LOCUS       NM_000926              13037 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens progesterone receptor (PGR), transcript variant 2,
            mRNA.
ACCESSION   NM_000926
VERSION     NM_000926.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13037)
  AUTHORS   Zhang,L., Verwer,R.W.H., van Heerikhuize,J., Lucassen,P.J.,
            Nathanielsz,P.W., Hol,E.M., Aronica,E., Dhillo,W.S., Meynen,G. and
            Swaab,D.F.
  TITLE     Progesterone receptor distribution in the human hypothalamus and
            its association with suicide
  JOURNAL   Acta Neuropathol Commun 12 (1), 16 (2024)
   PUBMED   38263257
  REMARK    GeneRIF: Progesterone receptor distribution in the human
            hypothalamus and its association with suicide.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13037)
  AUTHORS   Li,Z., Zhou,G., Li,Q., Jiang,L., He,J. and Ye,C.
  TITLE     USP7 promotes decidualization of ESCs by STAT3/PR axis during early
            pregnancy
  JOURNAL   Mol Cell Endocrinol 580, 112090 (2024)
   PUBMED   37890652
  REMARK    GeneRIF: USP7 promotes decidualization of ESCs by STAT3/PR axis
            during early pregnancy.
REFERENCE   3  (bases 1 to 13037)
  AUTHORS   Zhou,P., Ouyang,L., Jiang,T., Tian,Y., Deng,W., Wang,H., Kong,S.
            and Lu,Z.
  TITLE     Progesterone and cAMP synergistically induce SHP2 expression via
            PGR and CREB1 during uterine stromal decidualization
  JOURNAL   FEBS J 291 (1), 142-157 (2024)
   PUBMED   37786383
  REMARK    GeneRIF: Progesterone and cAMP synergistically induce SHP2
            expression via PGR and CREB1 during uterine stromal
            decidualization.
REFERENCE   4  (bases 1 to 13037)
  AUTHORS   Tsai,J.M., Aguirre,J.D., Li,Y.D., Brown,J., Focht,V., Kater,L.,
            Kempf,G., Sandoval,B., Schmitt,S., Rutter,J.C., Galli,P.,
            Sandate,C.R., Cutler,J.A., Zou,C., Donovan,K.A., Lumpkin,R.J.,
            Cavadini,S., Park,P.M.C., Sievers,Q., Hatton,C., Ener,E.,
            Regalado,B.D., Sperling,M.T., Slabicki,M., Kim,J., Zon,R.,
            Zhang,Z., Miller,P.G., Belizaire,R., Sperling,A.S., Fischer,E.S.,
            Irizarry,R., Armstrong,S.A., Thoma,N.H. and Ebert,B.L.
  TITLE     UBR5 forms ligand-dependent complexes on chromatin to regulate
            nuclear hormone receptor stability
  JOURNAL   Mol Cell 83 (15), 2753-2767 (2023)
   PUBMED   37478846
REFERENCE   5  (bases 1 to 13037)
  AUTHORS   Xia,Q., Li,F., Min,R., Sun,S., Han,Y.X., Feng,Z.Z. and Li,N.
  TITLE     Malignancy risk factors and prognostic variables of pancreatic
            mucinous cystic neoplasms in Chinese patients
  JOURNAL   World J Gastroenterol 29 (20), 3119-3132 (2023)
   PUBMED   37346158
  REMARK    GeneRIF: Malignancy risk factors and prognostic variables of
            pancreatic mucinous cystic neoplasms in Chinese patients.
REFERENCE   6  (bases 1 to 13037)
  AUTHORS   Ing,N.H., Beekman,J.M., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Members of the steroid hormone receptor superfamily interact with
            TFIIB (S300-II)
  JOURNAL   J Biol Chem 267 (25), 17617-17623 (1992)
   PUBMED   1517211
REFERENCE   7  (bases 1 to 13037)
  AUTHORS   Bagchi,M.K., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Ligand and DNA-dependent phosphorylation of human progesterone
            receptor in vitro
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2664-2668 (1992)
   PUBMED   1557371
REFERENCE   8  (bases 1 to 13037)
  AUTHORS   Kastner,P., Krust,A., Turcotte,B., Stropp,U., Tora,L.,
            Gronemeyer,H. and Chambon,P.
