LOCUS       NM_005392               5392 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PHD finger protein 2 (PHF2), mRNA.
ACCESSION   NM_005392
VERSION     NM_005392.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5392)
  AUTHORS   Aguirre,S., Pappa,S., Serna-Pujol,N., Padilla,N., Iacobucci,S.,
            Nacht,A.S., Vicent,G.P., Jordan,A., de la Cruz,X. and
            Martinez-Balbas,M.A.
  TITLE     PHF2-mediated H3K9me balance orchestrates heterochromatin stability
            and neural progenitor proliferation
  JOURNAL   EMBO Rep 25 (8), 3486-3505 (2024)
   PUBMED   38890452
  REMARK    GeneRIF: PHF2-mediated H3K9me balance orchestrates heterochromatin
            stability and neural progenitor proliferation.
REFERENCE   2  (bases 1 to 5392)
  AUTHORS   Jeong,D.W., Park,J.W., Kim,K.S., Kim,J., Huh,J., Seo,J., Kim,Y.L.,
            Cho,J.Y., Lee,K.W., Fukuda,J. and Chun,Y.S.
  TITLE     Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism
            through the SREBP1c axis in hepatocellular carcinoma
  JOURNAL   Nat Commun 14 (1), 6370 (2023)
   PUBMED   37828054
  REMARK    GeneRIF: Palmitoylation-driven PHF2 ubiquitination remodels lipid
            metabolism through the SREBP1c axis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5392)
  AUTHORS   Peng,L., Chen,J., Li,M. and Wang,R.
  TITLE     Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by
            Sponging miR-873-5p to Release PHF2
  JOURNAL   Biochem Genet 61 (3), 1015-1034 (2023)
   PUBMED   36380035
  REMARK    GeneRIF: Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression
            by Sponging miR-873-5p to Release PHF2.
REFERENCE   4  (bases 1 to 5392)
  AUTHORS   Luo,P., Zhang,Y.D., He,F., Tong,C.J., Liu,K., Liu,H., Zhu,S.Z.,
            Luo,J.Z. and Yuan,B.
  TITLE     HIF-1alpha-mediated augmentation of miRNA-18b-5p facilitates
            proliferation and metastasis in osteosarcoma through attenuation
            PHF2
  JOURNAL   Sci Rep 12 (1), 10398 (2022)
   PUBMED   35729160
  REMARK    GeneRIF: HIF-1alpha-mediated augmentation of miRNA-18b-5p
            facilitates proliferation and metastasis in osteosarcoma through
            attenuation PHF2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5392)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5392)
  AUTHORS   Horton,J.R., Upadhyay,A.K., Hashimoto,H., Zhang,X. and Cheng,X.
  TITLE     Structural basis for human PHF2 Jumonji domain interaction with
            metal ions
  JOURNAL   J Mol Biol 406 (1), 1-8 (2011)
   PUBMED   21167174
  REMARK    GeneRIF: the crystal structures of PHF2 Jumonji domain in the
            absence and presence of additional exogenous metal ions were
            determined.
REFERENCE   7  (bases 1 to 5392)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   8  (bases 1 to 5392)
  AUTHORS   Wen,H., Li,J., Song,T., Lu,M., Kan,P.Y., Lee,M.G., Sha,B. and
            Shi,X.
  TITLE     Recognition of histone H3K4 trimethylation by the plant homeodomain
            of PHF2 modulates histone demethylation
  JOURNAL   J Biol Chem 285 (13), 9322-9326 (2010)
   PUBMED   20129925
REFERENCE   9  (bases 1 to 5392)
  AUTHORS   Sinha,S., Singh,R.K., Alam,N., Roy,A., Roychoudhury,S. and
            Panda,C.K.
  TITLE     Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at
            chromosomal 9q22.3 region: pathological significance in early- and
            late-onset breast carcinoma
  JOURNAL   Mol Cancer 7, 84 (2008)
   PUBMED   18990233
  REMARK    GeneRIF: Differential association of alterations in FANCC and PTCH1
            with that of PHF2, XPA and two breast cancer susceptibility genes
            (BRCA1/BRCA2) in the two age groups suggests differences in their
            molecular pathogenesis.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5392)
  AUTHORS   Hasenpusch-Theil,K., Chadwick,B.P., Theil,T., Heath,S.K.,
            Wilkinson,D.G. and Frischauf,A.M.
