LOCUS       NM_016018               6233 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens PHD finger protein 20 like 1 (PHF20L1), transcript
            variant 1, mRNA.
ACCESSION   NM_016018
VERSION     NM_016018.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6233)
  AUTHORS   Francois,A.K., Rohani,A., Loftus,M., Dochnal,S., Hrit,J.,
            McFarlane,S., Whitford,A., Lewis,A., Krakowiak,P., Boutell,C.,
            Rothbart,S.B., Kashatus,D. and Cliffe,A.R.
  TITLE     Single-genome analysis reveals a heterogeneous association of the
            herpes simplex virus genome with H3K27me2 and the reader PHF20L1
            following infection of human fibroblasts
  JOURNAL   mBio 15 (4), e0327823 (2024)
   PUBMED   38411116
  REMARK    GeneRIF: Single-genome analysis reveals a heterogeneous association
            of the herpes simplex virus genome with H3K27me2 and the reader
            PHF20L1 following infection of human fibroblasts.
REFERENCE   2  (bases 1 to 6233)
  AUTHORS   Zhu,Q.C., Sun,J.H., Liang,M.J., Zhang,Z.Y. and Xia,Y.
  TITLE     PHF20L1 mediates PAX2 expression to promote angiogenesis and liver
            metastasis in colorectal cancer through regulating HIC1
  JOURNAL   Biol Chem 403 (10), 917-928 (2022)
   PUBMED   35357096
  REMARK    GeneRIF: PHF20L1 mediates PAX2 expression to promote angiogenesis
            and liver metastasis in colorectal cancer through regulating HIC1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6233)
  AUTHORS   Sierra-Ramirez,J.A., Sesena-Mendez,E., Godinez-Victoria,M. and
            Hernandez-Caballero,M.E.
  TITLE     An insight into the promoter methylation of PHF20L1 and the gene
            association with metastasis in breast cancer
  JOURNAL   Adv Clin Exp Med 30 (5), 507-515 (2021)
   PUBMED   33847474
  REMARK    GeneRIF: An insight into the promoter methylation of PHF20L1 and
            the gene association with metastasis in breast cancer.
REFERENCE   4  (bases 1 to 6233)
  AUTHORS   Hou,Y., Liu,W., Yi,X., Yang,Y., Su,D., Huang,W., Yu,H., Teng,X.,
            Yang,Y., Feng,W., Zhang,T., Gao,J., Zhang,K., Qiu,R. and Wang,Y.
  TITLE     PHF20L1 as a H3K27me2 reader coordinates with transcriptional
            repressors to promote breast tumorigenesis
  JOURNAL   Sci Adv 6 (16), eaaz0356 (2020)
   PUBMED   32494608
  REMARK    GeneRIF: PHF20L1 as a H3K27me2 reader coordinates with
            transcriptional repressors to promote breast tumorigenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6233)
  AUTHORS   Wang,Q., Yu,M., Ma,Y., Zhang,X., Zhang,H., Li,S., Lan,R. and Lu,F.
  TITLE     PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5
            complexes
  JOURNAL   Lab Invest 98 (12), 1627-1641 (2018)
   PUBMED   30089852
  REMARK    GeneRIF: associates with SOX2, antagonizes SOX2 ubiquitination and
            the sequential degradation induced by the MLL1/WDR5 complexes
REFERENCE   6  (bases 1 to 6233)
  AUTHORS   Zhang,C., Hoang,N., Leng,F., Saxena,L., Lee,L., Alejo,S., Qi,D.,
            Khal,A., Sun,H., Lu,F. and Zhang,H.
  TITLE     LSD1 demethylase and the methyl-binding protein PHF20L1 prevent
            SET7 methyltransferase-dependent proteolysis of the stem-cell
            protein SOX2
  JOURNAL   J Biol Chem 293 (10), 3663-3674 (2018)
   PUBMED   29358331
  REMARK    GeneRIF: Data suggest that, in human ovarian teratocarcinoma cell
            line, methylation-dependent proteolysis of SOX2 is controlled by
            LSD1 and PHF20L1 via regulation of SET7 activity; these data are
            consistent with previous studies in mouse primary stem cells. (SOX2
            = SRY-box 2 transcription factor; LSD1 = lysine demethylase-1A;
            PHF20L1 = PHD finger protein 20 like-1; SET7 = histone-lysine
            N-methyltransferase SETD7)
REFERENCE   7  (bases 1 to 6233)
  AUTHORS   Carr,S.M., Munro,S., Sagum,C.A., Fedorov,O., Bedford,M.T. and La
            Thangue,N.B.
