LOCUS       NM_015651               4149 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens PHD finger protein 19 (PHF19), transcript variant 1,
            mRNA.
ACCESSION   NM_015651 XM_045308
VERSION     NM_015651.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4149)
  AUTHORS   Johnson,T.S., Sudha,P., Liu,E., Becker,N., Robertson,S., Blaney,P.,
            Morgan,G., Chopra,V.S., Dos Santos,C., Nixon,M., Huang,K.,
            Suvannasankha,A., Zaid,M.A., Abonour,R. and Walker,B.A.
  TITLE     1q amplification and PHF19 expressing high-risk cells are
            associated with relapsed/refractory multiple myeloma
  JOURNAL   Nat Commun 15 (1), 4144 (2024)
   PUBMED   38755140
  REMARK    GeneRIF: 1q amplification and PHF19 expressing high-risk cells are
            associated with relapsed/refractory multiple myeloma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4149)
  AUTHORS   Xu,Y., Liu,W., Jiang,X., Li,J., Liu,Q., Su,F., Ruan,S., Zhang,Z.
            and Tao,F.
  TITLE     Regulation of hPCL3 isoforms' ubiquitination by TRIM21 in non-small
            cell lung cancer progression
  JOURNAL   Life Sci Alliance 6 (10), e202302060 (2023)
   PUBMED   37507137
  REMARK    GeneRIF: Regulation of hPCL3 isoforms' ubiquitination by TRIM21 in
            non-small cell lung cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4149)
  AUTHORS   Xiaoyun,S., Yuyuan,Z., Jie,X., Yingjie,N., Qing,X., Yuezhen,D. and
            Haiguang,X.
  TITLE     PHF19 activates hedgehog signaling and promotes tumorigenesis in
            hepatocellular carcinoma
  JOURNAL   Exp Cell Res 406 (1), 112690 (2021)
   PUBMED   34129846
  REMARK    GeneRIF: PHF19 activates hedgehog signaling and promotes
            tumorigenesis in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 4149)
  AUTHORS   Li,Y., Gong,J. and Zhang,L.
  TITLE     PHD finger protein 19 expression in multiple myeloma: Association
            with clinical features, induction therapy outcome, disease
            progression, and survival
  JOURNAL   J Clin Lab Anal 35 (9), e23910 (2021)
   PUBMED   34390275
  REMARK    GeneRIF: PHD finger protein 19 expression in multiple myeloma:
            Association with clinical features, induction therapy outcome,
            disease progression, and survival.
REFERENCE   5  (bases 1 to 4149)
  AUTHORS   Zhang,J., Lv,W., Liu,Y., Fu,W., Chen,B., Ma,Q. and Gao,X.
  TITLE     LINC_00355 promotes gastric cancer progression by upregulating
            PHF19 expression through sponging miR-15a-5p
  JOURNAL   BMC Cancer 21 (1), 657 (2021)
   PUBMED   34078310
  REMARK    GeneRIF: LINC_00355 promotes gastric cancer progression by
            upregulating PHF19 expression through sponging miR-15a-5p.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4149)
  AUTHORS   Ghislin,S., Deshayes,F., Middendorp,S., Boggetto,N. and
            Alcaide-Loridan,C.
  TITLE     PHF19 and Akt control the switch between proliferative and invasive
            states in melanoma
  JOURNAL   Cell Cycle 11 (8), 1634-1645 (2012)
   PUBMED   22487681
  REMARK    GeneRIF: PHF19 silencing reduces the cell proliferation rate and
            increases the transendothelial migration capacities of melanoma
            cell lines.
REFERENCE   7  (bases 1 to 4149)
  AUTHORS   Boulay,G., Rosnoblet,C., Guerardel,C., Angrand,P.O. and Leprince,D.
