LOCUS       NM_001100164            9633 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens phosphatase and actin regulator 2 (PHACTR2),
            transcript variant 1, mRNA.
ACCESSION   NM_001100164
VERSION     NM_001100164.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9633)
  AUTHORS   Shi,Q., Shi,Q.N., Xu,J.W., Wang,H.Y., Li,Y.J., Zhang,X.X., Fu,Y.H.,
            Tian,R.H., Jiang,R., Liu,C.C. and Sun,C.
  TITLE     rs9390123 and rs9399451 influence the DNA repair capacity of lung
            cancer by regulating PEX3 and PHACTR2-AS1 expression instead of
            PHACTR2
  JOURNAL   Oncol Rep 47 (3) (2022)
   PUBMED   35059740
  REMARK    GeneRIF: rs9390123 and rs9399451 influence the DNA repair capacity
            of lung cancer by regulating PEX3 and PHACTR2AS1 expression instead
            of PHACTR2.
REFERENCE   2  (bases 1 to 9633)
  AUTHORS   Lou,G., Zhang,Y., Bao,W. and Deng,D.
  TITLE     Association between polymorphisms in CHRNA3 and PHACTR2 gene and
            environment and NSCLC risk in Chinese population
  JOURNAL   Acta Biochim Pol 61 (4), 765-768 (2014)
   PUBMED   25399010
  REMARK    GeneRIF: The frequencies of genotype and allele in CHRNA3
            (rs8040868) and PHACTR2 (rs9390123) were not significantly
            different between the NSCLC cases and controls, or between either
            of the subgroups.
REFERENCE   3  (bases 1 to 9633)
  AUTHORS   Wang,L.E., Gorlova,O.Y., Ying,J., Qiao,Y., Weng,S.F., Lee,A.T.,
            Gregersen,P.K., Spitz,M.R., Amos,C.I. and Wei,Q.
  TITLE     Genome-wide association study reveals novel genetic determinants of
            DNA repair capacity in lung cancer
  JOURNAL   Cancer Res 73 (1), 256-264 (2013)
   PUBMED   23108145
REFERENCE   4  (bases 1 to 9633)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 9633)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 9633)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9633)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
  REMARK    GeneRIF: identified an association between Phactr2 SNP rs11155313
            and Parkinson's disease in US, Canadian and Irish patient
            populations, but not in a Norwegian population
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 9633)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   9  (bases 1 to 9633)
  AUTHORS   Kim,Y.C., Jung,Y.C., Xuan,Z., Dong,H., Zhang,M.Q. and Wang,S.M.
  TITLE     Pan-genome isolation of low abundance transcripts using SAGE tag
  JOURNAL   FEBS Lett 580 (28-29), 6721-6729 (2006)
   PUBMED   17113583
REFERENCE   10 (bases 1 to 9633)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC361499.1, CN361694.1, AB014580.1, AL049844.7 and DR980875.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001100164.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298263.1, SRR7346977.1595058.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440869.7/ ENSP00000417038.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DC361499.1         1-56
            57-794              CN361694.1         3-740
            795-4503            AB014580.1         610-4318
            4504-9526           AL049844.7         8007-13029
            9527-9633           DR980875.1         99-205
FEATURES             Location/Qualifiers
     source          1..9633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..9633
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:9749"
                     /db_xref="HGNC:HGNC:20956"
                     /db_xref="MIM:608724"
     exon            1..245
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2137
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 1"
