LOCUS       NM_024947              12652 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens polyhomeotic homolog 3 (PHC3), transcript variant 1,
            mRNA.
ACCESSION   NM_024947
VERSION     NM_024947.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12652)
  AUTHORS   Wang,H., Lan,S., Wang,L., Zhao,J., Jia,X., Xu,J., Sun,G., Liu,L.,
            Gong,S., Wang,N., Shan,B., Zhang,F. and Zhang,Z.
  TITLE     Expression of circ-PHC3 enhances ovarian cancer progression via
            regulation of the miR-497-5p/SOX9 pathway
  JOURNAL   J Ovarian Res 16 (1), 142 (2023)
   PUBMED   37468993
  REMARK    GeneRIF: Expression of circ-PHC3 enhances ovarian cancer
            progression via regulation of the miR-497-5p/SOX9 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12652)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 12652)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 12652)
  AUTHORS   Crea,F., Di Paolo,A., Liu,H.H., Polillo,M., Clermont,P.L.,
            Guerrini,F., Ciabatti,E., Ricci,F., Barate,C., Fontanelli,G.,
            Barsotti,S., Morganti,R., Danesi,R., Wang,Y., Petrini,M.,
            Galimberti,S. and Helgason,C.D.
  TITLE     Polycomb genes are associated with response to imatinib in chronic
            myeloid leukemia
  JOURNAL   Epigenomics 7 (5), 757-765 (2015)
   PUBMED   26343356
  REMARK    GeneRIF: Data show that polycomb-group proteins BMI1, PHC3, CBX6
            and CBX7 expression was significantly increased during imatinib
            treatment.
REFERENCE   5  (bases 1 to 12652)
  AUTHORS   Crea,F., Sun,L., Pikor,L., Frumento,P., Lam,W.L. and Helgason,C.D.
  TITLE     Mutational analysis of Polycomb genes in solid tumours identifies
            PHC3 amplification as a possible cancer-driving genetic alteration
  JOURNAL   Br J Cancer 109 (6), 1699-1702 (2013)
   PUBMED   23942079
  REMARK    GeneRIF: PHC3 amplification may emerge as a biomarker in cancer.
REFERENCE   6  (bases 1 to 12652)
  AUTHORS   Deshpande,A.M., Akunowicz,J.D., Reveles,X.T., Patel,B.B.,
            Saria,E.A., Gorlick,R.G., Naylor,S.L., Leach,R.J. and Hansen,M.F.
  TITLE     PHC3, a component of the hPRC-H complex, associates with E2F6
            during G0 and is lost in osteosarcoma tumors
  JOURNAL   Oncogene 26 (12), 1714-1722 (2007)
   PUBMED   17001316
  REMARK    GeneRIF: loss of PHC3 may favor tumorigenesis by potentially
            disrupting the ability of cells to remain in G(0)
REFERENCE   7  (bases 1 to 12652)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 12652)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 12652)
  AUTHORS   Tonkin,E., Hagan,D.M., Li,W. and Strachan,T.
