LOCUS       NM_001007157            3427 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PHD finger protein 14 (PHF14), transcript variant 1,
            mRNA.
ACCESSION   NM_001007157 XM_017012814
VERSION     NM_001007157.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3427)
  AUTHORS   Wei,L., Deng,C., Zhang,B., Wang,G., Meng,Y. and Qin,H.
  TITLE     SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by
            Activating PHF14 Transcription and Wnt/Beta-Catenin Signaling
  JOURNAL   Mol Cancer Res 22 (1), 55-69 (2024)
   PUBMED   37768180
  REMARK    GeneRIF: SP4 Facilitates Esophageal Squamous Cell Carcinoma
            Progression by Activating PHF14 Transcription and Wnt/Beta-Catenin
            Signaling.
REFERENCE   2  (bases 1 to 3427)
  AUTHORS   Gomez-Marin,E., Posavec-Marjanovic,M., Zarzuela,L.,
            Basurto-Cayuela,L., Guerrero-Martinez,J.A., Arribas,G., Yerbes,R.,
            Ceballos-Chavez,M., Rodriguez-Paredes,M., Tome,M., Duran,R.V.,
            Buschbeck,M. and Reyes,J.C.
  TITLE     The high mobility group protein HMG20A cooperates with the histone
            reader PHF14 to modulate TGFbeta and Hippo pathways
  JOURNAL   Nucleic Acids Res 50 (17), 9838-9857 (2022)
   PUBMED   36124662
  REMARK    GeneRIF: The high mobility group protein HMG20A cooperates with the
            histone reader PHF14 to modulate TGFbeta and Hippo pathways.
REFERENCE   3  (bases 1 to 3427)
  AUTHORS   Pan,G., Zhang,K., Geng,S., Lan,C., Hu,X., Li,C., Ji,H., Li,C.,
            Hu,X., Wang,Y., Lv,M. and Cui,H.
  TITLE     PHF14 knockdown causes apoptosis by inducing DNA damage and
            impairing the activity of the damage response complex in colorectal
            cancer
  JOURNAL   Cancer Lett 531, 109-123 (2022)
   PUBMED   35074497
  REMARK    GeneRIF: PHF14 knockdown causes apoptosis by inducing DNA damage
            and impairing the activity of the damage response complex in
            colorectal cancer.
            Erratum:[Cancer Lett. 2023 Aug 1;568:216290. doi:
            10.1016/j.canlet.2023.216290.. PMID: 37438200]
REFERENCE   4  (bases 1 to 3427)
  AUTHORS   Zhao,Y., He,J., Li,Y., Xu,M., Peng,X., Mao,J., Xu,B. and Cui,H.
  TITLE     PHF14 Promotes Cell Proliferation and Migration through the AKT and
            ERK1/2 Pathways in Gastric Cancer Cells
  JOURNAL   Biomed Res Int 2020, 6507510 (2020)
   PUBMED   32596345
  REMARK    GeneRIF: PHF14 Promotes Cell Proliferation and Migration through
            the AKT and ERK1/2 Pathways in Gastric Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3427)
  AUTHORS   Miao,L., Liu,H.Y., Zhou,C. and He,X.
  TITLE     LINC00612 enhances the proliferation and invasion ability of
            bladder cancer cells as ceRNA by sponging miR-590 to elevate
            expression of PHF14
  JOURNAL   J Exp Clin Cancer Res 38 (1), 143 (2019)
   PUBMED   30940184
  REMARK    GeneRIF: Study revealed that miR-590 was shown to directly target
            PHF14 thus affecting thus affecting bladder neoplasm cellular
            epithelial-mesenchymal transition.
            Erratum:[J Exp Clin Cancer Res. 2022 Mar 15;41(1):103. doi:
            10.1186/s13046-022-02326-0.. PMID: 35292080]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3427)
  AUTHORS   Zhang,L., Huang,Q., Lou,J., Zou,L., Wang,Y., Zhang,P., Yang,G.,
            Zhang,J., Yu,L., Yan,D., Zhang,C., Qiao,J., Wang,S., Wang,S.,
            Xu,Y., Ji,H., Chen,Z. and Zhang,Z.
  TITLE     A novel PHD-finger protein 14/KIF4A complex overexpressed in lung
            cancer is involved in cell mitosis regulation and tumorigenesis
  JOURNAL   Oncotarget 8 (12), 19684-19698 (2017)
   PUBMED   28160558
  REMARK    GeneRIF: High PHF14 expression is associated with lung cancer.
REFERENCE   7  (bases 1 to 3427)
  AUTHORS   Friedrichs,S., Malzahn,D., Pugh,E.W., Almeida,M., Liu,X.Q. and
            Bailey,J.N.