  TITLE     Two distinct estrogen-regulated promoters generate transcripts
            encoding the two functionally different human progesterone receptor
            forms A and B
  JOURNAL   EMBO J 9 (5), 1603-1614 (1990)
   PUBMED   2328727
REFERENCE   9  (bases 1 to 13037)
  AUTHORS   Guiochon-Mantel,A., Loosfelt,H., Lescop,P., Sar,S., Atger,M.,
            Perrot-Applanat,M. and Milgrom,E.
  TITLE     Mechanisms of nuclear localization of the progesterone receptor:
            evidence for interaction between monomers
  JOURNAL   Cell 57 (7), 1147-1154 (1989)
   PUBMED   2736623
REFERENCE   10 (bases 1 to 13037)
  AUTHORS   Misrahi,M., Atger,M., d'Auriol,L., Loosfelt,H., Meriel,C.,
            Fridlansky,F., Guiochon-Mantel,A., Galibert,F. and Milgrom,E.
  TITLE     Complete amino acid sequence of the human progesterone receptor
            deduced from cloned cDNA
  JOURNAL   Biochem Biophys Res Commun 143 (2), 740-748 (1987)
   PUBMED   3551956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Raymond Dalgleish. The reference sequence was
            derived from AP001533.4 and M15716.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 16, 2007 this sequence version replaced NM_000926.3.
            
            Summary: This gene encodes a member of the steroid receptor
            superfamily. The encoded protein mediates the physiological effects
            of progesterone, which plays a central role in reproductive events
            associated with the establishment and maintenance of pregnancy.
            This gene uses two distinct promotors and translation start sites
            in the first exon to produce several transcript variants, both
            protein coding and non-protein coding. Two of the isoforms (A and
            B) are identical except for an additional 165 amino acids found in
            the N-terminus of isoform B and mediate their own response genes
            and physiologic effects with little overlap. [provided by RefSeq,
            Sep 2015].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (B).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51730.1, SRR14038192.2587752.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325455.10/ ENSP00000325120.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               AP001533.4         111092-111797       c
            707-3582            M15716.1           139-3014
            3583-13037          AP001533.4         11608-21062         c
FEATURES             Location/Qualifiers
     source          1..13037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..13037
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /note="progesterone receptor"
                     /db_xref="GeneID:5241"
                     /db_xref="HGNC:HGNC:8910"
                     /db_xref="MIM:607311"
     exon            1..2380
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     CDS             744..3545
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /note="isoform B is encoded by transcript variant 2;
                     nuclear receptor subfamily 3 group C member 3"
                     /codon_start=1
