LOCUS       NM_001042371            3164 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.
ACCESSION   NM_001042371 NM_024118 XM_001130630 XM_001130859
VERSION     NM_001042371.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Mora Lagares,L., Perez-Castillo,Y. and Novic,M.
  TITLE     Exploring the dynamics of the ABCB1 membrane transporter
            P-glycoprotein in the presence of ATP and active/non-active
            compounds through molecular dynamics simulations
  JOURNAL   Toxicology 502, 153732 (2024)
   PUBMED   38272384
  REMARK    GeneRIF: Exploring the dynamics of the ABCB1 membrane transporter
            P-glycoprotein in the presence of ATP and active/non-active
            compounds through molecular dynamics simulations.
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Torres,G.G., Nygaard,M., Caliebe,A., Blanche,H., Chantalat,S.,
            Galan,P., Lieb,W., Christiansen,L., Deleuze,J.F., Christensen,K.,
            Strauch,K., Muller-Nurasyid,M., Peters,A., Nothen,M.M.,
            Hoffmann,P., Flachsbart,F., Schreiber,S., Ellinghaus,D., Franke,A.,
            Dose,J. and Nebel,A.
  TITLE     Exome-Wide Association Study Identifies FN3KRP and PGP as New
            Candidate Longevity Genes
  JOURNAL   J Gerontol A Biol Sci Med Sci 76 (5), 786-795 (2021)
   PUBMED   33491046
  REMARK    GeneRIF: Exome-Wide Association Study Identifies FN3KRP and PGP as
            New Candidate Longevity Genes.
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Segerer,G., Engelmann,D., Kaestner,A., Trotzmuller,M., Kofeler,H.,
            Stigloher,C., Thiele,C., Jeanclos,E. and Gohla,A.
  TITLE     A phosphoglycolate phosphatase/AUM-dependent link between
            triacylglycerol turnover and epidermal growth factor signaling
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (6), 584-594 (2018)
   PUBMED   29524543
  REMARK    GeneRIF: data explain how PGP exerts control over EGF-induced
            cellular protein tyrosine phosphorylation, and reveal an unexpected
            influence of triacylglycerol turnover on growth factor signaling.
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Beaudoin,G.A. and Hanson,A.D.
  TITLE     A Guardian Angel Phosphatase for Mainline Carbon Metabolism
  JOURNAL   Trends Biochem Sci 41 (11), 893-894 (2016)
   PUBMED   27544441
  REMARK    GeneRIF: Phosphoglycolate phosphatase rescues central carbon
            metabolism from toxic secondary metabolites in humans and yeast.
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Mugabo,Y., Zhao,S., Seifried,A., Gezzar,S., Al-Mass,A., Zhang,D.,
            Lamontagne,J., Attane,C., Poursharifi,P., Iglesias,J., Joly,E.,
            Peyot,M.L., Gohla,A., Madiraju,S.R. and Prentki,M.
  TITLE     Identification of a mammalian glycerol-3-phosphate phosphatase:
            Role in metabolism and signaling in pancreatic beta-cells and
            hepatocytes
  JOURNAL   Proc Natl Acad Sci U S A 113 (4), E430-E439 (2016)
   PUBMED   26755581
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   de Leon,J., Susce,M.T., Pan,R.M., Koch,W.H. and Wedlund,P.J.
  TITLE     Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and
            dopamine D2 and D3 receptors and their association with tardive
            dyskinesia in severe mental illness
  JOURNAL   J Clin Psychopharmacol 25 (5), 448-456 (2005)
   PUBMED   16160620
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Turzanski,J., Grundy,M., Shang,S., Russell,N. and Pallis,M.
  TITLE     P-glycoprotein is implicated in the inhibition of ceramide-induced
            apoptosis in TF-1 acute myeloid leukemia cells by modulation of the
            glucosylceramide synthase pathway
  JOURNAL   Exp Hematol 33 (1), 62-72 (2005)
   PUBMED   15661399
  REMARK    GeneRIF: cerp-gp confers resistance to ceramide-induced apoptosis,
            with modulation of the ceramide-glucosylceramide pathway GCS making
            a marked contribution to this resistance
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Zhou,S., Chan,E., Pan,S.Q., Huang,M. and Lee,E.J.
