LOCUS       NM_153812               3632 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PHD finger protein 13 (PHF13), mRNA.
ACCESSION   NM_153812
VERSION     NM_153812.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3632)
  AUTHORS   Sun,Y., Li,D., Liu,H., Huang,Y., Meng,F., Tang,J., Li,Z. and Xie,W.
  TITLE     PHF13 epigenetically activates TGFbeta driven epithelial to
            mesenchymal transition
  JOURNAL   Cell Death Dis 13 (5), 487 (2022)
   PUBMED   35597793
  REMARK    GeneRIF: PHF13 epigenetically activates TGFbeta driven epithelial
            to mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3632)
  AUTHORS   Reichel,A., Stilp,A.C., Scherer,M., Reuter,N., Lukassen,S.,
            Kasmapour,B., Schreiner,S., Cicin-Sain,L., Winterpacht,A. and
            Stamminger,T.
  TITLE     Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction
            Factor against Human Cytomegalovirus by Repressing the Major
            Immediate Early Promoter
  JOURNAL   J Virol 92 (14), e00342-18 (2018)
   PUBMED   29743358
  REMARK    GeneRIF: High SPOC1 expression is associated with Cytomegalovirus
            infections.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3632)
  AUTHORS   Hofmann,S., Dehn,S., Businger,R., Bolduan,S., Schneider,M.,
            Debyser,Z., Brack-Werner,R. and Schindler,M.
  TITLE     Dual role of the chromatin-binding factor PHF13 in the pre- and
            post-integration phases of HIV-1 replication
  JOURNAL   Open Biol 7 (10) (2017)
   PUBMED   29021215
  REMARK    GeneRIF: PHF13 has opposing effects throughout the HIV-1
            replication cycle (figure 8). After viral entry and nuclear import
            of the PIC, PHF13 can increase the number of integrated HIV-1
            proviral genomes. After integration, PHF13 acts as antiviral
            restriction factor and inhibits viral gene expression.
REFERENCE   4  (bases 1 to 3632)
  AUTHORS   Chung,H.R., Xu,C., Fuchs,A., Mund,A., Lange,M., Staege,H.,
            Schubert,T., Bian,C., Dunkel,I., Eberharter,A., Regnard,C.,
            Klinker,H., Meierhofer,D., Cozzuto,L., Winterpacht,A., Di Croce,L.,
            Min,J., Will,H. and Kinkley,S.
  TITLE     PHF13 is a molecular reader and transcriptional co-regulator of
            H3K4me2/3
  JOURNAL   Elife 5, e10607 (2016)
   PUBMED   27223324
  REMARK    GeneRIF: These experiments showed that PHF13 binds specifically to
            DNA and to two types of histone H3 methyl tags (lysine 4-tri-methyl
            or lysine 4-di-methyl) where it functions as a transcriptional
            co-regulator.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3632)
  AUTHORS   Schreiner,S., Kinkley,S., Burck,C., Mund,A., Wimmer,P.,
            Schubert,T., Groitl,P., Will,H. and Dobner,T.
  TITLE     SPOC1-mediated antiviral host cell response is antagonized early in
            human adenovirus type 5 infection
  JOURNAL   PLoS Pathog 9 (11), e1003775 (2013)
   PUBMED   24278021
  REMARK    GeneRIF: SPOC1-mediated restriction imposed upon Ad growth is
            relieved by its functional association with the Ad major core
            protein pVII that enters with the viral genome, followed by
            E1B-55K/E4orf6-dependent proteasomal degradation of SPOC1.
REFERENCE   6  (bases 1 to 3632)
  AUTHORS   Mund,A., Schubert,T., Staege,H., Kinkley,S., Reumann,K., Kriegs,M.,
            Fritsch,L., Battisti,V., Ait-Si-Ali,S., Hoffbeck,A.S., Soutoglou,E.
            and Will,H.
  TITLE     SPOC1 modulates DNA repair by regulating key determinants of
            chromatin compaction and DNA damage response
  JOURNAL   Nucleic Acids Res 40 (22), 11363-11379 (2012)
   PUBMED   23034801
  REMARK    Erratum:[Nucleic Acids Res. 2020 Sep 25;48(17):10013-10014. doi:
            10.1093/nar/gkaa754.. PMID: 32890405]
REFERENCE   7  (bases 1 to 3632)
  AUTHORS   Kinkley,S., Staege,H., Mohrmann,G., Rohaly,G., Schaub,T.,
            Kremmer,E., Winterpacht,A. and Will,H.
  TITLE     SPOC1: a novel PHD-containing protein modulating chromatin
            structure and mitotic chromosome condensation
  JOURNAL   J Cell Sci 122 (Pt 16), 2946-2956 (2009)
   PUBMED   19638409
  REMARK    GeneRIF: SPOC1 modulates chromatin structure and that tight
            regulation of its expression levels and subcellular localization
            during mitosis are crucial for proper chromosome condensation and
            cell division.
