LOCUS       NM_004426               5390 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens polyhomeotic homolog 1 (PHC1), transcript variant 1,
            mRNA.
ACCESSION   NM_004426 XM_208080
VERSION     NM_004426.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Chen,L., Tong,Q., Chen,X., Jiang,P., Yu,H., Zhao,Q., Sun,L.,
            Liu,C., Gu,B., Zheng,Y., Fei,L., Jiang,X., Li,W., Volpe,G.,
            Abdul,M.M., Guo,G., Zhang,J., Qian,P., Sun,Q., Neculai,D.,
            Esteban,M.A., Li,C., Wen,F. and Ji,J.
  TITLE     PHC1 maintains pluripotency by organizing genome-wide chromatin
            interactions of the Nanog locus
  JOURNAL   Nat Commun 12 (1), 2829 (2021)
   PUBMED   33990559
  REMARK    GeneRIF: PHC1 maintains pluripotency by organizing genome-wide
            chromatin interactions of the Nanog locus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 5390)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (bases 1 to 5390)
  AUTHORS   Ohta,H., Tokimasa,S., Zou,Z., Funaki,S., Kurahashi,H.,
            Takahashi,Y., Kimura,M., Matsuoka,R., Horie,M., Hara,J., Shimada,K.
            and Takihara,Y.
  TITLE     Structure and chromosomal localization of the RAE28/HPH1 gene, a
            human homologue of the polyhomeotic gene
  JOURNAL   DNA Seq 11 (1-2), 61-73 (2000)
   PUBMED   10902910
REFERENCE   8  (bases 1 to 5390)
  AUTHORS   Satijn,D.P., Gunster,M.J., van der Vlag,J., Hamer,K.M., Schul,W.,
            Alkema,M.J., Saurin,A.J., Freemont,P.S., van Driel,R. and Otte,A.P.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   9  (bases 1 to 5390)
  AUTHORS   Gunster,M.J., Satijn,D.P., Hamer,K.M., den Blaauwen,J.L., de
            Bruijn,D., Alkema,M.J., van Lohuizen,M., van Driel,R. and Otte,A.P.
  TITLE     Identification and characterization of interactions between the
            vertebrate polycomb-group protein BMI1 and human homologs of
            polyhomeotic
  JOURNAL   Mol Cell Biol 17 (4), 2326-2335 (1997)
   PUBMED   9121482
REFERENCE   10 (bases 1 to 5390)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006581.16, CN388285.1,
            CN388283.1, BC073964.1, CN388316.1, U89277.1, BX640639.1 and
            BM473731.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004426.2.
            
            Summary: This gene is a homolog of the Drosophila polyhomeotic
            gene, which is a member of the Polycomb group of genes. The gene
            product is a component of a multimeric protein complex that
            contains EDR2 and the vertebrate Polycomb protein BMH1. The gene
            product, the EDR2 protein, and the Drosophila polyhomeotic protein
            share 2 highly conserved domains, named homology domains I and II.