  TITLE     Pharmacokinetic interactions of drugs with St John's wort
  JOURNAL   J Psychopharmacol 18 (2), 262-276 (2004)
   PUBMED   15260917
  REMARK    GeneRIF: 'The available data indicate that St. John's wort is a
            potent induced of CYP 3A4 and P-glycoprotein (PgP), although it may
            inhibit or induce other CYPs...' See page 262.
            Review article
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Mulley,J.C., Barton,N. and Callen,D.F.
  TITLE     Localisation of human PGP and HAGH genes to 16p13.3
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 175-176 (1990)
   PUBMED   2164460
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Koeffler,H.P., Sparkes,R.S., Stang,H. and Mohandas,T.
  TITLE     Regional assignment of genes for human alpha-globin and
            phosphoglycollate phosphatase to the short arm of chromosome 16
  JOURNAL   Proc Natl Acad Sci U S A 78 (11), 7015-7018 (1981)
   PUBMED   6273902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009065.8, AW161386.1, BC035985.1, DA336356.1 and AK026146.1.
            
            On May 17, 2019 this sequence version replaced NM_001042371.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.10732.1,
                                           SRR1803616.239423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333503.8/ ENSP00000330918.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC009065.8         62572-62590
            20-55               AW161386.1         1-36
            56-1076             BC035985.1         1-1021
            1077-1494           DA336356.1         154-571
            1495-1611           AK026146.1         291-407
            1612-3155           AC009065.8         64267-65810
            3156-3164           AC009065.8         65811-65819
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3164
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /note="phosphoglycolate phosphatase"
                     /db_xref="GeneID:283871"
                     /db_xref="HGNC:HGNC:8909"
                     /db_xref="MIM:172280"
     exon            1..703
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1029
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.21"
                     /note="aspartate-based ubiquitous Mg(2+)-dependent
                     phosphatase"
                     /codon_start=1
                     /product="glycerol-3-phosphate phosphatase"
                     /protein_id="NP_001035830.1"
                     /db_xref="CCDS:CCDS42104.1"
                     /db_xref="GeneID:283871"
                     /db_xref="HGNC:HGNC:8909"
                     /db_xref="MIM:172280"
                     /translation="MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGET
                     AVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTA
                     YCTALYLRQRLAGAPAPKAYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAP
                     LEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCL
                     VRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKT
                     ILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPALQG"
     exon            704..3164
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /note="hexamer: AATAAA"
     polyA_site      1076
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /note="major polyA site"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /note="hexamer: ATTAAA"
     polyA_site      2760
                     /gene="PGP"
                     /gene_synonym="AUM; G3PP; PGPase"
                     /note="major polyA site"
ORIGIN      
        1 gagggcgccg cggcgggcgg ctgcgaggag cggccggcgg gcggcggcgg ccggcgggcg
       61 gcgatggcgg cggcggaggc cggtggcgac gacgcccgct gcgtgcggct gagcgccgag
