LOCUS       NM_017712               7081 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pyroglutamyl-peptidase I (PGPEP1), transcript variant
            1, mRNA.
ACCESSION   NM_017712
VERSION     NM_017712.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7081)
  AUTHORS   Wang,P., Chen,J., Ye,X., Wang,R., Chen,L. and Zhang,H.
  TITLE     Circ-PGPEP1 augments renal cell carcinoma proliferation, Warburg
            effect, and distant metastasis
  JOURNAL   Acta Biochim Pol 70 (3), 703-711 (2023)
   PUBMED   37722013
  REMARK    GeneRIF: Circ-PGPEP1 augments renal cell carcinoma proliferation,
            Warburg effect, and distant metastasis.
REFERENCE   2  (bases 1 to 7081)
  AUTHORS   Bai,H., Fang,B., Wang,X., Qin,W., Chen,Y., Zhang,D., Li,Y.,
            Peng,B., Yang,X., Fu,L. and Li,L.
  TITLE     Two-photon fluorogenic probe for visualizing PGP-1 activity in
            inflammatory tissues and serum from patients
  JOURNAL   Chem Commun (Camb) 57 (97), 13186-13189 (2021)
   PUBMED   34816269
  REMARK    GeneRIF: Two-photon fluorogenic probe for visualizing PGP-1
            activity in inflammatory tissues and serum from patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7081)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7081)
  AUTHORS   Perez,I., Blanco,L., Sanz,B., Errarte,P., Ariz,U., Beitia,M.,
            Fernandez,A., Loizate,A., Candenas,M.L., Pinto,F.M., Gil,J.,
            Lopez,J.I. and Larrinaga,G.
  TITLE     Altered Activity and Expression of Cytosolic Peptidases in
            Colorectal Cancer
  JOURNAL   Int J Med Sci 12 (6), 458-467 (2015)
   PUBMED   26078706
  REMARK    GeneRIF: cytosolic peptidases(puromycin-sensitive aminopeptidase
            (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) )
            may be involved in colorectal carcinogenesis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7081)
  AUTHORS   Megias,M.J., Alba-Araguez,F., Luna,J.D., Vives,F. and
            Ramirez-Sanchez,M.
  TITLE     Serum pyroglutamyl aminopeptidase activity: a promising novel
            biomarker candidate for liver cirrhosis
  JOURNAL   Endocr Regul 49 (1), 20-24 (2015)
   PUBMED   25687677
  REMARK    GeneRIF: The specific reduction of the levels of
            pyroglutamyl-aminopeptidase activity in serum of liver cirrhosis
            patients might be considered as a potential candidate to be
            included in a combination of markers for the diagnosis of this
            disease.
REFERENCE   6  (bases 1 to 7081)
  AUTHORS   Dando,P.M., Fortunato,M., Strand,G.B., Smith,T.S. and Barrett,A.J.
  TITLE     Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation
            of the recombinant human enzyme
  JOURNAL   Protein Expr Purif 28 (1), 111-119 (2003)
   PUBMED   12651114
  REMARK    GeneRIF: cloning and sequencing of the human (AJ278828)
            pyroglutamyl-peptidase I
REFERENCE   7  (bases 1 to 7081)
  AUTHORS   Gil,J., Larrinaga,G., Meana,J.J., Rodriguez-Puertas,R., Irazusta,J.
            and Casis,L.
  TITLE     Regional and subcellular distribution of soluble aminopeptidase in
            the human and the rat brain: a comparative study
  JOURNAL   Neuropeptides 35 (5-6), 276-284 (2001)
   PUBMED   12030812
REFERENCE   8  (bases 1 to 7081)
  AUTHORS   Cummins,P.M. and O'Connor,B.
  TITLE     Pyroglutamyl peptidase: an overview of the three known enzymatic
            forms
  JOURNAL   Biochim Biophys Acta 1429 (1), 1-17 (1998)
   PUBMED   9920379
  REMARK    Review article
REFERENCE   9  (bases 1 to 7081)
  AUTHORS   O'Cuinn,G., O'Connor,B. and Elmore,M.