                     /product="progesterone receptor isoform B"
                     /protein_id="NP_000917.3"
                     /db_xref="CCDS:CCDS8310.1"
                     /db_xref="GeneID:5241"
                     /db_xref="HGNC:HGNC:8910"
                     /db_xref="MIM:607311"
                     /translation="MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDT
                     LPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSS
                     PPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRV
                     LSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAA
                     VEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFS
                     APRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAG
                     AASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEE
                     GAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSS
                     ASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAA
                     PALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKI
                     CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL
                     RKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQ
                     LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFR
                     NLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLC
                     LTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAI
                     GLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIA
                     AQLPKILAGMVKPLLFHKK"
     exon            2381..2532
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2649
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2955
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3100
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3231
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3389
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..13037
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6011..6016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /note="hexamer: AATAAA"
     polyA_site      6034
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /note="major polyA site"
     regulatory      13015..13020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /note="hexamer: AATAAA"
     polyA_site      13037
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /note="major polyA site"
ORIGIN      
        1 agtccacagc tgtcactaat cggggtaagc cttgttgtat ttgtgcgtgt gggtggcatt
       61 ctcaatgaga actagcttca cttgtcattt gagtgaaatc tacaacccga ggcggctagt
      121 gctcccgcac tactgggatc tgagatcttc ggagatgact gtcgcccgca gtacggagcc
      181 agcagaagtc cgacccttcc tgggaatggg ctgtaccgag aggtccgact agccccaggg
      241 ttttagtgag ggggcagtgg aactcagcga gggactgaga gcttcacagc atgcacgagt
      301 ttgatgccag agaaaaagtc gggagataaa ggagccgcgt gtcactaaat tgccgtcgca
      361 gccgcagcca ctcaagtgcc ggacttgtga gtactctgcg tctccagtcc tcggacagaa
      421 gttggagaac tctcttggag aactccccga gttaggagac gagatctcct aacaattact
      481 actttttctt gcgctcccca cttgccgctc gctgggacaa acgacagcca cagttcccct
