LOCUS       NM_001144831            1379 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens prohibitin 2 (PHB2), transcript variant 1, mRNA.
ACCESSION   NM_001144831 NM_007273
VERSION     NM_001144831.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Wu,H., Sun,C., Cao,W., Teng,Q., Ma,X., Schioth,H.B., Dong,R.,
            Zhang,Q. and Kong,B.
  TITLE     Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP
            inhibitor and promotes cellular senescence in ovarian cancer
  JOURNAL   Cancer Lett 602, 217192 (2024)
   PUBMED   39181433
  REMARK    GeneRIF: Blockade of the lncRNA-PART1-PHB2 axis confers resistance
            to PARP inhibitor and promotes cellular senescence in ovarian
            cancer.
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Zhang,B., Li,W., Cao,J., Zhou,Y. and Yuan,X.
  TITLE     Prohibitin 2: A key regulator of cell function
  JOURNAL   Life Sci 338, 122371 (2024)
   PUBMED   38142736
  REMARK    GeneRIF: Prohibitin 2: A key regulator of cell function.
            Review article
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Xu,L., Xiang,W., Yang,J., Gao,J., Wang,X., Meng,L., Ye,K.,
            Zhao,X.H., Zhang,X.D., Jin,L. and Ye,Y.
  TITLE     PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to
            regulate AKT signaling in gastric cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 17 (2024)
   PUBMED   38200519
  REMARK    GeneRIF: PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4
            to regulate AKT signaling in gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Deng,Y., Lou,T., Kong,L. and Liu,C.
  TITLE     Prohibitin2/PHB2, Transcriptionally Regulated by GABPA, Inhibits
            Cell Growth via PRKN/Parkin-dependent Mitophagy in Endometriosis
  JOURNAL   Reprod Sci 30 (12), 3629-3640 (2023)
   PUBMED   37587393
  REMARK    GeneRIF: Prohibitin2/PHB2, Transcriptionally Regulated by GABPA,
            Inhibits Cell Growth via PRKN/Parkin-dependent Mitophagy in
            Endometriosis.
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Liu,F., Zhang,Y., Guo,Z. and Ren,A.J.
  TITLE     The Role of Prohibitin-2 in Diseases
  JOURNAL   Front Biosci (Landmark Ed) 28 (9), 211 (2023)
   PUBMED   37796696
  REMARK    GeneRIF: The Role of Prohibitin-2 in Diseases.
            Review article
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Montano,M.M., Ekena,K., Delage-Mourroux,R., Chang,W., Martini,P.
            and Katzenellenbogen,B.S.
  TITLE     An estrogen receptor-selective coregulator that potentiates the
            effectiveness of antiestrogens and represses the activity of
            estrogens
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6947-6952 (1999)
   PUBMED   10359819
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Coates,P.J., Jamieson,D.J., Smart,K., Prescott,A.R. and Hall,P.A.
  TITLE     The prohibitin family of mitochondrial proteins regulate
            replicative lifespan
  JOURNAL   Curr Biol 7 (8), 607-610 (1997)
   PUBMED   9259555
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Ansari-Lari,M.A., Shen,Y., Muzny,D.M., Lee,W. and Gibbs,R.A.
  TITLE     Large-scale sequencing in human chromosome 12p13: experimental and
            computational gene structure determination
  JOURNAL   Genome Res 7 (3), 268-280 (1997)
   PUBMED   9074930
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Ansari-Lari,M.A., Muzny,D.M., Lu,J., Lu,F., Lilley,C.E., Spanos,S.,
            Malley,T. and Gibbs,R.A.
  TITLE     A gene-rich cluster between the CD4 and triosephosphate isomerase
            genes at human chromosome 12p13
  JOURNAL   Genome Res 6 (4), 314-326 (1996)
   PUBMED   8723724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC110322.1 and U47924.1.
