LOCUS       NM_001385123            3267 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens polyhomeotic homolog 2 (PHC2), transcript variant 10,
            mRNA.
ACCESSION   NM_001385123
VERSION     NM_001385123.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Freire-Beneitez,V., Pomella,N., Millner,T.O., Dumas,A.A.,
            Niklison-Chirou,M.V., Maniati,E., Wang,J., Rajeeve,V., Cutillas,P.
            and Marino,S.
  TITLE     Elucidation of the BMI1 interactome identifies novel regulatory
            roles in glioblastoma
  JOURNAL   NAR Cancer 3 (1), zcab009 (2021)
   PUBMED   34316702
  REMARK    Erratum:[NAR Cancer. 2021 May 25;3(2):zcab020. doi:
            10.1093/narcan/zcab020.. PMID: 34319293]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Gray,F., Cho,H.J., Shukla,S., He,S., Harris,A., Boytsov,B.,
            Jaremko,L., Jaremko,M., Demeler,B., Lawlor,E.R., Grembecka,J. and
            Cierpicki,T.
  TITLE     BMI1 regulates PRC1 architecture and activity through homo- and
            hetero-oligomerization
  JOURNAL   Nat Commun 7, 13343 (2016)
   PUBMED   27827373
  REMARK    GeneRIF: Interaction of BMI1 with polyhomeotic protein PHC2 and
            homo-oligomerization via ubiquitin-like domain are necessary for
            H2A ubiquitination activity of PRC1 and for clonogenic potential of
            U2OS cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Tonkin,E., Hagan,D.M., Li,W. and Strachan,T.
  TITLE     Identification and characterisation of novel mammalian homologues
            of Drosophila polyhomeoticpermits new insights into relationships
            between members of the polyhomeotic family
  JOURNAL   Hum Genet 111 (4-5), 435-442 (2002)
   PUBMED   12384788
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Gunther,M., Laithier,M. and Brison,O.
  TITLE     A set of proteins interacting with transcription factor Sp1
            identified in a two-hybrid screening
  JOURNAL   Mol Cell Biochem 210 (1-2), 131-142 (2000)
   PUBMED   10976766
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Satijn,D.P., Gunster,M.J., van der Vlag,J., Hamer,K.M., Schul,W.,
            Alkema,M.J., Saurin,A.J., Freemont,P.S., van Driel,R. and Otte,A.P.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Gunster,M.J., Satijn,D.P., Hamer,K.M., den Blaauwen,J.L., de
            Bruijn,D., Alkema,M.J., van Lohuizen,M., van Driel,R. and Otte,A.P.
  TITLE     Identification and characterization of interactions between the
            vertebrate polycomb-group protein BMI1 and human homologs of
            polyhomeotic
  JOURNAL   Mol Cell Biol 17 (4), 2326-2335 (1997)
   PUBMED   9121482
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138837.12 and AL513327.34.