      541 gacgacagga tggaggccaa gggcaggagc tgaccagcgc cgccctcccc cgcccccgac
      601 ccaggaggtg gagatccctc cggtccagcc acattcaaca cccactttct cctccctctg
      661 cccctatatt cccgaaaccc cctcctcctt cccttttccc tcctcctgga gacgggggag
      721 gagaaaaggg gagtccagtc gtcatgactg agctgaaggc aaagggtccc cgggctcccc
      781 acgtggcggg cggcccgccc tcccccgagg tcggatcccc actgctgtgt cgcccagccg
      841 caggtccgtt cccggggagc cagacctcgg acaccttgcc tgaagtttcg gccataccta
      901 tctccctgga cgggctactc ttccctcggc cctgccaggg acaggacccc tccgacgaaa
      961 agacgcagga ccagcagtcg ctgtcggacg tggagggcgc atattccaga gctgaagcta
     1021 caaggggtgc tggaggcagc agttctagtc ccccagaaaa ggacagcgga ctgctggaca
     1081 gtgtcttgga cactctgttg gcgccctcag gtcccgggca gagccaaccc agccctcccg
     1141 cctgcgaggt caccagctct tggtgcctgt ttggccccga acttcccgaa gatccaccgg
     1201 ctgcccccgc cacccagcgg gtgttgtccc cgctcatgag ccggtccggg tgcaaggttg
     1261 gagacagctc cgggacggca gctgcccata aagtgctgcc ccggggcctg tcaccagccc
     1321 ggcagctgct gctcccggcc tctgagagcc ctcactggtc cggggcccca gtgaagccgt
     1381 ctccgcaggc cgctgcggtg gaggttgagg aggaggatgg ctctgagtcc gaggagtctg
     1441 cgggtccgct tctgaagggc aaacctcggg ctctgggtgg cgcggcggct ggaggaggag
     1501 ccgcggctgt cccgccgggg gcggcagcag gaggcgtcgc cctggtcccc aaggaagatt
     1561 cccgcttctc agcgcccagg gtcgccctgg tggagcagga cgcgccgatg gcgcccgggc
     1621 gctccccgct ggccaccacg gtgatggatt tcatccacgt gcctatcctg cctctcaatc
     1681 acgccttatt ggcagcccgc actcggcagc tgctggaaga cgaaagttac gacggcgggg
     1741 ccggggctgc cagcgccttt gccccgccgc ggagttcacc ctgtgcctcg tccaccccgg
     1801 tcgctgtagg cgacttcccc gactgcgcgt acccgcccga cgccgagccc aaggacgacg
     1861 cgtaccctct ctatagcgac ttccagccgc ccgctctaaa gataaaggag gaggaggaag
     1921 gcgcggaggc ctccgcgcgc tccccgcgtt cctaccttgt ggccggtgcc aaccccgcag
     1981 ccttcccgga tttcccgttg gggccaccgc ccccgctgcc gccgcgagcg accccatcca
     2041 gacccgggga agcggcggtg acggccgcac ccgccagtgc ctcagtctcg tctgcgtcct
     2101 cctcggggtc gaccctggag tgcatcctgt acaaagcgga gggcgcgccg ccccagcagg
     2161 gcccgttcgc gccgccgccc tgcaaggcgc cgggcgcgag cggctgcctg ctcccgcggg
     2221 acggcctgcc ctccacctcc gcctctgccg ccgccgccgg ggcggccccc gcgctctacc
     2281 ctgcactcgg cctcaacggg ctcccgcagc tcggctacca ggccgccgtg ctcaaggagg
     2341 gcctgccgca ggtctacccg ccctatctca actacctgag gccggattca gaagccagcc
     2401 agagcccaca atacagcttc gagtcattac ctcagaagat ttgtttaatc tgtggggatg
     2461 aagcatcagg ctgtcattat ggtgtcctta cctgtgggag ctgtaaggtc ttctttaaga
     2521 gggcaatgga agggcagcac aactacttat gtgctggaag aaatgactgc atcgttgata
     2581 aaatccgcag aaaaaactgc ccagcatgtc gccttagaaa gtgctgtcag gctggcatgg
     2641 tccttggagg tcgaaaattt aaaaagttca ataaagtcag agttgtgaga gcactggatg
     2701 ctgttgctct cccacagcca gtgggcgttc caaatgaaag ccaagcccta agccagagat
     2761 tcactttttc accaggtcaa gacatacagt tgattccacc actgatcaac ctgttaatga
     2821 gcattgaacc agatgtgatc tatgcaggac atgacaacac aaaacctgac acctccagtt
     2881 ctttgctgac aagtcttaat caactaggcg agaggcaact tctttcagta gtcaagtggt
     2941 ctaaatcatt gccaggtttt cgaaacttac atattgatga ccagataact ctcattcagt
     3001 attcttggat gagcttaatg gtgtttggtc taggatggag atcctacaaa cacgtcagtg
