   27777418
  REMARK    GeneRIF: PHF21b variants contribute significantly to differences in
            the levels of expression of this gene in several brain areas,
            including the hippocampus. Furthermore, using an animal model of
            stress, we found that Phf21b hippocampal gene expression is
            significantly decreased in animals resilient to chronic restraint
            stress when compared with non-chronically stressed animals.
REFERENCE   2  (bases 1 to 3976)
  AUTHORS   Li,Q., Ye,L., Guo,W., Wang,M., Huang,S. and Peng,X.
  TITLE     PHF21B overexpression promotes cancer stem cell-like traits in
            prostate cancer cells by activating the Wnt/beta-catenin signaling
            pathway
  JOURNAL   J Exp Clin Cancer Res 36 (1), 85 (2017)
   PUBMED   28645312
  REMARK    GeneRIF: PHF21B constitutively activated wnt/beta-catenin signaling
            by transcriptionally downregulating SFRP1 and SFRP2, which promotes
            prostate cancer stem cell-like phenotype.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3976)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 3976)
  AUTHORS   Bertonha,F.B., Barros Filho Mde,C., Kuasne,H., Dos Reis,P.P., da
            Costa Prando,E., Munoz,J.J., Roffe,M., Hajj,G.N., Kowalski,L.P.,
            Rainho,C.A. and Rogatto,S.R.
  TITLE     PHF21B as a candidate tumor suppressor gene in head and neck
            squamous cell carcinomas
  JOURNAL   Mol Oncol 9 (2), 450-462 (2015)
   PUBMED   25454821
  REMARK    GeneRIF: These data suggest that PHF21B is a novel tumor suppressor
            gene that can be inactivated by genetic and epigenetic mechanisms
            in the human cancer.
REFERENCE   5  (bases 1 to 3976)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   6  (bases 1 to 3976)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049760.26, BC012187.1 and Z83838.2.
            
            On Nov 23, 2018 this sequence version replaced NM_138415.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012187.1, KU178842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313237.10/ ENSP00000324403.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AL049760.26        2396-2700           c
            306-2992            BC012187.1         1-2687
            2993-2993           Z83838.2           67596-67596         c
            2994-3233           BC012187.1         2689-2928
            3234-3976           BC012187.1         2930-3672
FEATURES             Location/Qualifiers
     source          1..3976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..3976
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /note="PHD finger protein 21B"
                     /db_xref="GeneID:112885"
                     /db_xref="HGNC:HGNC:25161"
                     /db_xref="MIM:616727"
     exon            1..510
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2052
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /note="isoform 1 is encoded by transcript variant 1; PHD
                     finger protein 4"
                     /codon_start=1
                     /product="PHD finger protein 21B isoform 1"
                     /protein_id="NP_612424.1"
                     /db_xref="CCDS:CCDS14061.1"
                     /db_xref="GeneID:112885"
                     /db_xref="HGNC:HGNC:25161"
                     /db_xref="MIM:616727"
