LOCUS       NM_052891               2217 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens peptidoglycan recognition protein 3 (PGLYRP3), mRNA.
ACCESSION   NM_052891 XM_011509119
VERSION     NM_052891.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2217)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2217)
  AUTHORS   Hua,X., Yuan,X., Li,Z., Coursey,T.G., Pflugfelder,S.C. and Li,D.Q.
  TITLE     A Novel Innate Response of Human Corneal Epithelium to Heat-killed
            Candida albicans by Producing Peptidoglycan Recognition Proteins
  JOURNAL   PLoS One 10 (6), e0128039 (2015)
   PUBMED   26039076
  REMARK    GeneRIF: a significant induction of three PGLYRPs 2-4 in primary
            human corneal epithelial cells (HCECs) exposed to live or
            heat-killed Candida albicans, is reported.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2217)
  AUTHORS   Lu,X., Wang,M., Qi,J., Wang,H., Li,X., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins are a new class of human
            bactericidal proteins
  JOURNAL   J Biol Chem 281 (9), 5895-5907 (2006)
   PUBMED   16354652
  REMARK    GeneRIF: Results describe the function of mammalian antimicrobial
            peptidoglycan recognition proteins 3 and 4, and show that they are
            a new class of bactericidal and bacteriostatic proteins.
REFERENCE   7  (bases 1 to 2217)
  AUTHORS   Guan,R., Roychowdury,A., Ember,B., Kumar,S., Boons,G.J. and
            Mariuzza,R.A.
  TITLE     Crystal structure of a peptidoglycan recognition protein (PGRP) in
            complex with a muramyl tripeptide from Gram-positive bacteria
  JOURNAL   J Endotoxin Res 11 (1), 41-46 (2005)
   PUBMED   15826377
REFERENCE   8  (bases 1 to 2217)
  AUTHORS   Guan,R., Roychowdhury,A., Ember,B., Kumar,S., Boons,G.J. and
            Mariuzza,R.A.
  TITLE     Structural basis for peptidoglycan binding by peptidoglycan
            recognition proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (49), 17168-17173 (2004)
   PUBMED   15572450
REFERENCE   9  (bases 1 to 2217)
  AUTHORS   Guan,R., Malchiodi,E.L., Wang,Q., Schuck,P. and Mariuzza,R.A.
  TITLE     Crystal structure of the C-terminal peptidoglycan-binding domain of
            human peptidoglycan recognition protein Ialpha
  JOURNAL   J Biol Chem 279 (30), 31873-31882 (2004)
   PUBMED   15140887
REFERENCE   10 (bases 1 to 2217)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591704.7 and AL161636.21.
            
            On or before Jul 8, 2020 this sequence version replaced
            XM_011509119.1, NM_052891.2.
            
            Summary: This gene encodes a peptidoglycan recognition protein,
            which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
            These proteins are part of the innate immune system and recognize
            peptidoglycan, a ubiquitous component of bacterial cell walls. This
            antimicrobial protein binds to murein peptidoglycans of
            Gram-positive bacteria. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC069798.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000683862.1/
                                                  ENSP00000507327.1
            Protein has antimicrobial activity :: PMID: 16354652
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AL591704.7         8283-8592           c
            311-406             AL591704.7         6251-6346           c
            407-608             AL591704.7         2706-2907           c
            609-727             AL161636.21        136299-136417       c
            728-880             AL161636.21        135209-135361       c
            881-1079            AL161636.21        133761-133959       c
            1080-1198           AL161636.21        130465-130583       c
            1199-2217           AL161636.21        128468-129486       c
FEATURES             Location/Qualifiers
     source          1..2217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2217
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /note="peptidoglycan recognition protein 3"
                     /db_xref="GeneID:114771"
                     /db_xref="HGNC:HGNC:30014"
                     /db_xref="MIM:608197"
     exon            1..310
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     exon            311..406
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1377