REFERENCE   8  (bases 1 to 3632)
  AUTHORS   Mohrmann,G., Hengstler,J.G., Hofmann,T.G., Endele,S.U., Lee,B.,
            Stelzer,C., Zabel,B., Brieger,J., Hasenclever,D., Tanner,B.,
            Sagemueller,J., Sehouli,J., Will,H. and Winterpacht,A.
  TITLE     SPOC1, a novel PHD-finger protein: association with residual
            disease and survival in ovarian cancer
  JOURNAL   Int J Cancer 116 (4), 547-554 (2005)
   PUBMED   15825179
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB064673.1, AK097715.1 and AY069975.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153812.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038516.1, SRR1803615.136079.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377648.5/ ENSP00000366876.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB064673.1         36-66
            32-667              AK097715.1         1-636
            668-3632            AY069975.1         333-3297
FEATURES             Location/Qualifiers
     source          1..3632
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..3632
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /note="PHD finger protein 13"
                     /db_xref="GeneID:148479"
                     /db_xref="HGNC:HGNC:22983"
                     /db_xref="MIM:620054"
     exon            1..375
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1239
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /note="survival time-associated PHD protein in ovarian
                     cancer; PHD zinc finger protein PHF5; survival
                     time-associated PHD finger protein in ovarian cancer 1"
                     /codon_start=1
                     /product="PHD finger protein 13"
                     /protein_id="NP_722519.2"
                     /db_xref="CCDS:CCDS85.1"
                     /db_xref="GeneID:148479"
                     /db_xref="HGNC:HGNC:22983"
                     /db_xref="MIM:620054"
                     /translation="MDSDSCAAAFHPEEYSPSCKRRRTVEDFNKFCTFVLAYAGYIPY
                     PKEELPLRSSPSPANSTAGTIDSDGWDAGFSDIASSVPLPVSDRCFSHLQPTLLQRAK
                     PSNFLLDRKKTDKLKKKKKRKRRDSDAPGKEGYRGGLLKLEAADPYVETPTSPTLQDI
                     PQAPSDPCSGWDSDTPSSGSCATVSPDQVKEIKTEGKRTIVRQGKQVVFRDEDSTGND
                     EDIMVDSDDDSWDLVTCFCMKPFAGRPMIECNECHTWIHLSCAKIRKSNVPEVFVCQK
                     CRDSKFDIRRSNRSRTGSRKLFLD"
     exon            376..477
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1012
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..3632
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3569..3574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /note="hexamer: AATAAA"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /note="hexamer: AATATA"
     polyA_site      3599
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
                     /note="major polyA site"
     polyA_site      3604
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
     polyA_site      3632
                     /gene="PHF13"
                     /gene_synonym="PHF5; SPOC1"
ORIGIN      
        1 gccctccctc ccgagacacg agccgaactg ggcgtcaggt cggggagccg gtcgggttcc
       61 cgctcaccgc cgccgccgcc gccccctgca gccactctcc cgcctctacc gccgcgggag
      121 ctgcatcgtc cactccggtc ggcggtggaa ccgccagtcc ggggtcacag agcttgagaa
      181 gcgacgcgct gagcccccca tcacctccag cccgggcgac ccctcccggg tccgccctcg
      241 ccctgcgcag ccgcccgagc ccccagcccc gggcggcccc gctccagcat cccagctcct
      301 gcactctcgc agccgccgcc gccccccgcc cggaacatgg actctgactc ttgcgccgcc
      361 gccttccacc cggaggaata ctcccccagt tgcaagaggc gcaggaccgt ggaagacttc
      421 aacaaattct gcacctttgt cttggcctat gctggctaca tcccttatcc gaaggaggaa
      481 ctccctttaa ggagcagccc cagccctgct aacagcactg ctggtaccat tgacagcgac
      541 ggctgggacg cgggtttctc agacatcgcg tcctcagtgc ccttgccagt ctctgaccgc