                     /translation="MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQALGT
                     ITAVPVTGPQVSSLQRLAGQGAAVLPQVRPKTLIPDSLPVAPGRDRPPKQPPTFQKAT
                     VVSVKNPSPALPTANNTVSHVPAPGSQPQALAEPAALASPLSSAGVAYAIISTSPSNA
                     AAMAPSTAVSVVSDSIKVQPLLISADNKPPPRLLSSPHPATHHCPLHPSSLPLTPPSP
                     SLSPSPLHGIFQVIIIQPQVQTQPESTAESRPPTEEPSQGAQATKKKKEDRPPTQENP
                     EKIAFMVALGLVTTEHLEEIQSKRQERKRRSTANPAYSGLLETERKRLASNYLNNPLF
                     LTARANEDPCWKNEITHDEHCAACKRGANLQPCGTCPGAYHLSCLEPPLKTAPKGVWV
                     CPRCQQKALKKDEGVPWTGMLAIVHSYVTHKTVKEEEKQKLLQRGSELQNEHQQLEER
                     DRRLASAVQKCLELKTSLLARQRGTQSSLDRLRALLRLIQGEQLLQVTMTTTSPAPLL
                     AGPWTKPSVAATHPTVQHPQGHN"
     exon            511..576
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            577..669
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1020
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1287
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1339
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1416
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1471
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1494
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1653
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1729
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1833
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..3976
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /note="hexamer: ATTAAA"
     polyA_site      3976
                     /gene="PHF21B"
                     /gene_synonym="BHC80L; PHF4"
                     /note="major polyA site"
ORIGIN      
        1 actgccgaat tagcatcgtg ccgaggcaca actttgccga ggcccaacga gatccaggcg
       61 cgcgcgccgg aggaaatata gtccctgccc gcgggaggct cgcgcgggag gaggcggcgg
      121 cggcggcggc tgggcgggcg cgcgcggggc tgcgcggggc tcccggcgcc gggggggcca
      181 tgctccgggc cgcgccggca gcccggggac ccggcgcaac ttgccgggca gcctgaggag
      241 ttggggcagc cgagggctcg gcgccgcggc gcccggaagc ctgtcttccc cttcgccagc
      301 ccccttccct ttcggccgtg ggggaggggg ctcgtgtccc ccccaaccca gcccggaggc
      361 cgcgtccgcc cgcgcccgct ctggcccccg cggagccgcg caacttcccg ggagcccggg
      421 ccaaagtgag cgcaaagtgc tgcccaagtt gccgggatgg agctgcagag ccggcccgag
      481 gcgctcgccg tggaactcgc gcgccaccag aacggcgacc tcaagaagca gctccacgaa
      541 aggcagccgc ggatcgccgc gctcagcgac aaacaagctt tgggaacgat cactgcagtg
      601 cctgtcacgg gtcctcaggt cagctccttg cagaggttgg ccgggcaagg agcggcagtg
      661 ctacctcagg ttaggccaaa gactctgatt ccagacagcc tccccgttgc cccgggccgg
      721 gaccggccac ccaagcagcc cccaacattc cagaaggcca ccgtggtcag cgtcaagaac
      781 cccagcccag ccctccccac cgccaacaac actgtcagcc atgtgccagc gcccggcagc
      841 cagccccagg ccctcgccga gcccgccgcc ctcgcctctc cgctgagcag tgcgggggtg
      901 gcctacgcca tcatctccac ctcccccagc aatgccgccg ccatggcccc cagcaccgcc
      961 gtgtctgtgg tcagtgacag catcaaagtc cagcccctcc tcatcagtgc tgacaacaag
     1021 cctcctccac gcctcctctc ttcccctcac cccgcaaccc atcactgtcc cctccacccc
     1081 tcctctcttc ccctcacccc tccctcccca tcactgtccc cttcacccct ccatggcatc
     1141 ttccaggtca tcatcattca gcctcaagtg cagacgcagc ccgagagcac ggcagagtcg
     1201 cggccgccca cagaggagcc atctcaggga gctcaggcca ccaaaaagaa gaaggaagac
     1261 cggcccccga cccaggagaa ccccgagaaa atcgccttca tggtagcgct aggcctggtt
