LOCUS       NM_024419               2297 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens phosphatidylglycerophosphate synthase 1 (PGS1),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_024419
VERSION     NM_024419.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Ikari,N., Honjo,K., Sagami,Y., Nakamura,Y. and Arakawa,H.
  TITLE     Mieap forms membrane-less organelles involved in cardiolipin
            metabolism
  JOURNAL   iScience 27 (2), 108916 (2024)
   PUBMED   38322995
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Kawasaki,K., Kuge,O., Yamakawa,Y. and Nishijima,M.
  TITLE     Purification of phosphatidylglycerophosphate synthase from Chinese
            hamster ovary cells
  JOURNAL   Biochem J 354 (Pt 1), 9-15 (2001)
   PUBMED   11171073
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Kawasaki,K., Kuge,O., Chang,S.C., Heacock,P.N., Rho,M., Suzuki,K.,
            Nishijima,M. and Dowhan,W.
  TITLE     Isolation of a chinese hamster ovary (CHO) cDNA encoding
            phosphatidylglycerophosphate (PGP) synthase, expression of which
            corrects the mitochondrial abnormalities of a PGP
            synthase-defective mutant of CHO-K1 cells
  JOURNAL   J Biol Chem 274 (3), 1828-1834 (1999)
   PUBMED   9880566
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Adams,M.D., Dubnick,M., Kerlavage,A.R., Moreno,R., Kelley,J.M.,
            Utterback,T.R., Nagle,J.W., Fields,C. and Venter,J.C.
  TITLE     Sequence identification of 2,375 human brain genes
  JOURNAL   Nature 355 (6361), 632-634 (1992)
   PUBMED   1538749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK316147.1, BC108732.1, BI024108.1 and ES314549.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024419.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.616986.1,
                                           SRR3476690.41273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262764.11/ ENSP00000262764.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK316147.1         10-14
            6-1929              BC108732.1         1-1924
            1930-1949           BI024108.1         155-174
            1950-2197           BC108732.1         1945-2192
            2198-2211           ES314549.1         103-116             c
            2212-2297           ES314549.1         16-101              c
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2297
                     /gene="PGS1"
                     /note="phosphatidylglycerophosphate synthase 1"
                     /db_xref="GeneID:9489"
                     /db_xref="HGNC:HGNC:30029"
                     /db_xref="MIM:614942"
     exon            1..160
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1688
                     /gene="PGS1"
                     /EC_number="2.7.8.5"
                     /note="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase, mitochondrial; PGP synthase 1"
                     /codon_start=1
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase, mitochondrial precursor"
                     /protein_id="NP_077733.3"
                     /db_xref="CCDS:CCDS42391.1"
                     /db_xref="GeneID:9489"
                     /db_xref="HGNC:HGNC:30029"
                     /db_xref="MIM:614942"
                     /translation="MAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDR
                     QRRRSPWLLLAPLLSPAVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSS
                     PAEFFELMKGQIRVAKRRVVMASLYLGTGPLEQELVDCLESTLEKSLQAKFPSNLKVS
                     ILLDFTRGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGLLRLLIPERFNETIGL
                     QHIKVYLFDNSVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQL
                     QGDDTVQVVDGMVHPYKGDRAEYCKAANKRVMDVINSARTRQQMLHAQTFHSNSLLTQ
                     EDAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVYLTTGYFNLT
                     QAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFFSEVCSLGQQE
                     RVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTEN
                     QALQQQLHQEQEQLYLRSGVVSSATFEQPSRQVKLWVKMVTPLIKNFF"
     exon            161..350
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..428
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..528
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..718
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..897
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1419
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1568
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1698
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2297
                     /gene="PGS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGS1"
                     /note="hexamer: ATTATA"
     polyA_site      2197
                     /gene="PGS1"
                     /note="major polyA site"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGS1"
                     /note="hexamer: AATAAA"
     polyA_site      2297
                     /gene="PGS1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggcg agtctccatg gcggtggcgg cggcagctgc ggcgggaccc gtgttctgga
       61 ggcgactgct gggcctcctg cctggccgcc cagggctggc cgcgctcctg ggacgcctgt
      121 ccgaccgcct cggcaggaac cgggaccgcc agcgcaggag gtcaccatgg ctgttattgg
      181 ctcccttgct gtccccagct gttccccagg tcacctcccc accttgctgc ctgtgtccag
      241 aaggcgtgca ccggttccag tggatcagaa acctggttcc agaatttgga gtctccagtt
      301 ctcacgttag ggtgctttct tccccggcag agtttttcga gctcatgaag gggcagataa
      361 gagtagccaa gaggcgggtc gtgatggcat ccctctacct ggggacaggt cctttggaac
      421 aggagctggt ggactgcctg gaaagtactc tagaaaagtc actccaagca aagtttcctt
      481 caaatctcaa ggtctccatt ctcttagact tcacgcgggg ctcacgaggc cggaagaact
      541 cccgcacaat gctgctccca ctcctgcgga ggttcccaga gcaggtccga gtctccctct
      601 ttcacacgcc gcacctccgt gggctgcttc ggctcctcat ccctgagcgc ttcaacgaga
      661 ccatcggcct ccagcacatt aaggtgtacc tcttcgacaa cagcgtcatc ttgagcggtg
      721 caaacctgag tgactcctac ttcaccaacc gccaggaccg ctacgtgttc ctgcaggact
      781 gtgcggagat tgccgacttc ttcacggagc tggtggacgc ggtgggggat gtgtccctgc
      841 agctgcaggg ggacgacacg gtgcaggtgg tggatgggat ggtgcatcct tacaaagggg
      901 accgggccga gtactgcaag gcagccaata agagggtcat ggatgtgatc aactcagcca
      961 ggacccgcca gcagatgctg catgcccaga ccttccacag caactctctt ttgacccagg
     1021 aagatgcagc agctgctggg gatcgcagac cagcccctga cacctggatt tatccgctga
     1081 ttcagatgaa gcccttcgag attcaaatcg atgagattgt cactgagacc ctgttgactg
     1141 aggcggagcg cggggcaaag gtctacctca ccactggcta tttcaacctg acccaggcct
     1201 acatggacct ggtcttgggc actcgggctg agtaccagat cctgctggcc tcaccagagg
     1261 tgaatggctt ctttggggcc aagggggtgg ccggcgccat cccagcggcc tatgtgcaca
     1321 tcgagcgaca gttcttcagt gaggtgtgca gcctgggaca gcaggagcgg gtccagcttc
     1381 aggagtactg gcggaggggc tggacgttcc acgccaaagg cctctggctg tacctggcag
     1441 ggagcagcct gccctgtctc acgctgattg gctctcctaa ttttgggtac aggtcagttc
     1501 accgggacct ggaggcccag attgcgatcg tgacggagaa ccaggccctg cagcagcagc
     1561 ttcaccagga gcaagagcag ctctacctga ggtcaggtgt ggtgtcctct gccaccttcg
     1621 agcagccgag tcgccaggtg aagctgtggg tgaagatggt gactccactg atcaagaact
     1681 tcttctgagg acagacagga atggccttga tgaagatgac aggcatggcc ggggtcagct
     1741 ctttcagccg cgcttcagcg atgactccag tctgggtgtc ccagcgagcc cctgcaggga
     1801 cagtatggct gagggtcagg tgtgctgcca gtaagtgagg gaggggctgg caggaagggt
     1861 ggggtcctca cactccccgc cctctgcaga gctgggctct accccaaaag gcttcaggcc
     1921 agctgccacg gctggaagca gaggccttcg taggtgatgg cctgcatgtt gtaactaccc
     1981 cgtcccgctg ggctcaagga acagctcagc taaagccctc gggttccatc cgtttaaatc
     2041 tgtggcattt tcagagcctc atctgtcagc cttaatgtca gtggcaggaa gtcataactc
     2101 cagctaaaaa ttacagagta aagttccctg attcttaatg tgtaatgtct gccctatgtg
     2161 tacatacaca atataattat acatctgtgc atataaatat tgcctttaac cagactgcta
     2221 ttatttctac tcgccctatt taatggtgtt tttatttcct gtctgaaatc tcaaaataaa
     2281 caaacatgga gagctta
//
