LOCUS       NM_001048183            6048 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phosphatase and actin regulator 4 (PHACTR4),
            transcript variant 1, mRNA.
ACCESSION   NM_001048183
VERSION     NM_001048183.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6048)
  AUTHORS   Yu,B., Meng,M., Li,T. and Shi,Y.
  TITLE     Identification of PHACTR4 as A New Biomarker for Diabetic
            Nephropathy and Its Correlation with Glomerular Endothelial
            Dysfunction and Immune Infiltration
  JOURNAL   Iran J Kidney Dis 17 (6), 314-326 (2023)
   PUBMED   38043109
  REMARK    GeneRIF: Identification of PHACTR4 as A New Biomarker for Diabetic
            Nephropathy and Its Correlation with Glomerular Endothelial
            Dysfunction and Immune Infiltration.
REFERENCE   2  (bases 1 to 6048)
  AUTHORS   Solimini,N.L., Liang,A.C., Xu,C., Pavlova,N.N., Xu,Q., Davoli,T.,
            Li,M.Z., Wong,K.K. and Elledge,S.J.
  TITLE     STOP gene Phactr4 is a tumor suppressor
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), E407-E414 (2013)
   PUBMED   23319639
  REMARK    GeneRIF: Data indicate that Phactr4 acts as a tumor suppressor that
            is deleted and mutant in several cancers.
REFERENCE   3  (bases 1 to 6048)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   4  (bases 1 to 6048)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
  REMARK    GeneRIF: The authors show that rat Phactr1 inhibits PP1 activity in
            vitro, and mouse Phactr4 coimmunoprecipitates with actin and PP1 in
            human cells.
REFERENCE   5  (bases 1 to 6048)
  AUTHORS   Sagara,J., Higuchi,T., Hattori,Y., Moriya,M., Sarvotham,H.,
            Shima,H., Shirato,H., Kikuchi,K. and Taniguchi,S.
  TITLE     Scapinin, a putative protein phosphatase-1 regulatory subunit
            associated with the nuclear nonchromatin structure
  JOURNAL   J Biol Chem 278 (46), 45611-45619 (2003)
   PUBMED   12925532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL670471.4 and CR391992.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001048183.2.
            
            Summary: This gene encodes a member of the phosphatase and actin
            regulator (PHACTR) family. Other PHACTR family members have been
            shown to inhibit protein phosphatase 1 (PP1) activity, and the
            homolog of this gene in the mouse has been shown to interact with
            actin and PP1. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.Variants 1
            and 5 encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749449.1, BC029266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373839.8/ ENSP00000362945.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL670471.4         47183-47268         c
            87-140              AL670471.4         9545-9598           c
            141-314             CR391992.6         9458-9631
            315-395             CR391992.6         10585-10665
            396-560             CR391992.6         16058-16222
            561-947             CR391992.6         16755-17141
            948-1545            CR391992.6         23927-24524
            1546-1730           CR391992.6         26480-26664
            1731-1884           CR391992.6         30824-30977
            1885-1940           CR391992.6         39543-39598
            1941-2002           CR391992.6         41324-41385
            2003-2140           CR391992.6         42023-42160
            2141-2217           CR391992.6         43388-43464
            2218-6048           CR391992.6         46907-50737