  TITLE     Identification and characterisation of novel mammalian homologues
            of Drosophila polyhomeoticpermits new insights into relationships
            between members of the polyhomeotic family
  JOURNAL   Hum Genet 111 (4-5), 435-442 (2002)
   PUBMED   12384788
REFERENCE   10 (bases 1 to 12652)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP200133.1, BC131772.1, AC008040.7 and BC026001.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024947.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.135168.1,
                                           SRR1803617.7470.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000495893.7/ ENSP00000420294.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BP200133.1         17-21
            6-3127              BC131772.1         1-3122
            3128-11385          AC008040.7         6362-14619
            11386-12652         BC026001.1         4-1270
FEATURES             Location/Qualifiers
     source          1..12652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..12652
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="polyhomeotic homolog 3"
                     /db_xref="GeneID:80012"
                     /db_xref="HGNC:HGNC:15682"
                     /db_xref="MIM:620031"
     exon            1..32
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..3006
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="isoform 1 is encoded by transcript variant 1; early
                     development regulator 3; polyhomeotic-like protein 3;
                     homolog of polyhomeotic 3; early development regulatory
                     protein 3; polyhomeotic like 3"
                     /codon_start=1
                     /product="polyhomeotic-like protein 3 isoform 1"
                     /protein_id="NP_079223.3"
                     /db_xref="CCDS:CCDS46952.1"
                     /db_xref="GeneID:80012"
                     /db_xref="HGNC:HGNC:15682"
                     /db_xref="MIM:620031"
                     /translation="MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQ
                     QPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
                     SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSST
                     SGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSC
                     QSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSP
                     ESNKKGESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSH
                     HQLILQQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPS
                     PLTVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQ
                     STANQVQATAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSP
                     IPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEAL
                     VQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPP
                     PTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLP
                     AATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIE
                     QPVKKRPLLDNQVINSVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDSELLKCE
                     FCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGP
                     DGAAREHILRQLPITYPSAEEDLASHEDSVPSAMTTRLRRQSERERERELRDVRIRKM
                     PENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLM
                     SAMNIKLGPALKICARINSLKES"
