LOCUS       NM_052890               1879 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens peptidoglycan recognition protein 2 (PGLYRP2),
            transcript variant 1, mRNA.
ACCESSION   NM_052890
VERSION     NM_052890.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Luan,M., Jin,J., Wang,Y., Li,X. and Xie,A.
  TITLE     Association of PGLYRP2 gene polymorphism and sporadic Parkinson's
            disease in northern Chinese Han population
  JOURNAL   Neurosci Lett 775, 136547 (2022)
   PUBMED   35218888
  REMARK    GeneRIF: Association of PGLYRP2 gene polymorphism and sporadic
            Parkinson's disease in northern Chinese Han population.
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Huang,F., Liu,X., Cheng,Y., Sun,X., Li,Y., Zhao,J., Cao,D., Wu,Q.,
            Pan,X., Deng,H., Tian,M. and Li,Z.
  TITLE     Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel
            biomarker in rheumatoid arthritis
  JOURNAL   Clin Exp Rheumatol 39 (5), 988-994 (2021)
   PUBMED   33427621
  REMARK    GeneRIF: Antibody to peptidoglycan recognition protein (PGLYRP)-2
            as a novel biomarker in rheumatoid arthritis.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Li,H., Meng,D., Jia,J. and Wei,H.
  TITLE     PGLYRP2 as a novel biomarker for the activity and lipid metabolism
            of systemic lupus erythematosus
  JOURNAL   Lipids Health Dis 20 (1), 95 (2021)
   PUBMED   34461924
  REMARK    GeneRIF: PGLYRP2 as a novel biomarker for the activity and lipid
            metabolism of systemic lupus erythematosus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Chen,J., Han,Y.S., Yi,W.J., Huang,H., Li,Z.B., Shi,L.Y., Wei,L.L.,
            Yu,Y., Jiang,T.T. and Li,J.C.
  TITLE     Serum sCD14, PGLYRP2 and FGA as potential biomarkers for
            multidrug-resistant tuberculosis based on data-independent
            acquisition and targeted proteomics
  JOURNAL   J Cell Mol Med 24 (21), 12537-12549 (2020)
   PUBMED   32967043
  REMARK    GeneRIF: Serum sCD14, PGLYRP2 and FGA as potential biomarkers for
            multidrug-resistant tuberculosis based on data-independent
            acquisition and targeted proteomics.
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Kibardin,A.V., Mirkina,I.I., Zakeeva,I.R., Baranova,E.V.,
            Georgiev,G.P. and Kiselev,S.L.
  TITLE     [Expression analysis of proteins encoded by genes of the tag7/tagL
            (PGRP-S,L) family in human peripheral blood cells]
  JOURNAL   Genetika 39 (2), 244-249 (2003)
   PUBMED   12669421
  REMARK    GeneRIF: Various types of human blood cells were tested for
            expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which
            belong to the family of proteins possessing the lysozyme-like
            peptidoglycan recognition protein (PGRP) domain
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   De Pauw,P., Neyt,C., Vanderwinkel,E., Wattiez,R. and Falmagne,P.
  TITLE     Characterization of human serum N-acetylmuramyl-L-alanine amidase
            purified by affinity chromatography
  JOURNAL   Protein Expr Purif 6 (3), 371-378 (1995)
   PUBMED   7663175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB041324.1 and AF384856.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052890.3.