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /note="peptidoglycan recognition protein I alpha;
                     peptidoglycan recognition protein intermediate alpha"
                     /codon_start=1
                     /product="peptidoglycan recognition protein 3 precursor"
                     /protein_id="NP_443123.1"
                     /db_xref="CCDS:CCDS1035.1"
                     /db_xref="GeneID:114771"
                     /db_xref="HGNC:HGNC:30014"
                     /db_xref="MIM:608197"
                     /translation="MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPV
                     AYIITDQLPGMQCQQQSVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWN
                     IQGLHTQGYNNISLGIAFFGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLL
                     KEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVST
                     DCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIA
                     FIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIIS
                     TWPHFKH"
     exon            407..608
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     exon            609..727
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     exon            728..880
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1079
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1198
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2217
                     /gene="PGLYRP3"
                     /gene_synonym="PGLYRPIalpha; PGRP-Ialpha; PGRPIA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaagtttc tctgggtgct gtaaacagag ctggcttgga gcctcagccc tctgcctttc
       61 tcttctcttc catcttttgt tagggatcct gggctctcct cttctctctg ggaagccaga
      121 gcccaagtgc tccattccca gggagggagt gccctctagg gccaggggga gtgaaggcct
      181 gaggaggcac cagctggaga agaagggcag gtcctggagg ccaagtctgg aagggaagga
      241 gctgctggcc aatcaggggc gagccgactg caccctgacc tgctgggctg gaacagcaca
      301 gaacccacag ggctgccgtc cacactctcc cggtcagagt cctgggacca catggggacg
      361 ctgccatggc ttcttgcctt cttcattctg ggtctccagg cttgggatac tcccaccatc
      421 gtctcccgca aggagtgggg ggcaagaccg ctcgcctgca gggccctgct gaccctgcct
      481 gtggcctaca tcatcacaga ccagctccca gggatgcagt gccagcagca gagcgtttgc
      541 agccagatgc tgcgggggtt gcagtcccat tccgtctaca ccataggctg gtgcgacgtg
      601 gcgtacaact tcctggttgg ggatgatggc agggtgtatg aaggtgttgg ctggaacatc
      661 caaggcttgc acacccaggg ctacaacaac atttccctgg gcatcgcctt ctttggcaat
      721 aagataggca gcagtcccag ccctgctgcc ttatcagctg cagagggtct gatctcctat
      781 gccatccaga agggtcacct gtcgcccagg tatattcagc cacttcttct gaaagaagag
      841 acctgcctgg accctcaaca tccagtgatg cccaggaagg tttgccccaa catcatcaaa
      901 cgatctgctt gggaagccag agagacacac tgccctaaaa tgaacctccc agccaaatat
      961 gtcatcatca tccacaccgc tggcacaagc tgcactgtat ccacagactg ccagactgtc
     1021 gtccgaaaca tacagtcctt tcacatggac acacggaact tttgtgacat tggatatcac
     1081 ttcctggtgg gccaggatgg tggcgtgtat gaaggggttg gatggcacat ccaaggctct
     1141 cacacttatg gattcaacga tattgcccta ggaattgcct tcatcggcta ctttgtagaa
     1201 aagcctccaa atgctgcagc gctggaggcg gcccaggacc tgatccagtg tgccgtggtt
     1261 gaggggtacc tgactccaaa ctacctgctg atgggccaca gtgacgtggt caacatcctg
     1321 tcccctgggc aggctttgta taacatcatc agcacctggc ctcatttcaa gcactgaagg
     1381 aggccccact ccctttgaga ctgccctccc tcccctgctg ggtctctcca accctcacca
     1441 gccaaggtgg ctcagcacct tgtgtccccc tcccctgcca gcccatcctt tctcaggttt
     1501 gaatggtcat gtcctttcct gccaacatcc tccaggagcc cccaaacctc acagctgggc
     1561 attcacagcc ctcttggtct gagtttagac ttcccctctc ttttacctac ctctcccctg
     1621 ggcacttacc tcctcagtca ggcgagacaa tgggctggtc cttgtggcat ttctctctct
     1681 ctccccccaa cccctgtctc ctcttctttc tttctttgct tcctttctct ttctttcttt
     1741 ctttctttct tctttctttc tttctttctt tttctttctt tccttccttc cttccttcct
     1801 tccttccttc cttccttcct tccttccttc ctttcacctt ctttcttgct ttctcactct
     1861 ctctctctct ctctctctct ccccctctcc ccgcctctgc ctggtgagcc ttccctgttt
     1921 tctgcctgga agcccccacc cttcatccct cacccatgac ctaggtcagt gtgcccaccc
     1981 cccctctctg ctcacacatg gactggtaca tatttggatg cagcccttac ttaagggctg
     2041 taattattta tagatatgat ttatagatat gtctgtcctc tcctctgggt tgtaagtttc
     2101 tccaagggag gaattctatt ttattcatct ctatcctcag ttcctcagca gtgtttggag
     2161 tttaataggt tctacagatg tttgttaaag aaatggatga ataaatgaat gagtgga
//