     exon            33..198
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            199..354
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            355..432
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..591
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..690
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..937
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1806
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1960
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2211
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2371
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2486
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2619
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2851
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..12652
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4994..4999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="hexamer: ATTAAA"
     polyA_site      5015
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
     regulatory      12631..12636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="hexamer: AATAAA"
     polyA_site      12652
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="major polyA site"
ORIGIN      
        1 agtgatggag gagagaagat ggcggaagcg gaatttaagg accatagtac agctatggat
       61 actgaaccaa acccgggaac atcttctgtg tcaacaacaa ccagcagtac caccaccacc
      121 accatcacca cttcctcctc tcgaatgcag cagccacaga tctctgtcta cagtggttca
      181 gaccgacatg ctgtacaggt aattcaacag gcattgcatc ggccccccag ctcagctgct
      241 cagtaccttc agcaaatgta tgcagcccaa caacagcact tgatgctgca tactgcagct
      301 cttcagcagc agcatttaag cagctcccag cttcagagcc ttgctgctgt tcaggcaagt
      361 ttgtccagtg gaagaccatc tacatctccc acaggaagtg tcacacagca gtcaagtatg
      421 tcccaaacgt ctatcaacct ctccacttct cctacacctg cacagttaat aagccgttcc
      481 caggcttcca gttctaccag cggcagtatt acccaacaga ctatgttact agggagtact
      541 tcccctaccc taacggcaag ccaagctcaa atgtatctcc gagctcaaat gctgattttc
      601 acacccgcta ccactgtggc tgctgtacag tctgacattc ctgttgtctc gtcgtcatcg
      661 tcatcttcct gtcagtctgc agctactcag gttcagaatt taacattacg cagccagaag
      721 ttgggtgtat tatctagctc acagaatggt ccaccaaaaa gcactagtca aactcagtca
      781 ttgacaattt gtcataacaa aacaacagtg accagttcta aaatcagcca acgagatcct
      841 tctccagaaa gtaataagaa aggagagagc ccaagcctgg aatcacgaag cacagctgtc
      901 acccggacat caagtattca ccagttaata gcaccagctt catattctcc aattcagcct
      961 cattctctaa taaaacatca gcagattcct cttcattcac caccttccaa agtttcccat
     1021 catcagctga tattacaaca gcagcaacag caaattcagc caatcacact tcagaattca
     1081 actcaagacc cacccccatc ccagcactgt ataccactcc agaaccatgg ccttcctcca
     1141 gctcccagta atgcccagtc acagcattgt tcaccgattc agagtcatcc ctctccttta
     1201 acagtgtctc ctaatcagtc acagtcagca cagcagtctg tagtggtgtc tcctccacca
     1261 cctcattcac caagtcagtc tcctactata attattcatc cacaagcact tattcagcca
     1321 caccctcttg tgtcatcagc tctccagcca gggccaaatt tgcagcagtc cactgctaat
     1381 caggtgcaag ctacagcaca gttgaatctt ccatcccatc ttccacttcc agcttcccct
     1441 gttgtacaca ttggcccagt tcagcagtct gccttggtat ccccaggcca gcagattgtc
     1501 tctccatcac accagcaata ttcatccctg cagtcctctc caatcccaat tgcaagtcct
     1561 ccacagatgt cgacatctcc tccagctcag attccaccac tgcccttgca gtctatgcag
     1621 tctttacaag tgcagcctga aattctgtcc cagggccagg ttttggtgca gaatgctttg
     1681 gtgtcagaag aggaacttcc agctgcagaa gctttggtcc agttgccatt tcagactctt