      601 tgctttagcc acctgcagcc tactctcttg cagcgagcca agcccagtaa cttcctgctg
      661 gacagaaaga aaacggacaa gctgaagaag aagaagaaga ggaagcgcag ggacagtgat
      721 gcgcctggga aagaggggta cagggggggc ttgctgaagc tggaagccgc tgacccctac
      781 gtggagaccc ccacgagtcc caccttgcag gatatccccc aggctcccag cgacccctgc
      841 tcgggctggg actccgatac tccctcgagt ggatcttgtg ccactgtgtc acctgatcag
      901 gtcaaagaaa taaaaactga aggcaaacgg actatcgtcc ggcagggaaa gcaggtggtg
      961 ttccgagatg aggacagcac tggcaatgat gaggacatca tggtggactc agatgacgat
     1021 tcctgggacc tcgtgacctg cttctgcatg aagccatttg ccggccgccc catgatcgag
     1081 tgtaatgagt gccacacctg gattcacctg tcctgtgcga aaatccggaa atccaatgtt
     1141 ccagaagtgt ttgtctgcca aaagtgccgg gactccaagt ttgacatccg ccgttccaac
     1201 cgctcgcgga cgggctcccg gaagctgttc ctggactgac tgctggctgg cgaggaggct
     1261 gcgagcgtgg aatcggaagc gaccgcgggc ttttttgccc ttctcttagt tgagcacaga
     1321 accctcagct ctggtgcggg cagatccctg ccatttaggt gcctaagcaa aaggacaggc
     1381 tgtccaaggt agaaactgta catagccggt gaccgaatgc gacctttgcc agccagagct
     1441 gctgccagag ctgcgttccc tgcagtggag gtggactgga cacccacgtg cagcgggttt
     1501 ggctcatttg aaaatgaggg tccgtggtag ctgtgcgttt tgctatcatt gctaagagat
     1561 tcccgctgat tgggctcagt gccagctgtt attctgcttc cactgtgttg gggagaggtg
     1621 ttcggtttcc ccagcctgtt aatgaacagc catacgtgta agctttttct tgagtgttaa
     1681 gtcttttacc aaaagtgtct gtacagcagc catccaagtt gcccctactt agtggcttgc
     1741 cctctgcctg cctcagctgc tgcctgaccg gctgggggag gcactggcgg gaggcctcgg
     1801 gctcccctgg aagggcgctg ggctggcggg tcagctggtg gttcttaggt ttccttctgt
     1861 ttgttaaaag ggacaatgtg gccacttctc tgtggaaagg gagttggttg gggggttgag
     1921 atggcccgtg ttcataactc agtttcctgt tttgcacgat gtaaaaaccc tgtctttttg
     1981 cacgatacag ccaaaagtat tggctgattt cttgctgagt gccctcttag ttggtgtgtg
     2041 aggtcttggt gggctcaggc cagctgtttg cgagtgtggg aactcatagg ttctgtcttt
     2101 gtctcttcct ttcacctcat tctggtagca gcataaaggt taggcaatca ctgggacccg
     2161 catggtgttc ctccaaagaa tagggtaaag gagagctggg agggagccct ctccgttggg
     2221 tgactcttgt gtgcccttta gacaggctgg cctgccggtt ccacagggta cagttaggac
     2281 ttgagtcttt ctttttctgt tttgagttgg tgagtgagtg atagggtaac atgggccttc
     2341 aggatgaccc cttggaactg tgccgagttc cttaaatctc agctgggatc ctggacctgg
     2401 gaggcccctg tgagggccag ctctggaaaa acctgggagt tgatgccgga ggctgtggaa
     2461 gaactctgct cgagggcagg gtgccctgga acactggtag ttctggggct gggagggaga
     2521 ggggctccgg ctttctctga aatgaacact gctcttcagc agttcaagta cttgttctca
     2581 aaacattttc taattgattg gtaggttttc ataagcattg tttctttaag gcatggaaag
     2641 ggaagaatgc tcaagcaagt catgtttgtt ttcagtggga tgggcccgcg ttctcactgc
     2701 tgggggcttc cccttcatgt ggcacctttg tgccaggcca ccaggcagac tcttcccacc
     2761 ttctcccact gaagcaccaa ggggcttgaa ccgtaatttg gctaatcaga ggcatttttt
     2821 ttgtcctagt atctttcaca cttgtccaac cgtcttattt ttttaaaagt tctgttgctt
     2881 gtattaacac gaaactagag agaaatagtt tctgaagcca gtttattgtg aagatcccca
     2941 agggggaggt tcggtagaga aaaatagtaa gctggtttag aaactgacga gggcaaacag
     3001 ccaggacgca ttggagagga atttgccaaa gatctaccct gagataacgc ctgtccagtg
     3061 tcttcaccac gtgaataacc agcgctccaa agtgtttttc tgctttgaaa aaaaaaaatt
     3121 ccacaagctt ttaaaggtgc atttaagaat ccatgtgact ttagaatgga actgccggcc
     3181 ctggcaactg tcacgtgtgc tagaaggttc gatgcctctg gaatgcatgt gatactcatc
     3241 tccattttgt ttccttgatt gcatttttgt tcttttagca gatctgtccc tgtgggtggt
     3301 gtctaagaag tcggacacct tggtttttgt gttagattga gctgggcagc tgcaatcagc
     3361 ttctttatat gcaaattagg cacgacccat ctgtggttcc tggttggtgg ctaatgaagt
     3421 gaggggaggg agggatgtca ccccaaaagt aggccctccc attggctttg gccaggccag
     3481 acacttcaca tcgtttacat ggttctgtgt aattttaaag tttatgtgta taaagcgaag
     3541 ctgtttctgt gaaactgtat attttgtaaa taaatatatt gctactttga ggttcatgat
     3601 tcaaggttca ggcgattgcg ttctgtgctg aa
//