     3061 ggcagatgct gtattttgca cctgatctaa tactaaatga acagcggatg aaagaatcat
     3121 cattctattc attatgcctt accatgtggc agatcccaca ggagtttgtc aagcttcaag
     3181 ttagccaaga agagttcctc tgtatgaaag tattgttact tcttaataca attcctttgg
     3241 aagggctacg aagtcaaacc cagtttgagg agatgaggtc aagctacatt agagagctca
     3301 tcaaggcaat tggtttgagg caaaaaggag ttgtgtcgag ctcacagcgt ttctatcaac
     3361 ttacaaaact tcttgataac ttgcatgatc ttgtcaaaca acttcatctg tactgcttga
     3421 atacatttat ccagtcccgg gcactgagtg ttgaatttcc agaaatgatg tctgaagtta
     3481 ttgctgcaca attacccaag atattggcag ggatggtgaa accccttctc tttcataaaa
     3541 agtgaatgtc atctttttct tttaaagaat taaattttgt ggtatgtctt tttgttttgg
     3601 tcaggattat gaggtcttga gtttttataa tgttcttctg aaagccttac atttataaca
     3661 tcatagtgtg taaatttaaa agaaaaattg tgaggttcta attattttct tttataaagt
     3721 ataattagaa tgtttaactg ttttgtttac ccatattttc ttgaagaatt tacaagattg
     3781 aaaaagtact aaaattgtta aagtaaacta tcttatccat attatttcat accatgtagg
     3841 tgaggatttt taacttttgc atctaacaaa tcatcgactt aagagaaaaa atcttacatg
     3901 taataacaca aagctattat atgttatttc taggtaactc cctttgtgtc aattatattt
     3961 ccaaaaatga acctttaaaa tggtatgcaa aattttgtct atatatattt gtgtgaggag
     4021 gaaattcata actttcctca gattttcaaa agtattttta atgcaaaaaa tgtagaaaga
     4081 gtttaaaacc actaaaatag attgatgttc ttcaaactag gcaaaacaac tcatatgtta
     4141 agaccatttt ccagattgga aacacaaatc tcttaggaag ttaataagta gattcatatc
     4201 attatgcaaa tagtattgtg ggttttgtag gtttttaaaa taaccttttt tggggagaga
     4261 attgtcctct aatgaggtat tgcgagtgga cataagaaat cagaagatta tggcctaact
     4321 gtactcctta ccaactgtgg catgctgaaa gttagtcact cttactgatt ctcaattctc
     4381 tcacctttga aagtagtaaa atatctttcc tgccaattgc tcctttgggt cagagcttat
     4441 taacatcttt tcaaatcaaa ggaaagaaga aagggagagg aggaggaggg aggtatcaat
     4501 tcacatacct ttctcctctt tatcctccac tatcatgaat tcatattatg tttcagccat
     4561 gcaaatcttt ttaccatgaa atttcttcca gaattttccc cctttgacac aaattccatg
     4621 catgtttcaa ccttcgagac tcagccaaat gtcatttctg taaaatcttc cctgagtctt
     4681 ccaagcagta atttgccttc tcctagagtt tacctgccat tttgtgcaca tttgagttac
     4741 agtagcatgt tattttacaa ttgtgactct cctgggagtc tgggagccat ataaagtggt
     4801 caatagtgtt tgctgactga gagttgaatg acattttctc tctgtcttgg tattactgta
     4861 gatttcgatc attctttggt tacatttctg catatttctg tacccatgac tttatcactt
     4921 tcttctccca tgctttatct ccatcaatta tcttcattac ttttaaattt tccacctttg
     4981 cttcctactt tgtgagatct ctccctttac tgactataac atagaagaat agaagtgtat
     5041 tttatgtgtc ttaaggacaa tactttagat tccttgttct aagtttttaa actgaatgaa
     5101 tggaatatta tttctctccc taagcaaaat tccacaaaac aattatttct tatgtttatg
     5161 tagccttaaa ttgttttgta ctgtaaacct cagcataaaa actttcttca tttctaattt
     5221 cattcaacaa atattgattg aatacctggt attagcacaa gaaaaatgtg ctaataagcc
     5281 ttatgagaat ttggagctga agaaagacat ataactcagg aaagttacag tccagtagta
     5341 ggtataaatt acagtgcctg ataaataggc attttaatat ttgtacactc aacgtatact
     5401 aggtaggtgc aaaacattta catataattt tactgatacc catgcagcac aaaggtacta
     5461 actttaaata ttaaataaca cctttatgtg tcagtaattc atttgcatta aatcttattg
     5521 aaaaggcttt caatatattt tccccacaaa tgtcatccca agaaaaaagt atttttaaca
