LOCUS       NM_173582               8477 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens phosphoglucomutase 2 like 1 (PGM2L1), mRNA.
ACCESSION   NM_173582
VERSION     NM_173582.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8477)
  AUTHORS   Morava,E., Schatz,U.A., Torring,P.M., Abbott,M.A., Baumann,M.,
            Brasch-Andersen,C., Chevalier,N., Dunkhase-Heinl,U., Fleger,M.,
            Haack,T.B., Nelson,S., Potelle,S., Radenkovic,S., Bommer,G.T., Van
            Schaftingen,E. and Veiga-da-Cunha,M.
  TITLE     Impaired glucose-1,6-biphosphate production due to bi-allelic
            PGM2L1 mutations is associated with a neurodevelopmental disorder
  JOURNAL   Am J Hum Genet 108 (6), 1151-1160 (2021)
   PUBMED   33979636
  REMARK    GeneRIF: Impaired glucose-1,6-biphosphate production due to
            bi-allelic PGM2L1 mutations is associated with a neurodevelopmental
            disorder.
REFERENCE   2  (bases 1 to 8477)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 8477)
  AUTHORS   Maliekal,P., Sokolova,T., Vertommen,D., Veiga-da-Cunha,M. and Van
            Schaftingen,E.
  TITLE     Molecular identification of mammalian phosphopentomutase and
            glucose-1,6-bisphosphate synthase, two members of the
            alpha-D-phosphohexomutase family
  JOURNAL   J Biol Chem 282 (44), 31844-31851 (2007)
   PUBMED   17804405
  REMARK    GeneRIF: Study shows that PGM2L1 which shows 60% homology with PGM2
            actually corresponds to glucose-1,6-bisphosphate synthase.
REFERENCE   4  (bases 1 to 8477)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8477)
  AUTHORS   Drago,G.A., Hopkinson,D.A., Westwood,S.A. and Whitehouse,D.B.
  TITLE     Antigenic analysis of the major human phosphoglucomutase isozymes:
            PGM1, PGM2, PGM3 and PGM4
  JOURNAL   Ann Hum Genet 55 (4), 263-271 (1991)
   PUBMED   1840235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001085.5.
            
            On Aug 31, 2019 this sequence version replaced NM_173582.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019210.1, SRR14038193.1681000.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298198.5/ ENSP00000298198.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               AP001085.5         139513-139895       c
            384-551             AP001085.5         115877-116044       c
            552-658             AP001085.5         113173-113279       c
            659-743             AP001085.5         112364-112448       c
            744-827             AP001085.5         109954-110037       c
            828-1021            AP001085.5         92845-93038         c
            1022-1211           AP001085.5         88610-88799         c
            1212-1309           AP001085.5         88194-88291         c
            1310-1490           AP001085.5         86931-87111         c
            1491-1584           AP001085.5         84785-84878         c
            1585-1714           AP001085.5         84347-84476         c
            1715-1904           AP001085.5         83923-84112         c
            1905-2038           AP001085.5         79930-80063         c
            2039-8477           AP001085.5         71778-78216         c
FEATURES             Location/Qualifiers
     source          1..8477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..8477
