LOCUS       NM_006667               1879 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens progesterone receptor membrane component 1 (PGRMC1),
            transcript variant 1, mRNA.
ACCESSION   NM_006667
VERSION     NM_006667.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Guan,A., Dai,Z., Jiang,C., Sun,J., Yang,B., Xie,B. and Chen,Q.
  TITLE     PGRMC1 promotes NSCLC stemness phenotypes by disrupting
            TRIM56-mediated ubiquitination of AHR
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167440 (2024)
   PUBMED   39059592
  REMARK    GeneRIF: PGRMC1 promotes NSCLC stemness phenotypes by disrupting
            TRIM56-mediated ubiquitination of AHR.
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Wang,F., Ferreira,L.M.R., Mazzanti,A., Yu,H., Gu,B., Meissner,T.B.,
            Li,Q. and Strominger,J.L.
  TITLE     Progesterone-mediated remodeling of the maternal-fetal interface by
            a PGRMC1-dependent mechanism
  JOURNAL   J Reprod Immunol 163, 104244 (2024)
   PUBMED   38555747
  REMARK    GeneRIF: Progesterone-mediated remodeling of the maternal-fetal
            interface by a PGRMC1-dependent mechanism.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Badve,P. and Meier,K.K.
  TITLE     Defining Requirements for Heme Binding in PGRMC1 and Identifying
            Key Elements that Influence Protein Dimerization
  JOURNAL   Biochemistry 63 (7), 926-938 (2024)
   PUBMED   38489495
  REMARK    GeneRIF: Defining Requirements for Heme Binding in PGRMC1 and
            Identifying Key Elements that Influence Protein Dimerization.
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Liu,H., Franken,A., Bielfeld,A.P., Fehm,T., Niederacher,D.,
            Cheng,Z., Neubauer,H. and Stamm,N.
  TITLE     Progesterone-induced progesterone receptor membrane component 1
            rise-to-decline changes are essential for decidualization
  JOURNAL   Reprod Biol Endocrinol 22 (1), 20 (2024)
   PUBMED   38308254
  REMARK    GeneRIF: Progesterone-induced progesterone receptor membrane
            component 1 rise-to-decline changes are essential for
            decidualization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Tsuru,A., Yoshie,M., Negishi,R., Mukoyama,T., Yonekawa,R.,
            Kojima,J., Azumi,M., Kusama,K., Nishi,H. and Tamura,K.
  TITLE     Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression
            in human endometrial cells
  JOURNAL   J Pharmacol Sci 153 (4), 188-196 (2023)
   PUBMED   37973216
  REMARK    GeneRIF: Regulatory action of PGRMC1 on cyclic AMP-mediated COX2
            expression in human endometrial cells.
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Hand,R.A. and Craven,R.J.
  TITLE     Hpr6.6 protein mediates cell death from oxidative damage in MCF-7
            human breast cancer cells
  JOURNAL   J Cell Biochem 90 (3), 534-547 (2003)
   PUBMED   14523988
  REMARK    GeneRIF: Hpr6.6 regulates cell death through a novel oxidative
            damage response pathway.
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Shin,B.K., Wang,H., Yim,A.M., Le Naour,F., Brichory,F., Jang,J.H.,
            Zhao,R., Puravs,E., Tra,J., Michael,C.W., Misek,D.E. and
            Hanash,S.M.
  TITLE     Global profiling of the cell surface proteome of cancer cells
            uncovers an abundance of proteins with chaperone function
  JOURNAL   J Biol Chem 278 (9), 7607-7616 (2003)
   PUBMED   12493773
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Bernauer,S., Wehling,M., Gerdes,D. and Falkenstein,E.
  TITLE     The human membrane progesterone receptor gene: genomic structure
            and promoter analysis
  JOURNAL   DNA Seq 12 (1), 13-25 (2001)
   PUBMED   11697142
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Gerdes,D., Wehling,M., Leube,B. and Falkenstein,E.
  TITLE     Cloning and tissue expression of two putative steroid membrane
            receptors
  JOURNAL   Biol Chem 379 (7), 907-911 (1998)
   PUBMED   9705155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004835.2 and Y12711.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006667.4.
