LOCUS       NM_001033561            4506 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PHD finger protein 12 (PHF12), transcript variant 1,
            mRNA.
ACCESSION   NM_001033561
VERSION     NM_001033561.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4506)
  AUTHORS   Kong,Y., Jiang,R., Zhou,H., Ge,M., Lin,H., Wang,Y., Yao,R.,
            Wang,Q., Liang,X., Li,J. and Zhou,X.
  TITLE     PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT
            signaling pathway in non-small cell lung cancer
  JOURNAL   J Transl Med 22 (1), 689 (2024)
   PUBMED   39075515
  REMARK    GeneRIF: PHF12 regulates HDAC1 to promote tumorigenesis via
            EGFR/AKT signaling pathway in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4506)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4506)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4506)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 4506)
  AUTHORS   Xie,T., Graveline,R., Kumar,G.S., Zhang,Y., Krishnan,A., David,G.
            and Radhakrishnan,I.
  TITLE     Structural basis for molecular interactions involving MRG domains:
            implications in chromatin biology
  JOURNAL   Structure 20 (1), 151-160 (2012)
   PUBMED   22244764
REFERENCE   6  (bases 1 to 4506)
  AUTHORS   Kaadige,M.R. and Ayer,D.E.
  TITLE     The polybasic region that follows the plant homeodomain zinc finger
            1 of Pf1 is necessary and sufficient for specific phosphoinositide
            binding
  JOURNAL   J Biol Chem 281 (39), 28831-28836 (2006)
   PUBMED   16893883
REFERENCE   7  (bases 1 to 4506)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 4506)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4506)
  AUTHORS   Yochum,G.S. and Ayer,D.E.
  TITLE     Role for the mortality factors MORF4, MRGX, and MRG15 in
            transcriptional repression via associations with Pf1, mSin3A, and
            Transducin-Like Enhancer of Split
  JOURNAL   Mol Cell Biol 22 (22), 7868-7876 (2002)
   PUBMED   12391155
REFERENCE   10 (bases 1 to 4506)
  AUTHORS   Yochum,G.S. and Ayer,D.E.
  TITLE     Pf1, a novel PHD zinc finger protein that links the TLE corepressor
            to the mSin3A-histone deacetylase complex
  JOURNAL   Mol Cell Biol 21 (13), 4110-4118 (2001)
   PUBMED   11390640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024267.18, AY030283.1, AL161953.1 and AB040956.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001033561.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291420.1, SRR7346977.1840471.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332830.9/ ENSP00000329933.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC024267.18        144639-144666       c
            29-480              AY030283.1         1-452
            481-879             AL161953.1         734-1132
            880-1527            AY030283.1         854-1501
            1528-4503           AB040956.1         21-2996
            4504-4506           AC024267.18        98398-98400         c
FEATURES             Location/Qualifiers
     source          1..4506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4506
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /note="PHD finger protein 12"
                     /db_xref="GeneID:57649"
                     /db_xref="HGNC:HGNC:20816"
                     /db_xref="MIM:618645"
     exon            1..624
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             559..3573
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /note="isoform 1 is encoded by transcript variant 1; PHD
                     zinc finger transcription factor; PHD factor 1"
                     /codon_start=1
                     /product="PHD finger protein 12 isoform 1"
                     /protein_id="NP_001028733.1"
                     /db_xref="CCDS:CCDS32598.1"
                     /db_xref="GeneID:57649"
                     /db_xref="HGNC:HGNC:20816"
                     /db_xref="MIM:618645"
                     /translation="MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPE
                     KEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRC
                     TVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERR
                     ASRPGTPTSSASTETPTSEQNDVDEDIIDVDEEPVAAEPDYVQPQLRRPFELLIAAAM
                     ERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFT
                     CNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNR
                     CQVFDRFQDTVSQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPP
                     LIAPAAIRDGELICNGIPEESQMHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAK
                     QMPSHWDSEQTEKADIKPVIVTDSSVTTSLQTADKTPTPSHYPLSCPSGISTQNSLSC
                     SPPHQSPALEDIGCSSCAEKSKKTPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLP
                     GANTPLPGLSHRQGWPRPLTPPAAGGLQNHTVGIIVKTENATGPSSCPQRSLVPVPSL
                     PPSIPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGILA
                     TTANQRFSSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEI
                     EINMLDEKLIKFLALQRIHQLFPSRVQPSPGSVGTHQLASGGHHIEVQRKEVQARAVF
                     YPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLN
                     YSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSS
                     QAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQP
                     KGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP"
     exon            625..806
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..879
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1273
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1394
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1527
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1692
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1851
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2647
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2773
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2917
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3016
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3099
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3238
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..4506
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3988..3993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /note="hexamer: AATACA"
     polyA_site      4010
                     /gene="PHF12"
                     /gene_synonym="PF1"
     regulatory      4490..4495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /note="hexamer: AACAAA"
     polyA_site      4506
                     /gene="PHF12"
                     /gene_synonym="PF1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgagcgcc gatcccgggg cgcctgcgcg ggtggctttg cgggcgctcg cggtaagttt
       61 gcgccaagtg cgcggcagcc gggacgcaga cggcggcggc ggcgagaggc ggagcccggg
      121 gaccaccccc catcaccctc cccccagtca cctcacgtac cacaacctca cgtaacctct
      181 caccccccct ccgatacccc cagccccggg atggcagcgc ccgccagcct tcccggccgg
      241 accggctgtc gccagtgccg gctttagcct gtgggactag gccccgccga ggcctgaccc
      301 ccggagccgg gacccactgt gcagccagca gccgggccgg gactgagggg ccgctccccc
      361 ctcgcggccc gtcgggagga cgctgtcgtc ccggggactg ggggccgggg ggtggggggg
      421 agccagggcg aggaagtcgg gacccgtatt gggaaaaaag cggggccggg gtcaggagcg
      481 ccccctcccc tcacctcccc cctccccccg gggttggggg ggccggagca gagagcaccc
      541 agcccgggag gtggatgaat gtgggagaaa atggagacca agacgatcgt gtacgacttg
      601 gacacatcag gggggctgat ggagcaaatc caagctctgc tggctccccc caagacggac
      661 gaggcagaaa agcgcagtcg gaagcctgag aaggagcccc ggagaagcgg cagggccacc
      721 aaccacgaca gctgcgatag ctgcaaggaa ggtggagatc tcctgtgctg cgaccactgc
      781 ccggctgcct tccacctcca gtgctgtaac cctccactga gtgaagaaat gttgcctcct
      841 ggagagtgga tgtgtcaccg gtgcactgtt cgccgaaaga aacgagagca gaaaaaggag
      901 ctgggtcatg tcaatggact ggtggacaaa tctggcaaac ggactacatc ccccagcagt
      961 gacactgact tgttggacag atcggccagc aaaactgaac taaaggccat tgcccatgcc
     1021 cggatcctgg aaaggagagc cagcaggcct ggcacaccca catccagcgc cagcacagag
     1081 actcccacct ctgagcagaa tgatgtcgac gaagacatca ttgacgtgga tgaggaacca
     1141 gtagcagcgg agccagacta tgtgcagccc cagctgaggc ggccctttga gctgctgatt
