LOCUS       NM_000444               6288 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens phosphate regulating endopeptidase X-linked (PHEX),
            transcript variant 1, mRNA.
ACCESSION   NM_000444
VERSION     NM_000444.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6288)
  AUTHORS   Wu,H., Ying,H., Zhao,W., Sun,Y., Wang,Y., Chen,X., Li,G., Yao,Y.,
            Xu,S., Li,T., Fang,L., Sun,X., Wang,N., Xu,J., Guan,Q., Xia,W.,
            Wang,L., Gao,L., Zhao,J. and Xu,C.
  TITLE     Characterization of Novel PHEX Variants in X-linked
            Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation
  JOURNAL   J Clin Endocrinol Metab 109 (9), 2242-2255 (2024)
   PUBMED   38442738
  REMARK    GeneRIF: Characterization of Novel PHEX Variants in X-linked
            Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.
REFERENCE   2  (bases 1 to 6288)
  AUTHORS   Fraga,G., Herreros,M.A., Pybus,M., Aza-Carmona,M., Pilco-Teran,M.,
            Furlano,M., Garcia-Borau,M.J., Torra,R. and Ars,E.
  TITLE     A Mild Presentation of X-Linked Hypophosphatemia Caused by a
            Non-Canonical Splice Site Variant in the PHEX Gene
  JOURNAL   Genes (Basel) 15 (6), 679 (2024)
   PUBMED   38927615
  REMARK    GeneRIF: A Mild Presentation of X-Linked Hypophosphatemia Caused by
            a Non-Canonical Splice Site Variant in the PHEX Gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6288)
  AUTHORS   Yadav,P.S., Kobelski,M.M., Martins,J.S., Tao,T., Liu,E.S. and
            Demay,M.B.
  TITLE     Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23
            and Decreased 1,25-Dihydroxyvitamin D Signaling
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   38066669
  REMARK    GeneRIF: Impaired Growth Plate Maturation in XLH Is due to Both
            Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling.
REFERENCE   4  (bases 1 to 6288)
  AUTHORS   Ma,J., Zhang,Y., Ding,X., Liang,Z., Yang,C., Deng,Z., He,H.,
            Guan,Z., Zeng,C., Lin,Y. and Luo,X.
  TITLE     Co-occurrence of Spondyloepiphyseal Dysplasia and X-Linked
            Hypophosphatemia in a Three-Generation Chinese Family
  JOURNAL   Calcif Tissue Int 113 (3), 266-275 (2023)
   PUBMED   37278761
  REMARK    GeneRIF: Co-occurrence of Spondyloepiphyseal Dysplasia and X-Linked
            Hypophosphatemia in a Three-Generation Chinese Family.
REFERENCE   5  (bases 1 to 6288)
  AUTHORS   Lipman,M.L., Panda,D., Bennett,H.P., Henderson,J.E., Shane,E.,
            Shen,Y., Goltzman,D. and Karaplis,A.C.
  TITLE     Cloning of human PEX cDNA. Expression, subcellular localization,
            and endopeptidase activity
  JOURNAL   J Biol Chem 273 (22), 13729-13737 (1998)
   PUBMED   9593714
REFERENCE   6  (bases 1 to 6288)
  AUTHORS   Beck,L., Soumounou,Y., Martel,J., Krishnamurthy,G., Gauthier,C.,
            Goodyer,C.G. and Tenenhouse,H.S.
  TITLE     Pex/PEX tissue distribution and evidence for a deletion in the 3'
            region of the Pex gene in X-linked hypophosphatemic mice
  JOURNAL   J Clin Invest 99 (6), 1200-1209 (1997)
   PUBMED   9077527
REFERENCE   7  (bases 1 to 6288)
  AUTHORS   Grieff,M., Mumm,S., Waeltz,P., Mazzarella,R., Whyte,M.P.,
            Thakker,R.V. and Schlessinger,D.