     5581 tctcccaaat ataatagtta caggaaatct acctctgtga gagtgacacc tctcagaatg
     5641 aactgtgtga cacaagaaaa tgaatgtagg tctatccaaa aaaaacccca agaaacaaaa
     5701 acaatattat tagcccttta tgcttaagtg atggactcag ggaacagttg atgttgtgat
     5761 cattttatta tctgattctt gttactttga attaaaccaa tattttgatg atataaatca
     5821 tttccaccag catatattta atttccataa taactttaaa attttctaat ttcactcaac
     5881 tatgagggaa tagaatgtgg tggccacagg tttggctttt gttaaaatgt ttgatatctt
     5941 cgatgttgat ctctgtctgc aatgtagatg tctaaacact aggatttaat atttaaggct
     6001 aagctttaaa aataaagtac ctttttaaaa agaatatggc ttcaccaaat ggaaaatacc
     6061 taatttctaa atctttttct ctacaaagtc ctatctacta atgtctccat tactatttag
     6121 tcatcataac cattatcttc attttacatg tcgtgttctt tctggtagct ctaaaatgac
     6181 actaaatcat aagaagacag gttacatatc aggaaatact tgaaggttac tgaaatagat
     6241 tcttgagtta atgaaaatat tttctgtaaa aaggtttgaa aagccatttg agtctaaagc
     6301 attatacctc cattatcagt agttatgtga caattgtgtg tgtgtttaat gtttaaagat
     6361 gtggcacttt ttaataaggc aatgctatgc tattttttcc catttaacat taagataatt
     6421 tattgctata cagatgatat ggaaatatga tgaacaatat tttttttgcc aaaactatgc
     6481 cttgtaagta gccatggaat gtcaacctgt aacttaaatt atccacagat agtcatgtgt
     6541 ttgatgatgg gcactgtgga gataactgac ataggactgt gccccccttc tctgccactt
     6601 actagctgga tgagattaag caagtcattt aactgctctg attaaacctg cctttcccaa
     6661 gtgctttgta atgaatagaa atggaaacca aaaaaaacgt atacaggcct tcagaaatag
     6721 taattgctac tattttgttt tcattaagcc atagttctgg ctataatttt atcaaactca
     6781 ccagctatat tctacagtga aagcaggatt ctagaaagtc tcactgtttt atttatgtca
     6841 ccatgtgcta tgatatattt ggttgaattc atttgaaatt agggctggaa gtattcaagt
     6901 aatttcttct gctgaaaaaa tacagtgttt tgagtttagg gcctgtttta tcaaagttct
     6961 aaagagccta tcactcttcc attgtagaca ttttaaaata atgacactga ttttaacatt
     7021 tttaagtgtc tttttagaac agagagcctg actagaacac agcccctcca aaaacccatg
     7081 ctcaaattat ttttactatg gcagcaattc cacaaaaggg aacaatgggt ttagaaatta
     7141 caatgaagtc atcaacccaa aaaacatccc tatccctaag aaggttatga tataaaatgc
     7201 ccacaagaaa tctatgtctg ctttaatctg tcttttattg ctttggaagg atggctatta
     7261 catttttagt ttttgctgtg aatacctgag cagtttctct catccatact tatccttcac
     7321 acatcagaag tcaggataga atatgaatca ttttaaaaac ttttacaact ccagagccat
     7381 gtgcataaga agcattcaaa acttgccaaa acatacattt tttttcaaat ttaaagatac
     7441 tctatttttg tattcaatag ctcaacaact gtggtcccca ctgataaagt gaagtggaca
     7501 aggagacaag taatggcata agtttgtttt tcccaaagta tgcctgttca atagccattg
     7561 gatgtgggaa atttctacat ctcttaaaat tttacagaaa atacatagcc agatagtcta
     7621 gcaaaagttc accaagtcct aaattgctta tccttacttc actaagtcat gaaatcattt
     7681 taatgaaaag aacatcacct aggttttgtg gtttcttttt ttcttattca tggctgagtg
     7741 aaaacaacaa tctctgtttc tccctagcat ctgtggacta tttaatgtac cattattcca
     7801 cactctatgg tccttactaa atacaaaatt gaacaaaaag cagtaaaaca actgactctt
     7861 cacccatatt ataaaatata atccaagcca gattagtcaa catccataag atgaatccaa
     7921 gctgaactgg gcctagatta ttgagttcag gttggatcac atccctattt attaataaac
     7981 ttaggaaaga aggccttaca gaccatcagt tagctggagc taatagaacc tacacttcta