  TITLE     Functional characterization of human Polycomb-like 3 isoforms
            identifies them as components of distinct EZH2 protein complexes
  JOURNAL   Biochem J 434 (2), 333-342 (2011)
   PUBMED   21143197
  REMARK    GeneRIF: Functional characterization of human Polycomb-like 3
            isoforms identifies them as components of distinct EZH2 protein
            complexes
REFERENCE   8  (bases 1 to 4149)
  AUTHORS   Zhernakova,A., Stahl,E.A., Trynka,G., Raychaudhuri,S., Festen,E.A.,
            Franke,L., Westra,H.J., Fehrmann,R.S., Kurreeman,F.A., Thomson,B.,
            Gupta,N., Romanos,J., McManus,R., Ryan,A.W., Turner,G., Brouwer,E.,
            Posthumus,M.D., Remmers,E.F., Tucci,F., Toes,R., Grandone,E.,
            Mazzilli,M.C., Rybak,A., Cukrowska,B., Coenen,M.J., Radstake,T.R.,
            van Riel,P.L., Li,Y., de Bakker,P.I., Gregersen,P.K.,
            Worthington,J., Siminovitch,K.A., Klareskog,L., Huizinga,T.W.,
            Wijmenga,C. and Plenge,R.M.
  TITLE     Meta-analysis of genome-wide association studies in celiac disease
            and rheumatoid arthritis identifies fourteen non-HLA shared loci
  JOURNAL   PLoS Genet 7 (2), e1002004 (2011)
   PUBMED   21383967
REFERENCE   9  (bases 1 to 4149)
  AUTHORS   Gregersen,P.K., Amos,C.I., Lee,A.T., Lu,Y., Remmers,E.F.,
            Kastner,D.L., Seldin,M.F., Criswell,L.A., Plenge,R.M., Holers,V.M.,
            Mikuls,T.R., Sokka,T., Moreland,L.W., Bridges,S.L. Jr., Xie,G.,
            Begovich,A.B. and Siminovitch,K.A.
  TITLE     REL, encoding a member of the NF-kappaB family of transcription
            factors, is a newly defined risk locus for rheumatoid arthritis
  JOURNAL   Nat Genet 41 (7), 820-823 (2009)
   PUBMED   19503088
REFERENCE   10 (bases 1 to 4149)
  AUTHORS   Wang,S., Robertson,G.P. and Zhu,J.
  TITLE     A novel human homologue of Drosophila polycomblike gene is
            up-regulated in multiple cancers
  JOURNAL   Gene 343 (1), 69-78 (2004)
   PUBMED   15563832
  REMARK    GeneRIF: identification of a gene encoding a human homologue of the
            Drosophila polycomblike protein, hPCL3 gene, encoding two nuclear
            proteins, hPCL3S and hPCL3L; markedly overexpressed in many types
            of cancers
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM784783.1, BC125076.1, BC044224.1, BU632411.1 and AI193743.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015651.2.
            
            Transcript Variant: This variant (1) uses an alternate 5' terminal
            exon and it thus differs in its 5' UTR and initiates translation
            from a downstream in-frame start codon, compared to variant 3. The
            encoded isoform (a, also known as hPCL3L) is shorter at the
            N-terminus, compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122744.1, BC125076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373896.8/ ENSP00000363003.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                BM784783.1         141-228
            89-2197             BC125076.1         1-2109
            2198-4101           BC044224.1         1419-3322
            4102-4145           BU632411.1         18-61               c
            4146-4149           AI193743.1         22-25               c
FEATURES             Location/Qualifiers
     source          1..4149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..4149
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /note="PHD finger protein 19"
                     /db_xref="GeneID:26147"
                     /db_xref="HGNC:HGNC:24566"
                     /db_xref="MIM:609740"
     exon            1..98
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            99..299
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1856
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /note="isoform a is encoded by transcript variant 1;