  TITLE     Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma
            tumour suppressor protein
  JOURNAL   Cell Death Differ 24 (12), 2139-2149 (2017)
   PUBMED   28841214
  REMARK    GeneRIF: Authors find that the interplay between PHF20L1 and
            mono-methyl pRb is important for maintaining the integrity of a
            pRb-dependent G1-S-phase checkpoint. Results highlight the distinct
            roles that methyl-lysine readers have in regulating the biological
            activity of pRb.
REFERENCE   8  (bases 1 to 6233)
  AUTHORS   Jiang,Y., Liu,L., Shan,W. and Yang,Z.Q.
  TITLE     An integrated genomic analysis of Tudor domain-containing proteins
            identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate
            oncogene in breast cancer
  JOURNAL   Mol Oncol 10 (2), 292-302 (2016)
   PUBMED   26588862
  REMARK    GeneRIF: results demonstrated the oncogenic potential of PHF20L1
            and its association with poor prognostic parameters in breast
            cancer.
REFERENCE   9  (bases 1 to 6233)
  AUTHORS   Esteve,P.O., Terragni,J., Deepti,K., Chin,H.G., Dai,N., Espejo,A.,
            Correa,I.R. Jr., Bedford,M.T. and Pradhan,S.
  TITLE     Methyllysine reader plant homeodomain (PHD) finger protein 20-like
            1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1
            (DNMT1) proteasomal degradation
  JOURNAL   J Biol Chem 289 (12), 8277-8287 (2014)
   PUBMED   24492612
  REMARK    GeneRIF: Malignant brain tumor domain of PHF20L1 reads and controls
            enzyme levels of methylated DNMT1 in cells, thus representing a
            novel antagonist of DNMT1 degradation.
REFERENCE   10 (bases 1 to 6233)
  AUTHORS   Kim,J., Daniel,J., Espejo,A., Lake,A., Krishna,M., Xia,L., Zhang,Y.
            and Bedford,M.T.
  TITLE     Tudor, MBT and chromo domains gauge the degree of lysine
            methylation
  JOURNAL   EMBO Rep 7 (4), 397-403 (2006)
   PUBMED   16415788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB498348.1, BC002822.2, DA196349.1, AK057961.1 and AF230666.2.
            
            On Jun 2, 2019 this sequence version replaced NM_016018.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395386.7/ ENSP00000378784.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               DB498348.1         41-298
            259-1897            BC002822.2         247-1885
            1898-1956           DA196349.1         1-59
            1957-4254           AK057961.1         1-2298
            4255-6233           AF230666.2         45678-47656
FEATURES             Location/Qualifiers
     source          1..6233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..6233
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /note="PHD finger protein 20 like 1"
                     /db_xref="GeneID:51105"
                     /db_xref="HGNC:HGNC:24280"
                     /db_xref="MIM:620050"
     exon            1..258
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..378
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..3349
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /note="isoform 1 is encoded by transcript variant 1; PHD
                     finger protein 20-like protein 1; tudor domain-containing
                     protein PHF20L1; tudor domain containing 20B; up-regulated
                     in lung cancer 1"
                     /codon_start=1
                     /product="PHD finger protein 20-like protein 1 isoform 1"
                     /protein_id="NP_057102.4"
                     /db_xref="CCDS:CCDS6367.2"
                     /db_xref="GeneID:51105"
