LOCUS       NM_006320               2769 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens progesterone receptor membrane component 2 (PGRMC2),
            mRNA.
ACCESSION   NM_006320
VERSION     NM_006320.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Lintao,R.C.V., Richardson,L.S., Kammala,A.K., Chapa,J.,
            Yunque-Yap,D.A., Khanipov,K., Golovko,G., Dalmacio,L.M.M. and
            Menon,R.
  TITLE     PGRMC2 and HLA-G regulate immune homeostasis in a
            microphysiological model of human maternal-fetal membrane interface
  JOURNAL   Commun Biol 7 (1), 1041 (2024)
   PUBMED   39179795
  REMARK    GeneRIF: PGRMC2 and HLA-G regulate immune homeostasis in a
            microphysiological model of human maternal-fetal membrane
            interface.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Medina-Laver,Y., Gonzalez-Martin,R., de Castro,P.,
            Diaz-Hernandez,I., Alama,P., Quinonero,A., Palomar,A. and
            Dominguez,F.
  TITLE     Deciphering the role of PGRMC2 in the human endometrium during the
            menstrual cycle and in vitro decidualization using an in vitro
            approach
  JOURNAL   Hum Reprod 39 (5), 1042-1056 (2024)
   PUBMED   38452349
  REMARK    GeneRIF: Deciphering the role of PGRMC2 in the human endometrium
            during the menstrual cycle and in vitro decidualization using an in
            vitro approach.
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Yokouchi-Konishi,T., Liu,Y. and Feng,L.
  TITLE     Progesterone receptor membrane component 2 is critical for human
            placental extravillous trophoblast invasion
  JOURNAL   Biol Reprod 109 (5), 759-771 (2023)
   PUBMED   37665239
  REMARK    GeneRIF: Progesterone receptor membrane component 2 is critical for
            human placental extravillous trophoblast invasion.
REFERENCE   4  (bases 1 to 2769)
  AUTHORS   Velazquez Hernandez,D.M., Vazquez-Martinez,E.R. and
            Camacho-Arroyo,I.
  TITLE     The role of progesterone receptor membrane component (PGRMC) in the
            endometrium
  JOURNAL   Steroids 184, 109040 (2022)
   PUBMED   35526781
  REMARK    GeneRIF: The role of progesterone receptor membrane component
            (PGRMC) in the endometrium.
            Review article
REFERENCE   5  (bases 1 to 2769)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2769)
  AUTHORS   Menon,R., Pearce,B., Velez,D.R., Merialdi,M., Williams,S.M.,
            Fortunato,S.J. and Thorsen,P.
  TITLE     Racial disparity in pathophysiologic pathways of preterm birth
            based on genetic variants
  JOURNAL   Reprod Biol Endocrinol 7, 62 (2009)
   PUBMED   19527514
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2769)
  AUTHORS   Velez,D.R., Fortunato,S., Thorsen,P., Lombardi,S.J., Williams,S.M.
            and Menon,R.
  TITLE     Spontaneous preterm birth in African Americans is associated with
            infection and inflammatory response gene variants
  JOURNAL   Am J Obstet Gynecol 200 (2), 209 (2009)
   PUBMED   19019335
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2769)
  AUTHORS   Velez,D.R., Fortunato,S.J., Thorsen,P., Lombardi,S.J.,
            Williams,S.M. and Menon,R.
  TITLE     Preterm birth in Caucasians is associated with coagulation and
            inflammation pathway gene variants
  JOURNAL   PLoS One 3 (9), e3283 (2008)
   PUBMED   18818748
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2769)
  AUTHORS   Losel,R., Breiter,S., Seyfert,M., Wehling,M. and Falkenstein,E.
  TITLE     Classic and non-classic progesterone receptors are both expressed
            in human spermatozoa
  JOURNAL   Horm Metab Res 37 (1), 10-14 (2005)
   PUBMED   15702432
  REMARK    GeneRIF: The expression of a novel progesterone-binding protein
            (hmPR1/PGMRC1) was investigated. Transcripts of this protein have
            been detected in human sperm.
REFERENCE   10 (bases 1 to 2769)
  AUTHORS   Gerdes,D., Wehling,M., Leube,B. and Falkenstein,E.
  TITLE     Cloning and tissue expression of two putative steroid membrane
            receptors
  JOURNAL   Biol Chem 379 (7), 907-911 (1998)
   PUBMED   9705155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131272.1, AK091741.1 and AI375856.1.
