LOCUS       NM_001167902            1481 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens pyroglutamyl-peptidase I like (PGPEP1L), transcript
            variant 2, mRNA.
ACCESSION   NM_001167902
VERSION     NM_001167902.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK058162.1, AC036108.19, BC104744.1, BC104743.1 and AC069029.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001167902.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. It also represents
            the allele encoded by the GRCh38 reference genome. The encoded
            isoform (2) has a shorter N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK058162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535714.2/ ENSP00000437560.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK058162.1         4-9
            7-412               AC036108.19        145031-145436
            413-468             AK058162.1         416-471
            469-528             AC036108.19        147195-147254
            529-1134            BC104744.1         1-606
            1135-1430           BC104743.1         700-995
            1431-1480           AK058162.1         1435-1484
            1481-1481           AC069029.9         17579-17579
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..1481
                     /gene="PGPEP1L"
                     /note="pyroglutamyl-peptidase I like"
                     /db_xref="GeneID:145814"
                     /db_xref="HGNC:HGNC:27080"
     exon            1..434
                     /gene="PGPEP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            435..662
                     /gene="PGPEP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            663..785
                     /gene="PGPEP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1012
                     /gene="PGPEP1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             804..1232
                     /gene="PGPEP1L"
                     /EC_number="3.4.19.-"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pyroglutamyl-peptidase 1-like protein"
                     /codon_start=1
                     /product="pyroglutamyl-peptidase 1-like protein isoform 2"
                     /protein_id="NP_001161374.1"
                     /db_xref="CCDS:CCDS58400.1"
                     /db_xref="GeneID:145814"
                     /db_xref="HGNC:HGNC:27080"
                     /translation="MDTAAKAIILEQSGKNQGYRDADIRSFWPEGGVCLPGSPDVLES
                     GVCMKAVCKRVAVEGVDVIFSRDAGRYVCDYTYYLSLHHGKGCAALIHVPPLSRGLPA
                     SLLGRALRVIIQEMLEEVGKPKHRAQFEENSTMVLPAKGN"
     exon            1013..1481
                     /gene="PGPEP1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGPEP1L"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="PGPEP1L"
                     /note="major polyA site"
ORIGIN      
        1 agcaacttgc tggagtcgcc ttctgtgctg tggaagtttt gttgttttgc ttgtttgcaa
       61 taaccgttgc tgctgcttac tgtttgggtc cgcactgcct ttatgagctg taacgctcac
      121 cgtgaaggtc tgcagcttcg ttcttaaagc cagccacatc acggacccac cgggagaaac
      181 gaataactcc aaacacgcca ccttaagagc cgtagcactc atgatgaagg tccgtagctt
      241 cactcctgaa gtcagcgaga tcacgaatct gccagaagga agaaactccg aacacatgcg
      301 agcatcagaa gaaacaaact tgggacacgc tgcctttaaa aactgtaaca ctcaccgcca
      361 gggtccgcgg cttcgttctt gaagtcagtg agaccaagaa tccgccgatt ctggacacac
      421 catgacggaa ctagatcctt ggcctttcgg ggcccagaac gctacggacg ccgggcggcc
      481 aggaggggtt gggctcccgc tccaccccgg tccccggcga gcacgcggcc aggcagagaa
      541 ggtgcccgga gctcagagcg cgcagagccc ggccgctggg ccgctgcctg agccagggag
      601 gcgcagcgcg agctcccact tcgtcttcat ggattcccag cccagctgcg tggtggtgac
      661 tggagctctc caagctgggc ctggggaatg aaacagtggt gcagctgcgg actctggagc
      721 tgcctgtaga ttacagggag gctaagcgga gggtcaccgg aatctgggaa gatcatcagc
      781 cgcaactcgt cgtgcatgtg ggcatggaca ccgccgccaa ggcgatcatt ctggaacagt
      841 ctggcaagaa ccaaggctac cgggacgccg acatccgcag cttctggccc gagggcggcg
      901 tgtgcctacc tggcagccca gacgtgctgg agtcaggggt ctgcatgaag gcagtctgca
      961 agcgcgtagc tgtggagggt gtcgacgtga tcttttcccg agatgcaggc agatacgtct
     1021 gtgattatac ctattacctg tctctgcatc atggaaaggg ctgcgcggca ctcatccatg
     1081 tccctccact atcgcgcggg ctcccggcca gcctgctggg aagagccttg agagtcatca
     1141 tccaggaaat gctggaagag gtgggaaagc ccaagcacag agcccagttc gaagaaaact
     1201 caaccatggt ccttccagcc aaagggaact gaccggggga ttgctcctct agagaaaatt
     1261 gaatgtttca atcctgtatg tagcactcaa ctgtgcattg agaaactttt tcaaaaattg
     1321 cttgtaagac aaagagggtg gaaaactctg aattagccca acaaaatcac aaagggttat
     1381 tttattgtca ggagaaagaa cactctgaaa ggtggacatt tcacagggga tgaactagct
     1441 tcagttatgg ttttcatgac aataaaatga aatccgagtc a
//