            
            Summary: In Drosophila melanogaster, the 'Polycomb' group (PcG) of
            genes are part of a cellular memory system that is responsible for
            the stable inheritance of gene activity. PcG proteins form a large
            multimeric, chromatin-associated protein complex. The protein
            encoded by this gene has homology to the Drosophila PcG protein
            'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and
            colocalize with BMI1 in interphase nuclei of human cells. The
            specific function in human cells has not yet been determined. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL138837.12        42141-42260         c
            121-348             AL513327.34        173196-173423       c
            349-507             AL513327.34        170119-170277       c
            508-840             AL513327.34        152668-153000       c
            841-1006            AL513327.34        152231-152396       c
            1007-1209           AL513327.34        131920-132122       c
            1210-1339           AL513327.34        130105-130234       c
            1340-1454           AL513327.34        129178-129292       c
            1455-1596           AL513327.34        127901-128042       c
            1597-1873           AL513327.34        126700-126976       c
            1874-3267           AL513327.34        121456-122849       c
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..3267
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /note="polyhomeotic homolog 2"
                     /db_xref="GeneID:1912"
                     /db_xref="HGNC:HGNC:3183"
                     /db_xref="MIM:602979"
     exon            1..120
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            121..348
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2028
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /note="isoform g is encoded by transcript variant 10;
                     early development regulator 2 (homolog of polyhomeotic 2);
                     polyhomeotic-like protein 2; early development regulatory
                     protein 2; polyhomeotic-like 2"
                     /codon_start=1
                     /product="polyhomeotic-like protein 2 isoform g"
                     /protein_id="NP_001372052.1"
                     /db_xref="GeneID:1912"
                     /db_xref="HGNC:HGNC:3183"
                     /db_xref="MIM:602979"
                     /translation="MENELPVPHTSSSACATSSTSGASSSSGCNNSSSGGSGRPTGPQ
                     ISVYSGIPDRQTVQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQ
                     LQSLAAVQQPQPQQQQPPPQQSRPVLQAEPHPQLASVSPSVALQPSSEAHAMPLGPVT
                     PALPLQCPTANLHKPGGSQQCHPPTPDTGPQNGHPEGVPHTPQRRFQHTSAVILQLQP
                     ASPVPQQCVPDDWKEVAPGEKSVPETRSGPSPHQQAIVTAMPGGLPVPTSPNIQPSPA
                     HETGQGIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEG
                     FVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKE
                     EGAPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKAG
                     AATHNRRRASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHSQEDSSRCSDNSSYEEP
                     LSPISASSSTSRRRQGQRDLELPDMHMRDLVGMGHHFLPSEPTKWNVEDVYEFIRSLP
                     GCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKDS"
     exon            349..507
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..840
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1006
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1209
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1339
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1454
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1596
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1873
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..3267
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3249..3254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /note="hexamer: AATAAA"
     polyA_site      3267
                     /gene="PHC2"
