LOCUS       NM_005091                708 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.
ACCESSION   NM_005091
VERSION     NM_005091.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Bhusal,A., Kim,J.H., Kim,S.C., Hwang,E.M., Ryu,H., Ali,M.S.,
            Park,S.C., Lee,W.H. and Suk,K.
  TITLE     The microglial innate immune protein PGLYRP1 mediates
            neuroinflammation and consequent behavioral changes
  JOURNAL   Cell Rep 43 (3), 113813 (2024)
   PUBMED   38393947
  REMARK    GeneRIF: The microglial innate immune protein PGLYRP1 mediates
            neuroinflammation and consequent behavioral changes.
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Yakar,N., Emingil,G., Turedi,A., Sahin,C., Kose,T., Bostanci,N. and
            Silbereisen,A.
  TITLE     Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1beta
            levels during menopause
  JOURNAL   J Periodontal Res 58 (5), 1052-1060 (2023)
   PUBMED   37529985
  REMARK    GeneRIF: Value of gingival crevicular fluid TREM-1, PGLYRP1, and
            IL-1beta levels during menopause.
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Rathnayake,N., Gustafsson,A., Sorsa,T., Norhammar,A. and
            Bostanci,N.
  CONSRTM   PAROKRANK Steering Committee
  TITLE     Association of peptidoglycan recognition protein 1 to
            post-myocardial infarction and periodontal inflammation: A subgroup
            report from the PAROKRANK (Periodontal Disease and the Relation to
            Myocardial Infarction) study
  JOURNAL   J Periodontol 93 (9), 1325-1335 (2022)
   PUBMED   35344208
  REMARK    GeneRIF: Association of peptidoglycan recognition protein 1 to
            post-myocardial infarction and periodontal inflammation: A subgroup
            report from the PAROKRANK (Periodontal Disease and the Relation to
            Myocardial Infarction) study.
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Cui,X., Chang,Z., Dang,T., Meng,J., Wang,P., Wu,J. and Chai,J.
  TITLE     TNF upregulates peptidoglycan recognition protein 1 in esophageal
            cancer cells to clear the path to its signaling: Making the 'enemy'
            a friend
  JOURNAL   Arch Biochem Biophys 722, 109192 (2022)
   PUBMED   35367194
  REMARK    GeneRIF: TNF upregulates peptidoglycan recognition protein 1 in
            esophageal cancer cells to clear the path to its signaling: Making
            the ''enemy'' a friend.
REFERENCE   5  (bases 1 to 708)
  AUTHORS   Sharapova,T.N., Ivanova,O.K., Romanova,E.A., Sashchenko,L.P. and
            Yashin,D.V.
  TITLE     N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1
            Receptor
  JOURNAL   Int J Mol Sci 23 (10), 5752 (2022)
   PUBMED   35628562
  REMARK    GeneRIF: N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for
            TREM-1 Receptor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 708)
  AUTHORS   Wang,Z.M., Li,X., Cocklin,R.R., Wang,M., Wang,M., Fukase,K.,
            Inamura,S., Kusumoto,S., Gupta,D. and Dziarski,R.
  TITLE     Human peptidoglycan recognition protein-L is an
            N-acetylmuramoyl-L-alanine amidase
  JOURNAL   J Biol Chem 278 (49), 49044-49052 (2003)
   PUBMED   14506276
  REMARK    GeneRIF: identification as an N-acetylmuramoyl-l-alanine amidase
            and this function is conserved in prokaryotes, insects, and mammals
REFERENCE   7  (bases 1 to 708)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 708)
  AUTHORS   Kibardin,A.V., Mirkina,I.I., Zakeeva,I.R., Baranova,E.V.,
            Georgiev,G.P. and Kiselev,S.L.
  TITLE     [Expression analysis of proteins encoded by genes of the tag7/tagL
            (PGRP-S,L) family in human peripheral blood cells]
  JOURNAL   Genetika 39 (2), 244-249 (2003)
   PUBMED   12669421
  REMARK    GeneRIF: Various types of human blood cells were tested for
            expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which
            belong to the family of proteins possessing the lysozyme-like
            peptidoglycan recognition protein (PGRP) domain
REFERENCE   9  (bases 1 to 708)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
REFERENCE   10 (bases 1 to 708)
  AUTHORS   Kang,D., Liu,G., Lundstrom,A., Gelius,E. and Steiner,H.
  TITLE     A peptidoglycan recognition protein in innate immunity conserved
            from insects to humans
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10078-10082 (1998)
   PUBMED   9707603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN998360.1 and AF242517.1.
            
            On Nov 24, 2018 this sequence version replaced NM_005091.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF242517.1, AY358936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000008938.5/ ENSP00000008938.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DN998360.1         282-290
            10-708              AF242517.1         7-705
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..708
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /note="peptidoglycan recognition protein 1"
                     /db_xref="GeneID:8993"
                     /db_xref="HGNC:HGNC:8904"
                     /db_xref="MIM:604963"
     exon            1..319
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..623
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /note="TNF superfamily, member 3 (LTB)-like (peptidoglycan
                     recognition protein)"
                     /codon_start=1
                     /product="peptidoglycan recognition protein 1 precursor"
                     /protein_id="NP_005082.1"
                     /db_xref="CCDS:CCDS12680.1"
                     /db_xref="GeneID:8993"
                     /db_xref="HGNC:HGNC:8904"
                     /db_xref="MIM:604963"
                     /translation="MSRRSMLLAWALPSLLRLGAAQETEDPACCSPIVPRNEWKALAS
                     ECAQHLSLPLRYVVVSHTAGSSCNTPASCQQQARNVQHYHMKTLGWCDVGYNFLIGED
                     GLVYEGRGWNFTGAHSGHLWNPMSIGISFMGNYMDRVPTPQAIRAAQGLLACGVAQGA
                     LRSNYVLKGHRDVQRTLSPGNQLYHLIQNWPHYRSP"
     exon            320..441
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /inference="alignment:Splign:2.1.0"
     exon            442..708
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      689..694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /note="hexamer: AATAAA"
     polyA_site      708
                     /gene="PGLYRP1"
                     /gene_synonym="PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L"
                     /note="major polyA site"
ORIGIN      
        1 agcggtctcc cggaccctgc cgccctgcca ctatgtcccg ccgctctatg ctgcttgcct
       61 gggctctccc cagcctcctt cgactcggag cggctcagga gacagaagac ccggcctgct
      121 gcagccccat agtgccccgg aacgagtgga aggccctggc atcagagtgc gcccagcacc
      181 tgagcctgcc cttacgctat gtggtggtat cgcacacggc gggcagcagc tgcaacaccc
      241 ccgcctcgtg ccagcagcag gcccggaatg tgcagcacta ccacatgaag acactgggct
      301 ggtgcgacgt gggctacaac ttcctgattg gagaagacgg gctcgtatac gagggccgtg
      361 gctggaactt cacgggtgcc cactcaggtc acttatggaa ccccatgtcc attggcatca
      421 gcttcatggg caactacatg gatcgggtgc ccacacccca ggccatccgg gcagcccagg
      481 gtctactggc ctgcggtgtg gctcagggag ccctgaggtc caactatgtg ctcaaaggac
      541 accgggatgt gcagcgtaca ctctctccag gcaaccagct ctaccacctc atccagaatt
      601 ggccacacta ccgctccccc tgaggccctg ctgatccgca ccccattcct cccctcccat
      661 ggccaaaaac cccactgtct ccttctccaa taaagatgta gctcaaaa
//