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /note="phosphoglucomutase 2 like 1"
                     /db_xref="GeneID:283209"
                     /db_xref="HGNC:HGNC:20898"
                     /db_xref="MIM:611610"
     exon            1..383
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2141
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /EC_number="2.7.1.106"
                     /codon_start=1
                     /product="glucose 1,6-bisphosphate synthase"
                     /protein_id="NP_775853.2"
                     /db_xref="CCDS:CCDS8231.1"
                     /db_xref="GeneID:283209"
                     /db_xref="HGNC:HGNC:20898"
                     /db_xref="MIM:611610"
                     /translation="MAENTEGDLNSNLLHAPYHTGDPQLDTAIGQWLRWDKNPKTKEQ
                     IENLLRNGMNKELRDRLCCRMTFGTAGLRSAMGAGFCYINDLTVIQSTQGMYKYLERC
                     FSDFKQRGFVVGYDTRGQVTSSCSSQRLAKLTAAVLLAKDVPVYLFSRYVPTPFVPYA
                     VQKLKAVAGVMITASHNRKEDNGYKVYWETGAQITSPHDKEILKCIEECVEPWNGSWN
                     DNLVDTSPLKRDPLQDICRRYMEDLKKICFYRELNSKTTLKFVHTSFHGVGHDYVQLA
                     FKVFGFKPPIPVPEQKDPDPDFSTVKCPNPEEGESVLELSLRLAEKENARVVLATDPD
                     ADRLAAAELQENGCWKVFTGNELAALFGWWMFDCWKKNKSRNADVKNVYMLATTVSSK
                     ILKAIALKEGFHFEETLPGFKWIGSRIIDLLENGKEVLFAFEESIGFLCGTSVLDKDG
                     VSAAVVVAEMASYLETMNITLKQQLVKVYEKYGYHISKTSYFLCYEPPTIKSIFERLR
                     NFDSPKEYPKFCGTFAILHVRDVTTGYDSSQPNKKSVLPVSKNSQMITFTFQNGCVAT
                     LRTSGTEPKIKYYAEMCASPDQSDTALLEEELKKLIDALIENFLQPSKNGLIWRSV"
     exon            384..551
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            552..658
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            659..743
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            744..827
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1021
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1211
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1309
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1490
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1584
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1714
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1904
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2038
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..8477
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8456..8461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /note="hexamer: AATAAA"
     polyA_site      8477
                     /gene="PGM2L1"
                     /gene_synonym="BM32A; NEDHFS; PMMLP"
                     /note="major polyA site"
ORIGIN      
        1 atctgggact gttgttctct cgcggcgcga ccgcctcagt cacttcgccc agagacccgg
       61 acctggtccg ctggggagca ggcggccata aaccccctct ctcccggttc cctgacgccg
      121 cggcaggagc tgttacgaac accctgcggt tggtctccga tgcccttcag tgaggtgggg
      181 acgcctggac cctggtgagc gaaccccaag ccacccccca ccccaactca gtgtcttcgc
      241 cggcccccgg cccgtacgcc tgtctggtcg ccatggctga aaacacagag ggggatctga
      301 actccaacct gctccacgcc ccctaccaca ccggggaccc tcagctggac acggccatcg
      361 ggcagtggct ccgctgggat aagaatccca aaacaaaaga gcagattgaa aacctgttac
      421 ggaatgggat gaacaaggag ctgcgagatc gtctttgttg ccgaatgact tttgggactg
      481 caggacttcg ttctgccatg ggggcagggt tttgctatat taatgacctt acagtaatac