                     polycomb like 3; polycomb-like protein 3; tudor domain
                     containing 19B"
                     /codon_start=1
                     /product="PHD finger protein 19 isoform a"
                     /protein_id="NP_056466.1"
                     /db_xref="CCDS:CCDS35116.1"
                     /db_xref="GeneID:26147"
                     /db_xref="HGNC:HGNC:24566"
                     /db_xref="MIM:609740"
                     /translation="MENRALDPGTRDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQ
                     YVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNIC
                     LGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADQPLLTPWFCRRCIFALAVRKGGAL
                     KKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQ
                     WFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSK
                     KKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKK
                     CIFRLRIRVPPNPPGKLLPDKGLLPNENSASSELRKRGKSKPGLLPHEFQQQKRRVYR
                     RKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTD
                     AASTSGSASTSLSYDSRWTVGSRKRKLAAKAYMPLRAKRWAAELDGRCPSDSSAEGAS
                     VPERPDEGIDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEG
                     KVQYLVEWEGTTPY"
     exon            300..381
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            382..477
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            478..578
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            579..727
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            728..823
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            824..892
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1013
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1081
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1243
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1331
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1417
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1513
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..4149
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4104
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
                     /note="major polyA site"
     polyA_site      4149
                     /gene="PHF19"
                     /gene_synonym="MTF2L1; PCL3; TDRD19B"
ORIGIN      
        1 actcggccgg gcagccgcgg gccgagcgca gccgcctccg ccaccgatgc gcctggtggc
       61 cagactccaa gtgggaccgg cggacacgca gcctcgcgtg tcaggggaag ctgatggaga
      121 atcgagctct ggatccaggg actcgggact cctatggtgc caccagccac ctccccaaca
      181 agggggccct ggcgaaggtc aagaacaact tcaaagactt gatgtccaaa ctgacggagg
      241 gccagtatgt gctgtgccgg tggacagatg gcctgtacta cctcgggaag atcaagaggg
      301 tcagcagctc taagcaaagc tgcctcgtga ctttcgaaga taattccaaa tactgggtcc
      361 tatggaagga catacagcat gccggtgttc caggagagga gcccaagtgc aacatctgcc
      421 tagggaagac atcagggccg ctgaatgaga tcctcatctg cgggaagtgt ggcctgggtt
      481 accaccagca gtgccacatc cccatagcgg gcagtgctga ccagcccctg ctcacacctt
      541 ggttctgccg acgctgcatc ttcgcactgg ctgtgcggaa aggcggcgcg ctgaagaagg
      601 gcgccatcgc caggacgctg caggccgtga agatggtgct gtcctaccag cccgaggagc
      661 tcgagtggga ctcgccccat cgcaccaacc agcagcaatg ctactgctac tgcggcgggc
      721 ccggagaatg gtacctgcgg atgctgcaat gttaccggtg caggcagtgg ttccacgagg
      781 cctgcaccca gtgcctcaat gagcccatga tgtttggaga ccggttttac ctgttcttct
      841 gctccgtgtg taaccagggc ccagagtaca tcgagaggct gcccctgcga tgggtggatg
      901 tggttcacct ggccctctat aatctggggg tacagagcaa gaagaagtac tttgactttg
      961 aggagattct ggcctttgtc aaccaccact gggagctcct gcagcttggc aagctcacca
     1021 gcaccccagt gacagatcga ggaccacatc tcctcaacgc tctgaacagt tataaaagcc