  TITLE     PHF2, a novel PHD finger gene located on human chromosome 9q22
  JOURNAL   Mamm Genome 10 (3), 294-298 (1999)
   PUBMED   10051327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353629.22, CB990295.1,
            AL834263.1, BQ716020.1 and AL359181.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005392.3.
            
            Summary: This gene encodes a protein which contains a zinc
            finger-like PHD (plant homeodomain) finger, distinct from other
            classes of zinc finger motifs, and a hydrophobic and highly
            conserved domain. The PHD finger shows the typical Cys4-His-Cys3
            arrangement. PHD finger genes are thought to belong to a diverse
            group of transcriptional regulators possibly affecting eukaryotic
            gene expression by influencing chromatin structure. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359246.9/ ENSP00000352185.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL353629.22        130122-130164
            44-192              CB990295.1         28-176
            193-3022            AL834263.1         1-2830
            3023-3392           BQ716020.1         189-558
            3393-5392           AL359181.28        62281-64280
FEATURES             Location/Qualifiers
     source          1..5392
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..5392
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /note="PHD finger protein 2"
                     /db_xref="GeneID:5253"
                     /db_xref="HGNC:HGNC:8920"
                     /db_xref="MIM:604351"
     exon            1..288
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3481
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /note="jumonji C domain-containing histone demethylase 1E;
                     centromere protein 35"
                     /codon_start=1
                     /product="lysine-specific demethylase PHF2"
                     /protein_id="NP_005383.3"
                     /db_xref="CCDS:CCDS35069.1"
                     /db_xref="GeneID:5253"
                     /db_xref="HGNC:HGNC:8920"
                     /db_xref="MIM:604351"
                     /translation="MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPD
                     IDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAE
                     DVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVD
                     VTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWV
                     ENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASA
                     NISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAG
                     HFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLP
                     PHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVR
                     PEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKP
                     PKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGK
                     ATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEK
                     SPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSD
                     DGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLH
                     IDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGM
                     LSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDL
                     DDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSV
                     PRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSI
                     SAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAG
                     TFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKI
                     HRNGKLLL"
     exon            289..374
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            375..489
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            490..650
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            651..792
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            793..979