            These domains are involved in protein-protein interactions and may
            mediate heterodimerization of the protein encoded by this gene and
            the EDR2 protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.94174.1,
                                           SRR1803614.280198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544916.6/ ENSP00000437659.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC006581.16        63466-63676
            212-459             CN388285.1         1-248
            460-592             CN388283.1         147-279
            593-911             CN388283.1         287-605
            912-1284            BC073964.1         555-927
            1285-1463           CN388316.1         474-652
            1464-2069           U89277.1           1232-1837
            2070-2707           BC073964.1         1707-2344
            2708-3487           BX640639.1         2104-2883
            3488-4327           BC073964.1         3125-3964
            4328-4731           BM473731.1         342-745
            4732-5390           BC073964.1         4370-5028
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..5390
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="polyhomeotic homolog 1"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
     exon            1..319
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            320..481
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..3382
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="isoform a is encoded by transcript variant 1; early
                     development regulator 1 (homolog of polyhomeotic 1); early
                     development regulatory protein 1; polyhomeotic-like 1"
                     /codon_start=1
                     /product="polyhomeotic-like protein 1 isoform a"
                     /protein_id="NP_004417.2"
                     /db_xref="CCDS:CCDS8597.1"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
                     /translation="METESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQ
                     RQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNTSTTQQQTTTTQAS
                     INLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQ
                     VNRTLGRNVPLASQLILMPNGAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQ
                     GPQMQGSTQKAIPPGASPVSSLSQASSQALAVAQASSGATNQSLNLSQAGGGSGNSIP
                     GSMGPGGGGQAHGGLGQLPSSGMGGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESA
                     AAKKAEADGSGQQNVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQ
                     VVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQPQATTLTAPQP
                     PQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLSLPPDAAPKPPIPIQSKPPVAPIKPP
                     QLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLAAAVPTSRGMPGTVQSGQ
                     AHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKGGATTSSPVVAQVPAAFY
                     MQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVAESPKVMDEKSSLGEK
                     AESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMGDSKPPQAIVKPQILTHIIEG
                     FVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGGPLGVDSPSAELDKKANLL
                     KCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEANYARVRRR
                     GPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLG
                     NPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQAL
                     LLLKEEHLMSAMNIKLGPALKICAKINVLKET"
     exon            482..592
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            593..673
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            674..823
