LOCUS       XM_017018955            5587 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens polyhomeotic homolog 1 (PHC1), transcript
            variant X3, mRNA.
ACCESSION   XM_017018955
VERSION     XM_017018955.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017018955.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..5587
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="polyhomeotic homolog 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 59 ESTs, 4821 long SRA reads, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
     CDS             514..3579
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /codon_start=1
                     /product="polyhomeotic-like protein 1 isoform X1"
                     /protein_id="XP_016874444.1"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
                     /translation="METESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQ
                     RQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQVRGQQPAGPRGRGQALQATIAASRQAS
                     SPNTSTTQQQTTTTQASINLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLN
                     QSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVPSAQSPGVHAD
                     ADQVQNLAVRNQQASAQGPQMQGSTQKAIPPGASPVSSLSQASSQALAVAQASSGATN
                     QSLNLSQAGGGSGNSIPGSMGPGGGGQAHGGLGQLPSSGMGGGSCPRKGTGVVQPLPA
                     AQTVTVSQGSQTEAESAAAKKAEADGSGQQNVGMNLTRTATPAPSQTLISSATYTQIQ
                     PHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQ
                     QQQQQQPQATTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLSLPPDAAPK
                     PPIPIQSKPPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLA
                     AAVPTSRGMPGTVQSGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKG
                     GATTSSPVVAQVPAAFYMQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASP
                     VAESPKVMDEKSSLGEKAESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMGDSK
                     PPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGGP
                     LGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKR
                     KKMKEFQEANYARVRRRGPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPT
                     SPGPLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGC
                     QEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET"
ORIGIN      
        1 gggcatctgt ggatcagctt ctcactgtct tccagtttaa tttggaaaat tttgatacct
       61 ggtgctgccc aaactgtttg ttgtctccat tttttatatt taatcttgta gtcataatgt
      121 tgatcacaaa tgaatacatt tatgtgcccg ggatccagga atcctggttt tggtggcagt
      181 ttcccttgat tttattgaga cttttaagtt ggtcccttta catttttatt tctagttcac
      241 aatccaaaaa aaattattaa tcagaattca ggtttgggaa gacgaggggt catacggttt
      301 gtattttcac atgtgaatgt aggaattatg ttctctatac ctagcaaagg ggtctcgtgt
      361 ctctgagtcc agtgaactaa atccagtaat ctataaaact gtgccgtgct gcctctaatc
      421 cttacccact ttttttcttc acatgctgat aatgaggatt catgggtctt gagtcagaca
      481 gagcaccagc cttggggacc ctggaccact atcatggaga ctgagagcga gcagaactcc
      541 aattccacca atgggagttc tagctcaggg ggcagctctc ggccccagat agctcaaatg