                     /db_xref="HGNC:HGNC:24280"
                     /db_xref="MIM:620050"
                     /translation="MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKML
                     VHFERWSHRYDEWIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRY
                     YPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKSQHPLSWCCPIDPAG
                     SCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEET
                     STCIATPDVEKKEDLPTSSETFGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRA
                     RLNKITGLLASKAVGVDGAEKKEDYNETAPMLEQAISPKPQSQKKNEADISSSANTQK
                     PALLSSTLSSGKARSKKCKHESGDSSGCIKPPKSPLSPELIQVEDLTLVSQLSSSVIN
                     KTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEKVSSPSPATDGKVFSISSQNQ
                     QESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRNECPRAEKEDTQML
                     PNPSSKAIADGRGAPAAAGISKTEKKVKLEDKSSTAFGKRKEKDKERREKRDKDHYRP
                     KQKKKKKKKKKSKQHDYSDYEDSSLEFLERCSSPLTRSSGSSLASRSMFTEKTTTYQY
                     PRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIV
                     RCICEMDEENGFMIQCEECLCWQHSVCMGLLEESIPEQYICYICRDPPGQRWSAKYRY
                     DKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLLADVYGVTEVLHGLQLKIGILKNK
                     HHPDLHLWACSGKRKDQDQIIAGVEKKIAQDTVNREEKKYVQNHKEPPRLPLKMEGTY
                     ITSEHSYQKPQSFGQDCKSLADPGSSDDDDVSSLEEEQEFHMRSKNSLQYSAKEHGMP
                     EKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDVL
                     ESWLDFTGELEPPDPLARLPQLKRHIKQLLIDMGKVQQIATLCSV"
     exon            379..550
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..635
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..724
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..802
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1016
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1142
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1225
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1478
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1667
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1874
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1931
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2039
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2204
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2386
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2486
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2682
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..3043
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3206
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..6233
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6212..6217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /note="hexamer: AATAAA"
     polyA_site      6233
                     /gene="PHF20L1"
                     /gene_synonym="CGI-72; TDRD20B; URLC1"
                     /note="major polyA site"
ORIGIN      
        1 agggctggcc ggcggcggag gcggcggcgg cggcggcgat ggcagcggac cctgagcgag
       61 cttgagggct cggacccagc tccctcccgc gaaaccttgg gcggatccgg cgctgcggcc
      121 ccagctcgct ccgctcctgc tccctccccg gccgctgcct gggcggaggc agaggcagag
      181 gcccgggctg gccgccctgc tcgtgcccca gctcggcccc ggacggcccg gctgctgtgc
      241 agagaggagg ccgagtcggt agtgaaaaga gaatactgaa gaataggatc tcaagatgag
      301 taaaaagccc ccaaatcgcc ctggaatcac ttttgagatt ggtgctcgtt tggaggcact
      361 ggactactta caaaaatggt atccatcacg aattgaaaaa attgactatg aggagggcaa
      421 gatgttggtc cattttgagc gctggagtca tcgttatgat gagtggattt actgggatag