  TITLE     Filtering genetic variants and placing informative priors based on
            putative biological function
  JOURNAL   BMC Genet 17 Suppl 2 (Suppl 2), 8 (2016)
   PUBMED   26866982
  REMARK    GeneRIF: Results show that marker rs218966 in gene PHF14 and
            rs9836027 in MAP4 significantly associated with hypertension;
            additionally, rare variants in SNUPN significantly associated with
            systolic blood pressure.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3427)
  AUTHORS   Huang,Q., Zhang,L., Wang,Y., Zhang,C., Zhou,S., Yang,G., Li,Z.,
            Gao,X., Chen,Z. and Zhang,Z.
  TITLE     Depletion of PHF14, a novel histone-binding protein gene, causes
            neonatal lethality in mice due to respiratory failure
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 45 (8), 622-633 (2013)
   PUBMED   23688586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK294419.1, AB018326.1, BM834437.1, AA699404.1 and AA837024.1.
            
            On or before Dec 14, 2018 this sequence version replaced
            XM_017012814.2, NM_001007157.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000634607.2/ ENSP00000489535.1
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK294419.1         1-45
            46-795              AB018326.1         1-750
            796-1130            BM834437.1         110-444
            1131-3034           AB018326.1         1086-2989
            3035-3424           AA699404.1         1-390               c
            3425-3427           AA837024.1         12-14               c
FEATURES             Location/Qualifiers
     source          1..3427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.3"
     gene            1..3427
                     /gene="PHF14"
                     /note="PHD finger protein 14"
                     /db_xref="GeneID:9678"
                     /db_xref="HGNC:HGNC:22203"
                     /db_xref="MIM:619907"
     exon            1..453
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..3299
                     /gene="PHF14"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PHD finger protein 14 isoform 1"
                     /protein_id="NP_001007158.1"
                     /db_xref="GeneID:9678"
                     /db_xref="HGNC:HGNC:22203"
                     /db_xref="MIM:619907"
                     /translation="MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGN
                     GSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKK
                     EEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAV
                     NTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTV
                     VKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVL
                     SRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDAD
                     EIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQD
                     GIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFA
                     RTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKR
                     KNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLP
                     RPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYF
                     ERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNLNGKLRSEGQGI
                     WALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTSTLPAVLYSCGICKKNHDQHLL
                     LLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEADMAMETLPDGTK
                     RSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEEEKHEERVPRERRQRQS
                     VLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWI
                     CQECDSSSSKEDENEAERKNISQELNMEQKNPKK"
     exon            454..564
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            565..1352
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1497
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1657
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1769
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1907
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2054
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2325
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2432
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2528
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2632
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2764
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2933
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..2984
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3106
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3224
