LOCUS       NM_001413738            5179 bp    mRNA    linear   PRI 14-FEB-2025
DEFINITION  Homo sapiens polyhomeotic homolog 1 (PHC1), transcript variant 2,
            mRNA.
ACCESSION   NM_001413738
VERSION     NM_001413738.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5179)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5179)
  AUTHORS   Chen,L., Tong,Q., Chen,X., Jiang,P., Yu,H., Zhao,Q., Sun,L.,
            Liu,C., Gu,B., Zheng,Y., Fei,L., Jiang,X., Li,W., Volpe,G.,
            Abdul,M.M., Guo,G., Zhang,J., Qian,P., Sun,Q., Neculai,D.,
            Esteban,M.A., Li,C., Wen,F. and Ji,J.
  TITLE     PHC1 maintains pluripotency by organizing genome-wide chromatin
            interactions of the Nanog locus
  JOURNAL   Nat Commun 12 (1), 2829 (2021)
   PUBMED   33990559
  REMARK    GeneRIF: PHC1 maintains pluripotency by organizing genome-wide
            chromatin interactions of the Nanog locus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5179)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5179)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5179)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 5179)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (bases 1 to 5179)
  AUTHORS   Ohta,H., Tokimasa,S., Zou,Z., Funaki,S., Kurahashi,H.,
            Takahashi,Y., Kimura,M., Matsuoka,R., Horie,M., Hara,J., Shimada,K.
            and Takihara,Y.
  TITLE     Structure and chromosomal localization of the RAE28/HPH1 gene, a
            human homologue of the polyhomeotic gene
  JOURNAL   DNA Seq 11 (1-2), 61-73 (2000)
   PUBMED   10902910
REFERENCE   8  (bases 1 to 5179)
  AUTHORS   Satijn,D.P., Gunster,M.J., van der Vlag,J., Hamer,K.M., Schul,W.,
            Alkema,M.J., Saurin,A.J., Freemont,P.S., van Driel,R. and Otte,A.P.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   9  (bases 1 to 5179)
  AUTHORS   Gunster,M.J., Satijn,D.P., Hamer,K.M., den Blaauwen,J.L., de
            Bruijn,D., Alkema,M.J., van Lohuizen,M., van Driel,R. and Otte,A.P.
  TITLE     Identification and characterization of interactions between the
            vertebrate polycomb-group protein BMI1 and human homologs of
            polyhomeotic
  JOURNAL   Mol Cell Biol 17 (4), 2326-2335 (1997)
   PUBMED   9121482
REFERENCE   10 (bases 1 to 5179)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006581.16.
            
            Summary: This gene is a homolog of the Drosophila polyhomeotic
            gene, which is a member of the Polycomb group of genes. The gene
            product is a component of a multimeric protein complex that
            contains EDR2 and the vertebrate Polycomb protein BMH1. The gene
            product, the EDR2 protein, and the Drosophila polyhomeotic protein
            share 2 highly conserved domains, named homology domains I and II.
            These domains are involved in protein-protein interactions and may
            mediate heterodimerization of the protein encoded by this gene and
            the EDR2 protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.988529.1,
                                           SRR14038191.793635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC006581.16        62800-62907
            109-270             AC006581.16        66587-66748
            271-381             AC006581.16        68713-68823
            382-462             AC006581.16        69942-70022
            463-612             AC006581.16        70558-70707
            613-768             AC006581.16        71590-71745
            769-1261            AC006581.16        79392-79884
            1262-2049           AC006581.16        81520-82307
            2050-2197           AC006581.16        82822-82969
            2198-2409           AC006581.16        83224-83435
            2410-2524           AC006581.16        84081-84195
            2525-2633           AC006581.16        85813-85921
            2634-2784           AC006581.16        86133-86283
            2785-3016           AC006581.16        86786-87017
            3017-5179           AC006581.16        88262-90424
FEATURES             Location/Qualifiers
     source          1..5179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..5179
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="polyhomeotic homolog 1"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
     exon            1..108
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            109..270
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3171
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="isoform a is encoded by transcript variant 2; early
                     development regulator 1 (homolog of polyhomeotic 1); early