  TITLE     Expression and cloning of the human X-linked hypophosphatemia gene
            cDNA
  JOURNAL   Biochem Biophys Res Commun 231 (3), 635-639 (1997)
   PUBMED   9070861
REFERENCE   8  (bases 1 to 6288)
  AUTHORS   .
  TITLE     A gene (PEX) with homologies to endopeptidases is mutated in
            patients with X-linked hypophosphatemic rickets. The HYP Consortium
  JOURNAL   Nat Genet 11 (2), 130-136 (1995)
   PUBMED   7550339
REFERENCE   9  (bases 1 to 6288)
  AUTHORS   Laurent,M.R., Harvengt,P., Mortier,G.R. and Bockenhauer,D.
  TITLE     X-Linked Hypophosphatemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22319799
REFERENCE   10 (bases 1 to 6288)
  AUTHORS   Econs,M.J., Pericak-Vance,M.A., Betz,H., Bartlett,R.J., Speer,M.C.
            and Drezner,M.K.
  TITLE     The human glycine receptor: a new probe that is linked to the
            X-linked hypophosphatemic rickets gene
  JOURNAL   Genomics 7 (3), 439-441 (1990)
   PUBMED   2163973
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y10196.1, U82970.2, AD000712.1
            and AK298030.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000444.5.
            
            Summary: The protein encoded by this gene is a transmembrane
            endopeptidase that belongs to the type II integral membrane
            zinc-dependent endopeptidase family. The protein is thought to be
            involved in bone and dentin mineralization and renal phosphate
            reabsorption. Mutations in this gene cause X-linked
            hypophosphatemic rickets. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U82970.2, U75645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379374.5/ ENSP00000368682.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               Y10196.1           11343-11461
            120-465             U82970.2           4-349
            466-532             U82970.2           351-417
            533-573             AD000712.1         11-51
            574-592             AK298030.1         1-19
            593-2851            U82970.2           479-2737
            2852-3161           AK298030.1         2202-2511
            3162-6288           Y10196.1           227201-230327
FEATURES             Location/Qualifiers
     source          1..6288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..6288
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /note="phosphate regulating endopeptidase X-linked"
                     /db_xref="GeneID:5251"
                     /db_xref="HGNC:HGNC:8918"
                     /db_xref="MIM:300550"
     exon            1..799
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     CDS             682..2931
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphate regulating gene with homologies to
                     endopeptidases on the X chromosome (hypophosphatemia,
                     vitamin D resistant rickets); metalloendopeptidase homolog
                     PEX; X-linked hypophosphatemia protein; vitamin
                     D-resistant hypophosphatemic rickets protein;
                     phosphate-regulating neutral endopeptidase PHEX; phosphate
                     regulating endopeptidase homolog X-linked; PHEX peptidase"
                     /codon_start=1
                     /product="phosphate-regulating neutral endopeptidase PHEX
                     isoform 1"
                     /protein_id="NP_000435.3"
                     /db_xref="CCDS:CCDS14204.1"
                     /db_xref="GeneID:5251"
                     /db_xref="HGNC:HGNC:8918"
                     /db_xref="MIM:300550"
