LOCUS       NM_020393               2129 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens peptidoglycan recognition protein 4 (PGLYRP4), mRNA.
ACCESSION   NM_020393
VERSION     NM_020393.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Dabrowski,A.N., Shrivastav,A., Conrad,C., Komma,K., Weigel,M.,
            Dietert,K., Gruber,A.D., Bertrams,W., Wilhelm,J., Schmeck,B.,
            Reppe,K., N'Guessan,P.D., Aly,S., Suttorp,N., Hain,T. and
            Zahlten,J.
  TITLE     Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and
            Inflammation in Lungs by Control of the Gut Microbiota
  JOURNAL   Front Immunol 10, 2106 (2019)
   PUBMED   31616404
  REMARK    GeneRIF: Peptidoglycan Recognition Protein 4 Limits Bacterial
            Clearance and Inflammation in Lungs by Control of the Gut
            Microbiota.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Hua,X., Yuan,X., Li,Z., Coursey,T.G., Pflugfelder,S.C. and Li,D.Q.
  TITLE     A Novel Innate Response of Human Corneal Epithelium to Heat-killed
            Candida albicans by Producing Peptidoglycan Recognition Proteins
  JOURNAL   PLoS One 10 (6), e0128039 (2015)
   PUBMED   26039076
  REMARK    GeneRIF: a significant induction of three PGLYRPs 2-4 in primary
            human corneal epithelial cells (HCECs) exposed to live or
            heat-killed Candida albicans, is reported.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Goldman,S.M., Kamel,F., Ross,G.W., Jewell,S.A., Marras,C.,
            Hoppin,J.A., Umbach,D.M., Bhudhikanok,G.S., Meng,C., Korell,M.,
            Comyns,K., Hauser,R.A., Jankovic,J., Factor,S.A., Bressman,S.,
            Lyons,K.E., Sandler,D.P., Langston,J.W. and Tanner,C.M.
  TITLE     Peptidoglycan recognition protein genes and risk of Parkinson's
            disease
  JOURNAL   Mov Disord 29 (9), 1171-1180 (2014)
   PUBMED   24838182
  REMARK    GeneRIF: This study demonistrated that PGLYRP4 single-nucleotide
            polymorphisms is risk of Parkinson's disease.
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Cho,S., Wang,Q., Swaminathan,C.P., Hesek,D., Lee,M., Boons,G.J.,
            Mobashery,S. and Mariuzza,R.A.
  TITLE     Structural insights into the bactericidal mechanism of human
            peptidoglycan recognition proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 8761-8766 (2007)
   PUBMED   17502600
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Lu,X., Wang,M., Qi,J., Wang,H., Li,X., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins are a new class of human
            bactericidal proteins
  JOURNAL   J Biol Chem 281 (9), 5895-5907 (2006)
   PUBMED   16354652
  REMARK    GeneRIF: Results describe the function of mammalian antimicrobial
            peptidoglycan recognition proteins 3 and 4, and show that they are
            a new class of bactericidal and bacteriostatic proteins.
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   Sun,C., Mathur,P., Dupuis,J., Tizard,R., Ticho,B., Crowell,T.,
            Gardner,H., Bowcock,A.M. and Carulli,J.
  TITLE     Peptidoglycan recognition proteins Pglyrp3 and Pglyrp4 are encoded
            from the epidermal differentiation complex and are candidate genes
            for the Psors4 locus on chromosome 1q21
  JOURNAL   Hum Genet 119 (1-2), 113-125 (2006)
   PUBMED   16362825
  REMARK    GeneRIF: Data are consistent with previous reports of association
            of psoriasis with genes on 1q21, and suggest a role for Pglyrp4 in
            skin biology.
REFERENCE   8  (bases 1 to 2129)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292203.1, BC142636.1 and
            AF242518.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020393.3.