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1142
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1230
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1337
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1429
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1519
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1888
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2008
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2127
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2306
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2377
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2538
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2816
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2912
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3022
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3392
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..5392
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5364..5369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /note="hexamer: AGTAAA"
     polyA_site      5392
                     /gene="PHF2"
                     /gene_synonym="CENP-35; GRC5; JHDM1E; KDM7C"
                     /note="major polyA site"
ORIGIN      
        1 attgtgtgga cgcgcctggc cgggagcgcg cgcgggggct gtcgtgcgcc cccgtccccg
       61 tcccctcccg gccgcggcgc cgcctgcgcc ccgccgcccc cgccgccccc gcgcggcccg
      121 gcccccggcc cggcccggac cgacccgggc agcgcagcgg cggggccgag cggcggcgcg
      181 gcgcggcaac atggcgacgg tgcccgtgta ctgcgtctgc cggctcccct acgacgttac
      241 ccgcttcatg atcgagtgcg acgcctgcaa ggactggttc cacggcagct gtgttggggt
      301 ggaagaggag gaggcgcccg acatcgacat ataccactgc ccaaactgtg agaaaaccca
      361 tgggaagtcc accttaaaga agaagcggac ctggcacaaa cacggcccgg ggcaagcgcc
      421 tgacgtcaag cccgtgcaga atggcagcca gctcttcatc aaggagctgc ggagccggac
      481 ctttcccagt gctgaagacg tggtggcccg tgtgccagga agtcagctca cgctgggcta
      541 catggaggag cacggcttca ccgagcccat cctcgtccct aagaaagacg ggctgggtct
      601 ggctgtcccg gcccccacgt tctatgtcag tgacgtcgag aactacgtgg ggccggaacg
      661 gagtgtggat gtgacagatg tcaccaagca gaaggactgc aagatgaagc tgaaggagtt
      721 tgtggactat tactacagca ccaaccgcaa gcgggtcctc aacgtcacca acctcgagtt
      781 ctctgacacc cgaatgtcca gcttcgtgga gccacctgac attgtaaaga aactgtcatg
      841 ggtagaaaac tactggccag atgatgcatt gctggccaag cccaaagtga ccaagtactg
      901 cctaatctgc gtgaaggaca gttacaccga cttccacatc gactctgggg gcgcctctgc
      961 ctggtaccac gtgctcaagg gggagaagac cttctatctc atcaggccgg cctcggccaa
     1021 catctccctg tatgagcgct ggcggtctgc ctctaaccac agcgagatgt tctttgctga
     1081 ccaggtcgac aaatgctaca agtgcatcgt caagcagggc cagaccctct tcatcccctc
     1141 aggctggatc tacgccacac tcacccctgt ggactgcctg gccttcgcgg gacatttcct
     1201 ccacagcctg agtgtggaga tgcagatgag agcatatgaa gtggaaagga ggttgaaact
     1261 gggcagcctg actcagtttc ccaactttga aactgcgtgc tggtacatgg ggaagcacct
     1321 gctggaggca ttcaaaggct ctcacaaatc tgggaagcag ctgccccctc atctagtcca
     1381 aggagctaaa attctcaatg gtgctttccg atcgtggacg aagaagcagg ctttggcaga
     1441 gcatgaggac gagctcccgg agcacttcaa accttcacag ctaatcaaag acctggccaa
     1501 agagatccgg ctcagtgaga atgcctccaa agccgtccga ccggaagtga atactgtcgc
     1561 ctcgtcagat gaggtgtgtg acggggaccg ggagaaggag gagcccccgt ctcccattga
     1621 ggccaccccg cctcaatccc tcctggagaa agtgtccaaa aaaaagactc ccaaaactgt
     1681 gaagatgccc aagccatcca aaatccccaa gcccccgaag ccccctaagc ccccaaggcc
     1741 ccccaaaacg ctgaagctca aagatggagg caagaagaaa gggaagaagt cccgggagtc
     1801 agcctcaccc accatcccca acctggacct gctcgaagcc cacaccaagg aggcactgac
     1861 caagatggag ccgcccaaga agggcaaggc cacaaagagt gtcctgagtg tgcccaacaa
     1921 agatgtggtt cacatgcaga atgatgtgga gaggctggaa attcgagagc aaaccaagag
     1981 caagtcagag gccaagtgga agtacaagaa cagcaaacct gactccttac tgaagatgga
     2041 agaggagcag aagctagaga agtcgcctct agctggaaac aaagacaata agttctcttt
     2101 ttctttctcc aacaagaaac tcctcggctc caaggctctc aggcccccga cgagccctgg
     2161 tgtgttcggg gccttgcaga acttcaagga ggacaagccc aagcccgtgc gggatgagta