FEATURES             Location/Qualifiers
     source          1..6048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..6048
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /note="phosphatase and actin regulator 4"
                     /db_xref="GeneID:65979"
                     /db_xref="HGNC:HGNC:25793"
                     /db_xref="MIM:608726"
     exon            1..86
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            87..140
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2233
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 1, regulatory subunit 124"
                     /codon_start=1
                     /product="phosphatase and actin regulator 4 isoform 1"
                     /protein_id="NP_001041648.1"
                     /db_xref="CCDS:CCDS41293.1"
                     /db_xref="GeneID:65979"
                     /db_xref="HGNC:HGNC:25793"
                     /db_xref="MIM:608726"
                     /translation="MEDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIF
                     KPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAM
                     LKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVP
                     ENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLA
                     KTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAE
                     LSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSEL
                     LPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKK
                     EVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSD
                     SFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLRE
                     EEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSW
                     PCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLT
                     RKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEF
                     KSSEMEVHEESKHFTRYHRP"
     exon            141..314
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            315..395
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            396..560
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            561..947
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1545
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1730
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1884
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1940
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2002
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2140
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2217
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..6048
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5974..5979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /note="hexamer: AATAAA"
     polyA_site      5992
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
     regulatory      6019..6024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /note="hexamer: ATTAAA"
     polyA_site      6048
                     /gene="PHACTR4"
                     /gene_synonym="PPP1R124"
                     /note="major polyA site"
ORIGIN      
        1 cggctgctgc ctggcggcca acgggccagg taggatttcc gggagaggct gctgtggagg
       61 ctgaggaggc ggcggcggag atctggaaac agtatctcac ctccctaaac tggttaatag
      121 tggcatggaa gatccatttg aggaagcaga ccagcccact acagagccag gcatggtcct
      181 ggacagtgtg gaagcaggag acacaacacc tcctaccaaa aggaagagca agttctcagg
      241 ctttggcaag atcttcaagc cctggaaatg gaggaaaaaa aaaagtagtg ataaatttaa
      301 agagacttca gaagttttag aacggaaaat atctatgcga aagccaagag aagagctggt