            
            Summary: Summary: This gene encodes a peptidoglycan recognition
            protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2
            family. These proteins are part of the innate immune system and
            recognize peptidoglycan, a ubiquitous component of bacterial cell
            walls. This antimicrobial protein binds to murein peptidoglycans of
            Gram-positive bacteria. [provided by RefSeq, Oct 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292203.1, BC142636.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000359650.10/
                                                  ENSP00000352672.5
            Protein has antimicrobial activity :: PMID: 16354652
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK292203.1         1-25
            26-1939             BC142636.1         1-1914
            1940-2129           AF242518.1         1650-1839
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2129
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /note="peptidoglycan recognition protein 4"
                     /db_xref="GeneID:57115"
                     /db_xref="HGNC:HGNC:30015"
                     /db_xref="MIM:608198"
     exon            1..314
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            315..409
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1482
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /note="PGRP-I-beta; peptidoglycan recognition protein
                     I-beta; peptidoglycan recognition protein intermediate
                     beta"
                     /codon_start=1
                     /product="peptidoglycan recognition protein 4 precursor"
                     /protein_id="NP_065126.2"
                     /db_xref="CCDS:CCDS30871.1"
                     /db_xref="GeneID:57115"
                     /db_xref="HGNC:HGNC:30015"
                     /db_xref="MIM:608198"
                     /translation="MLPWLLVFSALGIQAWGDSSWNKTQAKQVSEGLQYLFENISQLT
                     EKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLREL
                     QAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHS
                     PSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSV
                     WGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNF
                     LVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAM
                     VKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH"
     exon            410..499
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            500..713
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            714..832
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            833..985
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1184
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1303
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..2129
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /note="hexamer: AATGAA"
     polyA_site      2129
                     /gene="PGLYRP4"
                     /gene_synonym="PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67"
                     /note="major polyA site"
ORIGIN      
        1 acttgcattt ctccaggtgc tgtgaaagga gctggctcag agccttgccc tctgtcttcc
       61 cttctcccca tcttttgtta gggatcctgg gctctcttct ctctgggaag ctagagcccg
      121 agtgctccat tcccagggag ggagtgccct ctagggctag ggagagtgaa ggctggagga
      181 gaaggcgcca gttggtgaag aagggcaggg cctggaggcc aagtctggaa gggaaggagc
      241 tgctggccaa tcaggggcaa gctgactgca ccctgacctg ctgggctggg acagcacagg
      301 acccacagat atctgctgcc atccacactc tccagattgg tgtcctggga ccacgtgggg
      361 atgctgccgt ggcttcttgt cttctctgct ctgggtatcc aggcctgggg tgattcctcc
      421 tggaacaaaa cacaagctaa acaggtatca gaggggctcc agtacctatt tgagaacatc
      481 tcccagctca ctgaaaaagg ccttcccaca gatgtctcca ccacggtctc tcgcaaggca
      541 tggggggcag aagctgttgg ctgcagtatt cagctgacca cgccagtgaa tgtccttgtt
      601 atacaccatg tccctggact ggagtgtcac gaccagacag tctgcagcca gagactgcgg
      661 gaactgcagg cccatcatgt ccacaacaac agtgggtgtg atgtggccta caacttcctg
      721 gttggggatg atggcagggt gtatgaaggt gttggctgga atatccaagg agtgcacacc
      781 caaggctaca acaacatctc cctgggcttt gccttctttg gcactaagaa aggccacagt
      841 cccagccctg ctgccctgtc ggccatggaa aacctaatca cctatgctgt ccagaagggc
      901 cacctgtcat ccagttatgt tcagccactt cttgggaaag gcgagaactg cctggcccct
      961 cggcagaaga caagcctgaa gaaggcttgc cccggcgttg tcccacggtc tgtgtgggga
     1021 gccagggaga cccactgtcc caggatgact ctcccagcga agtatggcat cattatccac
     1081 actgccggga ggacctgcaa catttctgat gagtgccgcc tgctggtccg ggacatccag
     1141 tctttctaca tagacaggct caagtcatgc gacattggtt ataacttcct ggtgggccag
     1201 gatggcgcca tttatgaagg ggtgggctgg aatgtccaag gctcctccac ccctggctac
     1261 gatgacattg ccctgggcat taccttcatg ggcaccttca caggtatacc acccaatgct
     1321 gcagcactag aggcagccca agacctgatc cagtgtgcca tggtcaaagg gtacctgact
     1381 cccaactacc tgctggtggg ccacagtgat gtggcccgaa ccttgtctcc tgggcaggct
     1441 ttgtacaaca tcatcagcac ctggcctcat ttcaaacact gagagaagcc ccaggtcctt
     1501 ctgagactgc tttccctccc ctgtcaggtc tctcctgtcc taaccatcca gcttggctca
     1561 acaccttttg ccctcctccc ctgccacaca gtcctgtgcc tcctttttca ggttgggatg
     1621 atcatgccct ctcctgccaa catcctccaa gggcctccaa acctcatagc tggacattca
     1681 cagccctctg agtctgagtc cagatttctt ctctccttac cttcctctcc cttggaaacc
     1741 caactcctca gccaggtgag acaatgggct ggttcttgtt tcatttctct ctctctctcc
     1801 attcccctct gcctggtgag ccttcccctg gtgtctgcct ggcagccccc acctcccacc
     1861 tatcacccct cacccataac tcaggtcaac gtgaccaacc ttccttgctt acacataaac
     1921 ttgtatatat ttggatgtag cccttattta atggctgtca ttatttatag atatgtctat
     1981 ccttgctact tggttgtgag tttctccagg ggaggaactg tgttttattc atctctatgt
     2041 cctctgtttc tcagcagtgt ctgaaattta atgggttcta ctgatgttta ttagagaaat
     2101 ggatgaataa atgaatgaag agatccaaa
//