  TITLE     Degradation of thyrotropin-releasing hormone and luteinising
            hormone-releasing hormone by enzymes of brain tissue
  JOURNAL   J Neurochem 54 (1), 1-13 (1990)
   PUBMED   2104543
  REMARK    Review article
REFERENCE   10 (bases 1 to 7081)
  AUTHORS   Charli,J.L., Mendez,M., Vargas,M.A., Cisneros,M., Assai,M.,
            Joseph-Bravo,P. and Wilk,S.
  TITLE     Pyroglutamyl peptidase II inhibition specifically increases
            recovery of TRH released from rat brain slices
  JOURNAL   Neuropeptides 14 (3), 191-196 (1989)
   PUBMED   2575716
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA315740.1, AK000215.1 and
            AC008397.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017712.3.
            
            Summary: The gene encodes a cysteine protease and member of the
            peptidase C15 family of proteins. The encoded protein cleaves amino
            terminal pyroglutamate residues from protein substrates including
            thyrotropin-releasing hormone and other neuropeptides. Expression
            of this gene may be downregulated in colorectal cancer, while
            activity of the encoded protein may be negatively correlated with
            cancer progression in colorectal cancer patients. Activity of the
            encoded protease may also be altered in other disease states
            including in liver cirrhosis, which is associated with reduced
            protease activity, and in necrozoospermia, which is associated with
            elevated protease activity. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP329806.1, SRR1803612.195312.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269919.11/ ENSP00000269919.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA315740.1         12-53
            43-521              AK000215.1         1-479
            522-7081            AC008397.7         132695-139254
FEATURES             Location/Qualifiers
     source          1..7081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..7081
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /note="pyroglutamyl-peptidase I"
                     /db_xref="GeneID:54858"
                     /db_xref="HGNC:HGNC:13568"
                     /db_xref="MIM:610694"
     exon            1..118
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..714
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /EC_number="3.4.19.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pyrrolidone-carboxylate peptidase; 5-oxoprolyl-peptidase;
                     pyroglutamyl-peptidase 1; pyroglutamyl aminopeptidase I;
                     pGlu-peptidase I"
                     /codon_start=1
                     /product="pyroglutamyl-peptidase 1 isoform 1"
                     /protein_id="NP_060182.1"
                     /db_xref="CCDS:CCDS12375.1"
                     /db_xref="GeneID:54858"
                     /db_xref="HGNC:HGNC:13568"
                     /db_xref="MIM:610694"
                     /translation="MEQPRKAVVVTGFGPFGEHTVNASWIAVQELEKLGLGDSVDLHV
                     YEIPVEYQTVQRLIPALWEKHSPQLVVHVGVSGMATTVTLEKCGHNKGYKGLDNCRFC
                     PGSQCCVEDGPESIDSIIDMDAVCKRVTTLGLDVSVTISQDAGRYLCDFTYYTSLYQS