                     /protein_id="NP_001093634.1"
                     /db_xref="CCDS:CCDS47493.1"
                     /db_xref="GeneID:9749"
                     /db_xref="HGNC:HGNC:20956"
                     /db_xref="MIM:608724"
                     /translation="MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGK
                     LSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDV
                     TVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKENTENHSET
                     PAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGASHKGDEVPPIKKNTKAPGKQAPVP
                     PPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTK
                     GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM
                     VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTN
                     RTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQ
                     ANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNI
                     LQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRL
                     SRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNE
                     FKSTEMEVHEESRQFTRFHRP"
     exon            246..413
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            414..494
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            495..653
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            654..893
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1431
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1631
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1788
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1844
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1906
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2044
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2121
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..9633
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3588..3593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /note="hexamer: ATTAAA"
     polyA_site      3616
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
     regulatory      9254..9259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /note="hexamer: AATAAA"
     polyA_site      9277
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /note="major polyA site"
     regulatory      9613..9618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
                     /note="hexamer: AATAAA"
     polyA_site      9633
                     /gene="PHACTR2"
                     /gene_synonym="C6orf56"
ORIGIN      
        1 atccgctggg caggatccgc cgcgccggct gcggccggcc gggctgggag acccgcgcgg
       61 ggtagaaggt gaggggaccc ggcgggccgc tcggcacagg ccgggacatg aacgcctgga
      121 agtctggctg ggagcggacc catgatcgaa ggaccaaagg agccgcttga tcgctggacc
      181 tggccctgcg accccagtca tgggccagac ctcggtgtcc acgctgtccc cgcagcccgg
      241 cagcgttgac ggactggaca aagcttctat agcaaactca gatggcccca cagcaggttc
      301 ccaaacacct cccttcaaaa gaaaggggaa actatccacc attggtaaaa tctttaagcc
      361 ttggaaatgg aggaaaaaga agaccagcga caaatttaga gaaacctcgg cagtattaga
      421 aaggaagata tccacacgac aaagtagaga ggagctgata agaaggggag tgcttaagga
      481 attgcctgat caagatggag atgtaacagt taactttgaa aattcaaacg ggcacatgat
      541 acccatcgga gaggaatcta cccgagagga aaatgtagta aagtctgaag aaggtaatgg
      601 ctctgtatct gaaaaaacac cacctctgga ggaacaggca gaagataaga aagagaacac
      661 tgaaaaccac tctgaaacac cggcagctcc tgctctacct ccttctgctc ctcctaagcc
      721 tagacccaaa cctaaaccca aaaaatcacc tgtgcctccg aaaggggcca ctgctggggc
      781 cagccacaaa ggtgatgaag tgcctcccat taaaaaaaat accaaggctc ctggtaagca
      841 ggcccccgtc cctccaccca agccagcaag ccgaaacacg acccgagagg ctgctggctc