     1741 cctcctccac agactgttgc ggtaaaccta caagtgcaac caccagcacc tgttgatcca
     1801 ccagtggttt atcaggtaga agatgtgtgt gaagaagaaa tgccagaaga gtcagatgaa
     1861 tgtgtccgga tggatagaac cccaccacca cccactttgt ctccagcagc tataacagtg
     1921 gggagaggag aagatttgac ttctgaacat cctttgttag agcaagtgga attacctgct
     1981 gtggcatcag tcagtgcttc agtaattaaa tctccatcag atccctcaca tgtttctgtt
     2041 ccaccacctc cattgttact tccagctgcc accacaagga gtaacagtac atctatgcac
     2101 agtagcattc ccagtataga gaacaaacct ccacaggcta ttgttaaacc acagatccta
     2161 acccatgtta ttgaaggctt tgtgattcag gagggattgg agccatttcc tgtgagtcgt
     2221 tcctctttgc taatagaaca gcctgtgaaa aaacggcctc ttttggataa tcaggtgata
     2281 aattcagtgt gtgttcagcc agagctacag aataatacaa aacatgcgga taattcatct
     2341 gacacagaga tggaagacat gattgctgaa gagacattag aagaaatgga cagtgagttg
     2401 ctcaagtgtg aattctgtgg gaaaatggga tatgctaatg aatttttgcg gtcaaaacga
     2461 ttctgcacta tgtcatgtgc caaaaggtac aatgttagct gttctaaaaa atttgcactt
     2521 agtcgttgga atcgtaagcc tgataatcaa agtcttgggc atcgtggccg tcgtccaagt
     2581 ggccctgatg gggcagcgag agaacatatc cttaggcagc ttccaattac ttatccatct
     2641 gcagaagaag acttggcttc tcatgaagat tctgtgccat ctgctatgac aactcgtctg
     2701 cgcaggcaga gcgagcggga aagagaacgt gagcttcggg atgtgagaat tcggaaaatg
     2761 cctgagaaca gtgacttgct accagttgca caaacagagc catctatatg gacagttgat
     2821 gatgtctggg ccttcatcca ttctttgcct ggctgccagg atatcgcaga tgaattcaga
     2881 gcacaggaga ttgatggaca ggcccttctc ttgctgaaag aagaccatct catgagtgca
     2941 atgaatatca agctaggccc agccctgaag atctgtgcac gcatcaactc tctgaaggaa
     3001 tcttaacagg aacatgaagc cttgataaaa cagcagtttt acttttctca caaaaacttg
     3061 taaggtaaag gcctaacttg gtctagaata tgacacttat tgtggtggat agccaagcac
     3121 attgggatct ccacatcaaa tactgacatt tcttctacag gtataataat tcatcatgca
     3181 ttttcataat taataaacat tggtaaaatt aattttacag gttacatgaa acattgaaag
     3241 acttgttaca gagggccatg atatttttca aagaaatgtg ttatactaga taattttttt
     3301 aaaggtgatg tttatcatta atataaagaa tccttttaaa agtaatttaa tgatttacat
     3361 ttctcctctt ttgattcaat tttcttatac attttttcta ccctattagt tttctaaagg
     3421 ttgtcatgag aggtatatta tggaataatt tagtagtcca gtgacagaat cgtatgaaat
     3481 cagtgtacat tttaaaaaac atgtctttta gacatatgct ttatctataa aaaaggaatt
     3541 gtgttctagt atgaacaata ctgatctgga agtgagaaga gttagtttct attccaaact
     3601 tgaccaagaa tttggtttga ctgagaacgt tttcctctca gtttttgtac atttatttag
     3661 agcagtggtt ctcagtggag gtcagttttg atcgccaggg gacatctggc aatgttgaga
     3721 cattttggtt gtcacagctt gggggtgggt tcaggggagg gttgctactg gtgtctagta
     3781 gttagaagcc agagatgttt ctaaacatct tataatgcac aggacagcac ccctccactg
     3841 taaagaatta ttggttcaaa aatatcggta ctgccaaggt tgagaaactc tgatatagaa
     3901 ggagtgataa atattgtttt cacccaaagg aatactttta aaggatgaag cttactaaac
     3961 atatatgatg gaagtattat tcagataaca ttaatattct gctgaataat tttttctagt
     4021 ttaatcatac tagaaaaaga aaaaaaatct acaaattgtc ctataaaata aggacaaaca
     4081 tgcaaataat ttaactctca gaaagtacta attcattctg attatctttc atacctctgt
     4141 gctcctctgc actgacgaag acataatatg attataccta tgaactagtg cacagccttt
     4201 tctggcaaga aaatagtttg tagcagatac gtggttgctc tttggatttt tttctattgt
     4261 tgaacatgct gggactagct agaatgcaca ttcctacttc ctttaccaaa cgtttgcatg
     4321 cttcctgcaa agcacttacc aagtgatttc tcttgaacca tcggatataa ttttgtatgt
     4381 acatgtttga ggaaaaaaat gtaaagcaaa accttttact gaacagtgtt ctatagaatt