            
            Summary: This gene encodes a putative membrane-associated
            progesterone steroid receptor. The protein is expressed
            predominantly in the liver and kidney. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12711.2, BC034238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217971.8/ ENSP00000217971.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC004835.2         33843-33857
            16-1879             Y12711.2           15-1878
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..1879
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /note="progesterone receptor membrane component 1"
                     /db_xref="GeneID:10857"
                     /db_xref="HGNC:HGNC:16090"
                     /db_xref="MIM:300435"
     exon            1..407
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..667
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     progesterone binding protein; membrane-associated
                     progesterone receptor component 1"
                     /codon_start=1
                     /product="membrane-associated progesterone receptor
                     component 1 isoform 1"
                     /protein_id="NP_006658.1"
                     /db_xref="CCDS:CCDS14576.1"
                     /db_xref="GeneID:10857"
                     /db_xref="HGNC:HGNC:16090"
                     /db_xref="MIM:300435"
                     /translation="MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYK
                     IVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTK
                     GRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQF
                     TFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND"
     exon            408..563
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1879
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /note="hexamer: AATAAA"
     polyA_site      1879
                     /gene="PGRMC1"
                     /gene_synonym="Dap1; HPR6.6; IZA; MPR"
                     /note="major polyA site"
ORIGIN      
        1 actcgctcgc tcagagggag gagaaagtgg cgagttccgg atccctgcct agcgcggccc
       61 aacctttact ccagagatca tggctgccga ggatgtggtg gcgactggcg ccgacccaag
      121 cgatctggag agcggcgggc tgctgcatga gattttcacg tcgccgctca acctgctgct
      181 gcttggcctc tgcatcttcc tgctctacaa gatcgtgcgc ggggaccagc cggcggccag
      241 cggcgacagc gacgacgacg agccgccccc tctgccccgc ctcaagcggc gcgacttcac
      301 ccccgccgag ctgcggcgct tcgacggcgt ccaggacccg cgcatactca tggccatcaa
      361 cggcaaggtg ttcgatgtga ccaaaggccg caaattctac gggcccgagg ggccgtatgg
      421 ggtctttgct ggaagagatg catccagggg ccttgccaca ttttgcctgg ataaggaagc
      481 actgaaggat gagtacgatg acctttctga cctcactgct gcccagcagg agactctgag
      541 tgactgggag tctcagttca ctttcaagta tcatcacgtg ggcaaactgc tgaaggaggg
      601 ggaggagccc actgtgtact cagatgagga agaaccaaaa gatgagagtg cccggaaaaa
      661 tgattaaagc attcagtgga agtatatcta tttttgtatt ttgcaaaatc atttgtaaca
      721 gtccactctg tctttaaaac atagtgatta caatatttag aaagttttga gcacttgcta
      781 taagtttttt aattaacatc actagtgaca ctaataaaat taacttctta gaatgcatga
      841 tgtgtttgtg tgtcacaaat ccagaaagtg aactgcagtg ctgtaataca catgttaata
      901 ctgtttttct tctatctgta gttagtacag gatgaattta aatgtgtttt tcctgagaga
      961 caaggaagac ttgggtattt cccaaaacag gtaaaaatct taaatgtgca ccaagagcaa
     1021 aggatcaact tttagtcatg atgttctgta aagacaacaa atcccttttt ttttctcaat
     1081 tgacttaact gcatgatttc tgttttatct acctctaaag caaatctgca gtgttccaaa
     1141 gactttggta tggattaagc gctgtccagt aacaaaatga aatctcaaaa cagagctcag
     1201 ctgcaaaaaa gcatattttc tgtgtttctg gactgcactg ttgtccttgc cctcacatag
     1261 acactcagac accctcacaa acacagtagt ctatagttag gattaaaata ggatctgaac
     1321 attcaaaaga aagctttgga aaaaaagagc tggctggcct aaaaacctaa atatatgatg
     1381 aagattgtag gactgtcttc ccaagcccca tgttcatggt ggggcaatgg ttatttggtt
     1441 attttactca attggttact ctcatttgaa atgagggagg gacatacaga ataggaacag
     1501 gtgtttgctc tcctaagagc cttcatgcac acccctgaac cacgaggaaa cagtacagtc
     1561 gctagtcaag tggtttttaa agtaaagtat attcataagg taacagttat tctgttgtta
     1621 taaaactata cccactgcaa aagtagtagt caagtgtcta ggtctttgat attgctcttt
     1681 tggttaacac taagcttaag tagactatac agttgtatga atttgtaaaa gtatatgaac
     1741 acctagtgag atttcaaact tgtaattgtg gttaaatagt cattgtattt tcttgtgaac
     1801 tgtgttttat gattttacct caaatcagaa aacaaaatga tgtgctttgg tcagttaata
     1861 aaaatggttt tacccacta
//
