LOCUS       NM_002634               1834 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens prohibitin 1 (PHB1), transcript variant 2, mRNA.
ACCESSION   NM_002634
VERSION     NM_002634.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Huang,Z.J., Li,Y.J., Yang,J., Huang,L., Zhao,Q., Lu,Y.F., Hu,Y.,
            Zhang,W.X., Liang,J.Z., Pan,J., Pan,Y.L., He,Q.Y. and Wang,Y.
  TITLE     PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate
            Epithelial-Mesenchymal and Mitofusion-Fission Transitions in
            Colorectal Cancer
  JOURNAL   Int J Biol Sci 20 (6), 2202-2218 (2024)
   PUBMED   38617530
  REMARK    GeneRIF: PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate
            Epithelial-Mesenchymal and Mitofusion-Fission Transitions in
            Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Fan,W., Cao,D., Yang,B., Wang,J., Li,X., Kitka,D., Li,T.W.H.,
            You,S., Shiao,S., Gangi,A., Posadas,E., Di Vizio,D., Tomasi,M.L.,
            Seki,E., Mato,J.M., Yang,H. and Lu,S.C.
  TITLE     Hepatic prohibitin 1 and methionine adenosyltransferase alpha1
            defend against primary and secondary liver cancer metastasis
  JOURNAL   J Hepatol 80 (3), 443-453 (2024)
   PUBMED   38086446
  REMARK    GeneRIF: Hepatic prohibitin 1 and methionine adenosyltransferase
            alpha1 defend against primary and secondary liver cancer
            metastasis.
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Kersten,R., Trampert,D.C., Hubers,L.M., Tolenaars,D., Vos,H.R., van
            de Graaf,S.F.J. and Beuers,U.
  TITLE     Galectin-3 and prohibitin 1 are autoantigens in IgG4-related
            cholangitis without clear-cut protective effects against toxic bile
            acids
  JOURNAL   Front Immunol 14, 1251134 (2024)
   PUBMED   38332916
  REMARK    GeneRIF: Galectin-3 and prohibitin 1 are autoantigens in
            IgG4-related cholangitis without clear-cut protective effects
            against toxic bile acids.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Zhou,X., Li,Y., Liu,J., Lu,W., Liu,S., Li,J. and He,Q.
  TITLE     Pan-cancer Analysis Combined with Experiments Deciphers PHB
            Regulation for Breast Cancer Cell Survival and Predicts Biomarker
            Function
  JOURNAL   Comb Chem High Throughput Screen 27 (18), 2753-2763 (2024)
   PUBMED   37957856
  REMARK    GeneRIF: Pan-cancer Analysis Combined with Experiments Deciphers
            PHB Regulation for Breast Cancer Cell Survival and Predicts
            Biomarker Function.
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Theiss,A.L., Obertone,T.S., Merlin,D. and Sitaraman,S.V.
  TITLE     Interleukin-6 transcriptionally regulates prohibitin expression in
            intestinal epithelial cells
  JOURNAL   J Biol Chem 282 (17), 12804-12812 (2007)
   PUBMED   17324931
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Jupe,E.R., Badgett,A.A., Neas,B.R., Craft,M.A., Mitchell,D.S.,
            Resta,R., Mulvihill,J.J., Aston,C.E. and Thompson,L.F.
  TITLE     Single nucleotide polymorphism in prohibitin 3' untranslated region
            and breast-cancer susceptibility
  JOURNAL   Lancet 357 (9268), 1588-1589 (2001)
   PUBMED   11377649
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Altus,M.S., Wood,C.M., Stewart,D.A., Roskams,A.J., Friedman,V.,
            Henderson,T., Owens,G.A., Danner,D.B., Jupe,E.R., Dell'Orco,R.T. et
            al.
  TITLE     Regions of evolutionary conservation between the rat and human
            prohibitin-encoding genes
  JOURNAL   Gene 158 (2), 291-294 (1995)
   PUBMED   7607556
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Jupe,E.R., Liu,X.T., Kiehlbauch,J.L., McClung,J.K. and
            Dell'Orco,R.T.
  TITLE     Prohibitin antiproliferative activity and lack of heterozygosity in
            immortalized cell lines
  JOURNAL   Exp Cell Res 218 (2), 577-580 (1995)
   PUBMED   7796893
REFERENCE   9  (bases 1 to 1834)
  AUTHORS   Sato,T., Saito,H., Swensen,J., Olifant,A., Wood,C., Danner,D.,
            Sakamoto,T., Takita,K., Kasumi,F., Miki,Y. et al.
  TITLE     The human prohibitin gene located on chromosome 17q21 is mutated in
            sporadic breast cancer
  JOURNAL   Cancer Res 52 (6), 1643-1646 (1992)
   PUBMED   1540973
REFERENCE   10 (bases 1 to 1834)
  AUTHORS   White,J.J., Ledbetter,D.H., Eddy,R.L. Jr., Shows,T.B.,
            Stewart,D.A., Nuell,M.J., Friedman,V., Wood,C.M., Owens,G.A.,
            McClung,J.K. et al.
  TITLE     Assignment of the human prohibitin gene (PHB) to chromosome 17 and
            identification of a DNA polymorphism
  JOURNAL   Genomics 11 (1), 228-230 (1991)
   PUBMED   1684951
  REMARK    Erratum:[Genomics 1991 Nov;11(3):782]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091180.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002634.3.