      901 ctctcattca aaaaaaacaa ctggctctaa agcatcagct tcgccatcca cttcatccac
      961 ctcatctcgt cccaaagctt caaaggagac agtttctagc aaagcaggga cagtggggac
     1021 caccaagggc aagagaaaaa ctgacaagca gccaataact tctcacctgt cctcagacac
     1081 aacaacttct ggcacatccg acctgaaagg agagcctgca gagaccagag tggagagttt
     1141 caaactcgaa cagactgtcc ctggagctga ggagcagaac acaggcaaat tcaagtccat
     1201 ggtccctcca ccccctgtgg ctccagcacc ttctcctctg gccccccctc tccctcttga
     1261 ggatcagtgc attactgcct cagacactcc agttgtcctc gtcagcgttg gagctgacct
     1321 gcccgtctct gccttagacc caagtcagct tctttgggct gaagagccga cgaacagaac
     1381 cactctctac tcaggcactg gcttaagtgt taacagagaa aatgcaaaat gtttcacaac
     1441 caaagaggag ctggggaaga cagtgcctca gctactgact cctgggctga tgggcgaatc
     1501 ttcagaatcc tttagtgcct cagaagatga aggccacagg gaataccaag ccaatgactc
     1561 tgactcggac gggcctatct tgtacaccga tgatgaggac gaagacgaag atgaggatgg
     1621 cagtggagaa agtgctttgg caagtaaaat acgccggagg gatactcttg ctatcaaact
     1681 tggcaacaga ccatctaaga aagaactaga ggacaaaaac atcttgcagc gtacatctga
     1741 agaagagagg caggaaatcc gacaacaaat tggaaccaag ttagtcagga ggctgagcca
     1801 gaggcccaca actgaagaat tagagcaaag aaacatccta aaacaaaaga atgaagaaga
     1861 ggaacaagaa gcaaaaatgg aacttaaacg cagactcagc agaaagctca gcctgagacc
     1921 cacagtggca gagctacaag ctcgaaggat cctgcgattt aacgagtatg tagaagtcac
     1981 ggattctcct gactatgacc gccgagcaga caagccctgg gccaggttaa cacctgcaga
     2041 caaggcagca ataaggaaag aactaaatga atttaaaagc acagaaatgg aagttcatga
     2101 agagagtcga cagtttacaa ggtttcatcg tccataacga agagtgagac tatttggaaa
     2161 cagagactga tcatctttgg gggaagccct gcttcctgaa aacctgatat tgcactggga
     2221 tttgaatgtg tgtgtttccg tttaacttgt ggtgaaggaa gtgtgtgact cagcttggct
     2281 gggaagtgct cctcacctgt gtggcccaga tggctccaac aagcaaaagg aaggatgcag
     2341 tgactcttgc tgcccagaat gcacagcgat ggtaagagac accgtggata ttcttcatca
     2401 gaagctttaa tcaaagaaga tgagcagaag acaatcactg gctccctgtt accagaaagc
     2461 caaattttat aatgcgggtg aaagaaaaat atagattaaa attgctgggc actgaaaagg
     2521 ggtgggagtt ggaaatcaga aagaaagaga aatatttcat tatgttaatg aagaaaagag
     2581 aaaattgaag cataaatgta tttttgaagt agttattcgg tagctgagaa cttattaagg
     2641 gatttaggaa tttaacctcc tgatgtggat tcctcaaaga cttgatcgga gaatactctt
     2701 gtttcaccat tatgttggta cagtatagta ccattatttt atgttgtgcc agtgaatcca
     2761 gttgccagaa ataagtctga atgttttcat gcatcttttt cttaaatgca agagcttcta
     2821 ctgactctta acaagcatgc ttacccaaat tttgttgcat gcttttaagt agcattagct
     2881 atgcacactt gacattttta aatatccctt tcctagtgta ccagccttca caggataaga
     2941 ggactgggaa taaagtcaga tgtaatgtga ccctagaaaa ctgtagcaag cttcagaaat
     3001 aaatcttttg atctttccct atcttgatta gatccaaagt caaagcaacc atacttcacc
     3061 tagagaagac agtattggca atcatgacac ctgtaataaa aacttgaatc caaagtcaaa
     3121 acttaagcaa gatacaaatg tgctgcctgc agttagtcct gcatgggaat aaggactagt
     3181 tattttttta gtgctgcatt tttttaaagt tggattgctg ctatttaaaa aaaaaaaaag
     3241 gacacagatc aaaaaaacac ccaaaggctt aacagaacat ggaaagttcc cactaagttg
     3301 tgtgtgagga aatcctcatc ttgtatttta agaatctgca gatggcatcc atagatacag
     3361 tacagtattt actgtcaatg caaaagaatc agtgaggtta aagtagtgga agttttccct
     3421 atgagcctac agtctgtatt gtttacatta agaaactctc tattattgtg ttgctatttt
     3481 ccatggagtc acaggcacac tatgacttct gctcccaaat acatatgacc atatgtaaat
     3541 accaccttgc atttcattgt tcttcacaag tgctttgtgc ccctttaatt aaaaacacat
     3601 gaaatgaata acaaaacaag acccaaatag agtttatttt attctcagag tttggactac
     3661 aattttctaa gatgtttctg gttcaagact gtcattttct atttcaaccg aaaagtaagc
     3721 atttaacccg gtgaataaat gtagatcctg ccattcattg gtattttaaa gaaccacttg