                     development regulatory protein 1; polyhomeotic-like 1"
                     /codon_start=1
                     /product="polyhomeotic-like protein 1 isoform a"
                     /protein_id="NP_001400667.1"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
                     /translation="METESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQ
                     RQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNTSTTQQQTTTTQAS
                     INLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQ
                     VNRTLGRNVPLASQLILMPNGAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQ
                     GPQMQGSTQKAIPPGASPVSSLSQASSQALAVAQASSGATNQSLNLSQAGGGSGNSIP
                     GSMGPGGGGQAHGGLGQLPSSGMGGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESA
                     AAKKAEADGSGQQNVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQ
                     VVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQPQATTLTAPQP
                     PQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLSLPPDAAPKPPIPIQSKPPVAPIKPP
                     QLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLAAAVPTSRGMPGTVQSGQ
                     AHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKGGATTSSPVVAQVPAAFY
                     MQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVAESPKVMDEKSSLGEK
                     AESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMGDSKPPQAIVKPQILTHIIEG
                     FVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGGPLGVDSPSAELDKKANLL
                     KCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEANYARVRRR
                     GPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLG
                     NPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQAL
                     LLLKEEHLMSAMNIKLGPALKICAKINVLKET"
     exon            271..381
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            382..462
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            463..612
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            613..768
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1261
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..2049
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2197
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2409
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2524
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2633
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2784
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3016
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..5179
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5158..5163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="hexamer: AAGAAA"
     polyA_site      5179
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="major polyA site"
ORIGIN      
        1 aaatgctatc caaaggaagt tacattaggt tgctgctttg aaaatgaagt caactcctaa
       61 tgggttagct gtttctgcag cattctttcc cgccttcttg gagttgaggt cttgagtcag
      121 acagagcacc agccttgggg accctggacc actatcatgg agactgagag cgagcagaac
      181 tccaattcca ccaatgggag ttctagctca gggggcagct ctcggcccca gatagctcaa
      241 atgtcacttt atgaacgaca agcagtgcag gctctgcaag cactgcagcg gcagcccaat
      301 gcagctcagt atttccacca gttcatgctc cagcagcagc tcagtaatgc ccagctgcat
      361 agcctggctg ccgtccagca ggccacaatt gctgccagtc ggcaggccag ctccccaaac
      421 accagcacta cacagcagca gactaccacc acccaggcct cgatcaatct ggccaccaca
      481 tcggccgccc agctcatcag ccgatcccag agtgtgagct ctcccagtgc taccaccttg
      541 acccaatctg tgctactggg gaacaccacc tccccacccc tcaaccagtc tcaggcccag
      601 atgtatctac ggccacagct gggaaaccta ttgcaggtaa accgaaccct gggtcggaat
      661 gtgcctctag cctcccaact catcctgatg cctaatgggg cggtggctgc agtccagcag
      721 gaggtgccat ctgctcagtc tcctggagtt catgcagatg cagatcaggt tcagaacttg
      781 gcagtaagga atcaacaggc ctcagctcaa ggacctcaga tgcaaggctc cactcagaag
      841 gccattcctc caggagcctc ccctgtctct agcctctccc aggcctctag ccaggcccta
      901 gcggtggcac aggcttcctc tggggccaca aaccagtccc tcaaccttag tcaagctggt
      961 ggaggcagtg ggaatagcat cccagggtcc atgggtccag gtggaggtgg gcaggcacat
     1021 ggtggtttgg gtcagttgcc ttcctcagga atgggtggtg ggagctgtcc cagaaagggt
     1081 acaggagtgg tgcagccctt gcctgcagcc caaacagtga ctgtgagcca gggcagccag
     1141 acagaggcag aaagtgcagc agccaagaag gcagaagcag atgggagtgg ccagcagaat
     1201 gtgggcatga acctgacacg gacagccaca cctgcgccca gccagacact tattagctca
     1261 gccacctaca cacagatcca gccccattca ctgattcagc aacagcaaca gatccacctc
     1321 cagcagaaac aggtggtgat ccagcagcag attgccatcc accaccagca gcagttccag
     1381 caccggcagt cccagctcct tcacacagct acacacctcc agttggcgca gcagcagcag