                     /translation="MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGL
                     LSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYG
                     VYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHIL
                     RHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEH
                     ILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLR
                     LEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIS
                     PSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRV
                     IQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDML
                     EKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQ
                     TRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYP
                     RSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSN
                     YYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQ
                     LFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMN
                     RGMDSCRLW"
     exon            800..868
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1030
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1117
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1344
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1413
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1530
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1614
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1760
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1854
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1983
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2085
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2163
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2267
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2326
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2381
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2449
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2580
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2646
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2751
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2828
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..6288
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3319..3324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /note="hexamer: ATTAAA"
     polyA_site      3339
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /note="major polyA site"
     regulatory      6267..6272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /note="hexamer: AATAAA"
     polyA_site      6288
                     /gene="PHEX"
                     /gene_synonym="HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH"
                     /note="major polyA site"
ORIGIN      
        1 aattgctact ttgcactgca ctggactatg actgattttt ggcacatgct atcatacaca
       61 aagttcctga aataaaatgc tccaggatat cctaggaact cttagaaggc tttaaaaagg
      121 gactcacaca ctgaaagaat atctttgatg aagacaattc aggcaagcag aatgattctt
      181 gcaacagaat tacatgatta attgagatct tgaagtgggt ccggtgaatc ctggccacct
      241 aacttatcat gatttggggg agtttcacga gaatccagtt ttgataaaac aattgttttt
      301 ttcctcccca agtgactata catttaaata gctaaaacat ctgttcagca acatagtaaa
      361 acatatatac tcggaacgct tgagagaaga gcctgccaaa cagggacttt gctgagggag
      421 agcaccaaga taaagcaaca ctgtttgttt tgtctagtca gggggaaagc caaggcaacc
      481 aatattttgg tttttataat tttcatttgt gaagaattat ttgagaaagg gtggcgaggg
      541 gagatttcct gacggcagtt tcttaagctg tccattagta gaagagcaag aaagccttgg
