LOCUS       NM_001352027            7451 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens PHD finger protein 21A (PHF21A), transcript variant 5,
            mRNA.
ACCESSION   NM_001352027 XM_011520173
VERSION     NM_001352027.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7451)
  AUTHORS   Mustafa,S., Abbas,S., Mahmood,A., Khan,A.Z., Zeb,S., Khan,A. and
            Umair,M.
  TITLE     A novel de novo variant in the PHF21A causes craniofacial
            abnormalities, intellectual disability and skeletal manifestations
  JOURNAL   Clin Genet 104 (1), 142-144 (2023)
   PUBMED   36843358
  REMARK    GeneRIF: A novel de novo variant in the PHF21A causes craniofacial
            abnormalities, intellectual disability and skeletal manifestations.
REFERENCE   2  (bases 1 to 7451)
  AUTHORS   Huang,J.Q., Ji,L.C., Jing,Q.A., He,Y.C., Ma,Y.Y. and Tong,X.M.
  TITLE     PHF21A expression as a biomarker of hepatocellular carcinoma
            progression and prognosis
  JOURNAL   Neoplasma 69 (6), 1349-1358 (2022)
   PUBMED   36305691
  REMARK    GeneRIF: PHF21A expression as a biomarker of hepatocellular
            carcinoma progression and prognosis.
REFERENCE   3  (bases 1 to 7451)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7451)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7451)
  AUTHORS   Kim,H.G., Rosenfeld,J.A., Scott,D.A., Benedicte,G., Labonne,J.D.,
            Brown,J., McGuire,M., Mahida,S., Naidu,S., Gutierrez,J., Lesca,G.,
            des Portes,V., Bruel,A.L., Sorlin,A., Xia,F., Capri,Y., Muller,E.,
            McKnight,D., Torti,E., Ruschendorf,F., Hummel,O., Islam,Z.,
            Kolatkar,P.R., Layman,L.C., Ryu,D., Kong,I.K., Madan-Khetarpal,S.
            and Kim,C.H.
  TITLE     Disruption of PHF21A causes syndromic intellectual disability with
            craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral
            problems including autism
  JOURNAL   Mol Autism 10, 35 (2019)
   PUBMED   31649809
  REMARK    GeneRIF: PHF21A is involved in autism spectrum disorder and
            intellectual disability, and its haploinsufficiency causes a
            diverse neurological phenotype.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7451)
  AUTHORS   Hailesellasse Sene,K., Porter,C.J., Palidwor,G., Perez-Iratxeta,C.,
            Muro,E.M., Campbell,P.A., Rudnicki,M.A. and Andrade-Navarro,M.A.
  TITLE     Gene function in early mouse embryonic stem cell differentiation
  JOURNAL   BMC Genomics 8, 85 (2007)
   PUBMED   17394647
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7451)
  AUTHORS   Shi,Y.J., Matson,C., Lan,F., Iwase,S., Baba,T. and Shi,Y.
  TITLE     Regulation of LSD1 histone demethylase activity by its associated
            factors
  JOURNAL   Mol Cell 19 (6), 857-864 (2005)
   PUBMED   16140033
REFERENCE   8  (bases 1 to 7451)
  AUTHORS   Iwase,S., Januma,A., Miyamoto,K., Shono,N., Honda,A., Yanagisawa,J.
            and Baba,T.
  TITLE     Characterization of BHC80 in BRAF-HDAC complex, involved in
            neuron-specific gene repression
  JOURNAL   Biochem Biophys Res Commun 322 (2), 601-608 (2004)
   PUBMED   15325272
  REMARK    GeneRIF: Presumably serves as a scaffold protein in BHC in neuronal
            as well as non-neuronal cells. Possible role in spermatogenesis.
REFERENCE   9  (bases 1 to 7451)
  AUTHORS   Hakimi,M.A., Dong,Y., Lane,W.S., Speicher,D.W. and Shiekhattar,R.
  TITLE     A candidate X-linked mental retardation gene is a component of a
            new family of histone deacetylase-containing complexes
  JOURNAL   J Biol Chem 278 (9), 7234-7239 (2003)
   PUBMED   12493763
REFERENCE   10 (bases 1 to 7451)
  AUTHORS   Hakimi,M.A., Bochar,D.A., Chenoweth,J., Lane,W.S., Mandel,G. and
            Shiekhattar,R.