      361 taaaagaggg gttctgttgg aagaccctga gcaaggtggt gaggatccag gaaagccaag
      421 cgatgccatg ttaaagaatg gccataccac ccccataggg aatgccagat catctagtcc
      481 agtccaagta gaggaagagc cagtaagatt agcaagtctt aggaaagcta ttccagaaga
      541 ggacctaaag aaacgactag gctcaactgg aagccagcct aattctgaag cagagtctgt
      601 tcctgagaat gtacccaaac cacctttact tcctcccaaa agacccttgt cctcttctca
      661 tgaagcaagt gaagggcaag caaaggatgc cacttcctct ggcggcacgg caaggttcat
      721 catctccacc tccatcacca cagcacccgc tgccaccact gctgccacaa gccttgcaaa
      781 gactgttaat ctctctgtca ccccttcccc agcacccagg actctgcctg ctgctcctgc
      841 cagcactaac actactgcta ccccaagcct cactcatatg gtccctgcca agcagccccc
      901 tatccctccc cctaaaccag ctcacagaaa tagcaaccct gtcattgctg aactgtccca
      961 agcaataaac agtggtacat tgttatcaaa accgtcccca cccttaccac ctaagagagg
     1021 cattccatca acctcagtac ccaccttgga gtctgctgct gccatcacca caaaaacacc
     1081 aagtgatgaa agagagaaga gcacgtgttc tatgggctcg gaactactac caatgatctc
     1141 acctcgctct ccgtcccccc cactgcctac tcatatacct ccagagcctc cacgcacccc
     1201 tccattccct gctaagactt ttcaagttgt gccagaaatt gagtttccac catccttaga
     1261 tctacaccag gagattcccc agcaggaaga tcagaaaaag gaagtcccca agaggatact
     1321 ggaccagaac tttggggagc cccatatacc ctctaggctg cctccactcc cactgcatat
     1381 tcgaatccag caggccctca ccagcccact tcccatgact cctattctgg agggttctca
     1441 cagagctcat tcgttgcttt ttgaaaacag tgacagcttt tctgaggaca gcagtacgct
     1501 gggtcggacc aggtctcttc ccatcactat tgaaatgcta aaagttccag acgatgaaga
     1561 agaagaggag caaacctgtc catccacatt cagtgaagaa atgacaccta cctcagtcat
     1621 tcctaaatta ccacagtgtc tacgggagga agaagagaag gagagcgact ctgattcaga
     1681 aggtcccatt cagtaccgag atgaagaaga tgaagatgaa agctatcaga gtgctctcgc
     1741 caacaaagtg aagaggaaag acacactggc aatgaagttg aaccacagac ccagtgaacc
     1801 agagttgaac ctgaattctt ggccttgtaa aagcaaggag gagtggaatg aaatacggca
     1861 ccagattgga aacacactga tccggcgact gagtcaaaga ccaacaccag aagaactaga
     1921 acaacgcaat atattgcaac ctaaaaatga agctgatcgt caggcagaaa aacgagaaat
     1981 taaacgtcgg ctcactagaa agctcagtca aaggccaact gtcgctgaac tccttgccag
     2041 gaagattctg aggtttaatg aatatgtaga ggtaacagat gctcaagatt atgaccggcg
     2101 agccgacaaa ccttggacca aactgacccc tgctgacaag gctgccataa gaaaagaatt
     2161 aaatgaattt aaaagctccg agatggaggt tcatgaagag agcaaacatt ttacacgcta
     2221 ccatcgtcca tgatgccaaa ggttgagaga ggaatcaaca tggctgcttt gctgcttcct
     2281 tctccaaagt gacatatgga gggaacttta gcacttccca gcacagccag aattgcatcc
     2341 tctgggatct tctgaggtgg acagcacttt gaatgtagca tttcactgga acagagtctt
     2401 atgtgctgca ccgggggcaa aacaacactt tgtcagtgct tttgaacctt tcaatattgt
     2461 agcatgcttg aggagttttt cccttactgg ccaccaaagt tctgaaccac ttgcaggttc
     2521 caggttttac tggctgcacc acaccccttc ccctagatga ctgcctgtgc agagacacag
     2581 tttgcaccat tagccttacc tgccctgccc tgattgtgag acccaaatgt gtaggctcta
     2641 aattccagcc atcaaatcca attcctggtg gggaaaacct tctggagacc cccaaccttc
     2701 tgataaaaga gtctctacct ccagggaaag ccttcttacc acactggcat atcagatgaa
     2761 agcattgcac tgtacctctc gtaacacagc aatacagtcc tcttgaggca ctcaagcctg
     2821 agaggaagct caggatctga catgttcttc cttttcctca caagtcatca tgatttttta
     2881 ttttaaaata atctggaagt aatgggaact tagtttttcc tgaactccaa ccagaatcca
     2941 aattggttag atgaggccag gcgcggtggc tcacgcctgt aatcccagca ctttgggagg
     3001 ccgaggtggg tggatcacct gaggtcagga gttcaagacc agcctggcca acatggtgaa
     3061 accccatctc tactaaaaat acaaaaatta gccaggtgtg gtggcgcctg gttgaggcat
     3121 gagaatcgct tgaacccagg aggtggaggt tgcagtgagc caagatcatg cctactgcac