     1321 accacggaac atttggaaga aatccagagc aagcgacagg agcggaagag aagaagcaca
     1381 gccaaccctg cctacagcgg cctcctggag accgagagga aacggctggc ctccaactat
     1441 ctcaacaacc ccctgttcct cacagcgaga gccaatgagg acccctgctg gaagaacgag
     1501 atcacccacg atgagcactg tgccgcctgc aagcgagggg ccaacctgca gccctgcggc
     1561 acctgcccgg gggcctacca cctcagctgc ctggagccgc ccctcaagac ggcgcccaag
     1621 ggcgtgtggg tgtgccccag gtgccagcag aaggccttaa agaaagacga gggtgtgccc
     1681 tggactggga tgctggccat cgtgcactct tatgtcaccc acaagacagt caaagaagag
     1741 gagaagcaga agctgctgca acgaggcagt gagctgcaga acgagcacca gcagctggag
     1801 gagcgggacc ggcggctggc gtcagcagtg cagaaatgcc tggagttgaa gacaagcctg
     1861 ctggcccgcc agaggggcac ccagtcatcc ctggaccgcc tgcgggccct cctgagactg
     1921 atacagggcg agcagctgct ccaggtcacc atgacgacca ctagccctgc cccactgctg
     1981 gccgggccct ggaccaagcc ctcagtggca gccacacacc ccaccgtcca gcacccccag
     2041 ggccacaact gaccccgagg gaccagtctt catacccacg gaaagttatt gggaccctgc
     2101 ttacacagcc tgggggttct gtcggcctta attcataaac actatgaatt tcagacaaaa
     2161 attaaccaga cagaggagag gagggaggaa gagctgggcg agaggcctag agccaggacc
     2221 aggtgggggt gcggccctgt gccctccaaa ttcacagggg gtacctagga gccaggtggg
     2281 gtacgacagg ctggggcaca cagtctcccc ccggccacct cggggctgcc tgggcctctg
     2341 gcttccaggc cctgctctcc acggcctccc tctggcccgt tggaggggca ggctgaggct
     2401 gtggagggga caagcacgcc ccccagaacg cagtctccac tgagggcacc gcctattggt
     2461 gtcctgtggg agggcgagct gagaacacat ggactagctg agtggtagcg gtagttggga
     2521 cgagaagcgg ggtagtggat ctaggtagtt cctcaatgcc ccacgctcct aggaggtccc
     2581 cctggggtgg gcgggcgggc ctggggcact ccgtcgcctt tgcagaacca cctgggcccc
     2641 tttctgtcag tattattagg gttacgaatt gcagctgttt aacttgaaag acactgtcgg
     2701 aggtgagcat ctgggcgccg ggacgctgca gtgatccccg ccagagcctg tgcccttcct
     2761 gctccgtctt tggggtcctc aaggctgcct ccttcctttt gccaatctct tggactcagt
     2821 ttgccgttga tgcgtttttc tcatggagtt tctgggcaga gtggagctgc aaccctgttg
     2881 tggggggcag catttggcag gttttctcct tggggttgaa tcattcaact taacgactga
     2941 agccctttct tgtctccttt ggaagagccg ataagtattc cactcctccc ttcttgccag
     3001 tgcagacact atgccaaaaa ataacttcac acttttgtat ggcgttttta ttgtgagata
     3061 tttaatgtga atggttgggg ggactctggc tgacttcctt tctgcttcta gtagtctctg
     3121 cttcaaggta caaatgggaa cacctcccct cgggaagcct ggccaagctg gaagatccgg
     3181 caggtttttt acgagccggg tggagggttg gggaggaaag aaagggcggt ggctcgggag
     3241 gttccggcct tcggggacca gacttgctgc caagggcttc tgcatccagg gtgggcagtg
     3301 gcagcttgtc acccttgccc gattcccaca tcccagtcct gagggactca gcacaacagg
     3361 ataagcgtcc aggagccacg ggctcccacc ccgagcatat cacatggtgc cgaattgcac
     3421 tgaacacgcg tgtgtgcatc gcacgcggcc acgaccacag acacgcatgc acacacgcag
     3481 aggtgcagag cgaggaggcc ggcaaatccc gcagctgcca cggtccctcc tgtcattctc
     3541 acgactccgg gagaaactgt gctgtatgat acagatctat tttaatacac ttaccactgg
     3601 gtgaacaaga tttttatatt cttttattga tgaacaaagt gaaccgtgtg aggcacacgt
     3661 cttctatatt ggctactctg tgccaagtat gcattaccgc gtggcttgcg atgtccatgt
     3721 cttcagcttc cttttctgtt ggtttggttt tcttcgcgga tggattgagt tacatgtttt
     3781 aacagtgtaa tgggaggatc tgaaaggttg gacccgggag gggtagctgc cgatgtgtct
     3841 tgagattgtt aggttttttt tggaccaagg aggaccgtcc agtgggtagt gaggatagag
     3901 aaaaagtgtt tgtcttaaat acgccaatgt agttttcctt ctttacaatg tattaaactc
     3961 gatcgatgat ttcaaa
//