      121 cgggcacagg cgctgctggc cgacgtggac acgctgctgt tcgactgcga cggcgtgctg
      181 tggcgcgggg agaccgccgt gcctggcgcg cccgaggccc tgcgggcgct gcgagcccgc
      241 ggcaagcgcc tgggcttcat caccaacaac agcagcaaga cccgcgctgc ctacgccgag
      301 aagctgcggc gcctgggctt cggcggcccc gcggggcccg gcgccagcct ggaggtcttc
      361 ggcacggcct actgcaccgc gctctacctg cgccagcgcc tggccggcgc ccccgcgccc
      421 aaggcctacg tgctgggcag cccagccctg gccgcggagc tggaggccgt gggcgtcgcc
      481 agcgtgggcg tggggcccga gccactgcag ggcgagggtc ccggcgactg gctgcacgcg
      541 ccgctggagc ccgacgtgcg cgcggtggtg gtgggctttg acccgcactt cagctacatg
      601 aagctcacca aggccctgcg ctacctgcag cagcccggct gcctgctcgt gggcaccaac
      661 atggacaacc ggcttccgct tgagaacggc cgcttcatcg cgggtaccgg gtgtctggtc
      721 cgagccgtgg agatggccgc ccagcgccag gccgacatca tcgggaagcc cagccgcttc
      781 attttcgact gcgtgtccca ggaatacggc atcaaccccg agcgcaccgt catggtggga
      841 gaccgcctgg acacagacat cctcctaggc gccacctgtg gcctgaagac catcctgacc
      901 ctcaccggag tctccactct aggggatgtg aagaataatc aggaaagtga ctgcgtgtct
      961 aagaagaaaa tggtccctga cttctatgtt gacagcatag ccgacctttt gcctgccctt
     1021 caaggttaaa gattgagtgt ctttaatctg cagaataaaa aaaaagaaat tgaaaaccag
     1081 ttacccaaat taataggtgg ggcttaagca tctgctcggc taagtggctt caaagagtgt
     1141 aattggagtt aagcaaaggc attcattgtt aaccttgtaa gtacacgttt gggggacgat
     1201 tttgtttaca gatgcttgta atcgaagatg cacttttagg cttggaaggc gttgtgggct
     1261 gggttctggg ccttgggtgg ggttggcagg ggcaggctct gcacctgtcc gggattcagg
     1321 taaccagggc ctgccgatgg gactgaggcg ggtctagggg tgtgtgtcct gtattttatt
     1381 gaaaaactca ttcagggatc cagcccctca gggggcagag ggactgatta ttctgactgt
     1441 tgggagaggc ttgcatggac cagagcccca tcagtatgac tgaaagtcca gcggagcctt
     1501 ctgtgtccct gtgcctccca gcagggtggg agtggaggag gcggctgctc ccaggtggca
     1561 tctccctgcc cttgggtgca aagtgctgcc ctcaccactc tcccacctcc cttacttcct
     1621 tgaaaaccac tctgatgtca caactgagtg tctgttccgt ttcagatacc cagggctgct
     1681 gcccagttct gtaaacgcag cccagctaaa gctctgctgt ctcaagtgtg catttatacc
     1741 caggtgattt ggacggagca gctaccatgg cgtggacgcc ttcactgaac tccgggctgc
     1801 agtgcaggga gctcagagca gtgctgctac cagtttttaa ctttgaacaa ctgtgtcagg
     1861 caatggattt gaattttaag tgtattaata gctgtgctct gtgtcgtagg caaaattcca
     1921 ctgaaggagc ctctgtgccc tgcagccggc agcgcggctg aagcatgtgt tggccaagga
     1981 atgcctgtca tccaggtgcc ctgcagccag cagcgcggct caagcatgtg ttggccaagg
     2041 aatgcctgtc agtcatccag ggctctggga ggggacgaga gttatgtccc caagaacagg
     2101 aagtccttta caaagcatcc agtctcttcc tgtcctcccc ttccctaggc tggggtaggg
     2161 gttagagact ggtggcccag gaggtcacct gccttgccct ggattccctc ttcagtggcc
     2221 agcaggactt ggcagggcca ccagctcgcc aaggttctgg gcggggctcc agcctctcct
     2281 gcctgctcct tggctctgct gacctttcac aggcctgaca gcagactcag cagggccatc
     2341 ccgggatgct gcaccttctg gctggctccc taccagcgcc tttccctgta cctggcagct
     2401 tctctcttgg ccccacagtc acagcactcc acttggtcac aaagacttca gagcaataag
     2461 aggcgtcctg agccttcagc acctcccagg cctgggatat cgggttcaga gggtgctgca
     2521 gagcagcatg agggtggctc cacccatgag gctggtgaca ctgacgctgg cttggctaag
     2581 ttggctcaag ccgggtctgg cctgacaggg tgcagtcaca ccaggagcgc atggcagatg
     2641 cagcctcagt gatgcctctc ttgccgggta ggggctggga gtccccgtgc atcctgtctc
     2701 tggcccatga ggggctgcag cactgtgggc gccagagcac agattaaact ctcaaaccca
     2761 cactggctca ggtgtccttg ctctcacctt gcattggccc gggtgatgcc gtctcaccac
     2821 gggtgggagg actcaaagta gatgggtaac tggggttcca actccagagc tggaatgcca
     2881 actgcccact cccagcctgg ttcagaggaa gatgttttga agaatgaggg aaagccaggc
     2941 acaaagggaa gccagggaag caaagggccc tggagtgaag ctggtgggct gccgtgtcag
     3001 agcgcccagg gcagggagca gagctcagaa gtaatgctgg cccgggcgca gtggctcaca
     3061 cccgtaatcc caacgctttg gaaggctgag gcaggtggat tacttgagat caggagttca
     3121 agaccagcct ggccaaaatg gtgaaaaccc atctctacta aaaa
//