     3181 tccagcctgg gcaacaaagt gggactctgt cttaaaaaaa aaaaaaaaaa aaaaatcggt
     3241 tagatgagaa agcatgtata ttttctatat acaaaaacaa gaaaggcgtt ttgagcccct
     3301 gtgctcaggc ccactcccac actgtggagt gtactttcat tttcaataaa tccccttatt
     3361 ccttccttgc aaaaaaaaaa aaaaaaaaag ccttagccag attcagtggc tcacgcctgt
     3421 aatcccaaca ctttgggagg ctgaggcggg tggatcacct gagttcagga gttcaagacc
     3481 agcctggcca acatggcaaa accctgtctc tactaaaaag taaaaaaaat tagccgggca
     3541 tggtggcttg tgccttgtag tcccagccac tggggaggct gaggcgggag aattgcttga
     3601 acctgggagg tggagattgc agtgagccga gatcgcgcca ctgcactcca gcctgggtga
     3661 cagagcgaga ctccgtctca aaaaaaaaaa aaaagcctta atattaatgc taacgtggca
     3721 gaaaactagc aggttacatt ttataggcta ttgtagtttt atttaccaaa tgatattctc
     3781 taaatcactt cgaccaataa atgtattctc ctccttaaag cagagttgta tcaactctgt
     3841 gggagcattt atgagctgtc agtccccaca cttctagcca gaatcacaat aaggtctggc
     3901 tgggtgtggg gtgctgcata ggaaagggtc tctggagaag caagaagggc acaatcatgg
     3961 cccactgctc ccctcttctt ctcagtgctc tttgccctct cctgctgcgt gcttcctctt
     4021 cactccagtg ctgatcctcc tgctctctct ggcagcttcc acctcacccg cccctcttcc
     4081 acactataac cagtatggtt ggtgctgggg cattgactca gcccccctgc tttctgcatt
     4141 tgtaatagat attaatatga tttcctaaaa cagaagattt tgttgctttc tttgaacttg
     4201 tattgaaaac catacagtct cactgttttg ctttaattcc tatccacact ataaatggaa
     4261 gaaaaaaatt aatagcttct gtttaatctg atgaatgtgg ctttttttcc cttcacttta
     4321 atgttcaaga agttgtggct atttcataga tttcttctga tttattctgt gggtccctgt
     4381 tatctgttct ttatgtaatc tttcagtaga ttttcatcct ttcatatcca cattcttatg
     4441 tggacttgct gaagaaacag aatatcagtt caaaacaaaa cctaggccag gcatggtggt
     4501 tcacgcctat aatctcagca ctttgggaag ccaaggcggt caggagtttg agaccagcct
     4561 gaccaacatg atgaaaccct gtctctacta aaaatacaaa aattagcctg gcgtggtggc
     4621 acgcatctgt aatcccaact actcaggacg ctgaggcagg agagtcgctt gaacccagga
     4681 ggcggagatt gcagtgagcc aagattgcac cactgcactc cagcctgggc aacagagcga
     4741 gactccatca aaaaaaaaaa aaaaaaagaa ggaaggaagg aaagcaagcc ctgaatccac
     4801 atctccttga agtttttttt gttttatttt gtttttgaga cagaattttg ctcttgttgc
     4861 ccaggccgga gtgcaatggt gcaatctcag ctcactgcaa cctccgcctc ccgggttgag
     4921 gcgattctcc tacctcagcc tcccaagtag ctaggattac aggcatgagc caccacgcct
     4981 ggctaatttt atatttctag tagagatgag gtttctccat gttggtcagg ctggtctcaa
     5041 actcccgacc tcaggtgatc cacccacctc agcctcccaa agtggtggga ttacaggcat
     5101 gagccaccgt gccgagcctt ccttgaagtt ttttgtttgg ttttgatttg ttttgttttg
     5161 ttttgttttg ttttgttttt ggagataggg tctcactctg ttacccatgc tggagtgcag
     5221 tggcacaatc ttggctcaga gcaacctctg cctcccaggc tcaagcaatc ctcccacttc
     5281 agtctaagta gctgggacta caggcacgtg ccaccaggcc cagctaattt ttgtgttttg
     5341 ttagagatga ggttttgcca tattgcccag gctcgtcttg aacaccgggg ctcaaggaat
     5401 ctgcccatct tcgcctccca aagttctgag atagcaggtg tgagtcatca tgcccagcct
     5461 ccttgaagtt tactaacaat tgggataact gagggaagag aagtgacaat tccactcagt
     5521 ctattagagg tctggatata aggtagccac acaataactc taacttgact tctaaccatt
     5581 ctatcttatt gatttggagg ctgtcttctg ccagattttt tgtggcttga gatgatattt
     5641 tcgaaccctt ctttcactac ctttcttacc cttaatgtgc caagcttgaa acaggatttg
     5701 atttcctgag ctacttgttc gccttctgtg cgtcaccaag taatctggtt catctttcgt
     5761 ctcattcatg ttattttcaa gtgaaacaag acattttggg ggtcaagtct ctttgggtgt
     5821 tttgttttta tgtatataaa aatggatttt gtgttccctt tccatgtaag taccaactta
     5881 tatggaaact cacaatcata atgtaaagaa gaaatgaaag cctggtgtat tgtacttcaa
     5941 gatgcctccc tgatgtatag aatctccttg taaaataaat aattgcattg tatatcagtc
     6001 ttctcatcaa tattaattat taaatatttt agaattttta aataccaa
//