     8041 aagttcggcc tagaatcaat gtggccttaa aagctgaaaa gaagcaggaa agaacagttt
     8101 tcttcaataa tttgtccacc ctgtcactgg agaaaattta agaatttggg ggtgttggta
     8161 gtaagttaaa cacagcagct gttcatggca gaaattattc aatacatacc ttctctgaat
     8221 atcctataac caaagcaaag aaaaacacca aggggtttgt tctcctcctt ggagttgacc
     8281 tcattccaag gcagagctca ggtcacaggc acaggggctg cgcccaagct tgtccgcagc
     8341 cttatgcagc tgtggagtct ggaagactgt tgcaggactg ctggcctagt cccagaatgt
     8401 cagcctcatt ttcgatttac tggctcttgt tgctgtatgt catgctgacc ttattgttaa
     8461 acacaggttt gtttgctttt tttccactca tggagacatg ggagaggcat tatttttaag
     8521 ctggttgaaa gctttaaccg ataaagcatt tttagagaaa tgtgaatcag gcagctaaga
     8581 aagcatactc tgtccattac ggtaaagaaa atgcacagat tattaactct gcagtgtggc
     8641 attagtgtcc tggtcaatat tcggatagat atgaataaaa tatttaaatg gtattgtaaa
     8701 tagttttcag gacatatgct atagcttatt tttattatct tttgaaattg ctcttaatac
     8761 atcaaatcct gatgtattca atttatcaga tataaattat tctaaatgaa gcccagttaa
     8821 atgtttttgt cttgtcagtt atatgttaag tttctgatct ctttgtctat gacgtttact
     8881 aatctgcatt tttactgtta tgaattattt tagacagcag tggtttcaag ctttttgcca
     8941 ctaaaaatac cttttatttt ctcctccccc agaaaagtct ataccttgaa gtatctatcc
     9001 accaaactgt acttctatta agaaatagtt attgtgtttt cttaatgttt tgttattcaa
     9061 agacatatca atgaaagctg ctgagcagca tgaataacaa ttatatccac acagatttga
     9121 tatattttgt gcagccttaa cttgatagta taaaatgtca ttgcttttta aataatagtt
     9181 agtcaatgga cttctatcat agctttccta aactaggtta agatccagag ctttggggtc
     9241 ataatatatt acatacaatt aagttatctt tttctaaggg ctttaaaatt catgagaata
     9301 accaaaaaag gtatgtggag agttaataca aacataccat attcttgttg aaacagagat
     9361 gtggctctgc ttgttctcca taaggtagaa atactttcca gaatttgcct aaactagtaa
     9421 gccctgaatt tgctatgatt agggatagga agagattttc acatggcaga ctttagaatt
     9481 cttcacttta gccagtaaag tatctccttt tgatcttagt attctgtgta ttttaacttt
     9541 tctgagttgt gcatgtttat aagaaaaatc agcacaaagg gtttaagtta aagccttttt
     9601 actgaaattt gaaagaaaca gaagaaaata tcaaagttct ttgtattttg agaggattaa
     9661 atatgattta caaaagttac atggagggct ctctaaaaca ttaaattaat tattttttgt
     9721 tgaaaagtct tactttaggc atcattttat tcctcagcaa ctagctgtga agcctttact
     9781 gtgctgtatg ccagtcactc tgctagattg tggagattac cagtgttccc gtcttctccg
     9841 agcttagagt tggatgggga ataaagacag gtaaacagat agctacaata ttgtactgtg
     9901 aatgcttatg ctggaggaag tacagggaac tattggagca cctaagagga gcacctacct
     9961 tgaatttagg ggttagcaga ggcatcctga aaaaagtcaa agctaagcca caatctataa
    10021 gcagtttagg aattagcaga acgtgcgtgg tgaggagatg ccaaaggcaa gaagagaaga
    10081 gtattccaaa caggagggat tccaaagaga gaagagtatc ccaaacaaca tttgcacaaa
    10141 cctgatgggg agagagaatg tggggtgggg atggatgatg agactgaaga agaaagccag
    10201 gtctagataa tcagtggcct tgtacaccat gttaaagagt gtagacttga ttctgttgta
    10261 aacaggaaag cagcacaatt catatgaata ttttagaaga ctcccactgg aatatggaga
    10321 ataaagttgg agatgactaa tcctggaagc agggagaaca tttttgagga agttgcacta
    10381 ttttggtgaa aatgatgatc ataaacatga agaattgtag gtgatcatga cctcctctct
    10441 aattttccag aagggttttg gaagatataa cataggaaca ttgacaggac tgacgaaagg
    10501 agatgaaata caccatataa attgtcaaac acaaggccag atgtctaatt attttgctta