  TITLE     A core-BRAF35 complex containing histone deacetylase mediates
            repression of neuronal-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7420-7425 (2002)
   PUBMED   12032298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024475.15 and AC068385.9.
            
            On Feb 3, 2020 this sequence version replaced NM_001352027.2.
            
            Summary: The PHF21A gene encodes BHC80, a component of a BRAF35
            (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex
            (BHC) that mediates repression of neuron-specific genes through the
            cis-regulatory element known as repressor element-1 (RE1) or neural
            restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed
            12032298]).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (5), as well as variants 3 and 4,
            encodes isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1461092.1,
                                           SRR14038191.2276146.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000676320.1/ ENSP00000502222.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               AC024475.15        113516-114035
            521-561             AC024475.15        142747-142787
            562-673             AC024475.15        144404-144515
            674-810             AC024475.15        150668-150804
            811-843             AC024475.15        155804-155836
            844-909             AC024475.15        158151-158216
            910-1116            AC068385.9         153704-153910       c
            1117-1368           AC068385.9         145060-145311       c
            1369-1458           AC068385.9         143759-143848       c
            1459-1752           AC068385.9         139259-139552       c
            1753-1851           AC068385.9         127471-127569       c
            1852-1903           AC068385.9         124150-124201       c
            1904-1983           AC068385.9         123346-123425       c
            1984-2044           AC068385.9         122830-122890       c
            2045-2208           AC068385.9         119784-119947       c
            2209-2364           AC068385.9         112101-112256       c
            2365-2440           AC068385.9         110438-110513       c
            2441-2544           AC068385.9         109580-109683       c
            2545-7451           AC068385.9         103263-108169       c
FEATURES             Location/Qualifiers
     source          1..7451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..7451
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /note="PHD finger protein 21A"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
     exon            1..520
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            521..561
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            562..673
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            674..810
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..2802
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /note="isoform c is encoded by transcript variant 5;
                     BRAF35/HDAC2 complex (80 kDa); BHC80a; BRAF35-HDAC complex
                     protein BHC80"
                     /codon_start=1
                     /product="PHD finger protein 21A isoform c"
                     /protein_id="NP_001338956.1"
                     /db_xref="CCDS:CCDS91465.1"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
                     /translation="MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKI
                     TALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQQYH
                     HHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVT
                     AINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQ
                     FIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLP
                     TSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTV
                     KSHTETDEKQTESRTITPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERK
                     RRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQ
                     SSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCS
                     RVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEE
                     KQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIR
                     LIHGIDLSKPVDSEATVGAISNGPDCTPPANAATSTPAPSPSSQSCTANCNQGEETK"
     exon            811..843
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            844..909
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1116
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1368
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1458
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1752
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1851
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1903
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1983
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2044
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2208
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2364
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2440
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2544
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..7451
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4183..4188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /note="hexamer: ATTAAA"
     polyA_site      4205
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /note="major polyA site"
     regulatory      7428..7433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /note="hexamer: AATAAA"
     polyA_site      7451
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
ORIGIN      
        1 gctgcggccc ggggccgggt ggtgaatggg ctggtggtgc tcgctgctgc tgctgagagg
       61 aggaggagga tgaagagttg ggcttgtttg tctcctacag tttctctcct gctgctctga
      121 ttcccccctc ccgattccgg cccggggcct gtgtgtgtcc ctcctggagg aggaggagga
      181 tccagttcct ccccccaacc ccctcctccc caccccccct tgcctgggga agaggaggaa
      241 agaaacagcc cagagagaga gagagagaga gagtgagtga gagagagagg agaggagagg
      301 aggaggagga ggagggagaa gggaacaacc taccatctta acacactaat atctaaaaag
      361 tgcgagaggc ccagagcagc agcagaagca gcagcagcag ctccagcttc ttccctccct
      421 ccccatgaag aagagttccc tcctcctcct cctcctgctt ctcctgctca gagttcctgc
      481 ctccagctgc caggggggac agccagccag cagcaggagg ggggctagag agctgaagga
      541 gagccagttt ccccaaaatt ggacttctca gaacctttaa tatgctaatg tgcattgtga
      601 atctccaaga gggggatatg atatgcagca ttcttgaata cttctaatga cagggagccc
      661 actacctcat aagctgcagt gagaagagga gtttgttact ttaaacagag gctgaagaaa
      721 ctatagaatt agcagagaaa gtggagaagg tagaggatgg agttgcagac tctacaggag
      781 gctcttaaag tggaaattca ggttcaccag aaactggttg ctcaaatgaa gcaggatcca
      841 cagaatgctg acttaaagaa acagcttcat gaactccaag ccaaaatcac agctttgagt
      901 gagaaacaga aaagagtagt tgaacagcta cggaagaacc tgatagtaaa gcaagaacaa
      961 ccggacaagt tccaaataca gccattgcca caatctgaaa acaaactaca aacagcacag
     1021 cagcaaccac tacagcaact acaacaacag cagcagtacc accaccacca cgcccagcag
     1081 tcagctgcag cctctcccaa cctgactgct tcacagaaga ctgtaactac agcttctatg
     1141 attaccacaa agacactacc tctcgtcttg aaagcagcaa ctgcgaccat gcctgcctct
     1201 gtggtgggcc agagacctac cattgctatg gtgaccgcca tcaacagtca gaaggctgtg
     1261 ctcagcactg atgtgcagaa cacaccagtc aacctccaga cgtctagtaa ggtcactggg
     1321 cctggggcag aggctgtcca aattgtggca aaaaacacag tcactctgca ggttcaggca
     1381 acacctcctc agcccatcaa agtaccacag tttatccccc ctcctagact cactccacgt