      541 agtcaacaca ggggatgtac aaataccttg agagatgttt ctcagacttc aagcagagag
      601 gctttgtggt tgggtatgac actcggggtc aagtaactag cagctgcagc agccagaggc
      661 ttgctaaact cactgctgca gtcttgctgg ccaaagatgt tcctgtgtac cttttttcaa
      721 gatatgttcc tacacctttt gtaccatatg cagttcagaa gctcaaagca gttgcaggtg
      781 tgatgattac tgcctctcac aaccgcaagg aagacaatgg atacaaggtt tactgggaaa
      841 ctggtgctca gatcacatct cctcatgata aagaaattct aaaatgtata gaagaatgtg
      901 tggaaccctg gaatggttcc tggaatgata atttagtgga taccagcccg ctgaagagag
      961 accctctgca ggacatttgc aggagataca tggaagatct gaaaaagatc tgtttttaca
     1021 gggagttaaa ctcgaagacc accttgaaat ttgtgcacac atcttttcat ggggtcggac
     1081 atgactatgt gcagttggct tttaaagtgt ttggttttaa gcctccaatt ccagtaccag
     1141 aacaaaaaga tcctgatcca gacttttcta ccgttaaatg tccaaatcct gaagaaggag
     1201 aatctgtgct ggaactttcc ttgagactgg cagagaaaga aaatgcccgg gtagtgctag
     1261 ccacagatcc tgatgcagac agactggcag cagcagaact tcaggagaat ggttgttgga
     1321 aagttttcac agggaatgag ttggcagctt tgtttggatg gtggatgttt gattgctgga
     1381 agaaaaataa atcaagaaat gctgatgtga agaacgttta tatgttagcc accacagtct
     1441 cttctaaaat tctgaaggca attgcactta aagaaggatt tcattttgaa gaaacattac
     1501 caggttttaa atggattgga agtaggataa tagacctcct ggaaaatggg aaagaagtcc
     1561 tttttgcatt tgaagagtct attggttttc tctgtggaac ttcagttttg gataaagatg
     1621 gggtgagtgc agctgttgtg gttgctgaga tggcatctta cctggaaacc atgaatataa
     1681 cattgaaaca gcaactggtt aaggtttatg aaaaatatgg ttatcatatt tcaaaaactt
     1741 cctatttctt gtgttatgaa ccacctacca tcaaaagtat atttgaaagg cttcgtaatt
     1801 ttgattctcc aaaagaatat ccaaaatttt gtggaacatt tgctatattg catgtacggg
     1861 acgttaccac tggatatgac agtagccagc ctaataagaa atcagtgctg cctgtgagta
     1921 aaaacagcca aatgattaca tttacttttc aaaatggctg tgttgctacc cttcggacaa
     1981 gtggaacaga accaaagata aagtattatg cagagatgtg tgcgtcacct gaccagagtg
     2041 acactgcttt actggaggaa gaactgaaga aactcattga tgctctgata gagaattttc
     2101 ttcagcctag taagaatgga ctgatctggc gttctgttta ggggtacacc aatatgtcat
     2161 gacactgtgt gggcatatgg aacagagcaa ccgagaactg catacattga accttgtgtt
     2221 agcattctct ctctatctca tctggccgag tatctttttc cttttatttt ctttcttttt
     2281 ggtcaactgg ctagactaaa caaagtataa gtttgaaatg aaatggtcta gagggaaatg
     2341 attcaaattt tttcataatt caaacaaaag ttattacact aaaagtatta tagtaacgta
     2401 ttgtccttcc gttaacagaa acatcacaat tcaaaagtga gttttcttat tatagtgtga
     2461 ttaagcctag ttctgtatct cgtaattgtg tatagcatgg taaaagaaaa aaaaaaagac
     2521 aggtaaatgt tatataattg tagggttagt taaggaaatt agtccataaa attggcaaga
     2581 aaatggtact ttccttgatt gttatgaaaa agtgtcattg tgacatcaca ggtattaatt
     2641 tacaaattag agtatttgaa ataggatatt tagcatttct gtagtttaga acagatgtta
     2701 cagtgtgtgg ttttggcatg tctgtttcag gtgcccttgg tgcagtataa atttactgta
     2761 tgtatttaaa attctgatgt ttactgaaca taaaacaata gtggcaacac tcctattggc
     2821 tttgttctta tcaaatttct cagtgccttc tcagggtctg gtgtgaacag aaaaaacagt
     2881 gttcctgcat ttaccataat ttaatcagtc aatttgcaga tagctaagga aaatcttcca
     2941 aaatctgtag gtgcttcctc tatatcaagt gagtttgctg attttaaaat cttaggaata
     3001 taaataaaga tcttaataaa agcaagctta atgtagttaa ggatcttcat attagaattg
     3061 tgtcatttat caaacctttt attacagaaa aaaatctgaa ctgagaaagg agctctgaat
     3121 ttatttgaca gtctaacttt tgaattacat ttttgtaagt agatttattc ttttatttta