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            824..979
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1472
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..2260
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2408
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2620
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2735
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2844
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2995
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3227
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..5390
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5369..5374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="hexamer: AAGAAA"
     polyA_site      5390
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="major polyA site"
ORIGIN      
        1 agcccggccc gcagcccctg gcctgcggcc cccaccttct cggccgggca ggaagtgaca
       61 ggcccggagc gagccccgga ggcctggctg agccgcggcc gggcccgcac ccggagcggc
      121 gggaggggcg gggagccgcg gtcgcgccgg gcgcctccca ccccgccctc ggcgcccccg
      181 cccctccagg aaggggagga ggcgagggga gcccgccgcg gaggccgagc gagcccccag
      241 cccagcctgg cgactgggga ccccggcaca tgaggtggac gcccccgggg aagacttggg
      301 tgcacagcca ggcgagaagg tcttgagtca gacagagcac cagccttggg gaccctggac
      361 cactatcatg gagactgaga gcgagcagaa ctccaattcc accaatggga gttctagctc
      421 agggggcagc tctcggcccc agatagctca aatgtcactt tatgaacgac aagcagtgca
      481 ggctctgcaa gcactgcagc ggcagcccaa tgcagctcag tatttccacc agttcatgct
      541 ccagcagcag ctcagtaatg cccagctgca tagcctggct gccgtccagc aggccacaat
      601 tgctgccagt cggcaggcca gctccccaaa caccagcact acacagcagc agactaccac
      661 cacccaggcc tcgatcaatc tggccaccac atcggccgcc cagctcatca gccgatccca
      721 gagtgtgagc tctcccagtg ctaccacctt gacccaatct gtgctactgg ggaacaccac
      781 ctccccaccc ctcaaccagt ctcaggccca gatgtatcta cggccacagc tgggaaacct
      841 attgcaggta aaccgaaccc tgggtcggaa tgtgcctcta gcctcccaac tcatcctgat
      901 gcctaatggg gcggtggctg cagtccagca ggaggtgcca tctgctcagt ctcctggagt
      961 tcatgcagat gcagatcagg ttcagaactt ggcagtaagg aatcaacagg cctcagctca
     1021 aggacctcag atgcaaggct ccactcagaa ggccattcct ccaggagcct cccctgtctc
     1081 tagcctctcc caggcctcta gccaggccct agcggtggca caggcttcct ctggggccac
     1141 aaaccagtcc ctcaacctta gtcaagctgg tggaggcagt gggaatagca tcccagggtc
     1201 catgggtcca ggtggaggtg ggcaggcaca tggtggtttg ggtcagttgc cttcctcagg
     1261 aatgggtggt gggagctgtc ccagaaaggg tacaggagtg gtgcagccct tgcctgcagc
     1321 ccaaacagtg actgtgagcc agggcagcca gacagaggca gaaagtgcag cagccaagaa
     1381 ggcagaagca gatgggagtg gccagcagaa tgtgggcatg aacctgacac ggacagccac
     1441 acctgcgccc agccagacac ttattagctc agccacctac acacagatcc agccccattc
     1501 actgattcag caacagcaac agatccacct ccagcagaaa caggtggtga tccagcagca
     1561 gattgccatc caccaccagc agcagttcca gcaccggcag tcccagctcc ttcacacagc
     1621 tacacacctc cagttggcgc agcagcagca gcagcaacaa cagcaacagc agcaacagca
     1681 gcagccgcaa gccaccaccc tcactgcccc tcagccacca caggtcccac ctactcagca
     1741 ggtcccacct tcccagtccc agcagcaagc ccaaaccctg gtcgttcagc ccatgcttca
     1801 gtcttcaccc ttgtctcttc cacctgatgc agcccctaag ccaccaattc ccatccaatc
     1861 caaaccacct gtagcaccta tcaagccgcc tcagttaggg gccgctaaga tgtcagctgc
     1921 ccagcaacca ccaccccata tccctgtgca agttgtaggc actcgacagc caggtacagc
     1981 ccaggcacag gctttggggt tggcacagct ggcagctgct gtacctactt cccgggggat
     2041 gccaggtaca gtgcagtctg gtcaggccca tttggcctcc tcgccacctt catcccaggc
     2101 tcctggtgca ctgcaggagt gccctcccac attggcccct gggatgaccc ttgctcctgt
     2161 gcaggggaca gcacatgtgg taaagggtgg ggctaccacc tcctcacctg ttgtagccca
     2221 ggtccctgct gccttctata tgcagtctgt gcacttgccg ggtaaacccc agacattggc
     2281 tgtcaaacgc aaggctgact ctgaggagga gagagatgat gtctccacat tgggttcaat
     2341 gcttcctgcc aaggcatctc cagtagcaga aagcccaaaa gtcatggacg agaagagcag