     4441 atgacactaa aacaaaattg tttgtggaag ccctgaaagc tttatagtcc tggacatcaa
     4501 aaattttatt tgagatgatg aatgttttgt tttcatcttt tcttatatta ccacaattga
     4561 gatattttag taattgaagg aacatacaca gatatttggc agaagtcgag taaggagggg
     4621 aaaaaaagag tccgtgagtt tcagtcattt tcactgctct tttcaaaaag attgtgttga
     4681 gctggtagaa gactaaagat gtcactgaag acatcacaga tactatattt atcttttggc
     4741 tttgtgtaca ttagagaatg ttgattattt ttatacaaaa atacagcggg taattttttt
     4801 aatctttaga tgcctcttgt ttgaatgtat gctttgtgga attctttgtg tagtaatgtt
     4861 ttaaaaaaag atgtttactg atagttacat gtaggattag aatatgtaat ataatataag
     4921 gctcatgttc cagacctacg atagcttgta gtctatgtta cgtatttctt tatatcacat
     4981 ttttaatcat tggattaaag tatcaaggaa agctaggtac tctataatga gttttcattt
     5041 attagcagtt aatcatcatg acagaattgt catatgcttg acttttccct cttcttggaa
     5101 tttcagaaca caaatacagg ctaagcatta gtaagagatg gcccacagta tgagagagag
     5161 aggtgcaacg gaaaatctcg cctggaatta aaacttttca tagattatcc acggttaata
     5221 caaaatttat tatatgggga tagactgctc cagcaataat gattacatcc tataactgta
     5281 ttacctatgg cctttaaggt atcaattttg aactgtgttg taggctctcc ttttatttgt
     5341 tctctttcct aatagcagcc attctgtact tattgaaagc ccctgtgcct actgctgtct
     5401 taagtattca ggaggggctt acaagagggt tttctattgg agaataccgt ataatcttaa
     5461 atctagtcca gatctctgtt gtccccactc aaaacataca caaaatatgc acttgctttt
     5521 ttcaagtgag tttttattta aaaatggctt gtttgctatc acattggtgc agctgtttct
     5581 ttcaagatga gttaatcatc ttaatttcaa agcttcagct atatataatg gatatataga
     5641 caacactgag catccacctc tctcctgagc tttaaagcag agtttcagta tgatataggt
     5701 ggggagagta aattgttttc atatcctttc atactactac taatagtttt aggattttga
     5761 ctggggagag ataatgacaa acagaaaggg aacatggagg ttcttcctac ttttgctacc
     5821 taagtttgca ttttctgact tccttgcagt gttgcactct ttgtcccatt gggataaaaa
     5881 gcataagttt gaaattttgc tttaagcctt gtgttcctgg ggaagttaaa caactaagag
     5941 agctgatttg taaaaattat tttttatatg acattaatat tcatcaagcc ttgtgtaggc
     6001 atgtgtaaga cacagctatg cagctttgag tagtcaatat agtatgagat agagtgttgt
     6061 cccaaatcct cctgtcactt tttaagtagc atattatttc cctgatggtc ctgttacttt
     6121 gctgttgaat gctctaaaca gaacttttta aaaggtgtgt tttaagagca gtcacctagg
     6181 agtagacaag gtggaatggg aggagagaaa tggtaatgca aaagcttgag catgggaaga
     6241 gtcagaggag gaggccatca tccttgttag cttagcctac ttcaacactg agcacatttc
     6301 tgcacttttg aagtgaaatt catgttttac ttagaagaaa taattttctt tcattaggga
     6361 tcccagttga tttttgtttc ctggtgtatc aaaatactta gaactatgaa acaagtatta
     6421 ttgtgatcat gcctttgaat aatttttgac gtagcttatc ttcatgtatc aagtataaaa
     6481 ttataatgag acatctattc acaaatacaa gtcttagatt gaattgaaat gtgttatagt
     6541 gccctgtctc ccactgactt gttcagttaa atgtcttaaa gtacattatg tacatcttca
     6601 ggcttttggt accacaatgg cacaagtatg gtagggaggc aatatagtct taggctatat
     6661 gcctatatta agtgtgtata aacaattttt gaaagaatac actattatag atgtatgtga
     6721 gtgatgctga cctgacagcc atatccagtg gatgaaactg actggacaca ctgttaaaat
     6781 gttttaaaga tgtattttca gccagaacag cctggttata gtttgtggtt ttcaccttgg
     6841 tggattgcag gaacacatgc agcctactgg cattgagcat tagctaatgg catgaaaggg
     6901 cctcatctca ctacctctct aaggcctcta gctccaagaa aaccatgaaa acttctttct
     6961 tggagagatc tttgtctcag aatccttaga gaggatttcg tatgggggct aactttagga
     7021 agggaggcag ctggggcagg actttctgat acctgacagt catgttccag agcaaccttt
     7081 gggcagtgga aactggcgca tctatgcaaa atgattgctc aatctctatc ttgtgtacta
     7141 catatgtaac tagctgggcc ctaaggaagg ttttctaggg ggaaggatag ggaagtagag