     3181 tgaagtaatg ttaattttac taagaataaa acatccaaat tttaagtatt atgaaatact
     3241 aaaactacat gttttaaaac agaggtccag tttattctaa catcttgctg acttctgtag
     3301 aatttctgat tgcatgacta ttatttatct tcttttagtg tagaaaataa ttttttacaa
     3361 aaagtcactt ttgggctggg cgcagtggct cacgcctgta atcccagcac tttgggaggc
     3421 tgaggcaggt ggatcacaat gtcaggagtt tgagactagc ctggccaata tggtgaaacc
     3481 ctgtctctac taaaaataca aaaattagcc gggtgtggtg gtgggcacct gtagtcccag
     3541 ctactcggga ggctgaggca ggagaattgc ttgaacctag gaggctgaga ttgcagtgag
     3601 ccgaaatcac gccactacac tccagcctgg gcaacagagg gagactccat ctcaaaaaaa
     3661 aaaaaagtca cttttggcta atcatgcagt cttctgaaaa ggtttaatag agaaatgctg
     3721 tttaggctgg gcttggtggc tcacatctgt aataccagcg ctttgggagg ctgaggcagg
     3781 aggattgctt gaggccagga gtttaagtta cagaactatg atcacactgc cgcactgaag
     3841 cctggatgac agagtgagac cttatctcaa aaaaaaaaaa aaaaagagag agagagagaa
     3901 aaagaaatgc tgtgtttaat cttcttaaaa tgtatcttgt cctacatagt tctcagaata
     3961 catatggggt atagttagga gataacaata acaagaccta aacaaattgc ttatgggaga
     4021 tagcactgta attagagaat ttatttcata taaaataata atataaagtt tgaactgatt
     4081 agaatgttcc ttaaatcatg gtttcgtttg ttgcagctgt cagctaacat ttggttgagc
     4141 tcatataatc caaacctaat tgtccaacta ttgtattgcc actattgtta atttgttcct
     4201 tccttacttt cttattgttg gatcttatat gactgtatga ctgtagataa tagacagcta
     4261 gctaaatgta gagcaccatt tttctcaatg agtttgtttt caaaggcttt gcactggaga
     4321 agatatgtgt agaatttttg ttttattttt aaaatgtgta aaacatcttt tgttttatat
     4381 gcttttaaga atgtagattg taatttagga aatggcatat attctgcaaa gtggtataat
     4441 gttgtatata tgaaaaacag gtatatttgg tttagttctg tgtttcagtg actgataaac
     4501 aaaaatgaag ctaaaatgaa tcaacggctc attcatagtt actaaagcca tgtcatgact
     4561 gtcattctat tatgaagaaa acagttttat ttgagtgctt taatataatg caacatttaa
     4621 gtcatcttaa ggtgaaaagt tattgaagtg ttcttctctc aagttaacaa aattttacaa
     4681 atgttcctga agtgtatcga ttgagggaat tattttattc tagcctgtca tgagtctgtc
     4741 tgagcatgat acttaacatg aacttgatgt agtaggtgca catttgccta acaggataaa
     4801 ttcagtgata gcccaagctg gtcaggagag acagaagtgc tggctaggag gtctcagcct
     4861 cgggcactac aatgtttatc tttttctttt tgaacaatat tgtgaaaatg attgcattct
     4921 cattgagcat gaaagtcaaa actggaattt tctaaagctt tggagaaaag gagagaatta
     4981 gtagggcaag atcaaagcat acattggaaa taaacagtag aaataagcaa acaatataaa
     5041 gagacacggg aaatgcttct cgtgaagggc aaatgtaaca ccataacagt agggaataaa
     5101 ctgtgtccca cctgtttact tgtgtttatt tgttgttatg atgagtatgc acctaccatt
     5161 ttcctttatt gtgatcacta aaatgaggcc aaggtttagg aggtgagaaa aagtatccct
     5221 tttacggatt cagttcctgc taggatgttg tatcagaatc atgtgagaac tcaggaagag
     5281 gtagagcaga aataaaaagg aagaaaatgt agattagaaa ataagacttc tgagaaaaag
     5341 ttcaaggaat aaagattgtt tgactctgga gaggagaaag ctgttgagat agtttgctaa
     5401 gtttgctaat aaagctttat tgagtctttt attgaagggt tcaaagtaag aaatactatg
     5461 ccatagtgtt ctccatctct agtgaagaca gaaccagagg gaataaggat ctttttttta
     5521 aagacagcat ggaaagttta agatttagga acttcttgag aaatcttcat aatatcttct
     5581 attcaaaatc ttttttttat ttttaaggga ataaaaattt taaaaattaa gagatataca
     5641 gatgactttt taagggtcct tctttccagc acattttttt taaaaactca ggttagaaca
     5701 aaaatgtcat aaagggcact aaaagtaaca tttgggtttc actccatatc tagaagaatt
     5761 tagctcacaa aacaattttt gtgtgttttg agtaactgat gcataagtgc aatgaataat