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3427
                     /gene="PHF14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3406..3411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF14"
                     /note="hexamer: AATAAA"
     polyA_site      3427
                     /gene="PHF14"
                     /note="major polyA site"
ORIGIN      
        1 acttcctttt cagagctgta tccgggtcgc tgctttccct attgtctgag gcagccgccc
       61 tcgcgctgtg caatttctgg tctttcgttg cttctggtcc aggctaataa agtttttctt
      121 tctttaattt tttttcttct agttttaacg ggagaaatta actccccggg gccgccgggt
      181 tgactgcgct gcctgggccg gaggtcttct ccggccaggg agcgctgtgg gaaggggctc
      241 gagcggccag ggccaggcga ggccgggggg gcggggggtt aggggaccgc ggggctactc
      301 ttgggagcgc ccctgtccgg ctggctgcgc gccggtttta aatagcatct ttcggacttg
      361 tcttcgcggc cccagtcccc gacctcggcg ctgcctgggc tcctgcagcc tctccctaag
      421 tcttctccaa acgaccacct cacggattcc ttatggatcg cagctccaag aggaggcagg
      481 tgaagccttt ggcagcttct ctgctggaag ctcttgatta tgatagttca gatgacagtg
      541 attttaaagt tggagatgcc tcagattctg aagggagtgg taatggaagt gaagatgctt
      601 caaaggacag tggagaaggt tcctgtagtg attctgaaga aaatatttta gaagaagaac
      661 tgaatgaaga tattaaagta aaagaagaac aacttaaaaa ttctgcagag gaagaagtac
      721 tatcatcaga aaaacaatta attaaaatgg aaaagaagga agaagaagaa aatggagaaa
      781 gacctagaaa gaaaaaggag aaagagaagg aaaaagaaaa ggaaaaggag aaagagaagg
      841 aaagagagaa ggaaaaagaa aaagcaacag tatctgagaa tgtggctgct tctgctgctg
      901 ccaccacacc agccacaagt cctcctgctg ttaacacatc cccttctgtt cccactacga
      961 caaccgctac agaggaacaa gtcagcgagc caaaaaaatg gaaccttcga cgaaaccgac
     1021 cacttctgga ttttgtgtcc atggaagagc tgaatgacat ggatgactat gacagtgagg
     1081 atgacaatga ttggcgacct actgtagtaa agagaaaagg gagatctgcg tctcagaaag
     1141 agggaagtga tggagacaat gaggatgatg aagatgaggg aagcgggagt gatgaagacg
     1201 agaatgatga aggcaatgat gaagatcata gtagccctgc cagtgaaggg ggttgcaaga
     1261 agaagaagag taaagttctt agcagaaaca gtgctgatga tgaggaactg accaatgata
     1321 gcctgaccct atctcaaagc aagagtaatg aggactcgct gattcttgag aagagtcaaa
     1381 actggagctc tcaaaaaatg gaccatattc tgatttgctg tgtttgtctg ggagataata
     1441 gtgaggacgc tgatgaaata attcagtgtg acaattgtgg cattacagtc catgaaggtt
     1501 gttatggagt tgatggagag agtgactcta ttatgagttc agcttctgaa aactccactg
     1561 aaccttggtt ttgtgatgcc tgtaaatgtg gtgtttctcc tagctgtgaa ctgtgtccta
     1621 atcaggatgg aattttcaag gagacagatg ctggaagatg ggttcatatt gtttgtgccc
     1681 tgtatgttcc tggagtagcc tttggagata ttgacaaatt acgaccagta acactaacgg
     1741 aaatgaacta ttccaaatat ggtgccaagg agtgtagctt ttgtgaagac cctcgctttg
     1801 ctagaactgg ggtttgcatt agctgtgatg cagggatgtg cagagcctat ttccatgtga
     1861 cctgtgctca aaaggaaggt ctgctttcag aggcagcggc ggaagaggat atagcagatc
     1921 cattctttgc ttattgtaag caacatgcag ataggttaga cagaaagtgg aagagaaaaa
     1981 actacttggc tctacagtcc tattgtaaaa tgtctttgca agagagagag aagcaactat
     2041 caccagaagc acaggcaagg atcaatgccc ggcttcagca gtatcgtgcc aaagcagaac
     2101 tagctcgatc taccagaccc caggcctggg ttccaaggga aaaattgccc agaccactca
     2161 ccagcagtgc ttcagctatt cgtaaactta tgcggaaagc agaactcatg gggatcagta
     2221 cagatatctt tccagtggac aattcagata ctagttctag tgtggatgga aggagaaaac
     2281 ataagcaacc agctctcact gcagattttg tgaattatta ttttgagaga aatatgcgca
     2341 tgattcaaat tcaggaaaat atggctgaac aaaagaatat aaaagataaa ttagagaatg
     2401 aacaagaaaa gcttcatgta gaatataata agctatgtga atctttagaa gaactacaaa
     2461 acctgaatgg aaaacttcga agtgaaggac aaggaatatg ggctttacta ggcagaatca
     2521 cagggcagaa gttgaatata ccggcaattt tgcgagcacc caaggagaga aaaccaagta
     2581 aaaaagaagg aggcacacaa aagacatcta ctcttcctgc agtactttat agttgtggga
     2641 tttgtaagaa gaaccatgat cagcatcttc ttttattgtg tgatacctgt aaactacatt
     2701 accatcttgg atgtctggat cctcctctta caaggatgcc aagaaagacc aaaaacagtt
     2761 attggcagtg ctcggaatgt gaccaggcag ggagcagtga catggaagca gatatggcca
     2821 tggaaaccct accagatgga accaaacgat caaggaggca gattaaggaa ccagtgaaat
     2881 ttgttccaca ggatgtgcca ccagaaccca agaagattcc gataagaaac acgagaacca
     2941 gaggacgaaa acgaagcttc gttcctgagg aagaaaaaca tgaggaaaga gttcctagag
     3001 agagaagaca aagacagtct gtgttgcaaa agaagcccaa ggctgaagat ttaagaactg
     3061 aatgtgcaac ttgcaaggga actggagaca atgaaaatct tgtcaggtgt gatgaatgca
     3121 gactctgcta ccattttggc tgtttggatc ctcctttgaa aaagtctcct aaacagacag
     3181 gctacggatg gatatgtcag gaatgtgatt cttcatcttc caaggaagat gaaaatgaag
     3241 ctgaaagaaa aaatatatct caggagctca acatggaaca gaaaaatcca aagaaataaa
     3301 agattttctg tagtgttttt gaaaagtttg cagcttatgt aatagcagat aaaatttcta
     3361 attgtaaaat gttaaattgt aaaatctaat ttgcaaaatg ttctcaataa agtcattcaa
     3421 aatgaaa
//