      601 tcactttatg aacgacaagc agtgcaggct ctgcaagcac tgcagcggca gcccaatgca
      661 gctcagtatt tccaccagtt catgctccag cagcagctca gtaatgccca gctgcatagc
      721 ctggctgccg tccagcaggt gagaggtcag cagccagctg gcccgagagg gaggggacag
      781 gcactacagg ccacaattgc tgccagtcgg caggccagct ccccaaacac cagcactaca
      841 cagcagcaga ctaccaccac ccaggcctcg atcaatctgg ccaccacatc ggccgcccag
      901 ctcatcagcc gatcccagag tgtgagctct cccagtgcta ccaccttgac ccaatctgtg
      961 ctactgggga acaccacctc cccacccctc aaccagtctc aggcccagat gtatctacgg
     1021 ccacagctgg gaaacctatt gcaggtaaac cgaaccctgg gtcggaatgt gcctctagcc
     1081 tcccaactca tcctgatgcc taatggggcg gtggctgcag tccagcagga ggtgccatct
     1141 gctcagtctc ctggagttca tgcagatgca gatcaggttc agaacttggc agtaaggaat
     1201 caacaggcct cagctcaagg acctcagatg caaggctcca ctcagaaggc cattcctcca
     1261 ggagcctccc ctgtctctag cctctcccag gcctctagcc aggccctagc ggtggcacag
     1321 gcttcctctg gggccacaaa ccagtccctc aaccttagtc aagctggtgg aggcagtggg
     1381 aatagcatcc cagggtccat gggtccaggt ggaggtgggc aggcacatgg tggtttgggt
     1441 cagttgcctt cctcaggaat gggtggtggg agctgtccca gaaagggtac aggagtggtg
     1501 cagcccttgc ctgcagccca aacagtgact gtgagccagg gcagccagac agaggcagaa
     1561 agtgcagcag ccaagaaggc agaagcagat gggagtggcc agcagaatgt gggcatgaac
     1621 ctgacacgga cagccacacc tgcgcccagc cagacactta ttagctcagc cacctacaca
     1681 cagatccagc cccattcact gattcagcaa cagcaacaga tccacctcca gcagaaacag
     1741 gtggtgatcc agcagcagat tgccatccac caccagcagc agttccagca ccggcagtcc
     1801 cagctccttc acacagctac acacctccag ttggcgcagc agcagcagca gcaacaacag
     1861 caacagcagc aacagcagca gccgcaagcc accaccctca ctgcccctca gccaccacag
     1921 gtcccaccta ctcagcaggt cccaccttcc cagtcccagc agcaagccca aaccctggtc
     1981 gttcagccca tgcttcagtc ttcacccttg tctcttccac ctgatgcagc ccctaagcca
     2041 ccaattccca tccaatccaa accacctgta gcacctatca agccgcctca gttaggggcc
     2101 gctaagatgt cagctgccca gcaaccacca ccccatatcc ctgtgcaagt tgtaggcact
     2161 cgacagccag gtacagccca ggcacaggct ttggggttgg cacagctggc agctgctgta
     2221 cctacttccc gggggatgcc aggtacagtg cagtctggtc aggcccattt ggcctcctcg
     2281 ccaccttcat cccaggctcc tggtgcactg caggagtgcc ctcccacatt ggcccctggg
     2341 atgacccttg ctcctgtgca ggggacagca catgtggtaa agggtggggc taccacctcc
     2401 tcacctgttg tagcccaggt ccctgctgcc ttctatatgc agtctgtgca cttgccgggt
     2461 aaaccccaga cattggctgt caaacgcaag gctgactctg aggaggagag agatgatgtc
     2521 tccacattgg gttcaatgct tcctgccaag gcatctccag tagcagaaag cccaaaagtc
     2581 atggacgaga agagcagtct tggagaaaaa gctgaatcag tggctaatgt gaatgctaat
     2641 actccaagca gtgaactagt agccttgacc cccgcccctt cagtaccgcc tcctacacta
     2701 gccatggtgt ctagacaaat gggtgactca aaacccccac aggccatcgt gaagccccag
     2761 attctcaccc acatcattga aggctttgtt atccaggaag gagcagaacc tttcccggtg
     2821 ggttgttctc agttactgaa ggagtctgag aagccactac agactggcct tccgacaggg
     2881 ctgactgaga atcagtcagg tggccctttg ggagtggaca gcccatctgc tgagttagat
     2941 aagaaggcga atctcctgaa gtgcgagtac tgtgggaagt acgcccccgc agagcagttt
     3001 cgtggctcta agaggttctg ctccatgact tgcgctaaga ggtacaatgt gagctgtagc