      481 caatagattg cgaccccttg agagaccagc actaagaaaa gaagggctaa aagatgagga
      541 agatttcttt gattttaaag ctggagaaga agttctggct cgttggacag actgtcgcta
      601 ttaccctgcc aagattgaag caattaacaa agaaggaaca tttacagttc agttttatga
      661 tggagtaatt cgttgtttaa aaagaatgca cattaaagcc atgcccgagg atgctaaggg
      721 gcaggtgaaa tcccagcatc cactaagctg gtgttgtcct atcgacccag ctggatcgtg
      781 taaccagtct atgggaagtg aggattggat agctttagtc aaagcagctg ctgcagctgc
      841 agccaagaac aaaacaggga gtaaacctcg aaccagcgct aacagcaata aagataagga
      901 taaagatgag agaaagtggt ttaaagtacc ttcaaagaag gaggaaactt caacttgtat
      961 agccacacca gacgtagaga agaaggaaga tctgcctaca tctagtgaaa catttggact
     1021 tcatgtagag aacgttccaa agatggtctt tccacagcca gagagcacat tatcaaacaa
     1081 gaggaaaaat aatcaaggca actcgtttca ggcaaagaga gctcgactta acaagattac
     1141 tggtttgttg gcatccaaag ctgttggggt tgatggtgct gaaaaaaagg aagactacaa
     1201 tgaaacagct ccaatgctgg agcaggcgat ttcacctaaa cctcaaagtc agaaaaaaaa
     1261 tgaagctgac attagcagtt ctgccaacac tcagaaacct gcactgttat cctcaacttt
     1321 gtcttcaggg aaggctcgca gcaagaaatg caaacatgaa tctggagatt cttctgggtg
     1381 tataaaaccc cctaaatcac cactttcccc agaattaata caagtcgagg atttgacgct
     1441 tgtatctcag ctttcttctt cagtgataaa taaaactagt cctccacagc ctgtgaatcc
     1501 ccctagacct ttcaagcata gtgagcggag aagaagatct cagcgtttag ccaccttacc
     1561 catgcctgat gattctgtag aaaaggtttc ttctccctct ccagccactg atgggaaagt
     1621 attctccatc agttctcaaa atcagcaaga atcttcagta ccagaggtgc ctgatgttgc
     1681 acatttgcca cttgagaagc tgggaccctg tctccctctt gacttaagtc gtggttcaga
     1741 agttacagca ccggtagcct cagattcctc ttaccgtaat gaatgtccca gggcagaaaa
     1801 agaggataca cagatgcttc caaatccttc ttccaaagca atagctgatg gaagaggagc
     1861 tccagcagca gcaggaatat cgaaaacaga aaaaaaagtg aaattggaag acaaaagctc
     1921 aacagcattt ggtaagagaa aagaaaaaga taaggaaaga agagagaaga gagacaaaga
     1981 tcactacaga ccaaaacaga agaagaagaa aaaaaagaaa aagaaatcta agcaacatga
     2041 ctattcagac tatgaagaca gttccctcga atttttggaa aggtgctctt ctccactaac
     2101 tcgatcttct gggagttctc tggcttcacg aagcatgttt acggagaaaa ctacaaccta
     2161 tcagtaccca agggcaattc tatccgttga tcttagtggt gaaaacttat cagatgtaga
     2221 cttcctagat gattcttcaa cggagagttt gcttctgagt ggggatgaat acaatcagga
     2281 ctttgattca accaattttg aggaatctca ggatgaggat gatgctctta atgaaattgt
     2341 gcgatgtatt tgtgagatgg atgaggagaa tggcttcatg atccagtgtg aagagtgctt
     2401 gtgttggcaa cacagcgtgt gcatggggct gctggaggag agcattccag agcagtacat
     2461 ctgctatatc tgccgggacc caccaggtca gaggtggagt gcaaaatatc gttatgataa
     2521 ggagtggttg aataatggga gaatgtgcgg gttatcattt ttcaaagaaa attattctca
     2581 tctcaatgcc aaaaagatag tttctacaca tcacctgctt gctgatgtct atggtgttac
     2641 agaagtgcta cacgggctac agctgaagat tggaatacta aagaataaac atcatcctga
     2701 ccttcatctc tgggcttgtt ccgggaagcg aaaagaccaa gatcaaataa tagctggggt
     2761 ggagaaaaaa atagctcaag acacagttaa tcgagaagaa aagaaatatg tacagaacca
     2821 taaagaacca cctcgtttgc ccctaaaaat ggaaggaact tatataacaa gtgagcatag
     2881 ctatcaaaag ccacaaagtt ttggtcagga ctgtaaatct ctcgcagacc ctgggagctc
     2941 agatgatgat gatgttagta gtttggaaga agaacaagaa ttccacatga gaagtaaaaa
     3001 cagtttacag tactcagcaa aagaacatgg aatgcctgaa aagaatccag ctgaagggaa
     3061 tacagtattt gtttataatg ataaaaaggg caccgaagac ccaggagact cacatcttca
     3121 gtggcagctc aatctcctta cacacataga aaatgtgcag aacgaagtta ccagcaggat
     3181 ggacctaata gaaaaagaag tcgatgttct ggaaagctgg cttgatttca caggggagtt
     3241 ggagccacca gatcctcttg caagattgcc ccaacttaaa cgccacataa aacagctcct
     3301 aattgacatg ggcaaagtac agcagatagc aactctttgc tctgtatgac aacagtgaac