     1441 ccaaactttc ttccacaggt tcgacccaag cctgtggccc agaataacat tcctattgcc
     1501 ccagcaccac ctcccatgct cgcagctcct cagcttatcc agaggcccgt catgctgacc
     1561 aagttcaccc ccacaaccct tcccacatcc cagaattcca tccaccccgt ccgtgtcgtc
     1621 aatgggcaga ctgcaaccat agccaaaacg ttccccatgg cccagctcac cagcattgtg
     1681 atagctactc cagggaccag actcgctgga cctcaaactg tacagcttag caagccaagt
     1741 cttgaaaaac agacagttaa atctcacaca gaaacagatg agaaacaaac agagagccgc
     1801 accatcaccc cacctgctgc acccaaacca aaacgggagg agaaccctca gaaacttgcc
     1861 ttcatggtgt ctctagggtt ggtaacacat gaccatctag aagaaatcca aagcaagagg
     1921 caagagcgaa aaagaagaac aacagcaaat ccggtctaca gtggagcagt ctttgagcca
     1981 gagcgtaaga agagtgcagt gacataccta aacagcacaa tgcaccctgg gacccggaag
     2041 agaggtcgtc ctccaaaata caatgcagtg ctggggtttg gagcccttac cccaacatcc
     2101 ccccaatcca gtcatcctga ctcccctgaa aatgaaaaga cagagaccac attcactttc
     2161 cctgcacctg ttcagcctgt gtccctgccc agccccacct ccacagacgg tgatattcat
     2221 gaggattttt gcagcgtttg cagaaaaagt ggccagttac tgatgtgcga cacatgttcc
     2281 cgtgtatatc atttggactg cttagacccc cctctgaaaa caattcccaa gggcatgtgg
     2341 atctgtccca gatgtcagga ccagatgctg aagaaggaag aagcaattcc atggcctgga
     2401 actttagcaa ttgttcattc ctatattgcc tacaaagcag caaaagaaga agagaaacag
     2461 aagttactta aatggagttc agatttaaaa caagaacgag aacaactaga gcaaaaggtg
     2521 aaacagctca gcaattccat aagtaaatgc atggaaatga agaacaccat cctggcccgg
     2581 cagaaggaga tgcacagctc cctggagaag gtaaaacagc tgattcgcct catccacggc
     2641 atcgacctct ccaaacctgt agactctgag gccactgtgg gggccatctc caatggcccg
     2701 gactgcaccc cccctgccaa tgccgccacc tccacgccgg ccccttcccc ctcctcccag
     2761 agctgcacag cgaactgtaa ccagggggaa gagactaaat aacagagccc ctctaggaga
     2821 agccacggga tcccggcggc aaggagaaca gaacactgaa gactctagaa aagcaaagcc
     2881 ggatttctgg aaagtgcaga attcttttgg ttctttggtt ccagagagag agaagatgct
     2941 tgtgccaggt ggcaccagag tttgccaatt gatccttctt attctgtgtg tacatgcaaa
     3001 gattggacca tgttacatga aatagtgcca gctggaggtt ctttgccagc accatgccaa
     3061 gtgaaataat atatttactc tctctattat acaccagtgt gtgcctgcag cagcctccac
     3121 agccacgatg ggtttgtttc tgttttcttg ggtggggagc agggacgggc ggagggagga
     3181 gagcaggttt cagatcctta cttgccgagc cgtttgttta ggtagagaag acaagtccaa
     3241 agagtgtgtg ggctttcctg tttctaaact ttcgctacta taaaaccaaa aaaaggaatt
     3301 gagatttcac caaccccagt gcccagaaga gggaagggga gtggctggag ggagcagggg
     3361 gtgggacagt gtatcaaata agcagtattt aatcacctct ggcgggggcc tcgtgcaagg
     3421 ggagactgac accaagaaca gccagtaggt tcttctcccc tgcactctgc tccctgcgcg
     3481 gtaaccccac cactcctgaa gcctgcccag tctccttcct tccctgcttg gtgagtcgcg
     3541 catctccgtg gttatcccgc tgtctcctct ccaagaacaa gcagagcccg ggccactggc
     3601 ccttgcccaa ggcagggaag aaggatgtgt gtgtccagga aggaaaaaaa ggtggatcag
     3661 tgattttact tgaaaacaag ctccatccct tttctatatt tataagaaga gaagatcttg
     3721 agtgaagcag cacgcgaccc aggtgtgtgt gaattgaatg gagacgtttc ttttctcttt
     3781 ctttaatttt tgtttttgtt ctttttttct ttaaggaaag ttttatttta ctgttcattt
     3841 tactttcttg gtaacaaaaa ctaaaataag gaatagaaaa gctgtttttc aggctgacag
     3901 tccaattaag ggtagccaag accttgcatg gtagagtagg aatcatagtg tcagtgaggt
     3961 cccgtgagtc tttgtgagtc cttgtgtcat cgttcgggca ctgttttttt atgcaagggc
     4021 aaaaatcttt gtatctgggg aaaaaaaact tttttttaaa ttaaaaagga aaataaaaga
     4081 tattgaggtc ttcctagtgt tacttaaatt aagatcaagg taagaaacat tgtaaaaaaa
     4141 aattacaaaa gtgctatttg tttcctaaaa acagtgattt ctattaaaaa ggtgtcagaa
     4201 ctggagaaaa tgccgtgtag ttataatttt ttagcacaga ccctgctgat cacgatgaca
     4261 ttttgccgtg tgtgtgtctc tagactggtg ggccagtctc cttgaaggac agaggcggag
     4321 ctccccaccc ttctctctcc tcagaaaaga ccgtgctctc ttcttggtgc agggatcttg
     4381 tctcctgttg tgaagcccaa atggaagcgt ggatggtatc agggccctac ccgtggtctt