      601 atgtcaacgc ctcgctcttg agaccagcca ccaaaccacg aaaagtgact ttcttctcgt
      661 gtgctctcta cggcccttct gatggaagca gaaacaggga gcagcgtgga gactggaaag
      721 aaggccaaca gaggcactcg aattgccctg gtcgtgtttg tcggtggcac cctagttctg
      781 ggcacgatcc tctttctagt gagtcaaggt ctcttaagtc tccaagctaa acaggagtac
      841 tgcctgaagc cagaatgcat cgaagcggct gctgccatct taagtaaagt aaatctgtct
      901 gtggatcctt gtgataattt cttccggttc gcttgtgatg gctggataag caataatcca
      961 attcccgaag atatgccaag ctatggggtt tatccttggc tgagacataa tgttgacctc
     1021 aagttgaagg aacttttgga gaaatcaatc agtagaaggc gggacaccga agccatacag
     1081 aaagccaaaa tcctttattc atcctgcatg aatgagaaag cgattgaaaa agcagatgcc
     1141 aagccactgc tacacatcct acggcattca cctttccgct ggcccgtgct tgaatctaat
     1201 attggccctg aaggggtttg gtcagagaga aagttcagcc ttctgcagac acttgcaacg
     1261 tttcgtggtc aatacagcaa ttctgtgttc atccgtttgt atgtgtcccc tgatgacaaa
     1321 gcatccaatg aacatatctt gaagctggac caagcaacac tctccctggc cgtgagggaa
     1381 gactaccttg ataacagtac agaagccaag tcttatcggg atgcccttta caagttcatg
     1441 gtggatactg ccgtgctttt aggagctaac agttccagag cagagcatga catgaagtca
     1501 gtgctcagat tggaaattaa gatagctgag ataatgattc cacatgaaaa ccgaaccagc
     1561 gaggccatgt acaacaaaat gaacatttct gaactgagtg ctatgattcc ccagttcgac
     1621 tggctgggct acatcaagaa ggtcattgac accagactct acccccatct gaaagacatc
     1681 agcccctccg agaatgtggt ggtccgcgtc ccgcagtact ttaaagattt gtttaggata
     1741 ttagggtctg agagaaagaa gaccattgcc aactatttgg tgtggagaat ggtttattcc
     1801 agaattccaa accttagcag gcgctttcag tatagatggc tggaattctc aagggtaatc
     1861 caggggacca caactttgct gcctcaatgg gacaaatgtg taaactttat tgaaagtgcc
     1921 ctcccttatg ttgttggaaa gatgtttgta gatgtgtact tccaggaaga taagaaggaa
     1981 atgatggagg aattggttga gggcgttcgc tgggccttta ttgacatgct agagaaagaa
     2041 aatgagtgga tggatgcagg aacgaaaagg aaagccaaag aaaaggcgag agctgttttg
     2101 gcaaaagttg gctatccaga gtttataatg aatgatactc atgttaatga agacctcaaa
     2161 gctatcaagt tttcagaagc cgactacttt ggcaacgtcc tacaaactcg caagtattta
     2221 gcacagtctg atttcttctg gctaagaaaa gccgttccaa aaacagagtg gtttacaaat
     2281 ccgacgactg tcaatgcctt ctacagtgca tccaccaacc agatccgatt tccagcagga
     2341 gagctccaga agcctttctt ttggggaaca gaatatcctc gatctctgag ttatggtgct
     2401 ataggagtaa ttgtcggaca tgaatttaca catggatttg ataataatgg tagaaaatat
     2461 gataaaaatg gaaacctgga tccttggtgg tctactgaat cagaagaaaa gtttaaggaa
     2521 aaaacaaaat gcatgattaa ccagtatagc aactattatt ggaagaaagc tggcttaaat
     2581 gtcaagggga agaggaccct gggagaaaat attgctgata atggaggcct gcgggaagct
     2641 tttagggctt acaggaaatg gataaatgac agaaggcagg gacttgagga gcctcttcta
     2701 ccaggcatca cattcaccaa caaccagctc ttcttcctga gttatgctca tgtgaggtgc
     2761 aattcctaca gaccagaagc tgcccgagaa caagtccaaa ttggtgctca cagtccccct
     2821 cagtttaggg tcaatggtgc aattagtaac tttgaagaat tccagaaagc ttttaactgt
     2881 ccacccaatt ccacgatgaa cagaggcatg gactcctgcc gactctggta gctgggacgc
     2941 tggtttatgg catcctgaga cagttgcaca gtgccagcgg aggctgcact gagccttcat
     3001 cgcccattgc tttaggcctg gagactttca tttttagtgc attttcatta tttgggtagg
     3061 tgacctgctt ggatctagac agcatctgtt caaagttgta gggcttataa agtggaatat
     3121 aagaatgaac taagtatgtt tctttagaaa atcaaaccaa caaaaataaa tccctaggct
     3181 acttttgtta aaatgctatc tgctaaattg ttgctattgt ccattttagg gtgttggcca
     3241 cagttatgtg gtacatagca tttcaatcta tagctttgtg ggaagcctaa attgatgtat
     3301 cctttaaaag ttcaatctat taaacttgta gcctctcaat gatgaagaca tgtgcatgaa
     3361 tacctgggag ggcttgctgc tctgtggaat gcagtgcacg tttttatgga cagtaattac