     1201 gctgccgcca tggagcggaa ccccacccaa tttcagttgc ccaatgaact gacttgtacc
     1261 actgcactac caggttctag caagaggaga agaaaggagg aaaccacagg gaaaaatgtt
     1321 aagaagacac agcatgaatt agatcacaat ggtctcgttc ccttacccgt caaagtctgc
     1381 ttcacgtgta acaggagttg ccgtgtggct cctctcatcc agtgtgacta ttgccctctc
     1441 ctgtttcaca tggattgcct cgagccgccg ctcactgcca tgcccctggg cagatggatg
     1501 tgtccgaatc acatcgaaca tgtggtgctg aaccagaaga atatgacact gagcaatcgg
     1561 tgccaggtgt ttgatcgttt ccaggacacc gtttcgcagc atgtcgtcaa agtggacttc
     1621 ctgaaccgaa tccacaagaa gcacccccct aaccggcgtg tgctccagtc ggtcaaaaga
     1681 agaagcttga aggttcctga tgctataaaa tctcagtacc agtttccacc ccctctcatt
     1741 gcacccgcgg ccattcggga cggggagctg atctgcaatg ggatccctga ggaatcacag
     1801 atgcaccttt tgaactctga gcacttagcc acccaagcag agcagcaaga gtggctctgt
     1861 agtgttgttg cgctccagtg cagcatattg aaacatttat ctgctaagca gatgccttcg
     1921 cattgggact ctgaacagac agagaaggct gatattaagc ctgttattgt gactgacagc
     1981 tcagtcacca cctccctgca aacagctgac aagacaccta caccttccca ctaccccttg
     2041 tcctgcccct cagggattag cacccagaat tccctgagct gctctccacc ccaccagtcc
     2101 ccagccctag aggacatcgg ctgcagttct tgtgcggaaa aatccaagaa aaccccttgt
     2161 gggactgcca atgggccagt gaacacagag gtgaaagcta atggcccaca cctctacagc
     2221 agccctactg attccacgga cccccggcga cttccaggcg ctaacacccc actaccaggc
     2281 ctctcacacc ggcaaggctg gccccggccc ctcacgccac cagcggctgg gggccttcag
     2341 aaccacaccg tcggcatcat tgtgaagaca gagaatgcca ctggccccag ctcttgcccc
     2401 cagaggagtt tggttcctgt cccaagcctg cccccttcca ttcccagctc ttgtgccagc
     2461 atcgagaaca ccagcacttt gcaaagaaag actgtccaat cacagatagg acctccgttg
     2521 acagattcaa ggccactggg ctcaccccca aacgccaccc gggtgctcac tcccccgcaa
     2581 gcagcaggag atggtatctt ggccacaaca gccaaccaac gattcagctc accagcgcca
     2641 tcgtcagatg gcaaggtcag ccccggcacg ttatccatag gaagcgcttt aaccgtaccc
     2701 tctttcccag ccaactctac tgccatggtg gacctcacca actcacttcg agcatttatg
     2761 gatgtcaatg gagaaatcga gataaatatg ctggacgaga agctgatcaa gtttctggcc
     2821 ttgcagagaa tacatcagct tttcccctcc cgggtccaac cttcaccggg cagtgtcggg
     2881 acacatcagc tggcttctgg agggcaccac atagaagtgc aaagaaagga ggtacaggcc
     2941 cgagctgtgt tctaccccct cttagggttg ggaggagctg tgaacatgtg ctatcgaacc
     3001 ctctacatcg ggacaggagc tgacatggat gtgtgcctta caaactatgg tcactgtaac
     3061 tacgtgtccg ggaaacatgc ctgcatattc tacgatgaga ataccaaaca ttatgagctg
     3121 ttaaactaca gtgagcatgg gacaacggtg gacaatgtgc tgtattcatg tgacttctcg
     3181 gagaagaccc cgccaacccc cccaagcagt attgttgcca aagtgcagag tgtcatcagg
     3241 cgccgccggc accagaaaca ggacgaagag ccaagtgagg aggcagccat gatgagttcc
     3301 caggcccagg ggccgcagcg gagaccctgc aattgcaaag ccagcagctc gagcttgatt
     3361 gggggcagtg gggccggctg ggagggcaca gccttactgc accatggcag ctacatcaag
     3421 ctgggctgcc tgcagtttgt cttcagcatc actgagtttg cgaccaaaca gcccaaaggc
     3481 gatgccagcc tgctgcagga tggggtcttg gccgagaagc tctctctcaa gccccaccag
     3541 ggccctgtgc tgcgctccaa ctctgttcct taggactggc ggctaccccg ccactggcct
     3601 gtacacccac ccaagactcc tgcaatgcaa aaatgtacac aaaccaagcc cgggtgtttt
     3661 ctatactcta ccagaaaccc ttcaactaca atctttgcat gaaatgaaga aaaccttttg
     3721 actgtttttt aaaaatcctt tttcttttct caagttctag ggggcatttg cacatatatt
     3781 tgtactcaac atttcatggg aaagcggcag acctgagctg aggaacagcg tgggcaggga
     3841 gggaaagacc cagggtctgg acacttcctc caacacaaaa cccttcccca cccacctcct
     3901 gctccctccc cctcgcccac cattgtaaaa taatcagaaa cttgttctat tttgtggcag
     3961 tgacaatagt tttatattaa aagaaaaaat acagttttca tacagcaaaa tctatacaat
     4021 atcattgttt tatttaatat aaagatcgct acccaccttc cttccatggt tcccaccctc
     4081 cacgttattt tccctttctg cagcggttgc actacaggta gctactgtgt attatggaca
     4141 aatgagaaat gaattctttt tctggctgtc catctatttt atttcaaata aggaaaagtg
     4201 tatttggatt ttgtgtaaat acatctagtg atgacatttt ttcaatgttt ttaaaaaccg
     4261 tgtacagtac tacatgtggt agagcgtttt ctcaaattgt ctattgtagc aaaaatgttt
     4321 ttgtcgtaaa cctgttttgt ctcctttttt tgttctcttg ccacttctct cctcttcctc
     4381 ctgcccctgg ttccctcctc tcctcccacc cccacaacca gtaccaatgt acatagtaat
     4441 tgtaatgttt tagactttac agaaactttc ctgtattctg tatataaaaa acaaaaatac
     4501 ttcaaa
//