     4441 ctcagattct gctagagcaa aaggctggtg cctaaataag atcccttcct ttggtgctgc
     4501 ttttggtctt tcagccacca gcattatgag tgcctggggg acacctccga gggaactggc
     4561 cagcggagct ctgtggtgcg cacgcaccct ggccgtgaca ggagggtgcg ggagtacagg
     4621 ctggctgcat cagcccttgg tgcttagaac agaggaggag tgacatgttt tgagggtacg
     4681 tctctgagac agagccccag cgtggccttc gctctgtctt gcctttgggg agaggtctga
     4741 agctcccact cctttctctg cctgttggct ccaggcacca gaaatttact ccactccacc
     4801 cacccacaag cctcctgggt gaccctgggc tagaattgct gcgcttgcct cggcttggcc
     4861 ggttgtggcc tctccttgag aaaaccaggg ttgtgaaaga ctcagaccat tctctcatct
     4921 tgccttgtca gaagtaaatt gtgtcagatt tgtgctctcg ctggagacct ttgccccttg
     4981 cgtgcccctg gccgatggga gggcggtgga ggctctgtac cctggccctg ctggagcatc
     5041 tcccccaagc ccactccagg ccctgggaat ggccagagtc taggagaggt agaaacgatc
     5101 ctatcagctt ctctcccacc caattaggcc cagagagaca aagacagatc tgaaagcaaa
     5161 tgcaacagag aagagacact tcttagagta aaatgtgtct catctctatc agccatcgcc
     5221 tttcatcttc ccaggggcct cagaagaagg aattaagtta ggctgaacag gcctcagagt
     5281 taggccctgg ctgcttgatt ggctgagggg gaaagagttc ccttttctca ttcagaaacc
     5341 aaggtgctgt gtctagtcag ggagccttgg agatgcctgg actagttgga ggaatcgttg
     5401 gcagaggatc agagaccagc agcaggctgt ctgccctgtc tagagctctt cccctcaact
     5461 tgtctgggcc catctggggg ttgccacaca acacctaact taccttttcc tgaaagaagt
     5521 tgggaaacca tcatcactag aggcctttgc tcagagagga gctgccttag gagtcttggg
     5581 tcggaggacg gggctaggaa ttgaccaggg ctttgcctgc cgccctcagc agtgtcgggt
     5641 acattctgac ctcgcctgca gctgggctgt ggattcttcc tgacattcag atgtgagctg
     5701 ttttgggagt cagctagtat ggagtacgag atgcaaccca gcccccaaac ctacattctg
     5761 cactcaaatt ccaaaacact gctttactgt aaagaagagg cccctggcac ccaatctccc
     5821 tgtccttcac tgtcccctca gacctgggcg gggagggggg ggggcctgtg accacctgag
     5881 acatacgctc gtgacactgc cccaccccag ccacctccac ttgcttcctc ctccttccct
     5941 ccgctgctct ttccccacgg cccagaattt agctgctctg acagccactt ttgagaccag
     6001 ctggctttgt agtcacttca gagagctgga gcggctgccc actgggccct gactgggagt
     6061 cccctgccag ctcctgatca ggcgctgcgc cctggtggca gtgatgactg ggagtcccct
     6121 gccagctcct gtccaggcgc tgcatcctgg taacagtgag gccatgttgc tgtcatctcc
     6181 acctctgcat tcttgctgcc tgtgggtcct ttttctttca tggagcctgc tgggtcttgt
     6241 ctcacctgtg ctgagctcct ctggggtttt gatttcttcc ttccttatca ggccctttgg
     6301 ggtaagcctg ctggttgtac ctgacatagg gaggcagtta ggggcagtcc ctggtggggc
     6361 cgccctggca gcctccagct ggcaccatcg tgtgcctggt ttccctgcaa cacctgcctc
     6421 tctgtccctg ctgctgcttg gctcaggccc aacaggcagc gtgcatggag gtggttacac
     6481 acagctgttt ccgtgagggt gaccgtgtct gcagcacgct tccgtctccg catgcacggc
     6541 tgcctctcca gccacctctg atacttctct cttggggcca tcagagcctc ccttgggctg
     6601 tcacctccca gctcacacac actcttcagt ggtttcctct cttcattctc ttatagggcg
     6661 tggtccttct tatttatcta aagggctgaa tttaggagac tttttaccca ggggcaaaag
     6721 gctcttaggg taatgagatg gatggtggcc caggtgcatt ttccagggcc tgggttctcc
     6781 agatcccgtg gcttctgttg agtggaggca actttgctct gtgtgaacct cgcccctgtc
     6841 cctctgccgg gcacccctgg caggaagcag gactcccatc ctcaccctga cttagactgt
     6901 cctctgagtc agctcctctc caagacagga gtgggcagcc ctgggcagtc ttctggcccc
     6961 ttgctaaagt gaggggcagg aagctggggc tgccctccag aaagccgggg taggaactct
     7021 gaaaaatacc tcctctaaac ggaagcaggg ctctccagtt ccacttggcg ccccctccca
     7081 caaggccctt cctccctgag gaccccaccc ccctacccct tccccagcag cctttggacc
     7141 ctcacctctc tccggtgtcc gtgggtcctc agcccagggt gagctgcagt caggcgggat
     7201 gggacgggca ggccagaggt cagccagctc ctagcagaga agagccagcc agaccccaac
     7261 cctgtctctt gtccatgccc tttgtgattt cagtcttggt agacttgtat ttggagtttt
     7321 gtgcttcaaa gtttttgttt ttgtttgttt ggtttttgtt ttgagggggt ggggggggat
     7381 acagagcagc tgatcaattt gtatttattt attttaacat tttactaaat aaagccaaat
     7441 aaagcctctc a
//
