LOCUS       NM_018288               2167 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PHD finger protein 10 (PHF10), transcript variant 1,
            mRNA.
ACCESSION   NM_018288
VERSION     NM_018288.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Bayramova,D.O., Azieva,A.M., Feoktistov,A.V., Georgieva,S.G. and
            Soshnikova,N.V.
  TITLE     Neuronal and Muscle Differentiation of Mammalian Cells Is
            Accompanied by a Change in PHF10 Isoform Expression
  JOURNAL   Dokl Biochem Biophys 514 (1), 23-27 (2024)
   PUBMED   38189889
  REMARK    GeneRIF: Neuronal and Muscle Differentiation of Mammalian Cells Is
            Accompanied by a Change in PHF10 Isoform Expression.
REFERENCE   2  (bases 1 to 2167)
  AUTHORS   Huang,C., Zhou,S., Zhang,C., Jin,Y., Xu,G., Zhou,L., Ding,G.,
            Pang,T., Jia,S. and Cao,L.
  TITLE     ZC3H13-mediated N6-methyladenosine modification of PHF10 is
            impaired by fisetin which inhibits the DNA damage response in
            pancreatic cancer
  JOURNAL   Cancer Lett 530, 16-28 (2022)
   PUBMED   35033590
  REMARK    GeneRIF: ZC3H13-mediated N6-methyladenosine modification of PHF10
            is impaired by fisetin which inhibits the DNA damage response in
            pancreatic cancer.
REFERENCE   3  (bases 1 to 2167)
  AUTHORS   Soshnikova,N.V., Tatarskiy,E.V., Tatarskiy,V.V., Klimenko,N.S.,
            Shtil,A.A., Nikiforov,M.A. and Georgieva,S.G.
  TITLE     PHF10 subunit of PBAF complex mediates transcriptional activation
            by MYC
  JOURNAL   Oncogene 40 (42), 6071-6080 (2021)
   PUBMED   34465901
  REMARK    GeneRIF: PHF10 subunit of PBAF complex mediates transcriptional
            activation by MYC.
REFERENCE   4  (bases 1 to 2167)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2167)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2167)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   7  (bases 1 to 2167)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   8  (bases 1 to 2167)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   9  (bases 1 to 2167)
  AUTHORS   Rogner,U.C., Heiss,N.S., Kioschis,P., Wiemann,S., Korn,B. and
            Poustka,A.
  TITLE     Transcriptional analysis of the candidate region for incontinentia
            pigmenti (IP2) in Xq28
  JOURNAL   Genome Res 6 (10), 922-934 (1996)
   PUBMED   8908511
REFERENCE   10 (bases 1 to 2167)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513547.16, DB460742.1 and
            BC110323.1.
            
            On Nov 30, 2018 this sequence version replaced NM_018288.3.
            
            Summary: This gene contains a predicted ORF that encodes a protein
            with two zinc finger domains. The function of the encoded protein
            is not known. Sequence analysis suggests that multiple
            alternatively spliced transcript variants are derived from this
            gene but the full-length nature of only two of them is known. These
            two splice variants encode different isoforms. A pseudogene for
            this gene is located on Xq28. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110323.1, SRR14038194.1711174.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000339209.9/
                                                ENSP00000341805.4
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               AL513547.16        91027-91516         c
            491-519             DB460742.1         1-29
            520-2164            BC110323.1         1-1645
            2165-2167           AL513547.16        70918-70920         c
FEATURES             Location/Qualifiers
     source          1..2167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..2167
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /note="PHD finger protein 10"
                     /db_xref="GeneID:55274"
                     /db_xref="HGNC:HGNC:18250"
                     /db_xref="MIM:613069"
     exon            1..656
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     CDS             570..2066
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /note="isoform a is encoded by transcript variant 1; PHD
                     zinc finger protein XAP135; BRG1-associated factor, 45-KD,
                     A; BRG1-associated factor 45a"
                     /codon_start=1
                     /product="PHD finger protein 10 isoform a"
                     /protein_id="NP_060758.2"
                     /db_xref="CCDS:CCDS5308.2"