                     HGRSAFVHVPPLGKPYNADQLGRALRAIIEEMLDLLEQSEGKINYCHKH"
     exon            119..171
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            172..288
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            289..521
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            522..7081
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7060..7065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /note="hexamer: AATAAA"
     polyA_site      7081
                     /gene="PGPEP1"
                     /gene_synonym="PAP-I; Pcp; PGI; PGP; PGP-I; PGPI"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcgcggc cgagaggctg cagcggcagc agctgtcgcg ccagtcgcaa cagaagcagg
       61 tccgaggcac agcccgatcc cgccatggag cagccgagga aggcggtggt agtgacggga
      121 tttggccctt ttggggaaca caccgtgaac gccagttgga ttgcagttca ggagctagaa
      181 aagctaggcc ttggcgacag cgtggacctg catgtgtacg agattccggt tgagtaccaa
      241 acagtccaga gactcatccc cgccctgtgg gagaagcaca gtccacagct ggtggtgcat
      301 gtgggggtgt caggcatggc gaccacagtc acactggaga aatgtggaca caacaagggc
      361 tacaaggggc tggacaactg ccgcttttgc cccggctccc agtgctgcgt ggaggacggg
      421 cctgaaagca ttgactccat catcgacatg gatgctgtgt gcaagcgagt caccacgttg
      481 ggcctggatg tgtcggtgac catctcgcag gatgccggca gatatctctg cgactttacc
      541 tactacacct ctttgtacca gagtcacggt cgatcagcct tcgtccacgt gcccccactg
      601 gggaagccgt acaacgcgga ccagctgggc agggcactga gagccatcat tgaggagatg
      661 ttggacctcc tggagcagtc agagggcaaa atcaactatt gccacaaaca ctgagggacg
      721 ctcaggtctc ctaagacctc atcctgctgg ggaccccacg aggggacatc caccctctgg
      781 ggtgtggcca ggaaaagaca agctcttcag cttggggatc cgatctggaa gagagattct
      841 gatctgccca cctcctcttc ctccttctct acaaaagctc cggttgattc gagggaagtg
      901 gtgaaaattt ttttttctcc cattttcctc cctgcatctg gggacacagc tgccgtgacc
      961 agggaggcca gcctgggagg tccagatgcc cagggagaat cttggtctgg tgaatccatg
     1021 agctgcgata ccacggctgg ggccatatgt tcacctgctt tcctgtccgt tggtgaagga
     1081 atttcagaat tcattttata tccaagactg gcttttacca aatttaaaag cctctcaatg
     1141 cgtcctcgac cttgaactgt gctcaacagc ctggcccttt ctggggccac cctgggatat
     1201 ggctggctgg ctggctttct ttctttcttt ctttctttct ttcttgcttt ctttctttct
     1261 tgctttcttt cttctctctc tctctttttt ttttttttta aatagtgcta gtttgggcac
     1321 agagtaattt atattccctt tggttaaaat gcaggctttt tagccaacaa caaaagtgtt
     1381 ttccccccac ccccactcgc ccaccagggt gatgccactt ttgcctcctg ccctgaaaat
     1441 tggacttaag atgccatgtc ttggccaggc gcagtggctc atgcctgtaa tcccagcact
     1501 ttggaaggcc agggtgggcg gatcacctga gatcaggagt tcaagatcag cctggccaac
     1561 atggtgaaac cctgcctcta ctaaaaatac aaaaattagc cgggcatggt gatgagtgcc
     1621 tgtagtccca gctactcggg aggctgaggc tggagaatcg cttgaacttg ggaggcagag
     1681 gttgcagtga gctgagattg cacagctgca ctccagcctg ggtgacagag cgagactctg
     1741 tctcaaaaca attggactta agatggcatg tctttgtttt agggccaaaa atgaggcccc
     1801 cttgcttaag gcatggggtc cgtggccagg caacggggtg ggactgctgc cccagatgtg
     1861 gccatggggg tcgtggtcct ttcaacacca agctatgagc tgtcgccatg gagaccaggg
     1921 ccacctgtgg aaaggcggat tttgtctgct tttgactttt cttttttaat atgtaaaact
     1981 ccacatcagc ggaaaccccc ccctacttct ggcctggagc ttcagggttt tggtgctggg