            
            On May 17, 2019 this sequence version replaced NM_001144831.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110322.1, AF126021.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535923.6/ ENSP00000441875.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1354              BC110322.1         90-1443
            1355-1379           U47924.1           177336-177360       c
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1379
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /note="prohibitin 2"
                     /db_xref="GeneID:11331"
                     /db_xref="HGNC:HGNC:30306"
                     /db_xref="MIM:610704"
     exon            1..248
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1021
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell associated protein; repressor of estrogen receptor
                     activity; D-prohibitin; B-cell receptor-associated protein
                     BAP37; B cell receptor associated protein 37"
                     /codon_start=1
                     /product="prohibitin-2 isoform 1"
                     /protein_id="NP_001138303.1"
                     /db_xref="CCDS:CCDS53741.1"
                     /db_xref="GeneID:11331"
                     /db_xref="HGNC:HGNC:30306"
                     /db_xref="MIM:610704"
                     /translation="MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVE
                     GGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMV
                     NISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQV
                     SLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAK
                     QEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTAD
                     NLVLNLQDESFTRGSDSLIKGKK"
     exon            249..333
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            334..413
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            414..598
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            599..728
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            729..832
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            833..910
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            911..987
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            988..993
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1379
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /note="hexamer: AATAAA"
     polyA_site      1354
                     /gene="PHB2"
                     /gene_synonym="BAP; Bap37; BCAP37; hBAP; p22; PNAS-141;
                     REA"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgccag ccttacgggc ccgaaccctc gtgtgaaggg tgcagtacct aagccggagc
       61 ggggtagagg cgggccggca cccccttctg acctccagtg ccgccggcct caagatcaga
      121 catggcccag aacttgaagg acttggcggg acggctgccc gccgggcccc ggggcatggg
      181 cacggccctg aagctgttgc tgggggccgg cgccgtggcc tacggtgtgc gcgaatctgt
      241 gttcaccgtg gaaggcgggc acagagccat cttcttcaat cggatcggtg gagtgcagca
      301 ggacactatc ctggccgagg gccttcactt caggatccct tggttccagt accccattat
      361 ctatgacatt cgggccagac ctcgaaaaat ctcctcccct acaggctcca aagacctaca
      421 gatggtgaat atctccctgc gagtgttgtc tcgacccaat gctcaggagc ttcctagcat
      481 gtaccagcgc ctagggctgg actacgagga acgagtgttg ccgtccattg tcaacgaggt
      541 gctcaagagt gtggtggcca agttcaatgc ctcacagctg atcacccagc gggcccaggt
      601 atccctgttg atccgccggg agctgacaga gagggccaag gacttcagcc tcatcctgga
      661 tgatgtggcc atcacagagc tgagctttag ccgagagtac acagctgctg tagaagccaa
      721 acaagtggcc cagcaggagg cccagcgggc ccaattcttg gtagaaaaag caaagcagga
      781 acagcggcag aaaattgtgc aggccgaggg tgaggccgag gctgccaaga tgcttggaga
      841 agcactgagc aagaaccctg gctacatcaa acttcgcaag attcgagcag cccagaatat
      901 ctccaagacg atcgccacat cacagaatcg tatctatctc acagctgaca accttgtgct
      961 gaacctacag gatgaaagtt tcaccagggg aagtgacagc ctcatcaagg gtaagaaatg
     1021 agcctagtca ccaagaactc cacccccaga ggaagtggat ctgcttctcc agtttttgag
     1081 gagccagcca ggggtccagc acagccctac cccgccccag tatcatgcga tggtccccca
     1141 caccggttcc ctgaacccct cttggattaa ggaagactga agactagccc cttttctggg
     1201 gaattacttt cctcctccct gtgttaactg gggctgttgg ggacagtgcg tgatttctca
     1261 gtgatttcct acagtgttgt tccctccctc aaggctggga ggagataaac accaacccag
     1321 gaattctcaa taaattttta ttacttaacc tgaagtcaag gcttcacgtg ttcatgaac
//