            
            Summary: This gene encodes a peptidoglycan recognition protein,
            which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
            This protein hydrolyzes the link between N-acetylmuramoyl residues
            and L-amino acid residues in bacterial cell wall glycopeptides, and
            thus may play a scavenger role by digesting biologically active
            peptidoglycan into biologically inactive fragments. [provided by
            RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073610.1, AK292292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340880.5/ ENSP00000345968.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               DB041324.1         4-107
            105-1879            AF384856.1         1-1775
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1879
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /note="peptidoglycan recognition protein 2"
                     /db_xref="GeneID:114770"
                     /db_xref="HGNC:HGNC:30013"
                     /db_xref="MIM:608199"
     exon            1..191
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1861
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /EC_number="3.5.1.28"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peptidoglycan recognition protein L;
                     N-acetylmuramoyl-L-alanine amidase; peptidoglycan
                     recognition protein long"
                     /codon_start=1
                     /product="N-acetylmuramoyl-L-alanine amidase isoform 1
                     precursor"
                     /protein_id="NP_443122.3"
                     /db_xref="CCDS:CCDS12330.2"
                     /db_xref="GeneID:114770"
                     /db_xref="HGNC:HGNC:30013"
                     /db_xref="MIM:608199"
                     /translation="MAQGVLWILLGLLLWSDPGTASLPLLMDSVIQALAELEQKVPAA
                     KTRHTASAWLMSAPNSGPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDV
                     REGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVA
                     IAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSL
                     LAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGA
                     LDGVILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQ
                     QVWGTLVLLQRLEPVHLQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAP
                     YRGRPKLLQLPLGFLYVHHTYVPAPPCTDFTRCAANMRSMQRYHQDTQGWGDIGYSFV
                     VGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAALPTEAALRTVRDTLPSCAV
                     RAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKRSRREPP
                     PRTLPATDLQ"
     exon            192..1262
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1473
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1771
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1879
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /note="hexamer: AATAAA"
     polyA_site      1879
                     /gene="PGLYRP2"
                     /gene_synonym="HMFT0141; PGLYRPL; PGRP-L; PGRPL; tagL;
                     tagL-alpha; tagl-beta; TAGL-like"
                     /note="major polyA site"
ORIGIN      
        1 attcgccgct ggactttgac agtggtcaaa ggctctgctc agttctctgt gcctgtctcc
       61 ctccagcact gccgaggttc tctgccgagg ccaaccagaa ataccccttg gaagctggaa
      121 tcctgcaaca atggcccagg gtgtcctctg gatcctactc ggattgctac tgtggtcaga
      181 cccagggaca gcctccctgc ccctgctcat ggactctgtc atccaggccc tggctgagct
      241 ggagcagaaa gtgccagctg ccaagaccag acacacagct tctgcgtggc tgatgtcagc
      301 tccaaactct ggcccccaca atcgcctcta ccacttcctg ctgggggcat ggagcctcaa
      361 tgctacagag ttggatccct gcccactaag cccagagctg ttaggcctga ccaaggaggt
      421 ggcccgacat gacgtacgag aagggaagga atatggggtg gtgctggcac ctgatggctc
      481 gaccgtggct gtggagcctc tgctggcggg gctggaggca gggctgcaag ggcgcagggt
      541 cataaatttg cccttggaca gcatggctgc cccttgggag actggagata cctttccaga
      601 tgttgtggcc attgctccag atgtaagagc cacctcctcc ccaggactca gggatggctc
      661 tccagatgtc accactgcag atattggagc caacactcca gatgctacaa aaggctgtcc
      721 agatgtccaa gcttccttgc cagatgccaa agccaagtcc ccaccgacca tggtggacag
      781 cctcctggca gtcaccctgg ctggaaacct gggcctgacc ttcctccgag gttcccagac
      841 ccagagccat ccagacctgg gaactgaggg ctgctgggac cagctctctg cccctcggac
      901 ctttacgctt ttggacccca aggcatctct gttaaccatg gccttcctca atggcgccct
      961 ggatggggtc atccttggag actacctgag ccggactcct gagccccggc catccctcag
     1021 ccacttgctg agccagtact atggggctgg ggtggccaga gacccagggt tccgcagcaa
     1081 cttccgacgg cagaacggtg ctgctctgac ttcagcctcc atcctggccc agcaggtgtg
     1141 gggaaccctt gtccttctac agaggctgga gccagtacac ctccagcttc agtgcatgag
     1201 ccaagaacag ctggcccagg tggctgccaa tgctaccaag gaattcactg aggccttcct
     1261 gggatgcccg gccatccacc cccgctgccg ctggggagcg gcgccttatc ggggccgccc
     1321 gaagctgctg cagctgccgc tgggattctt gtacgtgcat cacacctacg tgcctgcacc
     1381 accctgcacg gacttcacgc gctgcgcagc caacatgcgc tccatgcagc gctaccacca
     1441 ggacacgcaa ggctggggag acatcggcta cagtttcgtg gtgggctcgg acggctacgt
     1501 gtacgaggga cgcggctggc actgggtggg cgcccacacg ctcggccaca actcccgggg
     1561 cttcggcgtg gccatagtgg gcaactacac cgcggcgctg cccaccgagg ccgctctgcg
     1621 cacggtgcgc gacacgctcc cgagttgtgc ggtgcgcgcc ggcctcctgc ggccagacta
     1681 cgcgctgctg ggccaccgcc agctggtgcg caccgactgc cccggcgacg cgctcttcga
     1741 cctgctgcgc acctggccgc acttcaccgc gactgttaag ccaagacctg ccaggagtgt
     1801 ctctaagaga tccaggaggg agccaccccc aaggaccctg ccagccacag acctccaata
     1861 aagacagcat ggaaacaaa
//