     2041 acgagtttgt tgttctcctt agcggggtgg cgcggggggc tcaaaacggg ggcgcggggg
     2101 ctggagttgg cagagctctg catgtcccgg catgtctgag caggaggaat tccgggcggc
     2161 caaagggttt tatgtagatt gcttttggac actcgcccag gagtcaggag ttgattttta
     2221 tctcacttcc tggtaacctt gaacttacca ggcagggatg agatgacgta aacttcctca
     2281 gatgatgtaa gttcagccac atcttgctgc ccattaggga gagaggacga cccccacagt
     2341 gaaagtaatt gagtgaaatg cacgttctgg aaatcagttt ctattttggc ctggaggaat
     2401 gtggctatac tgcttccctg agtgtgacac agttggaatc taatcttgtt ggtttcccaa
     2461 catctaggtt tttgtttgtt tgtttgtttt tatgataggg tcttgttctg ttgaccaggc
     2521 tggagtacag tagtgtgatc atggatcact gcagcctcta cctcctgggc tcaagtgatc
     2581 ctcccatctc agcctcctga gtagctggga ctacaggcat gcaccaccac acctggctaa
     2641 tttttaaatt ttttatacag acagggtttc accatgttgc ccaggctggt ctcgaactcc
     2701 tggactcaaa ctgatcctcc tttctcggcc tcccaaagtg ctgggattac aggcatgagc
     2761 cactgcaccc agcccagttc tttcttaaaa cagctgagag ttttgttttc ttcagcgttc
     2821 accttccttg tctccagttc cgatgctggc agtggttcct acctctgttg ggtttctaga
     2881 tagtttggga acggggttga tgggtttctg tgaaacacat tttccaagtc ttgggctttc
     2941 tctggagggg aaggtggatg ctggcgggtg acttgcagtg ggcgcctggc agtgggtgtg
     3001 gactgtaact gacaggtgga aatgagtagg gacactattg ttccctccat gccagctttt
     3061 ttttttgctg gaaatgcccc ctccacaccc ctggtagctc tgtgtcctga gaaatccaga
     3121 gtgtgggaga catcactgca tctgtccccc cagcttctgt gaagggaagc tgtggcctct
     3181 tttgaatgtg gggaacaact gaagactcag gggtcaccca gaggtctggt ggaaagcaac
     3241 ttcaggtttc atcttgctct attcctcaaa ggtctggtct gtgggcctct gaggagaaaa
     3301 caggtctagc caagacaggg acaaaatggg gaaggggatg tgccaggcct gaactgagct
     3361 aagcacctgc cccgggctcc acacttccat ctttcttttg tcttcatttc acctctgtgt
     3421 ttaaagcact gtgtgacata gctccttaga gatataacct attgtctgct cattgtcacg
     3481 tgtgtgtgtg tcatctttgt attcttgcag tggtttcaca tttccttacc cagtcaagcc
     3541 agtatcccat ccttcctcat aatgcacaac atttggctca ttttattttt ctcattgtta
     3601 ttttttattt ttattttttg agatggattc tcacactgtt actcgggcta gagtgcaatg
     3661 gcgtgatctc ggctcactgc aacctccacc tcctgggttt acacaattct cctgcctcag
     3721 cctcccgagt agctgggatt acaggcgccc gtcaccacac ctggctaatt tttgtatttt
     3781 tagtagagat gcagcttcac catgttggcc aggctggtct tgaaatcctg acctcaggtg
     3841 atctgcctgc cttggcctcc caaagtgctg ggattacagg tgtgagctac tgcgcctggc
     3901 caagtttttt acaaatattt ttcttttggt ggaactcatc tgtgcactct ctggtgtgtt
     3961 tttccacctt tgttgggtct tggcttaaaa tatcctcatg tgggctaggt gtggttactc
     4021 acacctgtaa tcctagcact ttgggaggtt gaggcaggag aatcccttga gccaggagtt
     4081 caagaccagc ctgggcaaca tagcaagaga tcccatatct accaaaacat acaagaatta
     4141 gccagatgtg gtggtgcatg cctgtggtcc cagatactca ggaggctgag gcaggaggat
     4201 cacctatgcc tgggaggttg aagccccagt gagccatgat cacaccactg tagtccagcc
     4261 cgggtgacac agcaagactc tgtctcaaaa aaaaaaaaaa aaaaaatcct catgcaagaa
     4321 gggaaggacc aagtcccatt ccctcttgcc tcattttcag agcctggggt aggggctaca
     4381 ggtggcatag gaagggtctg caaggtgggt gggacttggc aggtgttggg aagaggaata
     4441 ggggtggcaa gtgtcaatgg tgaaaagaca ggctgagggg tgtggtggga aggctggggg
     4501 agaaaggtga gaagtgattg ggggggcttc cctgatgagt cctcatggag ggtgctgagg