            
            On Nov 29, 2018 this sequence version replaced NM_006320.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.349017.1,
                                           SRR11853562.25335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296425.10/ ENSP00000296425.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1659              AK131272.1         1017-2675
            1660-2301           AK091741.1         1613-2254
            2302-2769           AI375856.1         7-474               c
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.2"
     gene            1..2769
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /note="progesterone receptor membrane component 2"
                     /db_xref="GeneID:10424"
                     /db_xref="HGNC:HGNC:16089"
                     /db_xref="MIM:607735"
     exon            1..441
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..695
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /note="progesterone membrane binding protein; steroid
                     receptor protein DG6"
                     /codon_start=1
                     /product="membrane-associated progesterone receptor
                     component 2"
                     /protein_id="NP_006311.3"
                     /db_xref="CCDS:CCDS3739.3"
                     /db_xref="GeneID:10424"
                     /db_xref="HGNC:HGNC:16089"
                     /db_xref="MIM:607735"
                     /translation="MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAA
                     LALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRD
                     FSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCL
                     DKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKD
                     HNKQD"
     exon            442..597
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            598..2769
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /note="major polyA site"
     regulatory      2739..2744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
                     /note="hexamer: AATAAA"
     polyA_site      2769
                     /gene="PGRMC2"
                     /gene_synonym="DG6; PMBP"
ORIGIN      
        1 gaggaaggcg ctggcgggca gtgatggcgg ctggtgatgg ggacgtgaag ctaggcaccc
       61 tggggagtgg cagcgagagc agcaacgacg gcggcagcga gagtccaggc gacgcgggag
      121 cggcagcgga agggggaggc tgggcggcgg cggcgttggc gcttctgacg gggggcgggg
      181 aaatgctgct gaacgtggcg ctggtggctc tggtgctgct gggggcctac cggctgtggg
      241 tgcgctgggg gcggcggggt ctgggggccg gggccggggc gggcgaggag agccccgcca
      301 cctctctgcc tcgcatgaag aagcgggact tcagcttgga gcagctgcgc cagtacgacg
      361 gctcccgcaa cccgcgcatc ctgctcgcgg tcaatgggaa agtcttcgac gtgaccaaag
      421 gcagcaagtt ctacggcccg gcgggtccat atggaatatt tgctggtagg gatgcctcca
      481 gaggactggc cacattttgc ctagataaag atgcacttag agatgaatat gatgatctct
      541 cagatttgaa tgcagtacaa atggagagtg ttcgagaatg ggaaatgcag tttaaagaaa
      601 aatatgatta tgtaggcaga ctcctaaaac caggagaaga accatcagaa tatacagatg
      661 aagaagatac caaggatcac aataaacagg attgaacttt gtaaacaacc aaagtcaggg
      721 gccttcagaa ctgcaattct tactcccttt cacagactgt ccggagtctt tgggtttgat
      781 tcacctgctg cgaaaaacat tcaacaaatt gtgtacaaga taaattaatc tcactatgaa
      841 gatttgaata actagacatt atttatgctg ccaaactcat ttgttgcagt tgtttgtaat
      901 gtctagtggg gcttcatcat cctgaaaaga aggagacagg gattttttta aagagcaaga
      961 aagtcacaat attacttctt tccttccttt tttccttctt tcctttcttc tttctctttc
     1021 tttcttttta aaatatattg aagacaacca gatatgtatt tgctactcaa gtgtacagat
     1081 ctcctcaaga aacatcaagg gactcctgtg tcacatactg tgtttttatt ttaacatggg
     1141 tgagggaggc gacctgatca ggggaggtgg gggtacacat caatttgagt tgttcaggct
     1201 actgaaacat taaaatgtga attcccaaac ttttcttttt ggctttgtca gggaaaagaa
     1261 aaatatcttt ataaagaaat ctttggaaat taggagaagg aatttcaggt gggtttaagt
     1321 cagagctagt tccccaacag aaagatcatt tgaaaccagt ttttatccct tctctttcct
     1381 tccctttccc taaatcaaat caatattaat tgtgccttat ttcacttaac atagacttga
     1441 attattttta gggaaagccc ctataatgaa ttcagaaatc actacaagca gcattaagac
     1501 tgaagttgga atattctgtt gaccataaaa ccttgatatc attctgtgta tatagaatgt
     1561 aaaaggaata ttacagtgtt aactgccata tatgtaatat acacaaactc aattagcatt
     1621 gtaatggcca aatgcattcc cccatgcttt tctgttttca aaaaaattga aaaacaaatc
     1681 aactcttatc cccaacagct gcctaatttt aggagtctga ccctccacat ctcactggtg
     1741 tgggtgcatg gggctgtgga gtgggtgtca gtatggatgt gtctgaatgt gtgaggcctt
     1801 ggaagggact ctttctgcag atactgtaaa tacaagtacc attttaataa agcatgtaca
     1861 ataaaccaaa ataagcttga gttggacttt atatacagaa ctgtaagcca gtgcattatg
     1921 atacagttgt aagattgtgc atttgattca agataaggaa aaatcttgga aatgaaaagc
     1981 aggcactggt taaccaagtt gtacacattg taccacattc agcataactt taggaagaaa
     2041 ttccactttg tggaacattc tccagaaatc caagattatt caggtaagaa ttggtatatt
     2101 aaatgtacat ctttttactt tctattttga tgccaactga ttatactaga caattagcac
     2161 tccaggtggt tattgaacac aaaacagtaa aagaatattg cactgataga tactaaatta
     2221 ttattttatt aggttgaaaa agcccttact aaaagcccct catatatcaa ttactttatt
     2281 tcattatgac tacttaggtt ccgggctggg gacaagttca cttaaaaagg caatgttatt
     2341 taacaggtca ccagttaaga cttctgcttt gtagatacat gcagaagcca tcaaacaagg
     2401 gggagctttt aactgcaaca ataagctaaa gtatgtaaaa tactacattc tattcagtct
     2461 tggagtgttt tgtagaaagt tatcttcagc caaatctttg ctgaagactg gttgtggagt
     2521 gttggtaaat gctttgtgtt tttatgtaaa atattttcta aacaaaaaat gttaaaagta
     2581 catgtcctct gtagtaaact gatatctata tatatgaatc attcaagcct aaagtctagt
     2641 aataaactgt acttgtgaat agagaaaccc taaatattca tgcagaaaaa attatgcggt
     2701 ctgttaagaa aaatgagtaa tttgtgtttt ggacttgaaa taaacagtgt tctgtagata
     2761 attcctcaa
//