     3361 acttaatgaa agaatgtggc tttcttcagt caaagcattt ttattatcca cgtgatggct
     3421 aagtggataa tttaaaagct tagtaatgtc tggtcattca ctgatttgtg atgtcaatag
     3481 gatggcacct tggaaagaaa aatgaagaac aactttatca aggaagctag tatttaaaaa
     3541 caaattcatg agcaagctgc aaatgagaat gtgttatatg ccaaggaaca atgaagtaga
     3601 atataatgta tactaaggga tttcaagttc tcagaatttt tgagtagttg cttacgtgaa
     3661 gctcaagata cctgtagaaa gaaatatggt atatttgtat agtttttaat agaaagatct
     3721 atgtttataa accagcactt ggccaaaaac aaaattgtaa aggaaattta aattctggag
     3781 aattctacag ggttgctcta agaactgtct tctcagcagt tgatccagct gtacggaaat
     3841 ttagggtatt taaactttta aaggatcatg agctgtttct tgggcgatga atgttctcaa
     3901 tcagaaaact gacagtagaa atctcacttc tggggaaaac agttgtggaa ttcttacttc
     3961 attatgaatg tatttaaaaa acaaacacca aataattgga atatattgca ggcattaagc
     4021 tcattaaaaa caaactggct tgcagaaggg tccgatgtgc caagtgatca tgattctgct
     4081 ggaaagagga ttttaaatat tgtgggagtt ctcccaccct aagtcttaca taatgccacc
     4141 agtccatcca aaacctatat atcacctata ctatatatat catatatata gttgaatggc
     4201 agtattcagg ctcaacgtac agtttgatcc tgagtatgct tggtgtttgc cttcagaaaa
     4261 aaaaaaatac attgtaaata acctcagctg ggatgaggag tgacagaata tcaaaataat
     4321 ttgtggctgt ggattttttt aactgctagt agtggaatac tggaaaagct tcatttctga
     4381 agatgaattt tatttttaaa aaatacatgc acactcaaaa cttttagctt tgatcacaag
     4441 tggacaaatt tctgaaacca aaggcaacta agttgctgtg ttagctcttg ctggattttg
     4501 agcctaggtc ctactgtctg ccagtactca tgtgagttgt atgtgccccc agtgctacat
     4561 acgcaggtat gcgtaagtgt gtatgcttgt tttaaacaaa cactcaacgt acatatgtac
     4621 ataatctaca catatttata tcacatatct agttttatta ctatagacta tacgaattgg
     4681 tggttaacat gaaatgttac cttttaacag actgttttta aaaattaaaa atgtatgtat
     4741 aggttttgaa atttttttaa aaggggagaa agactgttaa gaggaggcta tttgatgaca
     4801 taacacttga atattttatg cctcattctg tttatcagtt ctcgcaatct gtataaatgc
     4861 attttagaac tgatagacag taaacttgaa tttatctttg ataagaatac atgccactgt
     4921 acattcagat attatttaaa tttgcaaaca cattgttcta tatgtaaggg tactgtatgt
     4981 aaaactctgt attaaaacta ttccacatat cctaaaattt cagcttgcct ttttgcggcc
     5041 ttatattttg atgtaaagat taaaagaatg tgcaaaacag tcagaaattt ttattgcctt
     5101 ttgagattct ccaacttgac aaatgtgcca aagatcaaca gacagaaaat atcatcctgt
     5161 gtatttactt gtcatacttt aactttgtga aagatcttac tgataaatga aaagctttag
     5221 cagaggtggt attgtggggt aattgcttaa atttacatat caaagtaaaa aagtagtgcc
     5281 tgtattccat gtgtggagta aatttgctaa tgtctatatt ttatgattga tactattatt
     5341 tttcctttgc attttaaaat agtggctcta atattttccc tgtcatggct acattctaga
     5401 cattgaattt atatcttctt tttttcagat acggagcaaa tagcatcctt aacctatgaa
     5461 taatggtgtt gcctagattc ttgtcacaca cacagaagac cctttgtacc tagtaacatt
     5521 catcctcttg attcctggtg aacacggtta aattcatgca catttgttct tgtagtttct
     5581 aaaaattaga tcaatttatt tgttagccag caaattgaaa attccattat tagattaatg
     5641 aaatttttgc tctgcttata tgtatacgaa ctggaaatct gaatttttaa atttagatct
     5701 ttaaatcaaa ttatttttat gcatattttc atttaatata gagtatacca atcgattgaa
     5761 gcctttcaca agtagtgcgc tgagcttttc ttattgaaga gagtgaatta gtttctgaga
     5821 agtcagtcta ttgtgaaaag tttcagatga gattattttc ttttagtctt tttaaatatc
     5881 actatatgta tttaaataga agcaataaac tagagagagt gtttcttgaa aagacaatgt
     5941 tttatttgcc accaggcaga acagaatgag cattggtaga gaaggctccc tcttggtatg
     6001 ttactgataa acttgtactt cctcatactt gtttgtggtt ctactgactt atttccaaac
     6061 ttaagagtaa tgtacttcga aaacaacttg gttattcttt aaatttcagg taaaacccct
     6121 tttcctaaca ctcatcttat ttccactgtc ttatttcctc tcagatgttc atatttcaca
     6181 tgttcaaaat gaagcgtact atttcccctc caataaacga agtctcctgc caa
//