                     /db_xref="GeneID:55274"
                     /db_xref="HGNC:HGNC:18250"
                     /db_xref="MIM:613069"
                     /translation="MAAAAGPGAALSPRPCDSDPATPGAQSPKDDNEDNSNDGTQPSK
                     RRRMGSGDSSRSCETSSQDLGFSYYPAENLIEYKWPPDETGEYYMLQEQVSEYLGVTS
                     FKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAE
                     YSVILQEKERQRITDHYKEYSQMQQQNTQKVEASKVPEYIKKAAKKAAEFNSNLNRER
                     MEERRAYFDLQTHVIQVPQGKYKVLPTERTKVSSYPVALIPGQFQEYYKRYSPDELRY
                     LPLNTALYEPPLDPELPALDSDGDSDDGEDGRGDEKRKNKGTSDSSSGNVSEGESPPD
                     SQEDSFQGRQKSKDKAATPRKDGPKRSVLSKSVPGYKPKVIPNAICGICLKGKESNKK
                     GKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMF
                     CDMCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG"
     exon            657..763
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            764..894
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            895..978
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1112
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1262
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1372
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1526
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1682
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1791
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1980
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2167
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /note="hexamer: AATAAA"
     polyA_site      2167
                     /gene="PHF10"
                     /gene_synonym="BAF45A; SMARCG4; XAP135"
                     /note="major polyA site"
ORIGIN      
        1 gagtacaacg ccgggccgtg gggagccagg cggcggcggg gctgaggcgg ccgcggggct
       61 gaggggagcg gcggggctga ggcgagcggc ggggctgagg cgagcggcgg ggctgaggcg
      121 gccgcggggc tgaggcgagc gagcggcggg gctgaggcga gcgagtggcg gggctgaagg
      181 gagtcgcggc ggcgctgagg ccagcggcgg agctgtgggg ggcaacggtg ctgaggcggt
      241 ggccgcggcc gggcgggttg ggctgacgtg agaagcgccg ccgccgctgg gcctcctcca
      301 ttccggcccg cagccccgcg ccctcccagc ctttggcgcc ctcccgcgcg ggcggcgcgc
      361 tggcgacggc catggcggtg gcggcggcgc tggcgggccg cggggcgcgc ggcggcaggg
      421 gccggccccc gggcgggcgg gcggaggggg cggggccggg gcggcggggg gcccgcgcgg
      481 cggcggcggc ggcggcggcg gcagcggcgg cggcggccgg gacaaggcgg aggcgacggc
      541 ggcggcggcg gcgcggggcg ctcgggctga tggcggcggc ggccgggccc ggggctgcgc
      601 tgtccccgcg gccgtgcgac agcgacccag ccacccccgg agcgcagtcc ccgaaggatg
      661 ataatgaaga taattcaaat gatgggaccc agccatccaa aaggaggcga atgggctcag
      721 gagatagttc taggagttgt gaaacttcaa gtcaagatct tggttttagt tactatccag
      781 cagaaaactt gatagagtac aaatggccac ctgatgaaac aggagaatac tatatgcttc
      841 aagaacaagt cagtgaatat ttgggtgtga cctcctttaa aaggaaatat ccagatttag
      901 agcgacgaga tttgtctcac aaggagaaac tctacctgag agagctaaat gtcattactg
      961 aaactcagtg cactctaggc ttaacagcat tgcgcagtga tgaagtgatt gatttaatga
     1021 taaaagaata tccagccaaa catgctgagt attctgttat tctacaagaa aaagaacgtc
     1081 aacgaattac agaccattat aaagagtatt cccaaatgca acaacagaat actcagaaag
     1141 ttgaagccag taaagtgcct gagtatatta agaaagctgc caaaaaagca gcagaattta
     1201 atagcaactt aaaccgggaa cgcatggaag aaagaagagc ttattttgac ttgcagacac
     1261 atgttatcca ggtacctcaa gggaagtaca aagttttgcc aacagagcga acaaaggtca
     1321 gttcttaccc agtggctctc atccccggac agttccagga atattataag aggtactcac
     1381 cagatgagct gcggtatctg ccattaaaca cagccctgta tgagccccct ctggatcctg
     1441 agctccctgc tctagacagt gatggtgatt cagatgatgg cgaagatggt cgaggtgatg
     1501 agaaacggaa aaataaaggc acttcggaca gctcctctgg caatgtatct gaaggggaaa
     1561 gccctcctga cagccaggag gactctttcc agggaagaca gaaatcaaaa gacaaagctg
     1621 ccactccaag aaaagatggt cccaaacgtt ctgtactgtc caagtcagtt cctgggtaca
     1681 agccaaaggt cattccaaat gctatatgtg gaatttgtct gaagggtaag gagtccaaca
     1741 agaaaggaaa ggctgaatca cttatacact gctcccaatg tgagaatagt ggccatcctt
     1801 cttgcctgga tatgacaatg gagcttgttt ctatgattaa gacctaccca tggcagtgta
     1861 tggaatgtaa aacatgcatt atatgtggac aaccccacca tgaagaagaa atgatgttct
     1921 gtgatatgtg tgacagaggt tatcatactt tttgtgtggg ccttggtgct attccatcag
     1981 gtcgctggat ttgtgactgt tgtcagcggg cccccccaac acccaggaaa gtgggcagaa
     2041 gggggaaaaa cagcaaagag ggataaaata gtttttgact ctaatactgt atatgcattt
     2101 aagtggaata tttggtgcca tttacaacat tattttcatg ccaataaaag attttttttg
     2161 caaatta
//