     2401 tcttggagaa aaagctgaat cagtggctaa tgtgaatgct aatactccaa gcagtgaact
     2461 agtagccttg acccccgccc cttcagtacc gcctcctaca ctagccatgg tgtctagaca
     2521 aatgggtgac tcaaaacccc cacaggccat cgtgaagccc cagattctca cccacatcat
     2581 tgaaggcttt gttatccagg aaggagcaga acctttcccg gtgggttgtt ctcagttact
     2641 gaaggagtct gagaagccac tacagactgg ccttccgaca gggctgactg agaatcagtc
     2701 aggtggccct ttgggagtgg acagcccatc tgctgagtta gataagaagg cgaatctcct
     2761 gaagtgcgag tactgtggga agtacgcccc cgcagagcag tttcgtggct ctaagaggtt
     2821 ctgctccatg acttgcgcta agaggtacaa tgtgagctgt agccatcagt tccggctgaa
     2881 gaggaaaaaa atgaaagagt ttcaagaagc caactatgct cgcgttcgca ggcgtggacc
     2941 ccgccgcagc tcctctgaca ttgcccgtgc caagattcag ggcaagtgcc accggggtca
     3001 agaagactct agccggggtt cagataattc cagttatgat gaagcactct ctccaacatc
     3061 tcctgggcct ttatcagtaa gagctgggca tggagaacgt gacctgggga atcccaatac
     3121 agctccacct acaccggaat tacatggcat caaccctgtg ttcctgtcca gtaatcccag
     3181 ccgttggagt gtagaggagg tgtacgagtt tattgcttct ctccaaggct gccaagagat
     3241 tgcagaggaa tttcgctcac aggagattga tggacaggcc cttttattac ttaaagaaga
     3301 acatcttatg agtgccatga acatcaagct gggccctgcc ctcaagatct gcgccaagat
     3361 aaatgtcctc aaggagacct aaggtggccc tcttgcacaa accagcctaa ggcagacact
     3421 ctccactgtc caggttataa cctggtacca gcagactttg cagggaagaa agagttgttc
     3481 caatcatgta accttctgta ggggattact gagacaggga agagaagtgc aagaattggt
     3541 tgctggtgct acatggcggc agctttgaca ttttctctgg gttctacttt attttttaaa
     3601 atctttacag ttctcaccat ttcacgtacc ttaatccaat ctttataaaa gaggcagtct
     3661 agagaactag gactgctcag ccttatcctg gagtggagca tttagcccag gtcttaattc
     3721 tccaagagga ggaatacata gtatggtaag gcaaggaact gggtggaatg tcaggttgcc
     3781 tgcccaatgg gagaggtagg gtttttctag cttgtgtgac agaagtagca aaatctggtc
     3841 ctcccccctc ccagtgtagc tgtggctcag agttttttct ttttgttgtc acttactccc
     3901 ttgtgattga attttttctc ctgcatccat ggcaggatcc ccagccagta tagagacttg
     3961 gttggcatct tctgctgcag ggactaaaag tatttgactg gggcacatgt ggctgttgtc
     4021 attctttctg catcccactg ttcccctcca atttatgtta ttttctaccc tgtttttcag
     4081 ttccatctct gctctgtcct atagctttat aaaaccagag tgtgtggggc tgaggtcagg
     4141 agtataagta cctgccttag gcactattcc ttatataaca aaaatattaa atattttttt
     4201 cctcagtaaa aggatgaaaa ttggtttcag ttgtcttact ctattccagt ctttgcccac
     4261 tttcacacaa atgacaaggc caatatgttt tgtttgtttt ttaatcatta agagtttttg
     4321 tacaaaaggt gatggttttt tttcttcatt ttaaaacacc agggtgtggg ggagggatgc
     4381 aaacaaataa caaaaaagat gcttttgtaa cattattttc cctgtttaga aagaaaaaaa
     4441 tcactccaat agtattgaaa agtccaaaga tgaaatagtt tcattttctt ttcctaaggc
     4501 ttataaaagg ccccctgcct gttgattcca tccctctttt gtgtccagtg gagccatgtt
     4561 actcttcagt ggcccagggg ttcactatta aagaaagatc agtccaggtt tctgggcaca
     4621 tggcctaaac aggaagatgg aagcatcaga ggattaaaaa cctttcccca cagaaatgtg
     4681 ggcaagaaga cacttccctg agccagcaga agggacaggt gcagcagcat tccacaccca
     4741 gcgcagagga cagcagagcc ctcgatgtcc cacttctgct tccgttccct ttctagaaga
     4801 ttgaaaaaaa ggtcaaaacc acatgcctgt ggagaaagtg cgacatgttt agaaatactg
     4861 gtagggaacc aggagtaaga aaagctttac cagcttttac tacaaatgga tgaaagacat
     4921 caggatccca ccaccgcaag gtaaagtgac ttcccttttc tggaacccct gtggcacagg
     4981 agtaccaatt ttcctttcca acgaactgga tttctggata ggcattttgg ctgtatgtgg
     5041 acagataaga ccacagtcct tagcccaatc ccagctatac agtcacccca atttccacaa
     5101 atgatgtgat ggtaccgtat aatcctgtaa ttgggaaatt tcacattttt cctgtcctaa
     5161 tctcagaggt gggagaagca agtctagaac atctccaggc tcagactaaa cgagagtact
     5221 tggactgcaa ccaagtaatc actgcaaagt agttccaagc agcaagaaat accagattct
     5281 catggaggct actatagggt acagaataac aacatgaaag caatcaaccc tgtataaata
     5341 atgtttcttg gcattttttt tttaattaaa gaaatccagt gtctcaaaaa
//