     2221 tgagtacgtg tcggatgacg gtgagctcaa gatcgacgag tttcccatca ggaggaagaa
     2281 aaacgccccg aaaagggact tgtccttctt gttggataag aaggctgtgc tgcccacgcc
     2341 tgtcacgaag ccaaagctgg actcggcagc gtacaagagt gatgactcct cggacgaggg
     2401 ttcgctgcac atcgacacag acaccaagcc cggccgcaat gccagagtca agaaggagag
     2461 tgggagctcg gcagctggca tcttggacct gctgcaggcc agtgaggagg ttggcgcgct
     2521 ggagtacaac cccagcagcc agcccccggc ctcccccagc acacaggaag ccattcaggg
     2581 aatgctgtcc atggccaacc tgcaggcctc cgactcctgc ctgcagacca cgtggggagc
     2641 tggccaggcc aaggggagct cgctggctgc ccatggtgcc cggaagaatg ggggtggcag
     2701 tggcaagagt gcaggcaaac gactgctgaa gagggctgcc aagaacagtg tcgacctgga
     2761 cgactacgag gaagagcagg accacctgga tgcctgcttc aaggactcag actacgttta
     2821 cccctcactg gagtcagatg aagacaaccc catctttaag tcccggtcga agaaaaggaa
     2881 aggctcagac gacgctccct acagcccaac agcaagggtc ggcccatcgg tgccaagaca
     2941 ggacaggcct gtgcgtgagg gtacacgggt ggcttccatc gagaccgggc tggcggctgc
     3001 tgcagctaag ttgtcccagc aggaggagca gaaaagcaag aaaaaaaaga gtgccaagag
     3061 gaagctgact cctaacacca cctccccttc cacctccacc tccatctctg ccggcaccac
     3121 ctccacctcc accacgccag cctctaccac cccggcctcc accaccccgg cctccaccag
     3181 cacggccagc agccaggcct cgcaggaggg cagctcgcca gagcccccgc ctgagtcgca
     3241 tagcagcagc ctggcggacc atgagtacac agccgctggc accttcaccg gggcccaggc
     3301 tggccgcacc tcccagccca tggcccctgg ggtctttctc acacagaggc ggccctccgc
     3361 atcgtctcca aacaacaaca ccgctgccaa aggaaaacgt acgaaaaagg gcatggcgac
     3421 cgccaagcag aggcttggga aaattttgaa aattcatcgg aacgggaaac tactccttta
     3481 agatttggaa agccaggatc cttctgctcc gctcaggacc cccggagccc cgcgaaaaca
     3541 tctgcctccc aggagggtgc cgagctgcct caccagggag ggccttgcct cttcccggct
     3601 gccatctccc caacaagcgt ctgtcccttc agccggcaga gcgagcccag cgtggcccct
     3661 caatttgaaa atggacgtct tttctcaagt tgctaagagt gatctgtccc agaaaagcgg
     3721 ccctgcaagt ttgaggaccg cttattccac tttaaggaca gccttcaggc cccctgagcg
     3781 tgggtgtgat tgcagggcct ctgcagctct gctgagagca tgagtccttc aaggaagaca
     3841 gagtgagcca atgctcacca gccccagagt cagagctggc cacaggctgg cagcctccag
     3901 gggcttaaaa aaaaaggcaa agaacacaga aagaggagga gcaagtggga tgtttatgtc
     3961 cccccttctc ttcctgagtg attctcagcc aagtccagac agtgctcggc gggtgaggaa
     4021 gggtctgccc cgagctttct ggttggcagg tggcagcagg atggtgggtg ttcagcctga
     4081 atgcccagga gcatttctgg ggggcagcta agactggcag ctgggttggt gtgttagcgg
     4141 gcaggggagc cattgtgggg tccccaggaa agggcaaggg ctcagccaca tcttggggtc
     4201 tgggaggccc aggctaagcc atgtggcagg gaccgtcttg ccctgctggc cacactctgg
     4261 agaagcactt ctcagccaag gcacccctgc cctgggactg gcagggcagg ggcaggggca
     4321 gggacagtgg ccaggcggcc cgaggactta cggtcggcac ttctctgttc tcccgtgtca
     4381 gcgtgtggtg tcgcctgcat gggtcgtacc tggatggtgt gtccaccatc gacacggagg
     4441 ggctggattt gtttctcagg caatcctgta ttttaatttt agatgtattt cctgaagcat
     4501 atttttcata gaatgtagcg tgtaaatagc tttttaaata acttcttttt tataagagta
     4561 aaagtatctt taggaatttc tttctataga gttcttcatt aacatttata cgagtttttt
     4621 gctgagtcag atggacagtt gggttctgat gctttttcct tctcctttcc ttttattatt
     4681 attatttttt tcttttaaga actaaggtat tgcctgaaaa acaagtgatg tctgtgcagc
     4741 cttacactct gtctttacag aagcaaatag tacacaaaag atctatttca gacacatttt
     4801 gaagatgaat cttcaacttt aataccagct ctttgttttc cttgtatgat gaggggattg
     4861 ggggatacag ttattttact agcaccttgt gaagtgtttc cgtgttttgt gatgctgtaa
     4921 tttattaatg tttgtagctt tttatatttg tacatttctt atgagctttg tttatatacc
     4981 cattacctgg atgtttttgt ccactgggag aggcagcttg gtggaggcct tatccactcc
     5041 cacttgtcct gtttggaggg acgcagtccc tagggcccga gactgggtgg gagaggggga
     5101 gtctcacggg gccccaggct tattcagaac tggtgttttt aaagtttcct ttaccctgcc
     5161 cttgttgaac atttatataa tctaacctgg acatcaagct gttctctctc tctctttttt
     5221 ttaattttat tattattatt ttggcaacat gtacatttct aacaaagttt atcgtggcta
     5281 ttaaagtgtt ttatttccca attcatatta ctcttgtatc gagtccatga ggtctaaggc
     5341 aacttagatc aaagttttaa aaaagtaaaa atatttcagg ttttgtacag aa
//