    10561 tgtgttgaaa ttacaaattt ttcatcagga aaccaaaaac tacaaaactt agttttccca
    10621 agtcccagaa ttctatctgt ccaaacaatc tgtaccactc cacctatatc cctacctttg
    10681 catgtctgtc caacctcaaa gtccaggtct atacacacgg gtaagactag agcagttcaa
    10741 gtttcagaaa atgagaaaga ggaactgagt tgtgctgaac ccatacaaaa taaacacatt
    10801 ctttgtatag attcttggaa cctcgagagg aattcaccta actcataggt atttgatggt
    10861 atgaatccat ggctgggctc ggcttttaaa aagccttatc tgggattcct tctatggaac
    10921 caagttccat caaagcccat ttaaaagcct acattaaaaa caaaattctt gctgcattgt
    10981 atacaaataa tgatgtcatg atcaaataat cagatgccat tatcaagtgg aattacaaaa
    11041 tggtataccc actccaaaaa aaaaaaaaaa gctaaattct cagtagaaca ttgtgacttc
    11101 atgagccctc cacagccttg gagctgagga gggagcactg gtgagcagta ggttgaagag
    11161 aaaacttggc gcttaataat ctatccatgt tttttcatct aaaagagcct tctttttgga
    11221 ttaccttatt caatttccat caaggaaatt gttagttcca ctaaccagac agcagctggg
    11281 aaggcagaag cttactgtat gtacatggta gctgtgggaa ggaggtttct ttctccaggt
    11341 cctcactggc catacaccag tcccttgtta gttatgcctg gtcatagacc cccgttgcta
    11401 tcatctcata tttaagtctt tggcttgtga atttatctat tctttcagct tcagcactgc
    11461 agagtgctgg gactttgcta acttccattt cttgctggct tagcacattc ctcataggcc
    11521 cagctctttt ctcatctggc cctgctgtgg agtcaccttg ccccttcagg agagccatgg
    11581 cttaccactg cctgctaagc ctccactcag ctgccaccac actaaatcca agcttctcta
    11641 agatgttgca gactttacag gcaagcataa aaggcttgat cttcctggac ttccctttac
    11701 ttgtctgaat ctcacctcct tcaactttca gtctcagaat gtaggcattt gtcctctttg
    11761 ccctacatct tccttcttct gaatcatgaa agcctctcac ttcctcttgc tatgtgctgg
    11821 aggcttctgt caggttttag aatgagttct catctagtcc tagtagcttt tgatgcttaa
    11881 gtccaccttt taaggatacc tttgagattt agaccatgtt tttcgcttga gaaagcccta
    11941 atctccagac ttgcctttct gtggatttca aagaccaact gaggaagtca aaagctgaat
    12001 gttgactttc tttgaacatt tccgctataa caattccaat tctcctcaga gcaatatgcc
    12061 tgcctccaac tgaccaggag aaaggtccag tgccaaagag aaaaacacaa agattaatta
    12121 tttcagttga gcacatactt tcaaagtggt ttgggtattc atatgaggtt ttctgtcaag
    12181 agggtgagac tcttcatcta tccatgtgtg cctgacagtt ctcctggcac tggctggtaa
    12241 cagatgcaaa actgtaaaaa ttaagtgatc atgtatttta acgatatcat cacatactta
    12301 ttttctatgt aatgttttaa atttccccta acatactttg actgttttgc acatggtaga
    12361 tattcacatt tttttgtgtt gaagttgatg caatcttcaa agttatctac cccgttgctt
    12421 attagtaaaa ctagtgttaa tacttggcaa gagatgcagg gaatctttct catgactcac
    12481 gccctattta gttattaatg ctactaccct attttgagta agtagtaggt ccctaagtac
    12541 attgtccaga gttatacttt taaagatatt tagccccata tacttcttga atctaaagtc
    12601 atacaccttg ctcctcattt ctgagtggga aagacatttg agagtatgtt gacaattgtt
    12661 ctgaaggttt ttgccaagaa ggtgaaactg tcctttcatc tgtgtatgcc tggggctggg
    12721 tccctggcag tgatggggtg acaatgcaaa gctgtaaaaa ctaggtgcta gtgggcacct
    12781 aatatcatca tcatatactt attttcaagc taatatgcaa aatcccatct ctgtttttaa
    12841 actaagtgta gatttcagag aaaatatttt gtggttcaca taagaaaaca gtctactcag
    12901 cttgacaagt gttttatgtt aaattggctg gtggtttgaa atgaatcatc ttcacataat
    12961 gttttcttta aaaatattgt gaatttaact ctaattcttg ttattctgtg tgataataaa
    13021 gaataaacta atttcta
//