     7201 gaggagacaa gtaggaggaa caaagcattc tagacccaag aggatagaag atatttagga
     7261 tagatatggc tttcatccat agttcaaaat aatgcgtttt gttagatgcc agttatagca
     7321 gtaaataggt tatagttttt atatgtcaag atttacctgt aatcagactc attctttcac
     7381 tctctatacc cactgtctcc atgcttggga gcatggatat taatagttcc agtgatgtag
     7441 aagttagtga tttttgattt ctgaaaaagg tgagaacctt ttattacagt tggagaatat
     7501 ttgtcaaaaa ttcaaaggtt gttgtaattg agttgccaga attacagagt ttccattttc
     7561 agatatcaca gttgaatcac ctctgtagat tgttataaag agaggcattt taagatagta
     7621 ttttatttgc taggttgtgt ctcagtctaa gaattgggaa aagaagagct ataggtttct
     7681 ctttcctagt ctggatttca gtaaacacaa gcctacctct gcttctttgg ttcacagcag
     7741 tgtggatcat gaaatgaact gtttacccac attcatcaat attggtattt tacaaatcta
     7801 cttggagcat ttaatttcat ctcaaagatt gtgatccact ttagataagc acaaatacag
     7861 tattaggaaa agtaaatatg caatcttact aaaatttcaa cttgttaagc tgtatatctt
     7921 aaaagaaatt atttggggct gggcatggtg gctcacacct gtaatcccag cactttggga
     7981 ggctgaggtg ggtagatcac ctgaggtcag gagttcgaga ccagcctgac caatatggtg
     8041 aaaccctatc tctactaaaa acacaaaaat tagctgggtg tggtggcatg cacctgtaat
     8101 tccagctact tgggaggctg agacaggaga attgcttgaa cccaggtggt ggaggttgca
     8161 gtgagccaag atcacacccc tgcactccag cctgggtgac agagcgagac tccatctcaa
     8221 aaaaacaaaa caaaaaatta tttgggaaga tacgtcctct tttattagaa gttcataaaa
     8281 tgtatcatat agttttgttc acagtagtta tataagcttt cttcaaataa atttaaaatt
     8341 agattacctt ctttggaaaa agaatttcct aaatttttaa gaattttcaa agttttacat
     8401 attagttttt agaacctaat ccgttttaaa attgtactat gagaaagctt ttttttgaaa
     8461 gttgtaaagc attaatacaa ataatacaaa tataattatt accatcacat tccagagaat
     8521 atggcttttt ctaaactttc aatttagaaa acatacatta agggagaatc tctgccctcc
     8581 ttttcagctc tgaagatcag cttttctact cagacacatg cacacacccc ttccaagtgt
     8641 catgtttatg ggaacatttg ggaaatgttt tccagatgtt ttattttttc ccttttatag
     8701 tttgttgaca tttaatttta cttaaagatg acaattttaa tcggaaatgt tagaggtaca
     8761 acatagtgag gttctagcta gctttatact tttgaaaaat atttttgttt ctactgcttt
     8821 ttacaagtac tagtcctctc agtgatactg gtggtgttca gtatgaatcc atagaaagaa
     8881 aacaaaattt gttgtttaaa aaaagcagag taatgaatga atttcagttt tgaaaacaac
     8941 ataatttgaa aacactgtta tactaacatg gcaaggtgtt aattaaatat aagagtaagg
     9001 tagtaagttc ttttagagca cctgtttaaa tttactccag taatcatctt aaggattgat
     9061 agtcaccatc acttattggc ttaaaagtta tatttcatgg aatattatca gtgttaaatc
     9121 caagctttgt ggagctttaa gtgatggtgg tgaaaaagtt ggtgtttatg agagagtggt
     9181 ggggtgtcta gtcattagtg aagttaaaca tcaacctgtt ttagaaagaa ttttttagtc
     9241 ttgcctaaag taaaccagaa gtgtctagtg tttaaatctt tatttagaat gcttctctta
     9301 aaagtatttt ttgttttggg tagtattaaa taatcagtaa ataatctatt tcagtagtaa
     9361 ataatgaatt aagatgatga tgaatgagga ttaacacact ggtctggaga ctggggtttt
     9421 atttcagtgg gttagctgtg tgtgacatgt tgggcaatta ctcagctgtt ttaacagctt
     9481 ccagatatgc agtatggtgc ctgtactact caaaagttga ttttggttta attcatcttt
     9541 aaggtacctc ccagctctaa aactatgatt ctaggctgtg taatggggtt attcctactt
     9601 tattctcttt ccttttttaa gggttcattt tatacttaat aagcatccat ttcttgggtc
     9661 acctacagtc tttgttctcc taaggattaa aatagaaaat tcatacataa caagcaaatg
     9721 atgacatttt cctaaatgct ccttattggt taaccactga atatatgaac acatatgaat
     9781 attgtcattc atgtacttaa attcatttag caaactattt gaacacttac atgtgcagtg
     9841 tttggtgaac atgacatgag gaactagtag taagtaaaat cttcccccca aaattcattg