     1441 cagcaacaac agcaacagca gcaacagcag cagccgcaag ccaccaccct cactgcccct
     1501 cagccaccac aggtcccacc tactcagcag gtcccacctt cccagtccca gcagcaagcc
     1561 caaaccctgg tcgttcagcc catgcttcag tcttcaccct tgtctcttcc acctgatgca
     1621 gcccctaagc caccaattcc catccaatcc aaaccacctg tagcacctat caagccgcct
     1681 cagttagggg ccgctaagat gtcagctgcc cagcaaccac caccccatat ccctgtgcaa
     1741 gttgtaggca ctcgacagcc aggtacagcc caggcacagg ctttggggtt ggcacagctg
     1801 gcagctgctg tacctacttc ccgggggatg ccaggtacag tgcagtctgg tcaggcccat
     1861 ttggcctcct cgccaccttc atcccaggct cctggtgcac tgcaggagtg ccctcccaca
     1921 ttggcccctg ggatgaccct tgctcctgtg caggggacag cacatgtggt aaagggtggg
     1981 gctaccacct cctcacctgt tgtagcccag gtccctgctg ccttctatat gcagtctgtg
     2041 cacttgccgg gtaaacccca gacattggct gtcaaacgca aggctgactc tgaggaggag
     2101 agagatgatg tctccacatt gggttcaatg cttcctgcca aggcatctcc agtagcagaa
     2161 agcccaaaag tcatggacga gaagagcagt cttggagaaa aagctgaatc agtggctaat
     2221 gtgaatgcta atactccaag cagtgaacta gtagccttga cccccgcccc ttcagtaccg
     2281 cctcctacac tagccatggt gtctagacaa atgggtgact caaaaccccc acaggccatc
     2341 gtgaagcccc agattctcac ccacatcatt gaaggctttg ttatccagga aggagcagaa
     2401 cctttcccgg tgggttgttc tcagttactg aaggagtctg agaagccact acagactggc
     2461 cttccgacag ggctgactga gaatcagtca ggtggccctt tgggagtgga cagcccatct
     2521 gctgagttag ataagaaggc gaatctcctg aagtgcgagt actgtgggaa gtacgccccc
     2581 gcagagcagt ttcgtggctc taagaggttc tgctccatga cttgcgctaa gaggtacaat
     2641 gtgagctgta gccatcagtt ccggctgaag aggaaaaaaa tgaaagagtt tcaagaagcc
     2701 aactatgctc gcgttcgcag gcgtggaccc cgccgcagct cctctgacat tgcccgtgcc
     2761 aagattcagg gcaagtgcca ccggggtcaa gaagactcta gccggggttc agataattcc
     2821 agttatgatg aagcactctc tccaacatct cctgggcctt tatcagtaag agctgggcat
     2881 ggagaacgtg acctggggaa tcccaataca gctccaccta caccggaatt acatggcatc
     2941 aaccctgtgt tcctgtccag taatcccagc cgttggagtg tagaggaggt gtacgagttt
     3001 attgcttctc tccaaggctg ccaagagatt gcagaggaat ttcgctcaca ggagattgat
     3061 ggacaggccc ttttattact taaagaagaa catcttatga gtgccatgaa catcaagctg
     3121 ggccctgccc tcaagatctg cgccaagata aatgtcctca aggagaccta aggtggccct
     3181 cttgcacaaa ccagcctaag gcagacactc tccactgtcc aggttataac ctggtaccag
     3241 cagactttgc agggaagaaa gagttgttcc aatcatgtaa ccttctgtag gggattactg
     3301 agacagggaa gagaagtgca agaattggtt gctggtgcta catggcggca gctttgacat
     3361 tttctctggg ttctacttta ttttttaaaa tctttacagt tctcaccatt tcacgtacct
     3421 taatccaatc tttataaaag aggcagtcta gagaactagg actgctcagc cttatcctgg
     3481 agtggagcat ttagcccagg tcttaattct ccaagaggag gaatacatag tatggtaagg
     3541 caaggaactg ggtggaatgt caggttgcct gcccaatggg agaggtaggg tttttctagc
     3601 ttgtgtgaca gaagtagcaa aatctggtcc tcccccctcc cagtgtagct gtggctcaga
     3661 gttttttctt tttgttgtca cttactccct tgtgattgaa ttttttctcc tgcatccatg
     3721 gcaggatccc cagccagtat agagacttgg ttggcatctt ctgctgcagg gactaaaagt
     3781 atttgactgg ggcacatgtg gctgttgtca ttctttctgc atcccactgt tcccctccaa
     3841 tttatgttat tttctaccct gtttttcagt tccatctctg ctctgtccta tagctttata
     3901 aaaccagagt gtgtggggct gaggtcagga gtataagtac ctgccttagg cactattcct
     3961 tatataacaa aaatattaaa tatttttttc ctcagtaaaa ggatgaaaat tggtttcagt
     4021 tgtcttactc tattccagtc tttgcccact ttcacacaaa tgacaaggcc aatatgtttt
     4081 gtttgttttt taatcattaa gagtttttgt acaaaaggtg atggtttttt ttcttcattt
     4141 taaaacacca gggtgtgggg gagggatgca aacaaataac aaaaaagatg cttttgtaac
     4201 attattttcc ctgtttagaa agaaaaaaat cactccaata gtattgaaaa gtccaaagat
     4261 gaaatagttt cattttcttt tcctaaggct tataaaaggc cccctgcctg ttgattccat
     4321 ccctcttttg tgtccagtgg agccatgtta ctcttcagtg gcccaggggt tcactattaa
     4381 agaaagatca gtccaggttt ctgggcacat ggcctaaaca ggaagatgga agcatcagag
     4441 gattaaaaac ctttccccac agaaatgtgg gcaagaagac acttccctga gccagcagaa
     4501 gggacaggtg cagcagcatt ccacacccag cgcagaggac agcagagccc tcgatgtccc
     4561 acttctgctt ccgttccctt tctagaagat tgaaaaaaag gtcaaaacca catgcctgtg
     4621 gagaaagtgc gacatgttta gaaatactgg tagggaacca ggagtaagaa aagctttacc
     4681 agcttttact acaaatggat gaaagacatc aggatcccac caccgcaagg taaagtgact
     4741 tcccttttct ggaacccctg tggcacagga gtaccaattt tcctttccaa cgaactggat
     4801 ttctggatag gcattttggc tgtatgtgga cagataagac cacagtcctt agcccaatcc
     4861 cagctataca gtcaccccaa tttccacaaa tgatgtgatg gtaccgtata atcctgtaat
     4921 tgggaaattt cacatttttc ctgtcctaat ctcagaggtg ggagaagcaa gtctagaaca
     4981 tctccaggct cagactaaac gagagtactt ggactgcaac caagtaatca ctgcaaagta
     5041 gttccaagca gcaagaaata ccagattctc atggaggcta ctatagggta cagaataaca
     5101 acatgaaagc aatcaaccct gtataaataa tgtttcttgg catttttttt ttaattaaag
     5161 aaatccagtg tctcaaaaa
//