     3061 catcagttcc ggctgaagag gaaaaaaatg aaagagtttc aagaagccaa ctatgctcgc
     3121 gttcgcaggc gtggaccccg ccgcagctcc tctgacattg cccgtgccaa gattcagggc
     3181 aagtgccacc ggggtcaaga agactctagc cggggttcag ataattccag ttatgatgaa
     3241 gcactctctc caacatctcc tgggccttta tcagtaagag ctgggcatgg agaacgtgac
     3301 ctggggaatc ccaatacagc tccacctaca ccggaattac atggcatcaa ccctgtgttc
     3361 ctgtccagta atcccagccg ttggagtgta gaggaggtgt acgagtttat tgcttctctc
     3421 caaggctgcc aagagattgc agaggaattt cgctcacagg agattgatgg acaggccctt
     3481 ttattactta aagaagaaca tcttatgagt gccatgaaca tcaagctggg ccctgccctc
     3541 aagatctgcg ccaagataaa tgtcctcaag gagacctaag gtggccctct tgcacaaacc
     3601 agcctaaggc agacactctc cactgtccag gttataacct ggtaccagca gactttgcag
     3661 ggaagaaaga gttgttccaa tcatgtaacc ttctgtaggg gattactgag acagggaaga
     3721 gaagtgcaag aattggttgc tggtgctaca tggcggcagc tttgacattt tctctgggtt
     3781 ctactttatt ttttaaaatc tttacagttc tcaccatttc acgtacctta atccaatctt
     3841 tataaaagag gcagtctaga gaactaggac tgctcagcct tatcctggag tggagcattt
     3901 agcccaggtc ttaattctcc aagaggagga atacatagta tggtaaggca aggaactggg
     3961 tggaatgtca ggttgcctgc ccaatgggag aggtagggtt tttctagctt gtgtgacaga
     4021 agtagcaaaa tctggtcctc ccccctccca gtgtagctgt ggctcagagt tttttctttt
     4081 tgttgtcact tactcccttg tgattgaatt ttttctcctg catccatggc aggatcccca
     4141 gccagtatag agacttggtt ggcatcttct gctgcaggga ctaaaagtat ttgactgggg
     4201 cacatgtggc tgttgtcatt ctttctgcat cccactgttc ccctccaatt tatgttattt
     4261 tctaccctgt ttttcagttc catctctgct ctgtcctata gctttataaa accagagtgt
     4321 gtggggctga ggtcaggagt ataagtacct gccttaggca ctattcctta tataacaaaa
     4381 atattaaata tttttttcct cagtaaaagg atgaaaattg gtttcagttg tcttactcta
     4441 ttccagtctt tgcccacttt cacacaaatg acaaggccaa tatgttttgt ttgtttttta
     4501 atcattaaga gtttttgtac aaaaggtgat ggtttttttt cttcatttta aaacaccagg
     4561 gtgtggggga gggatgcaaa caaataacaa aaaagatgct tttgtaacat tattttccct
     4621 gtttagaaag aaaaaaatca ctccaatagt attgaaaagt ccaaagatga aatagtttca
     4681 ttttcttttc ctaaggctta taaaaggccc cctgcctgtt gattccatcc ctcttttgtg
     4741 tccagtggag ccatgttact cttcagtggc ccaggggttc actattaaag aaagatcagt
     4801 ccaggtttct gggcacatgg cctaaacagg aagatggaag catcagagga ttaaaaacct
     4861 ttccccacag aaatgtgggc aagaagacac ttccctgagc cagcagaagg gacaggtgca
     4921 gcagcattcc acacccagcg cagaggacag cagagccctc gatgtcccac ttctgcttcc
     4981 gttccctttc tagaagattg aaaaaaaggt caaaaccaca tgcctgtgga gaaagtgcga
     5041 catgtttaga aatactggta gggaaccagg agtaagaaaa gctttaccag cttttactac
     5101 aaatggatga aagacatcag gatcccacca ccgcaaggta aagtgacttc ccttttctgg
     5161 aacccctgtg gcacaggagt accaattttc ctttccaacg aactggattt ctggataggc
     5221 attttggctg tatgtggaca gataagacca cagtccttag cccaatccca gctatacagt
     5281 caccccaatt tccacaaatg atgtgatggt accgtataat cctgtaattg ggaaatttca
     5341 catttttcct gtcctaatct cagaggtggg agaagcaagt ctagaacatc tccaggctca
     5401 gactaaacga gagtacttgg actgcaacca agtaatcact gcaaagtagt tccaagcagc
     5461 aagaaatacc agattctcat ggaggctact atagggtaca gaataacaac atgaaagcaa
     5521 tcaaccctgt ataaataatg tttcttggca tttttttttt aattaaagaa atccagtgtc
     5581 tcaaaaa
//