     9901 tggcttaaat aaatatgaac ataatcatta ctacttaata tactgagagg gaatcttaat
     9961 aaacttggaa ctgggaggga atatttgtat acattgggta aagggttagg ctagatgaca
    10021 tctaaggggt ctgagtgaat catatcataa tttttataac acatttcaca tactaaacat
    10081 cagttggccc catacctgat taagttacaa aatttaggag acttaacatt aaggacttac
    10141 aggttgagac agcccgtatt tcacaacatt attttgacac ttgactctat tccagagttg
    10201 ttgctataca aggcatgtgg cagaacaaaa aaaaagctgg tgttgatata agagcttttt
    10261 acccagtatt gacagtgagc aactttcttt cttttttttt ttttttcttt tttttttttt
    10321 tgagatgggt tcgctctgtt gcccaggctg gtgtgcagtg gtgcgatctc agctcactgc
    10381 aacctccacc tcccgggttg aagcgattgt cttgcctcag ccttccaagt agctggaatt
    10441 acaggtgccc gccgccacac ctggctaatt tttgtatttt tagtagagac ggggcttcac
    10501 catgttggcc aggctagtct cgaactcttg acctcaagtg atccacctgc cttggcctcc
    10561 ctaagtgctg ggattacagg catgagccac cacacctgtc cgacagtgta gcaactttct
    10621 aaaactgaaa aatctcaaag gagatcattg gaactgactt gttcatttat tttttgtttt
    10681 taaattaaga aagattacac aaaataagtg ttactgtact ttaagctatt acaaatatcc
    10741 aacttttaaa gatatgtaag aatcagtaat attctagaaa gcacatatat agtaaaaggg
    10801 catcctttaa atgtagaacg ggtaaacatg aaacagttcc atgcttgaat tgttaagtat
    10861 ctagggggta aacattgaat gggagaatca tttattgggt taaggtccct tccttgtcat
    10921 tctgggatct gtgaatcaca ttgtaattcc tgttgacaaa gctttacttg ttaacatcag
    10981 ttgatactga cattctccat aaagatatag aatgaaaata tctattaaaa atagtttatc
    11041 attgttttag cttttttgtt ttgtttgttt tgagacagag tctcactgtc acccaggctt
    11101 gagtgcagcg gtgtgatctt ggctcaatgc aacctccacc tcccaggttc aatagattct
    11161 cccaccttgg cctcccaagt agctgggatt actggcatgc accactatgc ctggccagtt
    11221 ttttgtattt ttagtagaga tggggtttca ccatgttggc caggctggac tcgaactcct
    11281 gacctcaagt gatccgccca cctcagcctc ccaaagtgcc gggattatag gcatgagcca
    11341 ctgcgcctag cctgttgcag ctttttaaag caggaaaata tccatataaa ctgttgggtt
    11401 agaatctata ttagaatctt tcaaactaat tgaaaacagg aagactatca tctaagtagc
    11461 cagataatct gggtttcaaa aagttattcc atggtactgg tttaaaaaat acttttcaag
    11521 tgttttaatt tttaaagtgt aactaattct tcaaatatgt tatgctgtta aaatatgtat
    11581 tccataagta ctttttgtat atgtattctt aaattttaaa aagtcaactg aatgcgcaaa
    11641 gatgatataa ttttggatgt agacatttaa actagattcc cagtcctctc cttcaaaagc
    11701 ttggtctttg tttttcctat agggaaaaaa gtcaaaataa gttccaaaaa ctatcctcaa
    11761 agtagtattg tgcttgtagt aaatgaaggt tggatggatg gatactgaca atggtggcag
    11821 gcatttcaag ccttttaaat tagtactttt tgtcgtcttg cttattaaaa ttttgttaat
    11881 tttagcaaag accaattgtt gtgataaact ggtgtttttt ggatgcttca agcacacgtt
    11941 aaccaatttt ttaattcccc ttttggttcc tcccattgtt ctaaaatagg actttcatat
    12001 tattaaaacc tcaaaagatg atccacccag gatgaacaaa gatcaccaag gggaaagaaa
    12061 acatttttta tctttacaga aaacatgtta agattatata tagatgtatt ctttacattg
    12121 gatattgtat tagagtcctc cttacaagaa atgaaatagt ttttagcact cttagcatta
    12181 gagttcctag attggtgttg atagctacag ttttaaaatg tataacctga aaatgaaggt
    12241 taattttgca ttgtaagagc acatttgatc tatgtaaaaa gtgtccattt ggtgtatttt
    12301 tttaaaaaag agaaagcact ttcatattaa gtagcatgtg tatgaattta gattttcata
    12361 tttgttgtgt ctgtattcag tgaagtaaat tgagcattta aatgtttgtt gatggcaaca
    12421 ttaactatta aattaaagca ccttatactc tgctgcttaa cttgcttgta attgcacctt
    12481 tgttacctgc acattttcat atagaatatt gttgtaacat tgcttcatgt gggtctggat
    12541 ggaagattag tgggcctaca ggatcattta tttatattgt ttatattaca ataatatatt
    12601 gtagatcagt tgtaagttca tttctttaca aataaaagcc tcttccattt ga
//