                     /gene_synonym="EDR2; HPH2; PH2"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcgggc agcgtccgag cagccagcag ggtgcgcggc gccgagccga gggggcgggc
       61 tgaggggcgg cccccgggag agagcggcca ggtggaggag gagcgcggag gcgaccgcag
      121 catctgcctg cccttctgcc atccgagcgc cctgactgcg ccacactgca ggccatggag
      181 aatgagctgc cagtcccaca tacatctagc agtgcctgtg ccaccagcag taccagcggg
      241 gccagtagca gcagtggctg caacaacagc agcagtggtg gaagtggccg ccccaccggg
      301 ccccagattt ctgtgtacag tggtattcca gaccggcaga ccgtgcaggt gatccagcag
      361 gccctgcaca gacagcccag cacggccgct cagtacctgc agcagatgta cgccgcccag
      421 cagcagcacc tcatgctgca gaccgcggcg ctccagcagc agcacctcag cagcgcccag
      481 ctccagagcc tggcagccgt acagcagcca cagccacaac agcagcagcc gccgccccag
      541 cagtcacggc ctgtgctcca agctgagccc cacccccagc tcgcctcagt ctctccaagc
      601 gtggccctcc agcccagctc agaggcccat gccatgccac taggcccggt tacacccgcc
      661 ctgccactcc agtgtcccac tgccaacctg cacaagcctg gcggcagtca gcagtgtcac
      721 cctcccacac ctgatactgg gcctcagaat ggacatcccg agggcgtgcc ccacacccct
      781 caacgcaggt tccagcacac ttcagctgtc atcttacaac tgcagcctgc ttcaccagtg
      841 ccccagcagt gtgtccctga tgactggaaa gaagtggcac caggggagaa aagtgtgcct
      901 gagacgcggt ctggcccatc accacatcag caggctattg tcactgccat gcctggtggc
      961 ctgcctgtac ccacgagccc taacatccag ccgtccccag ctcacgagac agggcagggc
     1021 attgttcatg cactgaccga cctcagcagc cccggcatga cctcagggaa cggaaactct
     1081 gcctccagca tcgccggcac tgccccccag aatggtgaga ataaaccacc acaggccatt
     1141 gtgaaacccc aaatcctgac gcatgttatc gaagggtttg tgatccagga gggggcggag
     1201 cctttcccgg tgggacgctc gtccctgctg gtggggaatc tcaagaagaa gtatgcacag
     1261 gggttcctgc ctgagaaact tccacagcag gatcacacca ccaccactga ctcggagatg
     1321 gaggagccct atctgcaaga atccaaagag gagggtgctc ccctcaaact caagtgtgag
     1381 ctctgtggcc gggtggactt tgcctataag ttcaagcgtt ccaagcgctt ctgttccatg
     1441 gcttgtgcaa agaggtacaa cgtgggatgc accaaacggg tgggactttt ccactcagac
     1501 cggagcaagc tgcagaaggc aggagctgcg acccacaacc gccgtcgggc cagcaaagcc
     1561 agtctgccac cacttaccaa ggataccaag aagcagccaa caggcactgt gcccctttcg
     1621 gttactgctg ctttgcagct aacacacagc caggaagact ccagccgttg ctcagataac
     1681 tcaagctatg aggaaccctt gtcacccatc tcagccagct catctacttc ccgccggcga
     1741 caaggccagc gggacctgga gctccccgac atgcatatgc gggacctggt gggcatggga
     1801 caccacttcc tgccaagtga gcccaccaag tggaatgtag aagacgtcta cgaattcatc
     1861 cgctctctgc caggctgcca ggagatagca gaggaattcc gtgcccagga aatcgacggg
     1921 caagccctgc tgctgctcaa ggaggaccac ctgatgagcg ccatgaacat caagctgggg
     1981 cccgccctga agatctacgc ccgcatcagc atgctcaagg actcctaggg ctggtggcag
     2041 ccaggattct ggcccagggc gcctcctccc gactgagcag agccagacag acattcctga
     2101 ggggcccaga aatggggccg gttggagggc aggggctctc cctaggggca tagctggtga
     2161 ggaggtctgg gcacctcctc catggctctc aggggccttt catttctgtg ggaggggcag
     2221 agaggtaggt ggcacagaag atggggcttt atgcttgtaa atattgatag cactggcttc
     2281 ctccaaagtc ccaatactct agccccgctc tcttcccctc tttctgtccc ccattttcca
     2341 gggggtatat ggtcagggct ccccaacctg agttgggtta cttcaagggc agccagcagg
     2401 cctggatgga ggcctagaaa gcccttgcct tccttcctcc cacttctttc tccaggcctg
     2461 gttaactctt ccgttgtcag cttctccccc ttcagcctgt ttctgcagca gccagggttc
     2521 tcccccctac accctctgca ggtggagaga gagaagctgg gcccagccgg gccgtgcctg
     2581 ctggcacaga cgccttaacg ctgtgtgtat gactgtgtga ctgtgtggga gcctggactg
     2641 acagataggc caagggctac tctctggcat ctccaggtgt tttgtagcaa acagccactt
     2701 agtgctttgt cctggactcc actcagcctc aggatgggga atagccaaga atggcagcct
     2761 cagcgcagag gcaaggtcag aaagagacgg cgcttcagag tttcctttcc agacacccct
     2821 ccccgcactg tgaagttccc ctgaccgccc tcctggttca caaagagcat taagaaagct
     2881 gcggtggtct gagcaacata gcccaaaggg ctgagcctcc tggcctgcct gcccgcccac
     2941 cctgggagtc ccagtggtga ggctcagaga actgctaagg ggaaagaaca gctggagttt
     3001 ctgttgatgt gaagaaggca gctcttggcc tcccactccc acacttcttt gcctataaat
     3061 cttcctagca gcaatttgag ctacctgagg aggaggcagg gcagaaaggg cgagggcctg
     3121 cctctgacct gccgtgtcct ttgcaggaag gaggtaggca cctttctgag cttattctat
     3181 tccccaccca cacccccagg cagggttgga aatgaaggac ttttttaacc tttgttttgt
     3241 tttttaaaaa taaatctgta aaatctg
//