     5821 tttcctgctt cactgttatt tttaatttaa cctggcaaat taagtgagac ttgaacaaaa
     5881 ttttgttcat cttgaagaat gtatagtggc ttaggttatt tgaggttttc gttttgaata
     5941 tatatgttgt tattttgatg tagatacgtt agcagatgga gaggttctaa gagattggat
     6001 actttggaat gtctttatat aggaaataga cctcccattt cttaagcaag ttgcttctgg
     6061 aattgatgca acagggatat tagctgtagt ttaatggata agttgttcta tgagctgctg
     6121 ctatcagtac ttttttccac attttccatt gatatttgtg atgcttgaaa aatccaaact
     6181 tcacttggat acatttaatt ttatgccttt ttctctctac ctcccacttt tcctaggcac
     6241 ccttgcacat tttgttactg tgaaggacta ttgccctgtt acctcactga taagaaatct
     6301 caactgtatt cattcagaat gctttaagct tagtcataaa ctacatttgc ctatggacct
     6361 ttggttattt tgttaatgtt gtcattatat ttaagactta ttgtaggaag taattttaaa
     6421 tctatttcat aacctgtttt gatctgtctg catactgcta tatgttaatt tattacggcc
     6481 ttttacaatt cacttgtcat ctgagattgt tctagaaact gatgaggaaa gagtcgtact
     6541 aaccaaaatg aatgggcaat tgacataaca ttctatttca ggtttccttg tacttgggga
     6601 gccaaagcac aagatctaag gaaatcttat tcacatttgt ccctcagagc atcttaccct
     6661 aagccataga ggtataaata gtaagatgag aattgctcat tgtctgactc cttgcacagc
     6721 atgaatttaa ttctagttgg aaacaaagtt agtgttgact actggttacc ttaaagtatt
     6781 caccatacta tatatttatt agaccatctt tcctctttgt ttattcaaga ctatgtactt
     6841 ataaaagaga acctataaga atgtgtagag tgaccaaata gggacaaagt gacataccta
     6901 gagtttgctg ctcaaatttt tccactagcg taaccctaaa gcagaggggc atgatgaagg
     6961 gggaaggggt tctgagagca aaatcagaat cagcctacca ctgacatgaa gtgtgttctg
     7021 tctttaaaat gtaagtgaat tttgcattct ttataataaa acttttaata taaaaatgat
     7081 atgtttaatc tttactgaaa cttatgccac cacaaaggag caccatgttc atcacgtggc
     7141 tgctcagttt tctcccccag tgccctcacc cccagtggag gcaagtcctt gagctacaca
     7201 cactggctgt agtgcaagat atataaacat aggccgggct cggtggctca tgcctgtaat
     7261 cctagcactt tgggaggccg aagcaggtgg atcatctgag gtcgggagat tgagactagc
     7321 ctgaccgaca tggagaaacc ctgtgtccac taaaaataca aaattagccg ggtgtggtgg
     7381 cacatgcctg taatcccagc tactcgggag gctgaggcag gagaatcact tgaacccagg
     7441 aggtggaggt tgtggtgagc caagatcgcg ccgttgcact ccagcctggg caacaagagt
     7501 gaaactccat ctcaaaaaaa aaaaaaaaag atatataaac atagaacata tccagactat
     7561 ttcctgccct tggaatctga ccttcagaag gattaatgcc aaactaaact gacctgaaac
     7621 agttttgtta ctattggcat tccttgacta aaaaggacca cctgatgctc agtcccgaga
     7681 gtaggaatcg tggtttatta tttttcatat ccataccacc tagttcagta cctgttatag
     7741 agtgtttaat tgctgatact aggaattaag ggatttttta aaagtagcaa atagtttaag
     7801 gaacaatcaa aaaatgaatt ttctaattca gttttttcaa tgaagtccca tcactgaact
     7861 ttataatgta atgtttatta agcagacatc cccttaaata ctcagtttct ttggagagag
     7921 caaagcatat ctctctgtgg aaattatata taatgcctgg tattttacac tcaaagcaag
     7981 gtgttggcca ggaaggtaaa gaaatggtgt ctatgtagac ttaatatcac tagtctaagt
     8041 gtcattttga gcctagtagc actaccttcc aagtgagtca caacaaattt gatcctattt
     8101 ggtatgtttt tgtccactgt tatgattcat catgtatctt acaagagcca ctcaagcaag
     8161 actctgcttc tatgtatggt gaggccttgt tgttctaggc tagaataaac tctttgtatg
     8221 cctcattgaa tatgccaggt aaaatttatg cagtcaagaa tgaattattt ttctgactaa
     8281 agtgtgtagc agtagttcaa aattgtgccc ttgttttaac agtttctgtc aacatcttct
     8341 catttttccc tacaaaaaca ccagggtgta ttataagtac tgcctgtgag aatttgcact
     8401 ttatgtattt gtgtgtggat ttcttgtggt tttagccaaa tgaagtgtta tcagtaataa
     8461 acaggtctct tcatagg
//