     3421 acagcattcc tcaactgtaa ggtagttaaa ttagaaatat gtttgatctc cattttacac
     3481 tttttgatga agttcttgcc ttcagctttg gagtctgttg gaatgaaact gtgtctcaca
     3541 gcttgcatct gatgtagcag attgccctgt tcaagtcagc atgaacaaag ctcgcagaaa
     3601 ggctactagg taacggattt gagtttattc agtagaaaaa aagggaatga ggacatatct
     3661 ttaggtccca gaagcagcaa aacctcctag ttacataaca gcagggaaac taggagatga
     3721 aatctccaaa attttgtcca gtctgtatga actgcagtga ttgtctgtct gctagacact
     3781 tttttttagc ctaattcttg ttcgtttcat taccttcata tgtgtgcatt gtactggttt
     3841 tgaaatgagc agacattgag aaaacaattt tctgattccc cattaggaac atatgatttt
     3901 catttccctt tagtgcaaag gaacaaacat cacattgagg agggagaagt gtacccttct
     3961 ttttcagctt aatgttacct ctctttaaaa aaaaaacatt tttgaaaaat ttcttgactg
     4021 atgacattct agaatttatt gattcaattt aaaattccct gcatagtcca aataaacata
     4081 atttttactc ttcaagtcat ctaaagagtt gtgagaaaga gcagtactat gtgttttatc
     4141 cttagagcat tatccttcta agtgaactcc tttcttatta ctgagcgtgt gtgtgtgtgt
     4201 gtgtgtgtgt gtgtgtgtag gataaaattg taatggcctt aaagttgtta cctggcattt
     4261 ttggtttctt aaaataggca tccccctact ccctttacat tattcattag acatgaggtg
     4321 ctgggttaag tgggccaata ggaaaatctc aaaagcaaaa tgacaaattc agattaacca
     4381 caggaagcca ttgtgtgtcc ctgtgatttg tgattctttt aaaaaaaaaa aaaatatata
     4441 tatatatata tatatatata tatatgtata tctacctaag tgtgtgccat gtccttttgt
     4501 agccatggga acgtttgaat ggagaaaaat ggaggggcac catcatgagg aaacaattat
     4561 actgcattag tcagaggaga gcgattttcc ctttgacttc ttcctctctg aatggataaa
     4621 cttgtgaagg gcagctacct tgtcctcctc ttaacctggc ttaatgtgac cttagtttgt
     4681 atttccaaaa acaagcagta ttaggttgga attgtatgtg tcttttctct ggaggaagca
     4741 ttctgacttg gtttagacat ataagatact ctgttttatt cctggacttg ggtgtttaaa
     4801 atcagctgag gtttatcatg cttatatgaa tagtgtttcc cttctagatt tcctttataa
     4861 actccaaata aacacattcc tgcaggtcag agaaagtgtt tgataaaagc atagaattat
     4921 ggctttggaa agacaaacta agtcacttgt tggtttagca aaactggttg gtgattagtt
     4981 ggggccctca cagtttctag atgagaagct taccttatcc tgattaactt tacttgctgt
     5041 aactgttata ccgaaaattg taggtaggat gtccattact caaacaaagc agaacaaaac
     5101 aacaaaccaa aagcagcaat accaaatcat cactactagc tagaacaatg agaaggattg
     5161 aatttccaaa tacatgctta tgtttaactc aactcttcca attacattct cattgtcctt
     5221 tctcttggat accgattgct aagataaaca gacactgatt aagtggtaga aagagaaagg
     5281 taaaatgcaa ctggaaggga aagaaaaaag tagggagaag ctggcctatg gatgtggctt
     5341 tgaagagaag acaggatttt ggcattcctt gctaagcacg ttcaatggag gagagccatg
     5401 aagttttaca aaaataatta tggtaaatta aaaggatatt agatattgga tctcagacta
     5461 gggctgctat aatacagttc tctgattcgc acaccagatg ttctgccagc gaactgttgt
     5521 ctgggcattg gaaggagtta ggttttttgt gtttgtgaaa atctcctgga ttagtaaaaa
     5581 aattttctag atataaagtg gttttatttg ggctcatgac cattgcccaa agtgtactga
     5641 gcttttcact aagtgctcag cattggcctc ctgttctcat ttattcattt tatgagatgg
     5701 acttggacat cactaatgca aacacaggat tcataaatta ttctgaagtt tatttagtgc
     5761 cttgcctcaa tggagcttaa agcatagcac ataaatttta tcttatttag ccctggagca
     5821 tcactaagaa gcagctagga actatggctt gccagacaga ttatgcttgt gccagagaag
     5881 tggagaagcc tgaaatccct tgtcaagtat tccacaggaa ggaaaggtag tctttgggct
     5941 ttggtctact gacctgtgga ttaaactcta tcccttagat tatcccattt ctaaatacat
     6001 ttattcaatc agtatttcta taatcactta gcatttgata ggcttcttcc ttgatacatt
     6061 taacataacg cctcagttgc atattacatt atggaagaat atacgattgc ttcatataac
     6121 aacattctca tcaccagtga cagtgtccta ctggtttgaa gaaagatatt cttggattat
     6181 gtgttttata tctaaatggt tattctgaga ctggttgtat tttcttctcc tactcgtgaa
     6241 acgatgtgaa caagcatttt aaggacaata aaaagttagc tggttgaa
//