     3781 aaatcggatc attttattta aaaataaaaa atgttaatgc cagttggcct actataaaaa
     3841 gccaggacca tgttagaatt aggaaaagta accagcatta ctgcacctct tgttagactc
     3901 tgtgcattaa taaaacacac ctagagtctg ttgtcatttc actaatagga taagacaaat
     3961 tttttgcttt gaaaaaattt ttctgcatgc ccaggtgtct gtctctggct gaggttttgt
     4021 ctattttaca gtgtttcaat ccagccataa aaattaactt gtgatttttt ttttcccaaa
     4081 gtcatgcttt tccttaatta tatttttatt ttattatttt agtgtcttga gaaaaatacc
     4141 aagagatata atgtttcttt taattgtcta tgcttaatca tctttaaaca ctttttaaat
     4201 ttctaaccac aagacctctc tataatggta aatgtaagac atcaccattt tatcactcaa
     4261 agtatgttat tgaaagtttc tatttggttg ataaaaggaa caattttttc ccacttttga
     4321 tgcctgtgat gcaatttttt attgcctaca atgagataca cttagtacaa aaaatgaaaa
     4381 tctggtattt caaaattgca tttcttgtat aataggtcag atttattaac tactcatact
     4441 ttttctttac actaatcgat acatttagaa aaaattttct aagttagaga caagtttaaa
     4501 agtaaaaaaa aaaaaaaatt agccactgct agtctactgt ttaggtaatc ggaatcacca
     4561 attattttat tagaatgatg gcttgagtaa aaagctgtgg aaagaattaa aggattatga
     4621 gctaagctgt attttgcaga atatggttct attttagtag agcagagatg agacatatcc
     4681 ccaccggcca cccagccaga ggtctcctac ctgggggccc taaagggatg cagaggtctg
     4741 gcccaccctc cgtgcatagg cacctctgtc caccaccagc gtttcagcaa tccaaccagt
     4801 aagcatatgc tgtataggaa aaataaaagt gtgtgggaat tggatttctt ttgttgtaac
     4861 acaattccag gtttttggct atttaaagtt tgacattagg ctgacatcga ggaagtaagt
     4921 gggttttcct gagttcccaa gatatgatta aggaagaaaa caaacccatc tccaggaaga
     4981 tcccaggcag gaaagaacta gacagatgta gaaaccaaag tgaccatttt agttttttta
     5041 ttggagaata aaacattaat attagggtat taagaagatg ctcagcaagc ttgatcagaa
     5101 tcttcatggt cattaccaat cagtctgaca aaatagttct ctggtagtca gcattcattt
     5161 aaggcagctt gcctgataat ttcctgtgtt atgtgaagtg tcttgcactt tcacatgtta
     5221 gctataattc cttaaattac ttaactgaaa tctgtaatag agaaccattt tggcatttga
     5281 acagctattt tacatggaga aaaagcaaac acatctgttt gctttaccca gaaaaactga
     5341 ctttctggtt tcatcttcat attgtttagt agcataatga gagtagtcct ttatctttct
     5401 ctaatgttag taaatatatt ctgttagtag gaagttctga aattgaaggg aaaatatatt
     5461 taaggaaata aaggaattca atacaccctt caaaagtcac caaatactga aaataagaga
     5521 tgagtcctta aaacctgagt caaaaaaggt ccagttttac agcctgcaat taattcaggg
     5581 ctgcgttggc attaaaaaag aaaatatata tatatatata tatatatata tatatatata
     5641 tatatatgta tattatatat acagtagctt acacttaaaa gaggaaaaat ttgcattaac
     5701 attgcatatt ctgatatgta ccatattaac acataacagg cattttattt atgcttcata
     5761 gaatcagaca gacacaactt tcaaaaatct tactgtattc acaatagaaa agggtagtct
     5821 tgtctaccac agaggagtat gtccacactt aataatgaaa actttcttcc tttcctgccc
     5881 aaaaatttct tcagtctgtt attattttta agtgcccctt gctgcaaatt tcaaacagag
     5941 caagaaatct tcctcagagt aggtggtatg aaattaaact agtacaatat atatgaattc
     6001 atgtcattta cccctgagta tggtagaatt gttaaagcat tcttaaattc caattatatg
     6061 aagcctatca ttactaggaa aagtatattc tttgggataa gaattaattt cttcacacta
     6121 ttagagcatg ttgtgagtag taaggaacta cttagatgca atttatttac agaattgtcc
     6181 cttgacctct tgaaatggct agatctttca ctactgtgta ggtagtctct acttactggt
     6241 aggatagatt acattgcttt actggacaaa gcagaatgaa cttatataac taaaatatgt
     6301 cctatattgg ctgggtgcgg tggcttacac ctgtaatacc agcactttgg gaggccaagg
     6361 tgggtggatc agttgaggtc aggagttcga gaccagcctg gccaacatgg tgaaaccctg
     6421 tctctactga aaatacaaaa aaaaaaaagt atctgggcat ggtggcttgt gcctgtaatc
     6481 ccagctactt gggaggctga ggcagggaaa tcgcttaaac ccgggaggtg gaggttgcag
     6541 tgggcccaga tcgtgccact ccactccagc ctgggagaca gagcaagact ccatctcaaa
     6601 ataataataa tagtaataat gaataaaata aaataaaata tgtcctccag ggaaaagcaa
     6661 tgacagagta atcaccaaat taataggaac atctttctag agaaagtaca tgcccagtta