     1081 ggttcctctg cggcaaggag atcaagaaga agaagtgcat cttccgcctg cgcatccgcg
     1141 tcccacccaa cccgccaggg aagctgctgc ctgacaaagg actgctgcca aatgagaaca
     1201 gcgcctcctc tgagctgcgt aagagaggaa agagcaagcc tggtttgttg cctcacgaat
     1261 tccagcagca gaaaaggcga gtttatagaa gaaaaagatc aaagtttttg ctggaagatg
     1321 ctattcccag tagtgacttc acctcagcct ggagcaccaa ccaccacctg gctagcatat
     1381 ttgacttcac gctggatgaa attcaaagtt taaaaagtgc cagctcaggc cagaccttct
     1441 tctcagatgt cgactccacc gacgctgcca gcacctctgg ctctgcctcc accagcctct
     1501 cctatgactc cagatggaca gtgggcagcc gaaagaggaa gctggcagcc aaggcataca
     1561 tgcccctgcg ggcaaagcgg tgggcagctg agctggatgg acgctgcccc tcggacagca
     1621 gtgcagaggg ggcttcagtc cccgagcggc cagacgaagg cattgacagc cacacatttg
     1681 agagcatcag tgaagatgac tcatccctgt cccacctcaa gtcatctatc accaactact
     1741 ttggtgcagc tgggcggttg gcctgtgggg agaagtacca ggtgttggct cggagggtca
     1801 cacctgaggg caaggttcag tacctggtgg agtgggaagg gaccacccct tactgactag
     1861 cccccggggg tgccaggggt cctgaaaacc aaaggaggag cagcagaagc cataggctcc
     1921 ccagctttct ccaggctggg gtgggagaag gaagcaggac agagctgcaa gtgcctggca
     1981 gaatgccctg cctgcctgcc tgccaggcca aggcctgcgt ctctctgctg taccagctct
     2041 gttccagggc ctcctcaggc tcgttacccc tgtgcctgtg tctctacaca ctccacaccc
     2101 cctcaaactc tgtttatctg ttctctgacc ttgtgtcccc tgcgctggga cccttcctcc
     2161 tgaggcccag gtctttgtcc ccagttgtgt gccttgacct ctctcgcccc tttctgggtg
     2221 tgttcgcaca tcctgtgtgt gcacagctgt ccctccactg gatccccttc acacgtgacc
     2281 cgtggggcag ccagtcctcc cagggactac ataacaggca cctttgagag agcatgggag
     2341 aaggtggata agaggatgct gctcagtgct tttctcttcc actttcctgc cactccccac
     2401 taccctcgga gagaggtggt gggatgggag agagcccctg tgaaagcctg tgaggatctg
     2461 aagagtaaag ggctgggtct gcctcagaag gcaccagcac cagggcccag gtattaaggc
     2521 tgagagtgaa ggctgccaat gtcagctttg gaggtcccag aagtcttctg ttctctggcc
     2581 tcaccccctc agtcgccata gagctgggcc tggccttgct ggaatggagg catccttcca
     2641 aacctggggg acgggggtgg ggggtggtag tggtgggagg gaaaccatgt cttgctaaac
     2701 ctgtttctgg tgcctcccat ccccagaccc accagacacc acacagcaga caatacacac
     2761 ccactcgcac aagcttccat ccacatgtgt tgtactttca gctctaggca tgcagacaac
     2821 cccacacggc cacaccacca catgcccaag tgtacacaca cagagccaca ccgtccctct
     2881 gggcctgctg gctcctccct tggctttccc ttggcccact tccagggccc aggtgctgca
     2941 actaaatgtg aaagctcagt ggccgctcct tctttcagcc catcaaccag cattggtccc
     3001 atagggaagc acaggggact caccctcttt catatccctt gccctgccct gaaatggaca
     3061 atcacttttt gggataggtt gaaattttta aagagcctgc atcatttggt tccctcaaag
     3121 ggaagccctt gccagtgggg gtttgaaaga gaatttttgg aaccaacatt caaattctgc
     3181 ctcatctgga gggaaaccaa aattgggagg gggaagagga cccctgatgt tttgctgctt
     3241 ccagagatat tagaaactga ctcacttgat tggaaaatgg acaaaagtgc cttgacgtgg
     3301 agggtgggca ccagatgggg accagccttg ccaactgctg ctgtggcctc cagcttggct
     3361 ggttttgcag gccgccagca ggaaggcgaa ggtggtagta cagcaagagg cactggcggg
     3421 gcagcaggcc tgcaggagct gtttttccat tgctaggcct gacccctctc tacctgtgag
     3481 cgttcagggg gtccctgaga tagtttagat gcccccccat cttagacctc agctcccaca
     3541 gtgcctttta agggggacct cacctcctgt gcacagccca cccactttcc tctgcttccc
     3601 tggcacagcc caggcataga cgagctggcg ttggacccag ttcttccccc ttttcagccc
     3661 cacagctgct gccacagggg ccaactaggg ccaggtggaa ggggagctga gaagccaacc
     3721 cctagcccag gggtgctgtg ggaactggga tccaatttgt agcttcctgc ctggcttcag
     3781 agagcccagc aaccttctag gcctgctttc cagacttctg agatagcctg ggatgagcaa
     3841 tcctgttata gtacatctgg accttcccta cctgggctct ggggaggctg tgggcctgga
     3901 gagggaaaag gagggagggg gtgtctgcac cacctgggaa gatagcacaa ggcctaatga
     3961 ggtcaccctg actccccacc ccagcatttc attcatacca gataatagct gcattactgc
     4021 caactgacct tataaccctc tgcaccttca aaaagattca tggtttttaa ttgctgcttt
     4081 taataacatt tgttaaagtt ataattaatg tgtctgattt atgatttaaa acctcccttt
     4141 gaacaatca
//