            
            Summary: This gene is evolutionarily conserved, and its product is
            proposed to play a role in human cellular senescence and tumor
            suppression. Antiproliferative activity is reported to be localized
            to the 3' UTR, which is proposed to function as a trans-acting
            regulatory RNA. Several pseudogenes of this gene have been
            identified. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.231733.1,
                                           SRR1803617.166476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152798 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300408.8/ ENSP00000300408.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC091180.20        121921-121968       c
            49-163              AC091180.20        120263-120377       c
            164-325             AC091180.20        118764-118925       c
            326-468             AC091180.20        116417-116559       c
            469-585             AC091180.20        116128-116244       c
            586-681             AC091180.20        113845-113940       c
            682-1834            AC091180.20        111138-112290       c
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..1834
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /note="prohibitin 1"
                     /db_xref="GeneID:5245"
                     /db_xref="HGNC:HGNC:8912"
                     /db_xref="MIM:176705"
     exon            1..48
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     exon            49..163
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..894
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /note="isoform 1 is encoded by transcript variant 2;
                     epididymis luminal protein 215; epididymis secretory sperm
                     binding protein Li 54e; prohibitin"
                     /codon_start=1
                     /product="prohibitin 1 isoform 1"
                     /protein_id="NP_002625.1"
                     /db_xref="CCDS:CCDS11548.1"
                     /db_xref="GeneID:5245"
                     /db_xref="HGNC:HGNC:8912"
                     /db_xref="MIM:176705"
                     /translation="MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRG
                     VQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQ
                     LPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT
                     FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDS
                     KAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ"
     exon            164..325
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     exon            326..468
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     exon            469..585
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     exon            586..681
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1834
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1022..1027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /note="hexamer: AATAAA"
     polyA_site      1051
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /note="major polyA site"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /note="hexamer: AATAAA"
     polyA_site      1834
                     /gene="PHB1"
                     /gene_synonym="BAP32; HEL-215; HEL-S-54e; PHB"
                     /note="major polyA site"
ORIGIN      
        1 gcagtatgtg tggttgggga attcatgtgg aggtcagagt ggaagcaggt gtgagagggt
       61 ccagcagaag gaaacatggc tgccaaagtg tttgagtcca ttggcaagtt tggcctggcc
      121 ttagctgttg caggaggcgt ggtgaactct gccttatata atgtggatgc tgggcacaga
      181 gctgtcatct ttgaccgatt ccgtggagtg caggacattg tggtagggga agggactcat
      241 tttctcatcc cgtgggtaca gaaaccaatt atctttgact gccgttctcg accacgtaat
      301 gtgccagtca tcactggtag caaagattta cagaatgtca acatcacact gcgcatcctc
      361 ttccggcctg tcgccagcca gcttcctcgc atcttcacca gcatcggaga ggactatgat
      421 gagcgtgtgc tgccgtccat cacaactgag atcctcaagt cagtggtggc tcgctttgat
      481 gctggagaac taatcaccca gagagagctg gtctccaggc aggtgagcga cgaccttaca
      541 gagcgagccg ccacctttgg gctcatcctg gatgacgtgt ccttgacaca tctgaccttc
      601 gggaaggagt tcacagaagc ggtggaagcc aaacaggtgg ctcagcagga agcagagagg
      661 gccagatttg tggtggaaaa ggctgagcaa cagaaaaagg cggccatcat ctctgctgag
      721 ggcgactcca aggcagctga gctgattgcc aactcactgg ccactgcagg ggatggcctg
      781 atcgagctgc gcaagctgga agctgcagag gacatcgcgt accagctctc acgctctcgg
      841 aacatcacct acctgccagc ggggcagtcc gtgctcctcc agctgcccca gtgagggccc
      901 accctgcctg cacctccgcg ggctgactgg gccacagccc cgatgattct taacacagcc
      961 ttccttctgc tcccacccca gaaatcactg tgaaatttca tgattggctt aaagtgaagg
     1021 aaataaaggt aaaatcactt cagatctcta attagtctat caaatgaaac tctttcattc
     1081 ttctcacatc catctacttt tttatccacc tccctaccaa aaattgccaa gtgcctatgc
     1141 aaaccagctt taggtcccaa ttcggggcct gctggagttc cggcctgggc accagcattt
     1201 ggcagcacgc aggcggggca gtatgtgatg gactggggag cacaggtgtc tgcctagatc
     1261 cacgtgtggc ctccgtcctg tcactgatgg aaggtttgcg gatgagggca tgtgcggctg
     1321 aactgagaag gcaggcctcc gtcttcccag cggttcctgt gcagatgctg ctgaagagag
     1381 gtgccgggga ggggcagaga ggaagtggtc tgtctgttac cataagtctg attctcttta
     1441 actgtgtgac cagcggaaac aggtgtgtgt gaactgggca cagattgaag aatctgcccc
     1501 tgttgaggtg ggtgggcctg actgttgccc cccagggtcc taaaacttgg atggacttgt
     1561 atagtgagag aggaggcctg gaccgagatg tgagtcctgt tgaagacttc ctctctaccc
     1621 cccaccttgg tccctctcag atacccagtg gaattccaac ttgaaggatt gcatcctgct
     1681 ggggctgaac atgcctgcca aagacgtgtc cgacctacgt tcctggcccc ctcattcaga
     1741 gactgccctt ctcacgggct ctatgcctgc actgggaagg aaacaaatgt gtataaactg
     1801 ctgtcaataa atgacaccca gaccttccgg ctca
//