     6721 gttcaaaccc aggtttcaaa gaagtagcac tgggctctac tgtaaaggca ggcagtgacc
     6781 aagaggtggt ggggagagag gtagagtacc ctcaaatcat tcccattttc acttccaatt
     6841 tcccttttgt aatcattaag cttaagctat gtatggaaat gcaaagcacc attagcattt
     6901 ctagaaagca gctggaacct tacccaccaa tgcttttttg aagacagtat catcccaaat
     6961 ttaaaaatcc tattgtatat gttgtaaaat ttctggcaaa gaaatggagg atcctgtggc
     7021 agctattccc acctaaagcc aaccctataa ggatgggtca ttttttagcc atgctaggat
     7081 ttactgcaca cacaaaaaat gtcatttagc ttgtcacatt gctagcacag ctgcacatat
     7141 gagcaaagca ctgttggtct gtgtttctca gtgggggtac tcttggcatt tggagctgga
     7201 taggtctttg ctgtacagaa tcatcccatg cattgccaga tgtttaatat cccaggcccc
     7261 tgctgactaa atgtcagtag cattctcagt cattgtaaac accaagaata aaaagcattc
     7321 ccccaggttc aaatgccctc cctgggaggt tggtatcacc tcccctgaat gccactgtct
     7381 actgcatttt gaggacacag ggagaaaaag tgcctatcct caaacattgt ctctgctgcc
     7441 ttgcatttct ttgggccctg aatggttttt ctcccttcat ttttcgagcc tttctctcag
     7501 tgcagctgtt cttcagggag gaggttactg ggcagccttg gccattcagt gggcatgggg
     7561 acttggccta gtccctatat atatatactt aaagtcccta tatatactta aaggagagat
     7621 catacatgaa gaaagctttt tttttttttt ttttttttgc cttacaactt ttctttagaa
     7681 ccacattatt ggtcataatc cttgttactg tcatgaggat tgttgcatgg gttaaacaca
     7741 aacacagact agcaatgcac ttgaacaaac ctggtggtct ttggaaataa atcaccatta
     7801 gatttcacct ggttatgctg catcccataa gttccaaatg aatcacctgc ttatcctatt
     7861 aacgaagcat ttaattcaca cacaaatgct tgaatttccc ctgtataaat gtagtcatgc
     7921 gattcaactt ttctaataag atttgtgaat gctgcatcat gatgaaaatg tggattaact
     7981 gtgggttgca tgcctgttgt tcatacttca gtgatggtca cacacaaaac aagatgagtt
     8041 ttacttaggt gaaacattat taaactgtac taacaataca gaaacatatt ctctttgtcg
     8101 ctttttatca ccaaaactga atggcaaata tgtcttgaca ttacttggat gaactgtggc
     8161 tagcaaaatg gaattaactt agccactata attttttaaa acattaaagt ttctaaattg
     8221 tttttggggc cgagtaacgc agagtcaata aaggtggtta tattgtaagc ttttagatgg
     8281 tgcttaagaa ttcttatctt tttaaatagc agtatttttt ttttaagaat aaattgtaag
     8341 gagcaaataa ggcagaatgc cactctaccc tcaggtcaat tttatggtat atgaaaatgc
     8401 cagtaatatt tgtgccactt gccaactcgg gggaggaggg gcttttccct tactggatac
     8461 ttttgttata gtttgactat gtcattatgt tgtttagaga gcctccacaa tgagaagttg
     8521 ccactgcagg gctaactcgc cttcagaaat aatcagaatg attcaagggt caaaccactt
     8581 tcatccctta aaatataggg actaatattt ctttttcttt tttttaaaaa aaacatttct
     8641 tctgtggctt agaaatgtgc cagtgtgttc aaaacattta caccaatttc accagattta
     8701 ggacctatta aaaattcaaa caagtttctt tttttttttt ttttttctgt gtaacaggga
     8761 tttttaaata acggactata tgcattcttt tgttatttca cacttcagtt aaagtgataa
     8821 caatggtaaa ctgtgatcat tatcagactg actgaatgct ttctgatttc cagtgagtga
     8881 tctagttcta cgtattacac aggtgtaata tctgtgagtg taaataactg gaactgtaca
     8941 ctgattaaca tgacagtttc tcttttgttg ttcttatctg tactgtatta tagtatgtgg
     9001 gtataaatat ctacaagtat acacacatat gtacttgtat tccactattg taacctgaaa
     9061 gaaagactat gtattccctt ttttaattcc gtactggtat ttgtgttatt taaaaagcaa
     9121 aattctgctc tatttagttg tataatatta gaggatactt tgctgtgcac aattccaagt
     9181 gccttagaac attgtttagc tttcctaagt atatataaat gcatatatgt ataaaattgg
     9241 gaaaagttac ctcaataaaa tcattgggaa atccccagtt ttagtttgtt ccagtttctc
     9301 ttatatttgg atagtgctca gcctttttaa atgaaaaaag aaaaaagagt aagacaactt
     9361 ccctaattgc ctgttatttc agcttcacct aagtttttaa cacctctttg tatgtaaggt
     9421 cttgagacat gtaaggcctg gtacttttta tttaaaatgt ctgtctaaag aattactgct
     9481 cttaaaagaa acttccagta ttttttttaa cttgctatct ttttatgtct gaggtatttg
     9541 atattgatgt ttttattgcc attattatat gtaaacataa aagatagtcc atttagagtt
     9601 tataatatag aaaataaaca gacttcctca tta
//