     4561 cagggaacag gggtgcaggg acagtgatca gggcacctgg taccctgacc aacttgatga
     4621 tggcatctct tttaagatgc ccaagtctgc gcacttttat tcctttattc ggcccctagc
     4681 accccctccc caccccaaag aaggtcagtt gcatgcgtgt ggggatgtag ctcaaaaaag
     4741 aaataagatg gagtggaaag gaaagaaagg aagaagcagg aattcaaggt gggtgggctg
     4801 agcttggggc cacctagccc acctgctcca atcaagggct ggaacaaacc tgaggccact
     4861 tggagaggca gggctgggca gggacagggg gtgggggccg aaatcacagc ttccccatca
     4921 gagccagatg tgtgaaggaa atgtcccaga tggcagtagt ttctcggcaa ggaggggaat
     4981 cctggagatg gttcatgtct gtgatcccag tgctttggga ggctgaggtg ggaggattgc
     5041 ttgagcccgg gagttcgaga ccagccctgg gcaacatggc gagaccccat ctctacagaa
     5101 attaaaaaaa aaaattagcc agttgtggtg tcaagcacct gtagtcccag ctacttggga
     5161 ggctgagttg ggaggcttat ctgagcccag gaggtgaagg ctgcaatgag ccatgattac
     5221 actactgtac cccagcctgg gcaacagagc aagaccctgc ctcaaaatta agaaaaaaaa
     5281 aaggggggcc aggcgcagtg gcttatgcct gttatcccag cactttggga ggccaaggca
     5341 gactgatcgc ttgaggccag gagtttgcga ccagcctggc caacatagca aaaccccatc
     5401 tctactaaaa atacaaaaat tagtcaagag tggatggtgc gtgcctgtaa tcccagctac
     5461 ctgggaggct gagacaggag aattgcttga acctgggagg cagaggttgc agtggtgtga
     5521 gatcacgcca ctgcattcca gactgggcaa catagcaaga ctctgtcaca aaaaaaaaaa
     5581 aaaaaaagaa ttccctgctc tgcttttctg ctcgttgctg gcatagaaac atctagaaca
     5641 gaaagtatcc actctggggc agatgggaga gctggaaaag tagattcaag atgcctttta
     5701 gtcttggaag tttcttccag gaagcaagac cagctggtat gtttacacct gcactccagt
     5761 gccctgggga ggtgaccagg tggaggggga tggctcatgg aaatctgtcc cgcacagctg
     5821 gccccctttt ggctgccact gtctagactg ttggcctttg acctctctgc ctcttgtggc
     5881 gtctgaacct agacgtccct tttggagaca gctggacaaa gccctattct ccgcagcccc
     5941 agcctctatc ctgaggcctc tgggagctgc gtgacggcca gcatggggtg ctgatcatgg
     6001 tcaaggaggc aggtctttgc caggttgccc catgcagcca cccatcctca gcatcctaac
     6061 ttgagggggc aggagagggc tttgttttta taatccggat taaatttccc ttccctgggc
     6121 acaagtgcct catgagggcc cggggctgct ggttgggagg gaaagcatcc ccgtttttgc
     6181 agtgaggagg ccggccgagg gctggggttc cacttagacc cttggcagaa tggctgttga
     6241 ggggcaggcg ctgcccagtg cccacgtctg gaaagctaat tcccgggtgg acgctgaaca
     6301 tacctgctga gagactctgt cccctggttt ccaggacagt tgtcacaagc tgagtggggg
     6361 gggactccca ggacttgagg gacccagtcc caccccaaac tgctccccct cccccaaatt
     6421 ccctttctcc tcctgctctt tctccccgct gtgcctcccc cagttaccca cagaagtgcc
     6481 tgcctctcca gcgctcacag aacacacaaa aagggacagg aattggtcac tgggtagtgg
     6541 ccgtggctcc tgacgatcca gaccagcgtc tggcccaagc cattcagagg tggggtctgg
     6601 ggcctggggg ttttgtgtcg tgacactttg tctcaaggag attccacata gggatttgaa
     6661 ttaggctttc tgcttgccaa ggcctgtggc atctgagcct ggctgagggc cgggcaagcc
     6721 tcccctgagc ctttggaagc cgagttcact ctctgcctgc ccaggggagc accggcttgg
     6781 ttctgggggc tcctctaaca tctcaggttt ttatcttgtc ttaaatttct ttctaggaaa
     6841 aaacccttcc ctgccaaagg tgactgtgtt ttctgccgcc gaaggagggc ccggtccctc
     6901 caggctcagt gtggcttctc cctgaccccc gccctagaac ttttgccagt gccttttctg
     6961 aaactcctgt gtcccgggcc ccccaggcgg agaaggatat gccggattct gcctggggct
     7021 gggctctagg agaccccaaa tttgacacca cagaaagcaa ataaaacact tgaaatacgc
     7081 a
//
